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المؤلفون: Sneh Lata, Ritu Mishra, Ravi P. Arya, Pooja Arora, Anismrita Lahon, Akhil C. Banerjea, Vikas Sood
المصدر: Journal of Molecular Biology
مصطلحات موضوعية: DDX, DEAD-box RNA helicase, CDG1C, congenital disorder of N-linked glycosylation type 1C, CDGS, carbohydrate-deficient glycoprotein syndrome, RSV, Respiratory Syncytial Virus, CSNK2B, casein kinase 2 subunit beta, Review Article, VPS, vacuolar protein sorting, SREBP3, sterol regulatory element binding protein 3, Structural Biology, PP2A, protein phosphatase 2A, Clustered Regularly Interspaced Short Palindromic Repeats, ALG, Alpha-1,3-glucosyltransferase, TMPRSS2, transmembrane protease serine 2, HDACS, histone deacetylases, TLR, toll-like receptors, DENV, Dengue Virus, C1QTNF7, C1q and tumor necrosis factor-related protein 7, CIRV, Carnation Italian ringspot virus, VACV, vaccinia virus, HIV-1, Human Immunodeficiency Virus 1, LRRN2, leucine-rich repeat neuronal protein 2, HPV, Human Papilloma Virus, IAV, Influenza A virus, SBV, Schmallenberg virus, CRISPR, HSV-1, Herpes Simplex Virus-1, SNPs, single nucleotide polymorphisms, Host factors, EBV, Epstein–Barr virus, TMV, Tobacco Mosaic Virus, BCOR, BCL6 interacting co-repressor, COVID-19, coronavirus disease 19, CTRP, C1q complement/TNF-related protein, Host-Derived Cellular Factors, Viral diseases, ACE2, angiotensin-converting enzyme 2, VSV, Vesicular Somatitis Virus, CHIKV, Chikungunya Virus, HCV, Hepatitis C virus, Humans, COG, conserved oligomeric Golgi, RRA, robust-rank aggregation, Molecular Biology, Pandemics, ComputingMethodologies_COMPUTERGRAPHICS, Host Microbial Interactions, SARS-CoV-2, ARPP-19, cyclic adenosine monophosphate-regulated phosphoprotein 19, COVID-19, LIMA-1, LIM domain and actin binding-1, GDI2, GDP dissociation inhibitor beta, TBSV, Tomato bushy stunt virus, EPLIN, epithelial protein lost in neoplasm, HCC, hepatocellular carcinoma, SLC35B2, solute carrier family 35 member B2
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المؤلفون: Qiuying Cheng, John M. Ong'echa, Angela O. Achieng, Bernard Guyah, Collins Ouma, Christophe G. Lambert, Douglas J Perkins
المصدر: EBioMedicine
مصطلحات موضوعية: Male, 0301 basic medicine, Research paper, medicine.medical_treatment, Interleukin-1beta, PBMCs, Peripheral blood mononuclear cells, LAIR2, Leukocyte-associated immunoglobulin like receptor-2, PfHz, Plasmodium falciparum haemozoin, LAIR1, Leukocyte-associated immunoglobulin like receptor-1, SHP-1, SH2 domain-containing tyrosine phosphatase-1, Pathogenesis, chemistry.chemical_compound, 0302 clinical medicine, PCN, Pigment containing neutrophils, TNF-α, Tumor necrosis factor alpha, Malaria, Falciparum, Receptors, Immunologic, 050207 economics, Receptor, Leukocyte-associated immunoglobulin like receptor-1, Leukocyte-associated immunoglobulin like receptor-2, P. falciparum, Plasmodium falciparum, 050208 finance, CLL, Chronic lymphocytic leukaemia, ITIM, immuno-tyrosine inhibition motifs, biology, Protein Tyrosine Phosphatase, Non-Receptor Type 6, 05 social sciences, Anemia, General Medicine, SMA, Severe malarial anaemia, 3. Good health, HFRS, haemorrhagic fever with renal syndrome, Child, Preschool, HIV-1, Human immunodeficiency virus 1, 030220 oncology & carcinogenesis, IL-6, Interleukin 6, Female, Tumor necrosis factor alpha, Antibody, Signal Transduction, C1q, Complement component 1q, Hemeproteins, SHP-2, SH2 domain-containing tyrosine phosphatase-2, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Immune system, Phagocytosis, SLE, Systemic lupus erythematosus, Complement component 1q, In vivo, 0502 economics and business, medicine, Humans, SMA, severe malarial anaemia, Interleukin 6, Plasmodium falciparum malaria, Interleukin-6, Tumor Necrosis Factor-alpha, business.industry, Complement C1q, LAIR1, Plasmodium falciparum haemozoin, Antagonist, Infant, PCM, Pigment containing monocytes, NF-κB, Immunotherapy, AML, Acute myeloid leukaemia, 030104 developmental biology, chemistry, NF-κB, Nuclear factor-kappa beta, Immunology, Leukocytes, Mononuclear, IL-1β, Interleukin 1 beta, biology.protein, PCR, Polymerase chain reaction, business, Biomedical sciences
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المؤلفون: Thomas Efferth, Franz Oesch, Barbara Oesch-Bartlomowicz
المصدر: Phytomedicine
مصطلحات موضوعية: 2019-20 coronavirus outbreak, medicine.medical_specialty, Relative toxicity, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pharmaceutical Science, Review, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, 03 medical and health sciences, Cytochrome P450, Phytochemicals, 0302 clinical medicine, SOD, superoxide dismutase, Drug Discovery, Medicine, Animals, Humans, Oral application, IKK, inhibitor of κB kinase, 030304 developmental biology, Pharmacology, Rational phytotherapy, 0303 health sciences, Public health, COVID-19, Coronavirus disease 2019, JNK, c-Jun N-terminale kinase, NO, nitric oxide, Plants, Medicinal, Traditional medicine, Toxicity, ACE2, angiotensin converting enzyme 2, business.industry, SARS-CoV-2, COVID-19, Th2, T helper cells, type 2, NF-κB, nuclear factor- κ B cells, Complementary and alternative medicine, 030220 oncology & carcinogenesis, Molecular Medicine, CYP, cytochrome P450 monooxygenase, HIV-1, human immunodeficiency virus 1, business, Selection criterion, MAPK, mitogen-activated protein kinase, Drugs, Chinese Herbal
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المؤلفون: Semir Vranic, Maha Al-Asmakh, Ishita Gupta, Ahmed H. Amarah, Muhammad Umar Sohail, Ala-Eddin Al Moustafa, Khaled E. Elzawawi
المصدر: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 1654-1660 (2021)مصطلحات موضوعية: RAS, renin-angiotensin, ERK, extracellular signal-regulated kinases, TJP3, tight junction protein 3, ALCAM, activated leukocyte cell adhesion molecule, RR, relative risk, Review, medicine.disease_cause, Biochemistry, Lung Disease, 0302 clinical medicine, ACEIs, Angiotensin‐converting enzyme inhibitors, IFN, Interferons, Structural Biology, ARBs, angiotensin receptor blockers, Pandemic, HDAC6, histone deacetylase 6, Coronavirus, COVID-19, coronavirus disease 2019, 0303 health sciences, Smoking, Oral disease, Computer Science Applications, CTNNB1, catenin beta 1, 030220 oncology & carcinogenesis, Ang, angiotensin, JNK, c-Jun N-terminal kinase, HIV-1, human immunodeficiency virus 1, CLDN7, claudin 7, R0, R-nought, Biotechnology, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), MCN, mucin, Biophysics, MERS, middle-East respiratory syndrome, TMPRSS2, 03 medical and health sciences, ACE2, angiotensin-converting enzyme-2, Genetics, medicine, ADAM17, ADAM metallopeptidase domain 17, IR, Ionizing radiation, BatCoV, bat coronavirus, nAChR, α7 nicotinic acetylcholine receptor, Oral Disease, ARDS, acute respiratory distress syndrome, 030304 developmental biology, ComputingMethodologies_COMPUTERGRAPHICS, NO, nitric oxide, business.industry, IPF, Idiopathic pulmonary fibrosis, SARS-CoV-2, TMPRSS, transmembrane serine protease, COVID-19, medicine.disease, COPD, chronic obstructive pulmonary disease, SARS-CoV-2, severe acute respiratory syndrome coronavirus, Infectious disease (medical specialty), Lung disease, Immunology, Middle East respiratory syndrome, Cytokine storm, business, hrsACE2, human recombinant soluble ACE-2, TP248.13-248.65
وصف الملف: application/pdf
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المؤلفون: Dubert, Marie, Visseaux, Benoit, Isernia, Valentina, Bouadma, Lila, Deconinck, Laurène, Patrier, Juliette, Wicky, Paul-Henri, Le Pluart, Diane, Kramer, Laura, Rioux, Christophe, Le Hingrat, Quentin, Houhou-Fidouh, Nadhira, Yazdanpanah, Yazdan, Ghosn, Jade, Lescure, Francois-Xavier
المصدر: International Journal of Infectious Diseases
مصطلحات موضوعية: SARS-CoV-2 viral load, UNL, upper normal limit, HIV-1, Human immunodeficiency virus 1, antiviral therapy, case reports, VL, viral load, viral pneumonia, remdesivir, ICU, intensive care unit, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, Article
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المؤلفون: Manuel Garcia-Moreno, Alfredo Castello, Kate Dicker, Aino I. Järvelin
المصدر: Seminars in Cell & Developmental Biology
مصطلحات موضوعية: 0301 basic medicine, viruses, RNA-binding protein, Review, ZIKV, Zika virus, Virus Replication, Genome, 0302 clinical medicine, RBP, dsRNA, Double-stranded RNA, HBV, Hepatitis B virus, CLIP-seq, Crosslinking and immunoprecipitation followed by sequencing, Infectivity, RNP, Ribonucleoprotein, RNA-Binding Proteins, Protein-RNA interaction, vRNP, Viral ribonucleoprotein, Virus, IAV, Influenza A virus, Virus Diseases, HIV-1, Human immunodeficiency virus 1, Proteome, Host-Pathogen Interactions, Viruses, RSV, Respiratory syncytial virus, RNA, Viral, RBP, RNA-binding protein, ivRBP, In virion RNA-binding protein, dsDNA, Double-stranded DNA, Protein Binding, Signal Transduction, Virus infection, Computational biology, Biology, vRNA, Viral RNA, HCV, Hepatitis C virus, pgRNA, Pre-genomic RNA, 03 medical and health sciences, Viral Proteins, GO, Gene Ontology, RIC, RNA-interactome capture, Humans, RNA, Messenger, RBD, RNA-binding domain, Virus Assembly, MeV, Measles virus, Virion, RNA, RNA virus, Cell Biology, biology.organism_classification, RRM, RNA-recognition motif, 030104 developmental biology, RVFV, Rift Valley fever virus, Viral replication, Gene Expression Regulation, Protein Biosynthesis, PAMP, Pathogen associated molecular pattern, VSV, Vesicular stomatitis virus, SINV, Sindbis virus, DENV, Dengue virus, 4SU, 4-thiouridine, Ribosomes, 030217 neurology & neurosurgery, Developmental Biology
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المؤلفون: Eliana M. Coccia, Angela Battistini
المصدر: Seminars in Immunology
مصطلحات موضوعية: Evasion mechanism, ssRNA, single-stranded RNA, DHX, DEAH box protein, IRF, IFN regulatory factor, miR, microRNA, TLRs, Toll-like receptors, TREX1, three prime repair exonuclease 1, CARD, caspase recruitment domain, MAM, mitochondrial associated membranes, tRNA, transfer RNA, PRR, pattern-recognition receptors, NSP, nonstructural protein, DDX, DEAD box protein, SIV, simian immunodeficiency virus, LRRFIP1, extrachromosomal histone, CypA, cyclophilin A, RT, reverse transcription, ASC, apoptosis-associated speck-like protein containing a CARD, CLRs, C-type lectin receptors, Acquired immune system, Virus, STAT, signal transducer and activator of transcription, iNOS, inducible nitric oxide synthase 1, Interferon Type I, MAVS, mitochondrial antiviral signaling protein, Interferon, JAK, Janus kinase, AIM2, absent in melanoma 2, dNTPase, deoxynucleotide triphosphate triphosphohydrolase, RLRs, (RIG)-I-like receptors, Immunology, IFN-α/β, IFN-I, JEV, Japanese encephalitis virus, H2B, leucine rich repeat (in FLII) interacting protein, TRAF, TNF receptor associated factor, CDNs, cyclic dinucleotides, cIAP, cellular inhibitors of apoptosis, Article, AIM2, APOBEC, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like, ssDNA, single-stranded DNA, SLFN11, schlafen family member 11, SAMHD1, SAM domain and HD domain-containing protein 1, DAI, DNA-dependent activator of IFN-regulatory factors, SARS, severe acute respiratory syndrome, Immune Evasion, MDA5, melanoma differentiation-associated gene-5, NO, nitric oxide, Bacteria, ITIM, immunoreceptor tyrosine-based inhibition motif, MERS, Middle East respiratory syndrome, ISRE, IFN-stimulated response element, Virology, Signaling, RIG-I, retinoic acid-inducible gene 1, cGAS, cyclic GMP-AMP synthase, TRIF, TIR domain-containing adaptor inducing IFN-β, Viral replication, TBK1, TANK-binding kinase 1, ISG15, IFN-stimulated gene 15, NLRs, nucleotide-binding oligomerization domain-like receptors, SAMHD1, PACT, PKR-associated activator, TRIM, tripartite motif, DENV, dengue virus, ISGF3, interferon-stimulated gene factor 3, IFN-stimulated genes, MyD88, myeloid differentiation primary response gene 88, DNA, deoxyribonucleic acid, pDCs, plasmacytoid dendritic cells, CPSF6, cleavage and polyadenylation specificity factor subunit 6, PKR, double-stranded RNA-activated protein kinase, CoV, Coronavirus, Immunology and Allergy, IKK, inhibitor of kB kinase, MAPKs, mitogen-activated protein kinases, SOCS, suppressor of cytokine signaling, RIG-I, NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells, Pattern recognition receptor, IFITM, IFN-induced transmembrane protein, MDA5, Bacterial Infections, mRNA, messenger RNA, RIP, receptor-interacting serine-threonine kinase, dsRNA, double-strand RNA, WNV, West Nile virus, Virus Diseases, HCV, hepatitis C virus, Viruses, HIV-1, human immunodeficiency virus 1, LPS, lipopolysaccharide, DCs, dendritic cells, PAMP, pathogen-associated molecular pattern, Signal Transduction, TIR, Toll-Interleukin-1 receptor, NLRP3, NACHT LRR and PYD domains-containing protein 3, Biology, PLP, papain-like protease, ER, endoplasmic reticulum, NOD, nucleotide-binding oligomerization domain, IRAK, IL-1R-associated kinases, IFI16, interferon gamma-interferon-inducible protein 16, IFN, interferon, IFI16, NADPH, nicotinamide adenine dinucleotide phosphate, STING, stimulator of IFN genes protein, IFIT, IFN-induced tetratricopeptide repeat proteins, RNA, ribonucleic acid, IPS1, IFN-β-promoter stimulator 1, Type II IFN, IFN-II, ISGs, IFN stimulated genes
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المؤلفون: Teresa, Kaserer, Veronika, Temml, Zsofia, Kutil, Tomas, Vanek, Premysl, Landa, Daniela, Schuster
المصدر: European Journal of Medicinal Chemistry
مصطلحات موضوعية: Models, Molecular, Drug Evaluation, Preclinical, AA, arachidonic acid, PGE2, Prostaglandin E2, ECFP4, Extended-connectivity fingerprints 4, Docking, Method comparison, SEA, Similarity Ensemble Approach, MNA, multilevel neighborhoods of atoms, FCFP6, Functional-class fingerprints 6, HBD, hydrogen bond donor, Acc, accuracy, Tc, Tanimoto coefficient, Molecular Structure, R, ring feature, NI, negative ionizable feature, XVOL, exclusion volume, GFA, genetic function approximation, Cyclooxygenase, EE, early enrichment, HIV-1, human immunodeficiency virus 1, OEST, ROCS OpenEye shape Tanimoto, Original Article, DES, diethylstilbestrol, TP, true positive hits, WOMBAT, World of Molecular Bioactivity, ACE, angiotensin-converting enzyme, FN, false negative hits, FP, false positive hits, KEGG, Kyoto Encyclopedia of Genes and Genomes, Structure-Activity Relationship, Shape-based modeling, C, cation, TN, true negative hits, Humans, Cyclooxygenase Inhibitors, ROCS, Rapid Overlay of Chemical Structures, SERMs, selective estrogen receptor modulators, Pharmacophore modeling, Ar, aromatic feature, OE, overall enrichment, Dose-Response Relationship, Drug, MB, metal binding feature, OECS, ROCS OpenEye ComboScore, DUD, Directory of Useful Decoys, m. p., melting point, COX, cyclooxygenase, H, hydrophobic feature, Cyclooxygenase 2, HBA, hydrogen bond acceptor, Cyclooxygenase 1, PASS, Prediction of Activity Spectra for Substances, A, anion, PDB, Protein Databank, 2D similarity-based search
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المؤلفون: Marilyn Kozak
المصدر: Gene
مصطلحات موضوعية: Five prime untranslated region, Internal ribosome entry site, LEF1, lymphoid enhancer factor-1, Codon, Initiator, Leaky scanning, Biology, C/EBP, CCAAT/enhancer binding protein, eIF, eukaryotic initiation factor, Article, TPO, thrombopoietin, R, purine, Start codon, AdoMetDC, S-adenosylmethionine decarboxylase, ORF, open reading frame, CTL, cytotoxic T-lymphocyte, Eukaryotic initiation factor, Upstream open reading frame, Genetics, OGP, osteogenic growth peptide, Animals, Humans, RNA, Messenger, A2AR, A2A adenosine receptor, Peptide Chain Initiation, Translational, Models, Genetic, upORF, upstream open reading frame, Shine-Dalgarno sequence, Translational control, General Medicine, EGFP, enhanced green fluorescent protein, Open reading frame, UTR, untranslated region, Thrombopoietin, IRES, internal ribosome entry site, Protein Biosynthesis, 5′ untranslated region, AUG context, Dicistronic mRNA, HIV-1, human immunodeficiency virus 1, Reinitiation
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