يعرض 1 - 10 نتائج من 629 نتيجة بحث عن '"HERG channel"', وقت الاستعلام: 0.80s تنقيح النتائج
  1. 1
    مؤتمر
    Effect of arsenic trioxide on human ventricular myocytes: a model study

    المؤلفون: Li, Yacong, Liu, Jun, Wan, Runlan, Ma, Lei, Zhang, Henggui

    المصدر: 2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) Bioinformatics and Biomedicine (BIBM), 2022 IEEE International Conference on. :2640-2647 Dec, 2022

    Relation: 2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

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  2. 2
    دورية أكاديمية
    Structural modeling of hERG channel-drug interactions using Rosetta.

    المؤلفون: Emigh Cortez, Aiyana, DeMarco, Kevin, Furutani, Kazuharu, Bekker, Slava, Sack, Jon, Wulff, Heike, Clancy, Colleen, Vorobyov, Igor, Yarov-Yarovoy, Vladimir

    مصطلحات موضوعية: Rosetta, drug block, hERG channel, potassium channel, state-dependent

    وصف الملف: application/pdf

    URL الوصول: https://escholarship.org/uc/item/2vk5v4zs

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  3. 3
    دورية أكاديمية
    Structural modeling of the hERG potassium channel and associated drug interactions

    المؤلفون: Maly, Jan, Emigh, Aiyana M, DeMarco, Kevin R, Furutani, Kazuharu, Sack, Jon T, Clancy, Colleen E, Vorobyov, Igor, Yarov-Yarovoy, Vladimir

    مصطلحات موضوعية: Medical Physiology, Biomedical and Clinical Sciences, Heart Disease, Cardiovascular, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, hERG channel, potassium channel, inactivation, drug block, Rosetta, Pharmacology and Pharmaceutical Sciences, Pharmacology and pharmaceutical sciences

    وصف الملف: application/pdf

    URL الوصول: https://escholarship.org/uc/item/1wx8q1xs
    https://escholarship.org/content/qt1wx8q1xs/qt1wx8q1xs.pdf

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  4. 4
    دورية أكاديمية
    Structural modeling of hERG channel–drug interactions using Rosetta

    المؤلفون: Aiyana M. Emigh Cortez, Kevin R. DeMarco, Kazuharu Furutani, Slava Bekker, Jon T. Sack, Heike Wulff, Colleen E. Clancy, Igor Vorobyov, Vladimir Yarov-Yarovoy

    المصدر: Frontiers in Pharmacology, Vol 14 (2023)

    مصطلحات موضوعية: hERG channel, potassium channel, state-dependent, drug block, Rosetta, Therapeutics. Pharmacology, RM1-950

    وصف الملف: electronic resource

    Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1244166/full; https://doaj.org/toc/1663-9812

    URL الوصول: https://doaj.org/article/fd59e24e40c74bc3bfc831b84aa37187

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  5. 5
    دورية أكاديمية
    Intracellular Binding of Terfenadine Competes with Its Access to Pancreatic ß-cell ATP-Sensitive K+ Channels and Human ether-à-go-go-Related Gene Channels

    المؤلفون: Zünkler, Bernd J.Aff1, Aff2, IDs0023202200252y_cor1, Wos-Maganga, Maria, Bohnet, Stefanie, Kleinau, Anne, Manns, Detlef, Chatterjee, Shivani

    المصدر: The Journal of Membrane Biology. 256(1):63-77

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  6. 6
    hERG-toxicity prediction using traditional machine learning and advanced deep learning techniques

    المؤلفون: Ylipää, Erik, Chavan, Swapnil, Bånkestad, Maria, Broberg, Johan, Glinghammar, Björn, Norinder, Ulf, 1956, Cotgreave, Ian

    المصدر: Current Research in Toxicology. 5

    مصطلحات موضوعية: Deep Learning, Graph -neural Network, hERG Channel, Random Forest, Recurrent -neural Network, Support -vector Machines

    وصف الملف: print

    URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-223947
    https://doi.org/10.1016/j.crtox.2023.100121

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  7. 7
    دورية أكاديمية
    Facilitation of hERG Activation by Its Blocker: A Mechanism to Reduce Drug-Induced Proarrhythmic Risk

    المؤلفون: Kazuharu Furutani

    المصدر: International Journal of Molecular Sciences, Vol 24, Iss 22, p 16261 (2023)

    مصطلحات موضوعية: hERG channel, IKr, drug-induced arrhythmias, molecular pharmacology, structural model, Biology (General), QH301-705.5, Chemistry, QD1-999

    وصف الملف: electronic resource

    Relation: https://www.mdpi.com/1422-0067/24/22/16261; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067

    URL الوصول: https://doaj.org/article/b1c80729b19740078afcc695825f83cd

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  8. 8
    دورية أكاديمية
    hERG Blockade Prediction by Combining Site Identification by Ligand Competitive Saturation and Physicochemical Properties

    المؤلفون: Himanshu Goel, Wenbo Yu, Alexander D. MacKerell

    المصدر: Chemistry, Vol 4, Iss 3, Pp 630-646 (2022)

    مصطلحات موضوعية: SILCS, hERG channel, physicochemical properties, multiple linear regression, FragMaps, Chemistry, QD1-999

    وصف الملف: electronic resource

    Relation: https://www.mdpi.com/2624-8549/4/3/45; https://doaj.org/toc/2624-8549

    URL الوصول: https://doaj.org/article/b4da44b444bb4915870fd72b30c63809

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  9. 9
    دورية أكاديمية
    Importance of modelling hERG binding in predicting drug-induced action potential prolongations for drug safety assessment

    المؤلفون: Hui Jia Farm, Michael Clerx, Fergus Cooper, Liudmila Polonchuk, Ken Wang, David J. Gavaghan, Chon Lok Lei

    المصدر: Frontiers in Pharmacology, Vol 14 (2023)

    مصطلحات موضوعية: drug binding, drug trapping, IC50 (50% inhibition concentration), mathematical modelling, hERG channel, action potential predictions, Therapeutics. Pharmacology, RM1-950

    وصف الملف: electronic resource

    Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1110555/full; https://doaj.org/toc/1663-9812

    URL الوصول: https://doaj.org/article/dffab7b5dfe14ccc99d7e8b7c58bb678

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  10. 10
    دورية أكاديمية
    Derivation of Highly Predictive 3D-QSAR Models for hERG Channel Blockers Based on the Quantum Artificial Neural Network Algorithm

    المؤلفون: Taeho Kim, Kee-Choo Chung, Hwangseo Park

    المصدر: Pharmaceuticals, Vol 16, Iss 11, p 1509 (2023)

    مصطلحات موضوعية: hERG channel blockers, 3D-QSAR, structural alignment, molecular ESP descriptor, artificial neural network, Medicine, Pharmacy and materia medica, RS1-441

    وصف الملف: electronic resource

    Relation: https://www.mdpi.com/1424-8247/16/11/1509; https://doaj.org/toc/1424-8247

    URL الوصول: https://doaj.org/article/aa96ba85aeb346c1846009cfd54f653b

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