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1
المؤلفون: Sandra M. Sanabria-Bohórquez, J. N. de Hoon, K. Van Laere, Richard Hargreaves, Raymond E. Gibson, Spencer J. Tye, Leslie J. Street, Ruth M. McKernan, I De Lepeleire, Robert W. Carling, Keith A. Wafford, Andrew Pike, John R. Atack, Guy Bormans, Christine Ryan, David James Hallett, HD Burns, M. G Murphy, Wai-Si Eng, A. Van Hecken, G. R. Dawson
المصدر: Journal of Psychopharmacology. 25:329-344
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Elevated plus maze, Time Factors, Adolescent, Hydrocarbons, Fluorinated, medicine.drug_class, Population, Anxiety, Pharmacology, Heterocyclic Compounds, 4 or More Rings, Anxiolytic, Partial agonist, Rats, Sprague-Dawley, Mice, Young Adult, Species Specificity, Internal medicine, Animals, Humans, Medicine, Pharmacology (medical), GABA-A Receptor Agonists, education, Saimiri, education.field_of_study, Benzodiazepine, Dose-Response Relationship, Drug, business.industry, GABAA receptor, Antagonist, Middle Aged, Receptors, GABA-A, Rats, Disease Models, Animal, Protein Subunits, Psychiatry and Mental health, Endocrinology, Anti-Anxiety Agents, Flumazenil, business, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea0a5ae22a6d2851dd26b1e9a8bbbb4
https://doi.org/10.1177/0269881109354928 -
2
المؤلفون: J. N. de Hoon, Guy Bormans, John R. Atack, M. G Murphy, Sandra M. Sanabria-Bohórquez, I De Lepeleire, A. Van Hecken, Keith A. Wafford, G. R. Dawson, K. Van Laere, Richard Hargreaves, Leslie J. Street, Ruth M. McKernan, Spencer J. Tye, HD Burns
المصدر: Journal of Psychopharmacology. 25:314-328
مصطلحات موضوعية: Adult, Male, Agonist, medicine.medical_specialty, Adolescent, Hydrocarbons, Fluorinated, medicine.drug_class, Sedation, Drug Evaluation, Preclinical, Anxiety, Pharmacology, Heterocyclic Compounds, 4 or More Rings, Anxiolytic, Partial agonist, Chlordiazepoxide, Rats, Sprague-Dawley, Mice, Young Adult, Species Specificity, Internal medicine, medicine, Animals, Humans, Tissue Distribution, Pharmacology (medical), GABA-A Receptor Agonists, Saimiri, Benzodiazepine, Binding Sites, Dose-Response Relationship, Drug, Chemistry, GABAA receptor, Brain, Middle Aged, Rats, Disease Models, Animal, Protein Subunits, Psychiatry and Mental health, Endocrinology, Anti-Anxiety Agents, Flumazenil, Positron-Emission Tomography, medicine.symptom, Protein Binding, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e190b386986f0d8f06dedccdb3ce130
https://doi.org/10.1177/0269881109354927 -
3
المؤلفون: Terence G. Hamill, Sandra Sanabria, Stephen Krause, Liza Gantert, H. Sleph, John J. Renger, Shigeru Tokita, Wai-Si Eng, Makoto Jitsuoka, Zhizhen Zeng, Robert Iannone, Patricia Miller, Scott M. Doran, Susan L. Garson, HD Burns, Shil Patel, Kerry Riffel, Christine Ryan, Nagaaki Sato, Richard Hargreaves, Tsing-Bau Chen
المصدر: NeuroImage. 41:T22
مصطلحات موضوعية: chemistry.chemical_compound, Neurology, chemistry, Cognitive Neuroscience, Radiochemistry, Fluorine, chemistry.chemical_element, Inverse agonist, Pet tracer, Carbon, Histamine
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4دورية أكاديمية
المؤلفون: Hostetler ED; Imaging, Merck Research Laboratories, West Point, PA 19486, USA. eric_hostetler@merck.com, Sanabria-Bohórquez S, Eng W, Joshi AD, Patel S, Gibson RE, O'Malley S, Krause SM, Ryan C, Riffel K, Bi S, Okamoto O, Kawamoto H, Ozaki S, Ohta H, de Groot T, Bormans G, Depré M, de Hoon J, De Lepeleire I, Reynders T, Cook JJ, Burns HD, Egan M, Cho W, van Laere K, Hargreaves RJ
المصدر: NeuroImage [Neuroimage] 2013 Mar; Vol. 68, pp. 1-10. Date of Electronic Publication: 2012 Dec 11.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 9215515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9572 (Electronic) Linking ISSN: 10538119 NLM ISO Abbreviation: Neuroimage Subsets: MEDLINE
مواضيع طبية MeSH: Benzimidazoles/*pharmacokinetics , Brain/*diagnostic imaging , Fluorine Radioisotopes/*pharmacokinetics , Piperidines/*pharmacokinetics , Positron-Emission Tomography/*methods , Radiopharmaceuticals/*pharmacokinetics , Receptors, Opioid/*metabolism, Adult ; Animals ; Benzimidazoles/chemistry ; Brain/metabolism ; Fluorine Radioisotopes/chemistry ; Humans ; Macaca mulatta ; Male ; Middle Aged ; Piperidines/chemistry ; Radiopharmaceuticals/chemistry ; Tissue Distribution ; Young Adult ; Nociceptin Receptor
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5دورية أكاديمية
المؤلفون: Hamill TG; Discovery Imaging, Merck Research Laboratories, West Point, Pennsylvania 19486, USA. terence_hamill@merck.com, Eng W, Jennings A, Lewis R, Thomas S, Wood S, Street L, Wisnoski D, Wolkenberg S, Lindsley C, Sanabria-Bohórquez SM, Patel S, Riffel K, Ryan C, Cook J, Sur C, Burns HD, Hargreaves R
المصدر: Synapse (New York, N.Y.) [Synapse] 2011 Apr; Vol. 65 (4), pp. 261-70.
نوع المنشور: Comparative Study; Journal Article
بيانات الدورية: Publisher: Country of Publication: United States NLM ID: 8806914 Publication Model: Print Cited Medium: Internet ISSN: 1098-2396 (Electronic) Linking ISSN: 08874476 NLM ISO Abbreviation: Synapse Subsets: MEDLINE
مواضيع طبية MeSH: Carbon Radioisotopes*/blood , Fluorine Radioisotopes*/blood, Benzamides/*chemical synthesis , Glycine Plasma Membrane Transport Proteins/*blood , Positron-Emission Tomography/*methods , Pyridines/*chemical synthesis , Sulfonamides/*chemical synthesis, Animals ; Benzamides/blood ; Cell Line ; Drug Evaluation, Preclinical/methods ; Glycine Plasma Membrane Transport Proteins/metabolism ; Humans ; Macaca mulatta ; Pyridines/blood ; Sulfonamides/blood
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6دورية أكاديمية
المؤلفون: Atack JR; Neuroscience Research Centre, Merck Sharp & Dohme Research Laboratories, Harlow, UK. JAtack1@its.jnj.com, Hallett DJ, Tye S, Wafford KA, Ryan C, Sanabria-Bohórquez SM, Eng WS, Gibson RE, Burns HD, Dawson GR, Carling RW, Street LJ, Pike A, De Lepeleire I, Van Laere K, Bormans G, de Hoon JN, Van Hecken A, McKernan RM, Murphy MG, Hargreaves RJ
المصدر: Journal of psychopharmacology (Oxford, England) [J Psychopharmacol] 2011 Mar; Vol. 25 (3), pp. 329-44. Date of Electronic Publication: 2010 Feb 15.
نوع المنشور: Controlled Clinical Trial; Journal Article
بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 8907828 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1461-7285 (Electronic) Linking ISSN: 02698811 NLM ISO Abbreviation: J Psychopharmacol Subsets: MEDLINE
مواضيع طبية MeSH: Anti-Anxiety Agents/*pharmacology , Anxiety/*drug therapy , GABA-A Receptor Agonists/*pharmacology , Heterocyclic Compounds, 4 or More Rings/*pharmacology , Hydrocarbons, Fluorinated/*pharmacology, Adolescent ; Adult ; Animals ; Anti-Anxiety Agents/administration & dosage ; Anti-Anxiety Agents/adverse effects ; Disease Models, Animal ; Dose-Response Relationship, Drug ; GABA-A Receptor Agonists/administration & dosage ; GABA-A Receptor Agonists/adverse effects ; Heterocyclic Compounds, 4 or More Rings/administration & dosage ; Heterocyclic Compounds, 4 or More Rings/adverse effects ; Humans ; Hydrocarbons, Fluorinated/administration & dosage ; Hydrocarbons, Fluorinated/adverse effects ; Male ; Mice ; Middle Aged ; Protein Subunits ; Rats ; Rats, Sprague-Dawley ; Receptors, GABA-A/drug effects ; Receptors, GABA-A/metabolism ; Saimiri ; Species Specificity ; Time Factors ; Young Adult
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7دورية أكاديمية
المؤلفون: Atack JR; Neuroscience Research Centre, Merck Sharp & Dohme Research Laboratories, Harlow, UK. JAtack1@its.jnj.com, Wafford KA, Street LJ, Dawson GR, Tye S, Van Laere K, Bormans G, Sanabria-Bohórquez SM, De Lepeleire I, de Hoon JN, Van Hecken A, Burns HD, McKernan RM, Murphy MG, Hargreaves RJ
المصدر: Journal of psychopharmacology (Oxford, England) [J Psychopharmacol] 2011 Mar; Vol. 25 (3), pp. 314-28. Date of Electronic Publication: 2010 Feb 10.
نوع المنشور: Comparative Study; Controlled Clinical Trial; Journal Article
بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 8907828 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1461-7285 (Electronic) Linking ISSN: 02698811 NLM ISO Abbreviation: J Psychopharmacol Subsets: MEDLINE
مواضيع طبية MeSH: Anti-Anxiety Agents/*pharmacology , Anxiety/*drug therapy , GABA-A Receptor Agonists/*pharmacology , Heterocyclic Compounds, 4 or More Rings/*pharmacology , Hydrocarbons, Fluorinated/*pharmacology, Adolescent ; Adult ; Animals ; Anti-Anxiety Agents/administration & dosage ; Anti-Anxiety Agents/adverse effects ; Binding Sites ; Brain/metabolism ; Chlordiazepoxide/administration & dosage ; Chlordiazepoxide/pharmacology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; GABA-A Receptor Agonists/administration & dosage ; GABA-A Receptor Agonists/adverse effects ; Heterocyclic Compounds, 4 or More Rings/administration & dosage ; Heterocyclic Compounds, 4 or More Rings/adverse effects ; Humans ; Hydrocarbons, Fluorinated/administration & dosage ; Hydrocarbons, Fluorinated/adverse effects ; Male ; Mice ; Middle Aged ; Positron-Emission Tomography ; Protein Binding ; Protein Subunits ; Rats ; Rats, Sprague-Dawley ; Saimiri ; Species Specificity ; Tissue Distribution ; Young Adult
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8دورية أكاديمية
المؤلفون: Hostetler ED; Imaging, Merck Research Laboratories, West Point, PA 19486, USA. eric_hostetler@merck.com, Sanabria-Bohórquez S, Fan H, Zeng Z, Gantert L, Williams M, Miller P, O'Malley S, Kameda M, Ando M, Sato N, Ozaki S, Tokita S, Ohta H, Williams D, Sur C, Cook JJ, Burns HD, Hargreaves R
المصدر: NeuroImage [Neuroimage] 2011 Feb 14; Vol. 54 (4), pp. 2635-42. Date of Electronic Publication: 2010 Nov 13.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 9215515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9572 (Electronic) Linking ISSN: 10538119 NLM ISO Abbreviation: Neuroimage Subsets: MEDLINE
مواضيع طبية MeSH: Brain/*diagnostic imaging , Fluorine Radioisotopes/*pharmacokinetics , Radiopharmaceuticals/*chemical synthesis , Radiopharmaceuticals/*pharmacokinetics , Receptors, Neuropeptide Y/*biosynthesis, Animals ; Autoradiography ; Humans ; Macaca mulatta ; Positron-Emission Tomography ; Radioactive Tracers
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9دورية أكاديمية
المؤلفون: Hostetler ED; Imaging, Merck Research Laboratories, West Point, Pennsylvania 19486, USA. eric_hostetler@merck.com, Eng W, Joshi AD, Sanabria-Bohórquez S, Kawamoto H, Ito S, O'Malley S, Krause S, Ryan C, Patel S, Williams M, Riffel K, Suzuki G, Ozaki S, Ohta H, Cook J, Burns HD, Hargreaves R
المصدر: Synapse (New York, N.Y.) [Synapse] 2011 Feb; Vol. 65 (2), pp. 125-35.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Country of Publication: United States NLM ID: 8806914 Publication Model: Print Cited Medium: Internet ISSN: 1098-2396 (Electronic) Linking ISSN: 08874476 NLM ISO Abbreviation: Synapse Subsets: MEDLINE
مواضيع طبية MeSH: Excitatory Amino Acid Agents*/chemical synthesis , Excitatory Amino Acid Agents*/chemistry , Excitatory Amino Acid Agents*/pharmacokinetics , Positron-Emission Tomography*, Brain/*diagnostic imaging , Brain/*drug effects , Receptors, Metabotropic Glutamate/*metabolism, Animals ; Autoradiography/methods ; Binding Sites/drug effects ; Brain/metabolism ; Brain Mapping ; Dose-Response Relationship, Drug ; Fluorine Radioisotopes/chemistry ; Fluorine Radioisotopes/pharmacokinetics ; Humans ; Indoles/chemical synthesis ; Indoles/pharmacokinetics ; Inhibitory Concentration 50 ; Ligands ; Macaca mulatta ; Tissue Distribution ; Triazoles/chemical synthesis ; Triazoles/pharmacokinetics
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10دورية أكاديمية
المؤلفون: Eng W; Imaging Department, Merck & Co. Inc., West Point, PA, USA., Atack JR, Bergstrom M, Sanabria S, Appel L, Dawson GR, Sciberras D, Hargreaves RJ, Langstrom B, Burns HD
المصدر: Neuropharmacology [Neuropharmacology] 2010 Dec; Vol. 59 (7-8), pp. 635-9. Date of Electronic Publication: 2010 Aug 07.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE
مواضيع طبية MeSH: Flumazenil/*metabolism , GABA-A Receptor Agonists/*pharmacokinetics , Phthalazines/*pharmacokinetics , Receptors, GABA-A/*metabolism , Triazoles/*pharmacokinetics, Adult ; Brain/diagnostic imaging ; Brain/metabolism ; Carbon Radioisotopes ; Drug Inverse Agonism ; Humans ; Male ; Positron-Emission Tomography ; Protein Subunits/agonists ; Protein Subunits/metabolism ; Young Adult