يعرض 1 - 10 نتائج من 34 نتيجة بحث عن '"HR23B"', وقت الاستعلام: 1.88s تنقيح النتائج
  1. 1
    دورية أكاديمية
    A Phase 2a cohort expansion study to assess the safety, tolerability, and preliminary efficacy of CXD101 in patients with advanced solid-organ cancer expressing HR23B or lymphoma

    المؤلفون: Stephen W. Booth, Toby A. Eyre, John Whittaker, Leticia Campo, Lai Mun Wang, Elizabeth Soilleux, Daniel Royston, Gabrielle Rees, Murali Kesavan, Catherine Hildyard, Farasat Kazmi, Nick La Thangue, David Kerr, Mark R. Middleton, Graham P. Collins

    المصدر: BMC Cancer, Vol 21, Iss 1, Pp 1-10 (2021)

    مصطلحات موضوعية: Histone deacetylase (HDAC), HR23B, Biomarker, Lymphoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

    وصف الملف: electronic resource

    Relation: https://doaj.org/toc/1471-2407

    URL الوصول: https://doaj.org/article/ed0569a0654b401a969430ba23e234a6

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  2. 2
    دورية أكاديمية
    A Phase 2a cohort expansion study to assess the safety, tolerability, and preliminary efficacy of CXD101 in patients with advanced solid-organ cancer expressing HR23B or lymphoma

    المؤلفون: Booth, Stephen W.Aff1, Eyre, Toby A., Whittaker, John, Campo, Leticia, Wang, Lai Mun, Soilleux, Elizabeth, Royston, Daniel, Rees, Gabrielle, Kesavan, Murali, Hildyard, Catherine, Kazmi, Farasat, La Thangue, NickAff3, Aff2, Kerr, DavidAff3, Aff2, Middleton, Mark R., Collins, Graham P.

    المصدر: BMC Cancer. 21(1)

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  3. 3
    دورية أكاديمية
    HR23B pathology preferentially co-localizes with p62, pTDP-43 and poly-GA in C9ORF72-linked frontotemporal dementia and amyotrophic lateral sclerosis

    المؤلفون: Frederike W. Riemslagh, Hannes Lans, Harro Seelaar, Lies-Anne W. F. M. Severijnen, Shamiram Melhem, Wim Vermeulen, Eleonora Aronica, R. Jeroen Pasterkamp, John C. van Swieten, Rob Willemsen

    المصدر: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-13 (2019)

    مصطلحات موضوعية: C9ORF72, ALS, FTD, HR23B, ERAD, NGly1, Neurology. Diseases of the nervous system, RC346-429

    وصف الملف: electronic resource

    Relation: http://link.springer.com/article/10.1186/s40478-019-0694-6; https://doaj.org/toc/2051-5960

    URL الوصول: https://doaj.org/article/5debd3538a644bb98910b0ae83f699e8

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  4. 4
    دورية أكاديمية
    HR23B pathology preferentially co-localizes with p62, pTDP-43 and poly-GA in C9ORF72-linked frontotemporal dementia and amyotrophic lateral sclerosis

    المؤلفون: Riemslagh, Frederike W.Aff1, Lans, HannesAff2, Seelaar, HarroAff3, Severijnen, Lies-Anne W. F. M.Aff1, Melhem, ShamiramAff3, Vermeulen, WimAff2, Aronica, EleonoraAff4, Pasterkamp, R. JeroenAff5, van Swieten, John C.Aff3, Willemsen, RobAff1

    المصدر: Acta Neuropathologica Communications. 7(1)

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  5. 5
    A Phase 2a cohort expansion study to assess the safety, tolerability, and preliminary efficacy of CXD101 in patients with advanced solid-organ cancer expressing HR23B or lymphoma

    المؤلفون: Farasat Kazmi, Leticia Campo, Mark R. Middleton, Toby A. Eyre, Nicholas B. La Thangue, Gabrielle G. Rees, Graham P. Collins, Stephen Booth, Murali Kesavan, Daniel Royston, David J. Kerr, John Whittaker, Lai Mun Wang, Catherine Hildyard, Elizabeth J. Soilleux

    المساهمون: Booth, Stephen W. [0000-0003-2687-0234], Apollo - University of Cambridge Repository, Booth, Stephen W [0000-0003-2687-0234]

    المصدر: BMC Cancer, Vol 21, Iss 1, Pp 1-10 (2021)
    BMC Cancer

    مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Lymphoma, Follicular lymphoma, Gene Expression, Neutropenia, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, Internal medicine, Biomarkers, Tumor, Genetics, medicine, Humans, Adverse effect, RC254-282, Aged, Neoplasm Staging, HR23B, business.industry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cancer, Biomarker, Middle Aged, medicine.disease, Immunohistochemistry, Histone deacetylase (HDAC), DNA-Binding Proteins, Histone Deacetylase Inhibitors, DNA Repair Enzymes, Treatment Outcome, 030104 developmental biology, Tolerability, 030220 oncology & carcinogenesis, Cohort, Biomarker (medicine), Female, business, Research Article, Experimental therapeutics and drug development

    وصف الملف: application/zip; application/pdf; text/xml

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b692505f6b19346560b40340f6f62b7
    https://doi.org/10.1186/s12885-021-08595-w

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  6. 6
    دورية أكاديمية
    The DNA repair-ubiquitin-associated HR23 proteins are constituents of neuronal inclusions in specific neurodegenerative disorders without hampering DNA repair

    المؤلفون: Steven Bergink, Lies-Anne Severijnen, Nils Wijgers, Kaoru Sugasawa, Humaira Yousaf, Johan M. Kros, John van Swieten, Ben A. Oostra, Jan H. Hoeijmakers, Wim Vermeulen, Rob Willemsen

    المصدر: Neurobiology of Disease, Vol 23, Iss 3, Pp 708-716 (2006)

    مصطلحات موضوعية: HR23B, Neurodegenerative disorders, Ubiquitin, Inclusions, DNA repair, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

    وصف الملف: electronic resource

    Relation: http://www.sciencedirect.com/science/article/pii/S0969996106001458; https://doaj.org/toc/1095-953X

    URL الوصول: https://doaj.org/article/3745910c010e4c4ea7ef66e775436bb7

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  7. 7
    HR23B pathology preferentially co-localizes with p62, pTDP-43 and poly-GA in C9ORF72-linked frontotemporal dementia and amyotrophic lateral sclerosis

    المؤلفون: R. Jeroen Pasterkamp, Wim Vermeulen, Lies Anne Severijnen, Rob Willemsen, Shamiram Melhem, Fréderike W. Riemslagh, Hannes Lans, Eleonora Aronica, John C. van Swieten, Harro Seelaar

    المساهمون: Clinical Genetics, Molecular Genetics, Neurology, Pathology, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, AII - Inflammatory diseases, APH - Mental Health, APH - Aging & Later Life

    المصدر: Acta neuropathologica communications (online), 7:39. BioMed Central Ltd.
    Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-13 (2019)
    Acta neuropathologica communications, 7(1). BioMed Central
    Acta Neuropathologica Communications

    مصطلحات موضوعية: Male, 0301 basic medicine, Pathology, medicine.medical_specialty, RAD23B, Ataxia, DPRs, Clinical Neurology, C9ORF72, Hippocampal formation, Biology, lcsh:RC346-429, Pathology and Forensic Medicine, Protein Aggregates, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, C9orf72, medicine, Humans, NGly1, Amyotrophic lateral sclerosis, lcsh:Neurology. Diseases of the nervous system, Aged, C9orf72 Protein, HR23B, Research, Dentate gyrus, Amyotrophic Lateral Sclerosis, Proteins, RNA-Binding Proteins, FTD, Poly-GA, Middle Aged, ERAD, medicine.disease, 3. Good health, DNA-Binding Proteins, DNA Repair Enzymes, 030104 developmental biology, Frontotemporal Dementia, Spinocerebellar ataxia, Female, Neurology (clinical), medicine.symptom, ALS, 030217 neurology & neurosurgery, Frontotemporal dementia

    وصف الملف: application/pdf; image/pdf

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf9c871ce9c9aee38b493f82808b0b4
    http://www.scopus.com/inward/record.url?scp=85062867044&partnerID=8YFLogxK

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  8. 8
    A phase I study to assess the safety, tolerability, and pharmacokinetics of CXD101 in patients with advanced cancer

    المؤلفون: Eyre, TA, Collins, GP, Gupta, A, Coupe, N, Sheikh, S, Whittaker, J, Wang, LM, Campo, L, Soilleux, E, Tysoe, F, Cousins, R, La Thangue, N, Folkes, LK, Stratford, MRL, Kerr, D, Middleton, MR

    المساهمون: Soilleux, Elizabeth [0000-0002-4032-7249], Apollo - University of Cambridge Repository

    مصطلحات موضوعية: CXD101 histone deacetylase (HDAC), phase 1 trial, HR23B, hemic and lymphatic diseases, biomarker, demethylation

    وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462ba0397642be66177ba59f65148c1a

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  9. 9
    Predictive biomarkers for disease sensitivity in lymphoma – the holy grail for HDAC inhibitors?

    المؤلفون: Toby A. Eyre

    المصدر: Oncotarget

    مصطلحات موضوعية: business.industry, HR23B, Correction, Disease, medicine.disease, Lymphoma, Holy Grail, T cell lymphoma, CXD101, Editorial, Oncology, HDAC inhibitor, Cancer research, medicine, Hodgkin lymphoma, T-cell lymphoma, business, Predictive biomarker

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230122e04d3db083d99805ed0a5752a5
    http://europepmc.org/articles/PMC6324661

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  10. 10
    دورية أكاديمية

    لا يتم عرض هذه النتيجة على الضيوف.

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