يعرض 1 - 10 نتائج من 25 نتيجة بحث عن '"HDM201"', وقت الاستعلام: 5.78s تنقيح النتائج
  1. 1
    دورية أكاديمية
    p52-ZER6: a determinant of tumor cell sensitivity to MDM2-p53 binding inhibitors

    المؤلفون: Li, Wen-fangAff1, Aff2, Alfason, LeaderAff1, Aff2, Huang, Can, Tang, YuAff1, Aff2, Qiu, LiAff1, Aff2, Miyagishi, Makoto, Wu, Shou-rongAff1, Aff2, Aff5, IDs41401022009739_cor7, Kasim, ViviAff1, Aff2, Aff5, IDs41401022009739_cor8

    المصدر: Acta Pharmacologica Sinica. 44(3):647-660

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  2. 2
    دورية أكاديمية
    Translational Modeling of Anticancer Efficacy to Predict Clinical Outcomes in a First-in-Human Phase 1 Study of MDM2 Inhibitor HDM201

    المؤلفون: Guerreiro, Nelson, Jullion, Astrid, Ferretti, Stephane, Fabre, Claire, Meille, ChristopheAff1

    المصدر: The AAPS Journal: An Official Journal of the American Association of Pharmaceutical Scientists. 23(2)

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  3. 3
    دورية أكاديمية
    TP53 mutant cell lines selected for resistance to MDM2 inhibitors retain growth inhibition by MAPK pathway inhibitors but a reduced apoptotic response

    المؤلفون: Chiao-En Wu, Tsin Shue Koay, Yi-Hsuan Ho, Penny Lovat, John Lunec

    المصدر: Cancer Cell International, Vol 19, Iss 1, Pp 1-15 (2019)

    مصطلحات موضوعية: Melanoma, p53, MDM2, Nutlin-3, RG7388, HDM201, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

    وصف الملف: electronic resource

    Relation: http://link.springer.com/article/10.1186/s12935-019-0768-3; https://doaj.org/toc/1475-2867

    URL الوصول: https://doaj.org/article/d52f6c520f674aa0ad3934c0311b3100

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  4. 4
    دورية أكاديمية
    WIP1 Inhibition by GSK2830371 Potentiates HDM201 through Enhanced p53 Phosphorylation and Activation in Liver Adenocarcinoma Cells

    المؤلفون: Chiao-En Wu, Chen-Yang Huang, Chiao-Ping Chen, Yi-Ru Pan, John Wen-Cheng Chang, Jen-Shi Chen, Chun-Nan Yeh, John Lunec

    المصدر: Cancers, Vol 13, Iss 15, p 3876 (2021)

    مصطلحات موضوعية: HDM201, GSK2830371, MDM2, WIP1, p53, cholangiocarcinoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

    وصف الملف: electronic resource

    Relation: https://www.mdpi.com/2072-6694/13/15/3876; https://doaj.org/toc/2072-6694

    URL الوصول: https://doaj.org/article/2df48b81eb1e467e9e44c93104b28474

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  5. 5
    دورية أكاديمية
    Targeting negative regulation of p53 by MDM2 and WIP1 as a therapeutic strategy in cutaneous melanoma

    المؤلفون: Wu, Chiao-EnAff1, Aff2, Esfandiari, Arman, Ho, Yi-Hsuan, Wang, Nan, Mahdi, Ahmed KhairallahAff1, Aff4, Aptullahoglu, Erhan, Lovat, Penny, Lunec, JohnAff1

    المصدر: British Journal of Cancer. 118(4):495-508

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  6. 6
    دورية أكاديمية
    TP53 mutant cell lines selected for resistance to MDM2 inhibitors retain growth inhibition by MAPK pathway inhibitors but a reduced apoptotic response

    المؤلفون: Wu, Chiao-EnAff1, Aff2, Koay, Tsin ShueAff1, Ho, Yi-HsuanAff1, Lovat, PennyAff3, Lunec, JohnAff1

    المصدر: Cancer Cell International. 19(1)

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  7. 7
    دورية أكاديمية
    ATM Dependent DUSP6 Modulation of p53 Involved in Synergistic Targeting of MAPK and p53 Pathways with Trametinib and MDM2 Inhibitors in Cutaneous Melanoma

    المؤلفون: Chiao-En Wu, Tsin Shue Koay, Arman Esfandiari, Yi-Hsuan Ho, Penny Lovat, John Lunec

    المصدر: Cancers, Vol 11, Iss 1, p 3 (2018)

    مصطلحات موضوعية: trametinib, nutlin-3, RG7388, HDM201, p53, DUSP6, melanoma, MDM2, ATM, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

    وصف الملف: electronic resource

    Relation: https://www.mdpi.com/2072-6694/11/1/3; https://doaj.org/toc/2072-6694

    URL الوصول: https://doaj.org/article/22f6e92920d544c898540df1f42f51a2

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  8. 8
    Targeting negative regulation of p53 by MDM2 and WIP1 as a therapeutic strategy in cutaneous melanoma

    المؤلفون: Penny E. Lovat, Ahmed Khairallah Mahdi, Chiao-En Wu, Arman Esfandiari, John Lunec, Nan Wang, Yi-Hsuan Ho, Erhan Aptullahoglu

    المصدر: British Journal of Cancer

    مصطلحات موضوعية: p53, 0301 basic medicine, Cancer Research, Pyrrolidines, Skin Neoplasms, Cell cycle checkpoint, WIP1, Aminopyridines, Piperazines, chemistry.chemical_compound, nutlin-3, para-Aminobenzoates, Cytotoxic T cell, Phosphorylation, Melanoma, Gene knockdown, biology, Protein Stability, Cell Cycle, Imidazoles, Drug Synergism, Proto-Oncogene Proteins c-mdm2, Dipeptides, Gene Expression Regulation, Neoplastic, Protein Phosphatase 2C, Oncology, Mdm2, Growth inhibition, Protein Binding, Cell Survival, cutaneous melanoma, 03 medical and health sciences, MDM2, Cell Line, Tumor, medicine, Humans, RG7388, Clonogenic assay, HDM201, Cell Proliferation, Gene Expression Profiling, medicine.disease, 030104 developmental biology, chemistry, Cutaneous melanoma, Mutagenesis, Site-Directed, Cancer research, biology.protein, Tumor Suppressor Protein p53, Translational Therapeutics

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5eb4d23b68abb8cddea9f908ca5832
    https://doi.org/10.1038/bjc.2017.433

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  9. 9
    TP53 mutant cell lines selected for resistance to MDM2 inhibitors retain growth inhibition by MAPK pathway inhibitors but a reduced apoptotic response

    المؤلفون: Penny E. Lovat, Yi-Hsuan Ho, Chiao-En Wu, John Lunec, Tsin Shue Koay

    المصدر: Cancer Cell International
    Cancer Cell International, Vol 19, Iss 1, Pp 1-15 (2019)

    مصطلحات موضوعية: MAPK/ERK pathway, p53, Cancer Research, Caspase 3, lcsh:RC254-282, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, MDM2, Trametinib, Genetics, medicine, lcsh:QH573-671, Vemurafenib, RG7388, Melanoma, HDM201, lcsh:Cytology, Chemistry, Nutlin-3, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Oncology, Cell culture, Apoptosis, 030220 oncology & carcinogenesis, Cancer research, Growth inhibition, Primary Research, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7781441058bca3a9cfc372a797f2c20c
    http://europepmc.org/articles/PMC6407233

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  10. 10
    ATM Dependent DUSP6 Modulation of p53 Involved in Synergistic Targeting of MAPK and p53 Pathways with Trametinib and MDM2 Inhibitors in Cutaneous Melanoma

    المؤلفون: Tsin Shue Koay, Chiao-En Wu, John Lunec, Penny E. Lovat, Yi-Hsuan Ho, Arman Esfandiari

    المصدر: Cancers
    Cancers; Volume 11; Issue 1; Pages: 3
    Cancers, Vol 11, Iss 1, p 3 (2018)

    مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, p53, Cancer Research, Cell cycle checkpoint, DUSP6, lcsh:RC254-282, Article, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, nutlin-3, MDM2, medicine, melanoma, RG7388, neoplasms, HDM201, Trametinib, trametinib, biology, Chemistry, Melanoma, MEK inhibitor, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, ATM, biology.protein, Cancer research, Mdm2

    وصف الملف: application/pdf

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0311d14b779824c9a879482d559e8b
    http://europepmc.org/articles/PMC6356368

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