المؤلفون: Bebber CM; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Clinic I for Internal Medicine, Medical Faculty, University Hospital of Cologne, Cologne, Germany., Thomas ES; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Imperial College London, London, UK., Stroh J; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany., Chen Z; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany., Androulidaki A; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany., Schmitt A; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Clinic I for Internal Medicine, Medical Faculty, University Hospital of Cologne, Cologne, Germany., Höhne MN; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Department for Chemistry, Institute for Biochemistry, University of Cologne, Cologne, Germany., Stüker L; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany., de Pádua Alves C; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany., Khonsari A; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; Institute of Pathology, Medical Faculty, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, Medical Faculty, University Hospital of Cologne, Cologne, Germany., Dammert MA; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; Institute of Pathology, Medical Faculty, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, Medical Faculty, University Hospital of Cologne, Cologne, Germany., Parmaksiz F; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; Institute of Pathology, Medical Faculty, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, Medical Faculty, University Hospital of Cologne, Cologne, Germany., Tumbrink HL; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; Institute of Pathology, Medical Faculty, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, Medical Faculty, University Hospital of Cologne, Cologne, Germany., Beleggia F; Clinic I for Internal Medicine, Medical Faculty, University Hospital of Cologne, Cologne, Germany., Sos ML; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; Institute of Pathology, Medical Faculty, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, Medical Faculty, University Hospital of Cologne, Cologne, Germany., Riemer J; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Department for Chemistry, Institute for Biochemistry, University of Cologne, Cologne, Germany., George J; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany., Brodesser S; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany., Thomas RK; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; Institute of Pathology, Medical Faculty, University Hospital of Cologne, Cologne, Germany.; DKFZ, German Cancer Research Center, German Cancer Consortium (DKTK), Heidelberg, Germany., Reinhardt HC; Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, German Cancer Consortium (DKTK partner site Essen), Essen, Germany., von Karstedt S; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany. s.vonkarstedt@uni-koeln.de.; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany. s.vonkarstedt@uni-koeln.de.; Center for Molecular Medicine Cologne, Medical Faculty, University Hospital of Cologne, Cologne, Germany. s.vonkarstedt@uni-koeln.de.

المصدر: Nature communications [Nat Commun] 2021 Apr 06; Vol. 12 (1), pp. 2048. Date of Electronic Publication: 2021 Apr 06.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Ferroptosis*, Neuroendocrine Tumors/*pathology , Small Cell Lung Carcinoma/*pathology, Animals ; Antioxidants/metabolism ; Apoptosis ; Biomarkers, Tumor/metabolism ; Cell Line, Tumor ; Cell Survival ; Humans ; Lipid Metabolism ; Male ; Mice, Nude ; Models, Biological ; Necroptosis ; Phospholipid Hydroperoxide Glutathione Peroxidase/metabolism ; Phospholipids/metabolism ; Prognosis ; Thioredoxins/metabolism ; Mice

المؤلفون: Szczepanowska K; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne, 50931, Cologne, Germany. karolina.szczepanowska@uk-koeln.de.; Institute for Mitochondrial Diseases and Aging, Medical Faculty, University of Cologne, 50931, Cologne, Germany. karolina.szczepanowska@uk-koeln.de., Senft K; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne, 50931, Cologne, Germany.; Institute for Mitochondrial Diseases and Aging, Medical Faculty, University of Cologne, 50931, Cologne, Germany., Heidler J; Functional Proteomics, ZBC, Faculty of Medicine, Goethe University, 60590, Frankfurt am Main, Germany., Herholz M; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne, 50931, Cologne, Germany.; Institute for Mitochondrial Diseases and Aging, Medical Faculty, University of Cologne, 50931, Cologne, Germany., Kukat A; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne, 50931, Cologne, Germany.; Institute for Mitochondrial Diseases and Aging, Medical Faculty, University of Cologne, 50931, Cologne, Germany., Höhne MN; Department of Chemistry, Institute of Biochemistry, University of Cologne, 50674, Cologne, Germany., Hofsetz E; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne, 50931, Cologne, Germany.; Institute for Mitochondrial Diseases and Aging, Medical Faculty, University of Cologne, 50931, Cologne, Germany., Becker C; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne, 50931, Cologne, Germany.; Institute for Mitochondrial Diseases and Aging, Medical Faculty, University of Cologne, 50931, Cologne, Germany., Kaspar S; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne, 50931, Cologne, Germany.; Institute for Mitochondrial Diseases and Aging, Medical Faculty, University of Cologne, 50931, Cologne, Germany., Giese H; Molecular Bioinformatics, Goethe-Universität Frankfurt am Main, 60325, Frankfurt am Main, Germany., Zwicker K; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590, Frankfurt am Main, Germany., Guerrero-Castillo S; Nijmegen Centre for Mitochondrial Disorders, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.; Cluster of Excellence Frankfurt 'Macromolecular Complexes', Goethe-University, 60590, Frankfurt am Main, Germany., Baumann L; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne, 50931, Cologne, Germany.; Institute for Mitochondrial Diseases and Aging, Medical Faculty, University of Cologne, 50931, Cologne, Germany., Kauppila J; Department of Mitochondrial Biology, Max Planck Institute for Biology of Aging, 50931, Cologne, Germany., Rumyantseva A; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne, 50931, Cologne, Germany.; Institute for Mitochondrial Diseases and Aging, Medical Faculty, University of Cologne, 50931, Cologne, Germany., Müller S; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne, 50931, Cologne, Germany., Frese CK; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne, 50931, Cologne, Germany., Brandt U; Nijmegen Centre for Mitochondrial Disorders, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.; Cluster of Excellence Frankfurt 'Macromolecular Complexes', Goethe-University, 60590, Frankfurt am Main, Germany., Riemer J; Department of Chemistry, Institute of Biochemistry, University of Cologne, 50674, Cologne, Germany., Wittig I; Functional Proteomics, ZBC, Faculty of Medicine, Goethe University, 60590, Frankfurt am Main, Germany., Trifunovic A; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine (CMMC), University of Cologne, 50931, Cologne, Germany. aleksandra.trifunovic@uk-koeln.de.; Institute for Mitochondrial Diseases and Aging, Medical Faculty, University of Cologne, 50931, Cologne, Germany. aleksandra.trifunovic@uk-koeln.de.

المصدر: Nature communications [Nat Commun] 2020 Apr 02; Vol. 11 (1), pp. 1643. Date of Electronic Publication: 2020 Apr 02.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Electron Transport Complex I/*metabolism, Animals ; Electron Transport Complex I/genetics ; Endopeptidase Clp/genetics ; Endopeptidase Clp/metabolism ; Mice ; Mice, Knockout ; Mitochondria/genetics ; Mitochondria/metabolism ; Myoblasts/metabolism ; Protein Subunits/genetics ; Protein Subunits/metabolism