المؤلفون: Laurie H. Sanders, Josée Laganière, Oliver Cooper, Sally K. Mak, B. Joseph Vu, Y. Anne Huang, David E. Paschon, Malini Vangipuram, Ramya Sundararajan, Fyodor D. Urnov, J. William Langston, Philip D. Gregory, H. Steve Zhang, J. Timothy Greenamyre, Ole Isacson, Birgitt Schüle

المصدر: Neurobiology of Disease, Vol 62, Iss , Pp 381-386 (2014)

مصطلحات موضوعية: Parkinson's disease, LRRK2, Mitochondrial DNA damage, Stem cells, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S096999611300288X; https://doaj.org/toc/1095-953X

URL الوصول: https://doaj.org/article/d505d3408a924944819f08f5874cf168

المؤلفون: Yasaman Ataei, Larry Park, D. James Surmeier, B. Joseph Vu, Seung Kwak, Richard T. Surosky, Anand Narayanan, David A. Shivak, Josee Laganiere, Christer Halldin, Andrea Varrone, Matthew C. Mendel, Karsten Tillack, Lei Zhang, Bryan Zeitler, Dmitry Guschin, Lexi Kopan, Sarah J. Hinkley, Kimberly Marlen, Jocelynn R. Pearl, Qi Yu, Taneli Heikkinen, Annette Gärtner, Yalda Sedaghat, Christina Thiede, Miklós Tóth, Jennifer M. Cherone, David Paschon, Jyothisri Kondapalli, Andrea E. Kudwa, Ladislav Mrzljak, Rainier Amora, Kimmo Lehtimäki, Edward J. Rebar, Lenke Tari, Ignacio Munoz-Sanjuan, Jeffrey C. Miller, Sylvie Ramboz, Marie Svedberg, Steven Froelich, Irina Ankoudinova, Philip D. Gregory, Stephen Lam, Michelle Day, Jonathan Bard, Hoang Oanh B. Nguyen, Fyodor D. Urnov, Davis Li, Jenny Haggkvist, H. Steve Zhang, Guijuan Qiao

المصدر: Nature Medicine. 25:1131-1142

مصطلحات موضوعية: 0301 basic medicine, Zinc finger, congenital, hereditary, and neonatal diseases and abnormalities, Mutant, General Medicine, Biology, medicine.disease, General Biochemistry, Genetics and Molecular Biology, nervous system diseases, Cell biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Huntington's disease, Transcription (biology), 030220 oncology & carcinogenesis, mental disorders, medicine, Gene silencing, Allele, Gene, Transcription factor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d19307c1ae395108f0cf1b74fb590fb6
https://doi.org/10.1038/s41591-019-0478-3

المؤلفون: Susanne Wegmann, Bradley T. Hyman, Annemarie Ledeboer, Jeffrey C. Miller, Marta Perez-Rando, Kimberly Marlen, Richard T. Surosky, Bryan Zeitler, Caitlin Commins, Alison Chase, Michael C. Holmes, Sarah J. Hinkley, Alicia Goodwin, Riley N. Bannon, Lei Zhang, Brigit E. Riley, Hoang-Oanh B. Nguyen, Sarah L. DeVos, Edward J. Rebar, Ashley B. Robbins, Stephen Lam, Rainier Amora, Irina Ankoudinova, Qi Yu, Amy M. Pooler, Hung Tran, Nicholas A. Scarlott, Bianca T. Corjuc, Danny MacKenzie, Fyodor D. Urnov, H. Steve Zhang, Lisa Diez, Rachel E. Bennett

المصدر: Science advances 7(12), eabe1611-(2021). doi:10.1126/sciadv.abe1611
Science Advances

مصطلحات موضوعية: Endogeny, Plaque, Amyloid, genetics [Alzheimer Disease], genetics [Dependovirus], Transduction (genetics), pathology [Alzheimer Disease], Mice, 0302 clinical medicine, Research Methods, metabolism [Transcription Factors], genetics [Zinc Fingers], Research Articles, Zinc finger, 0303 health sciences, Gene knockdown, Multidisciplinary, Chemistry, Brain, SciAdv r-articles, Zinc Fingers, Human brain, Dependovirus, genetics [Transcription Factors], Cell biology, medicine.anatomical_structure, ddc:500, Research Article, metabolism [Amyloid beta-Peptides], tau Proteins, 03 medical and health sciences, Alzheimer Disease, mental disorders, medicine, Animals, pathology [Plaque, Amyloid], Transcription factor, 030304 developmental biology, Messenger RNA, Amyloid beta-Peptides, therapy [Alzheimer Disease], Neurotoxicity, medicine.disease, metabolism [tau Proteins], Disease Models, Animal, genetics [tau Proteins], metabolism [Brain], metabolism [Dependovirus], 030217 neurology & neurosurgery, Transcription Factors, Neuroscience

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1e249560ae8a0539e415f467dba78e

المؤلفون: Bryan, Zeitler, Steven, Froelich, Kimberly, Marlen, David A, Shivak, Qi, Yu, Davis, Li, Jocelynn R, Pearl, Jeffrey C, Miller, Lei, Zhang, David E, Paschon, Sarah J, Hinkley, Irina, Ankoudinova, Stephen, Lam, Dmitry, Guschin, Lexi, Kopan, Jennifer M, Cherone, Hoang-Oanh B, Nguyen, Guijuan, Qiao, Yasaman, Ataei, Matthew C, Mendel, Rainier, Amora, Richard, Surosky, Josee, Laganiere, B Joseph, Vu, Anand, Narayanan, Yalda, Sedaghat, Karsten, Tillack, Christina, Thiede, Annette, Gärtner, Seung, Kwak, Jonathan, Bard, Ladislav, Mrzljak, Larry, Park, Taneli, Heikkinen, Kimmo K, Lehtimäki, Marie M, Svedberg, Jenny, Häggkvist, Lenke, Tari, Miklós, Tóth, Andrea, Varrone, Christer, Halldin, Andrea E, Kudwa, Sylvie, Ramboz, Michelle, Day, Jyothisri, Kondapalli, D James, Surmeier, Fyodor D, Urnov, Philip D, Gregory, Edward J, Rebar, Ignacio, Muñoz-Sanjuán, H Steve, Zhang

المصدر: Nature medicine. 25(7)

مصطلحات موضوعية: Male, Huntingtin Protein, Transcription, Genetic, Zinc Fingers, Neuroprotection, Mice, Inbred C57BL, Disease Models, Animal, Mice, Huntington Disease, Trinucleotide Repeats, Mutation, Mice, Inbred CBA, Animals, Humans, Female, Alleles, Cells, Cultured

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::4d3620bad8fe21aa64bd37ef53578561
https://pubmed.ncbi.nlm.nih.gov/31263285

المؤلفون: H Steve, Zhang, Dingang, Liu, Yan, Huang, Stefan, Schmidt, Reed, Hickey, Dmitry, Guschin, Haili, Su, Ion S, Jovin, Mike, Kunis, Sarah, Hinkley, Yuxin, Liang, Linda, Hinh, S Kaye, Spratt, Casey C, Case, Edward J, Rebar, Barbara E, Ehrlich, Barbara, Ehrlich, Philip D, Gregory, Frank J, Giordano

المصدر: Molecular Therapy

مصطلحات موضوعية: Blotting, Western, Druggability, Repressor, 030204 cardiovascular system & hematology, Biology, Adenoviridae, Cell Line, 03 medical and health sciences, 0302 clinical medicine, Calcium-binding protein, Drug Discovery, Genetics, Animals, Humans, Myocytes, Cardiac, Molecular Biology, Gene, Psychological repression, Transcription factor, 030304 developmental biology, Pharmacology, Zinc finger, Heart Failure, 0303 health sciences, Reverse Transcriptase Polymerase Chain Reaction, Calcium-Binding Proteins, Zinc Fingers, 3. Good health, Cell biology, Phospholamban, Rats, Kinetics, 030220 oncology & carcinogenesis, Molecular Medicine, Original Article, Corrigendum, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf6d75f77ecc7bd1ea7a45b7b9474c4
http://europepmc.org/articles/PMC3412484

المؤلفون: Philip D. Gregory, Edward J. Rebar, Dirk Hockemeyer, Lauren K. Fong, Xiangdong Meng, Lei Zhang, Vikram Khurana, Richard H. Myers, B. Joseph Vu, Susan Lindquist, Qing Gao, Lawrence I. Golbe, Rudolf Jaenisch, H. Steve Zhang, Fyodor D. Urnov, Frank Soldner, Albert W. Cheng, Josee Laganiere, Dmitry Guschin, Raaji Alagappan

المصدر: Cell. 146:318-331

مصطلحات موضوعية: Genetics, 0303 health sciences, Biochemistry, Genetics and Molecular Biology(all), Somatic cell, Point mutation, 05 social sciences, Biology, Phenotype, Zinc finger nuclease, Isogenic human disease models, General Biochemistry, Genetics and Molecular Biology, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Genome editing, 0502 economics and business, Induced pluripotent stem cell, Gene, 050203 business & management, 030217 neurology & neurosurgery, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28903e051b95b7215ea5ebd0fb54f544
https://doi.org/10.1016/j.cell.2011.06.019

المؤلفون: H. Steve Zhang, Guijuan Qiao, Sarah J. Hinkley, Fyodor D. Urnov, Jianbin Wang, Elo Leung, Gladys P Dulay, Xiangdong Meng, Michael C. Holmes, Philip D. Gregory, Kyle A. Barlow, Jeffrey C. Miller, David Paschon, Kevin Hua, Lei Zhang, Gregory J. Cost, Irina Ankoudinova, Danny F Xia, Siyuan Tan, Edward J. Rebar

المصدر: Nature Biotechnology. 29:143-148

مصطلحات موضوعية: Vascular Endothelial Growth Factor A, Transcription Activator-Like Effectors, Xanthomonas, Receptors, CCR5, Molecular Sequence Data, Biomedical Engineering, Bioengineering, Biology, Applied Microbiology and Biotechnology, Genome, Genome engineering, Bacterial Proteins, TAL effector, Genome editing, Combinatorial Chemistry Techniques, Humans, Deoxyribonucleases, Type II Site-Specific, Gene, Genetics, Transcription activator-like effector nuclease, Binding Sites, Base Sequence, DNA, Zinc finger nuclease, Mutagenesis, Site-Directed, Molecular Medicine, Genetic Engineering, K562 Cells, Transcription Factors, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a45a36df92f95d6b3e7e95fe95788e8
https://doi.org/10.1038/nbt.1755

المؤلفون: Deveroux Ferguson, Jessica J. Walsh, Ming-Hu Han, Michelle S. Mazei-Robison, James P. Herman, Sam A. Golden, Elizabeth A. Heller, Mark A. Gerber, HaoSheng Sun, Hannah M. Cates, Scott W. Knight, Li Shen, Catherine Jensen Pena, Jian Feng, Ning-Yi Shao, Scott J. Russo, Carol S. Tamminga, Christian Nievera, Eric J. Nestler, Feng Zhang, H. Steve Zhang, Rachael L. Neve

المساهمون: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research at MIT, Neve, Rachael L., Zhang, Feng

المصدر: PMC

مصطلحات موضوعية: General Neuroscience, Addiction, media_common.quotation_subject, Biology, Chromatin remodeling, Chromatin, Histone, Histone methylation, biology.protein, Epigenetics, Neuroscience, Transcription factor, FOSB, media_common

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42aea5022cd1865fb3a39f4ae95eb84e
http://hdl.handle.net/1721.1/102587

المؤلفون: Bryan Zeitler, Omar L. Francone, David Thomson, Kimberly Marlen, Chiocco Matthew, David Paschon, H. Steve Zhang, Steven Froelich, Qi Yu, Jeffrey C. Miller, Debra Klatte, Vivian Choi, Anne-Renee Graham, Fyodor D. Urnov, Philip D. Gregory, Edward J. Rebar

المصدر: Journal of Neurology, Neurosurgery & Psychiatry. 87:A2.4-A3

مصطلحات موضوعية: 0301 basic medicine, Huntingtin, Genetic enhancement, Disease, Biology, Bioinformatics, medicine.disease, 03 medical and health sciences, Psychiatry and Mental health, Exon, 030104 developmental biology, 0302 clinical medicine, Huntington's disease, Mutant protein, medicine, Surgery, Neurology (clinical), Trinucleotide repeat expansion, Gene, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e04b2cc9d748316148d928bf6df863f1
https://doi.org/10.1136/jnnp-2016-314597.7

المؤلفون: H. Steve Zhang, Josee Laganiere, Philip D. Gregory, B. Joseph Vu, Y. Anne Huang, Sally K. Mak, David Paschon, Birgitt Schüle, J. Timothy Greenamyre, Ramya Sundararajan, Fyodor D. Urnov, Malini Vangipuram, J. William Langston, Laurie H. Sanders, Oliver Cooper, Ole Isacson

المصدر: Neurobiology of Disease, Vol 62, Iss, Pp 381-386 (2014)

مصطلحات موضوعية: Adult, Male, Mitochondrial DNA, DNA Repair, DNA damage, DNA repair, Parkinson's disease, Induced Pluripotent Stem Cells, Mitochondrial DNA damage, Stem cells, Biology, Protein Serine-Threonine Kinases, medicine.disease_cause, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, DNA, Mitochondrial, Article, lcsh:RC321-571, Neural Stem Cells, medicine, Humans, Induced pluripotent stem cell, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Aged, Genetics, Mutation, LRRK2, Parkinson Disease, Zinc Fingers, Middle Aged, Neural stem cell, nervous system diseases, Neurology, Cancer research, Female, Stem cell, DNA Damage, Targeted Gene Repair

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54da75b1fafd8e00f22eea6ef429a641
https://europepmc.org/articles/PMC3877733/