المؤلفون: Jianbo Sun, Hui Zhong, Li Chen, Na Li, Kun Wang

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 11, Pp 3417-3432 (2021)

مصطلحات موضوعية: CoA, coenzyme A, Future studies, LC−MS, liquid chromatography−mass spectrometry, Computer science, MTDLs, multitarget-directed ligands, RM1-950, Review, Positive data, HTS, high-throughput screening, Machine learning, computer.software_genre, 03 medical and health sciences, 0302 clinical medicine, Multi target, QSAR, quantitative structure–activity relationship, GSH, glutathione, ROS, radicals and oxygen reactive species, Multitarget-directed ligands, HER2, human epidermal growth factor receptor 2, General Pharmacology, Toxicology and Pharmaceutics, ALARM NMR, a La assay to detect reactive molecules by nuclear magnetic resonance, 030304 developmental biology, 0303 health sciences, AD, Alzheimer disease, Fair trial, business.industry, Highly selective, In silico filtering, EGFR, epidermal growth factor receptor, Fair trial strategy, PAINS, pan-assay interference compounds, 030220 oncology & carcinogenesis, Biochemical experiment, CADD, computer-aided drug design technology, PAINS suspects, Therapeutics. Pharmacology, Artificial intelligence, business, computer

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862abd0b2f76391c84b2238b548f152a
https://doi.org/10.1016/j.apsb.2021.02.023

المؤلفون: Zulkar Nain, Mohaimenul Islam Tareq, Abdullah-Al-Mamun, Suza Mohammad Nur, Thamer A. Bouback, Raihan Rahman Imon, Ishtiaq Qadri, Shahedur Rahman, Foysal Ahammad, Saddam Hossen, Rahat Alam, Tomasz M. Karpiński, Abdus Samad, Enamul Kabir Talukder, Sushil Pokhrel

المصدر: International Journal of Biological Macromolecules

مصطلحات موضوعية: RO5, rule of five, MERS, Middle East Respiratory Syndrome, PBVS, pharmacophore based virtual screening, Drug Evaluation, Preclinical, ACE2, Ligands, Biochemistry, Chemical synthesis, COVID-2019, RMSD, root mean square deviation, Molecular dynamics, HTS, High Throughput Screening, AA, amino acids, Structural Biology, COVID-19, coronavirus disease 2019, chemistry.chemical_classification, MM/GBSA, +ssRNA, positive single strand RNA, General Medicine, 3D, three dimensional, MD, molecular dynamics, Structure-based pharmacophore model, DUDE, Database of Useful Decoys, Molecular Docking Simulation, SB, structure-based, Molecular docking, Spike Glycoprotein, Coronavirus, SBPM, structure-based pharmacophore model, Angiotensin-Converting Enzyme 2, Pharmacophore, Decoy, 2D, two dimensional, ADT, Auto Dock Tools, Protein Binding, Virtual screening, medicine.drug_class, Computational biology, Molecular Dynamics Simulation, ACE2, angiotensin-converting enzyme 2, Antiviral Agents, Article, WHO, World Health Organization, RMSF, root mean square fluctuation, Structure-Activity Relationship, PDB, Protein Data Bank, medicine, TMPRSS2, transmembrane protease serine protease 2, Humans, Computer Simulation, Binding site, Molecular Biology, Biological Products, Binding Sites, SARS-CoV-2, ICTV, International Committee on Taxonomy of Viruses, Enzyme, chemistry, SARS-CoV2, sever acute respiratory syndrome coronavirus 2, T.E.S.T., Toxicity Estimation Software Tool, Antiviral drug, ADMET, absorption, distribution, metabolism, excretion, and toxicity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e497649ef3b10bf02881728e8cfa000
https://doi.org/10.1016/j.ijbiomac.2021.09.146

المؤلفون: Katja Stefan, Jens Pahnke, Vigneshwaran Namasivayam, Sven Marcel Stefan

المصدر: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 6490-6504 (2021)

مصطلحات موضوعية: ATP, Adenosine-triphosphate, NBD, nucleotide binding domain, GSH, reduced glutathione, Polypharmacology, Alzheimer’s disease (AD), ATP-binding cassette transporter, HTS, high-throughput screening, Biochemistry, ABCA7, Structural Biology, PLIF, protein ligand interaction, MSD, membrane spanning domain, PDB, protein data bank, TM, transmembrane helix, ABC, ATP-binding cassette, Multitarget modulation (PANABC), RMSD, root mean square distance, ABC transporter (ABCA1, ABCA4, ABCA7), Computer Science Applications, MOE, Molecular Operating Environment, Pharmacophore, SNP, single-nucleotide polymorphism, Biotechnology, Research Article, BBB, blood-brain barrier, Biophysics, Drug design, Computational biology, Biology, AD, Alzheimer’s disease, PET, positron emission tomography, IC, intracellular helix, APP, amyloid precursor protein, cryo-EM, cryogenic-electron microscopy, Genetics, Homology modeling, Binding site, Rational drug design and development, ComputingMethodologies_COMPUTERGRAPHICS, NBD-cholesterol, 7-nitro-2-1,3-benzoxadiazol-4-yl-cholesterol, Transporter, PSO, particle swarm optimization, PET tracer (PETABC), ECD, extracellular domain, R-domain/region, regulatory domain/region, ABCA1, biology.protein, EH, extracellular helix, TP248.13-248.65, BODIPY-cholesterol, 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-cholesterol

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c495bacbe4f6d5dd1686380857969678
http://europepmc.org/articles/PMC8666613

المؤلفون: Hemmilä, Ilkka^Aff1_10, Laitala, Ville^Aff1_10

المساهمون: Hänninen, Pekka, editor^AffID1, Härmä, Harri, editor^AffID2

المصدر: Lanthanide Luminescence : Photophysical, Analytical and Biological Aspects. 7:361-380

المؤلفون: Fatemeh Ahmadi, Reza H. Sajedi, Mehdi Zeinoddini

المصدر: Iranian South Medical Journal, Vol 18, Iss 3, Pp 497-507 (2015)

مصطلحات موضوعية: photoprotein, i-Photina, bioluminescence signal intensity, HTS (High-Throughput Screening), Medicine (General), R5-920

وصف الملف: electronic resource

Relation: http://ismj.bpums.ac.ir/browse.php?a_code=A-10-3-605&slc_lang=en&sid=1; https://doaj.org/toc/1735-4374; https://doaj.org/toc/1735-6954

URL الوصول: https://doaj.org/article/f687ddf2aac14f5c985b440c638032f0

المؤلفون: Kewei Wang, Zongtao Liu, Yani Liu

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1412-1433 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: PASMC, pulmonary artery smooth muscle cells, PIP2, phosphatidylinositol 4,5-bisphosphate, ASM, airway smooth muscle, Drug target, ANO1, Review, HNSCC, head and neck squamous cell carcinoma, HTS, high-throughput screening, CaCCs, Ca2+ activated chloride channels, 0302 clinical medicine, ENaC, epithelial sodium channels, IPAH, idiopathic pulmonary arterial hypertension, General Pharmacology, Toxicology and Pharmaceutics, BBB, blood–brain barrier, VGCC, voltage gated calcium channel, VRAC, volume regulated anion channel, Cancer, 0303 health sciences, biology, Smooth muscle contraction, ICC, interstitial cells of Cajal, GI, gastrointestinal, Phenotype, DRG, dorsal root ganglion, VSMC, vascular smooth muscle cells, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Chloride channel, ANO1, anoctamin-1, ESCC, esophageal squamous cell carcinoma, NF-κB, nuclear factor κB, PAH, pulmonary arterial hypertension, Signal transduction, CAMK, Ca2+/calmodulin-dependent protein kinase, Anoctamin-1, CaCCinh-A01, FRT, fisher rat thyroid, PKD, polycystic kidney disease, RM1-950, Cystic fibrosis, ER, endoplasmic reticulum, GIST, gastrointestinal stromal tumor, 03 medical and health sciences, Channelopathy, TGF-β, transforming growth factor-β, medicine, CFTR, cystic fibrosis transmembrane conductance regulator, T16Ainh-A01, 030304 developmental biology, CF, cystic fibrosis, TMEM16A, Ang II, angiotensin II, business.industry, PAR2, protease activated receptor 2, medicine.disease, YFP, yellow fluorescent protein, Epithelium, EGFR, epidermal growth factor receptor, Ca2+-activated Cl– channels (CaCCs), GPCR, G-protein coupled receptor, biology.protein, Therapeutics. Pharmacology, business, Neuroscience, MAPK, mitogen-activated protein kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b93ad5ed1da50ffcb970b7aa59df7fe
https://doi.org/10.1016/j.apsb.2020.12.003

المؤلفون: Hong-Min Liu, Ya-Hong Wu, Yihui Song, Min Zhao, Bin Yu

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 750-762 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: PMSF, phenylmethanesulfonyl fluoride, LS, LEOPARD syndrome, Mutant, IC50, half maximal inhibitory concentration, Protein tyrosine phosphatase, HTS, high-throughput screening, chemistry.chemical_compound, 0302 clinical medicine, DiFMUP, 6,8-difluoro-4-methylumbelliferyl phosphate, General Pharmacology, Toxicology and Pharmaceutics, AML, acute myelogenous leukemia, Tm, melting temperature, 0303 health sciences, LB, lysogeny broth, SDS-PAGE, sodium dodecyl sulphate polyacyrlamide gel electrophoresis, High-throughput screening, R2, coefficient of determination, S/B, signal over background, STAT, signal transducer and activator of transcription, SHP2, Src homology phosphotyrosyl phosphatase 2, Biochemistry, 030220 oncology & carcinogenesis, Original Article, BTLA, B and T lymphocyte attenuator, PTP, protein tyrosine phosphatase, SH2, Src homology 2, Proto-oncogene tyrosine-protein kinase Src, Thermal shift assay, Allosteric regulation, Phosphatase, JAK, janus kinase, AKT, protein kinase B, SHP2-WT, wild type Src homology phosphotyrosyl phosphatase 2, SHP2-PTP, protein tyrosine phosphatase domain of Src homology phosphotyrosyl phosphatase 2, 03 medical and health sciences, PI3K, phosphatidylinositol 3 kinase, NS, Noonan syndrome, RAS, rat sarcoma, FI, fluorescence intensity, NPC, no protein control, 030304 developmental biology, ΔTm, melting temperature change, DiFMU, 6,8-difluoro-4-methylumbelliferyl hydroxid, ALK, anaplastic lymphoma kinase, lcsh:RM1-950, HEPES, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, MEK, extracellular regulated protein kinase kinases, JMML, juvenile myelomonocytic leukaemia, Enzyme assay, PD-1, programmed death 1, p-IRS1, phosphorylated insulin receptor substrate 1, Bis-tris, bis-(2-hydroxyethyl)amino-tris(hydroxymethyl)methane, OD, optical density, lcsh:Therapeutics. Pharmacology, chemistry, DTT, dithiothreitol, SHP2, Allosteric inhibitors, Bioisostere, LOC, ligand only control, SD, standard deviation, MAPK, mitogen-activated protein kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114cd1e4de1acb4de79002f71ffaa0be
https://doi.org/10.1016/j.apsb.2020.10.021

المؤلفون: Liang Ouyang, Yao Liu, Jie Liu, Lu Feng, Guan Wang, Yi Chen, Meng Wang, Tingting Jiang

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 355-372 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: NTRK, neurotrophic receptor tyrosine kinase, FISH, fluorescence in situ hybridization, Review, Tropomyosin receptor kinase B, HNSCC, head and neck squamous cell carcinoma, Tropomyosin receptor kinase A, HTS, high-throughput screening, ring finger and WD repeat domain 2, E3 ubiquitin protein ligase, Tropomyosin receptor kinase C, LMNA, lamin A/C, Receptor tyrosine kinase, TPM3, tropomyosin 3, 0302 clinical medicine, MASC, mammary analogue secretory carcinoma, PROTAC proteolysis targeting chimera, QKI, SQSTM1, sequestosome 1, TPR, translocated promoter region, General Pharmacology, Toxicology and Pharmaceutics, RABGTPase activating protein 1-like, RFWD2, AML, acute myeloid leukemia, 0303 health sciences, ICC, intrahepatic cholangiocarcinoma, TRK, tropomyosin receptor kinase, Neurotrophic receptor tyrosine kinase fusions, PPL, periplakin, TP53, tumor protein P53, SBC, secretory breast carcinoma, OAK, osteoarthritis of the knee, TFG, TRK-fused gene, ARHGEF2, Rho/Rac guanine nucleotide exchange factor 2, NT3, neurotrophin-3, quaking I protein, RABGAP1L, ETV6, ETS translocation variant 6, 030220 oncology & carcinogenesis, CR, complete response, CRC, colorectal cancer, BCAN, brevican, BDNF, brain-derived neurotrophic factor, BTBD1, BTB (POZ) domain containing 1, RTK, receptor tyrosine kinase, DOR, durable objective responses, CDK-2, cyclin-dependent kinase 2, Tyrosine kinase, EWG, electron-withdrawing group, ORR, overall response rate, Neurotrophin, NCCN, National Comprehensive Cancer Network, VCL, vinculin, NGF, nerve growth factor, MPRIP, myosin phosphatase Rho interacting protein, Biology, PAN3, poly(A) nuclease 3, TRIM24, tripartite motif containing 24, Small-molecule inhibitor, NTRK fusion cancer, SCYL3, SCY1 like pseudokinase 3, 03 medical and health sciences, NACC2, NACC family member 2, NSCLC, non-small cell lung cancer, SAR, structure–activity relationship, Protein kinase B, VEGFR2, vascular endothelial growth factor receptor 2, 030304 developmental biology, DFG, Asp-Phe-Gly, CTCs, sequencing of circulating tumor cells, lcsh:RM1-950, GBM, glioblastoma multiforme, NFASC, neurofascin, NGS, next-generation sequencing of tumor tissue, FDA, U.S. Food and Drug Administration, lcsh:Therapeutics. Pharmacology, nervous system, Trk receptor, IG-C2, Ig-like C2 type I, Cancer research, biology.protein, Tropomyosin receptor kinase, AFAP1, actin filament-associated protein 1

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c737a8f0c0bb6776695689290564cb8a
http://www.sciencedirect.com/science/article/pii/S2211383520305864

المؤلفون: Tingting Chen, Ancheng Shen, Ao Zhang, Chunyong Ding, Zilan Song

المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 12, Pp 2272-2298 (2020)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: PD-L1, programmed death ligand 1, TBK1, medicine.medical_treatment, ICI, immune checkpoint inhibitor, DC50, concentration for 50% degradation, Review, ACMA, 9-amino-6-chloro-2-methoxyacridine, PD-1, programmed death receptor 1, ULD, ubiquitin-like domain, Anti-tumor, ABZI, amidobenzimidazole, 0302 clinical medicine, GMP, guanosine monophosphate, LBD, ligand-binding domain, GTP, guanosine triphosphate, PRRs, pattern recognition receptors, Interferon, cAIMP, cyclic adenosine-inosine monophosphate, Medicine, CMA, 10-carboxymethyl-9-acridanone, General Pharmacology, Toxicology and Pharmaceutics, IKK, IκB kinase, ISG, interferon stimulated gene, MinEC5×, minimum effective concentration for inducing 5-fold luciferase activity, 0303 health sciences, KD, kinase domain, dsDNA, double-stranded DNA, MG, Mangostin, ITC, isothermal titration calorimetry, Immunogenicity, PBMCs, peripheral-blood mononuclear cells, MDCK, Madin–Darby canine kidney, PROTACs, proteolysis targeting chimeras, FAA, flavone-8-acetic acid, CTD, C-terminal domain, DMXAA, 5,6-dimethylxanthenone-4-acetic acid, DSDP, dispiro diketopiperzine, STAT, signal transducer and activator of transcription, medicine.anatomical_structure, 030220 oncology & carcinogenesis, CDN, cyclic dinucleotide, QC, quinacrine, FP, fluorescence polarization, PDK1, 3-phosphoinositide-dependent protein kinase 1, Immunotherapy, Signal transduction, DCs, dendritic cells, CDA, cyclic diadenosine monophosphate (c-di-AMP), medicine.drug, Ntase, nucleotidyl transferase, ATP, adenosine triphosphate, CDG, cyclic diguanosine monophosphate (c-di-GMP), T cell, SDD, scaffold and dimerization domain, NF-κB, nuclear factor-κB, STING, stimulator of interferon genes, TNFRSF, tumor necrosis factor receptor superfamily, EM, cryo-electron microscopy, ER, endoplasmic reticulum, 03 medical and health sciences, MLK, mixed lineage kinase, Immune system, CBD, cyclic dinucleotide-binding domain, THIQCs, tetrahydroisoquinolone acetic acids, SAR, structure–activity relationship, HCQ, hydrochloroquine, ENPP1, ecto-nucleotide pyrophosphatase/phosphodiesterase, HTS, high throughput screening, 030304 developmental biology, MI, maximum induction, CXCL, chemokine (C-X-C motif) ligand, Innate immune system, PDE, phosphodiesterases, IO, immune-oncology, business.industry, IRF3, interferon regulatory factor 3, i.t., intratumoral, CTT, C-terminal tail, lcsh:RM1-950, BNBC, 6-bromo-N-(naphthalen-1-yl)benzo[d][1,3]dioxole-5-carboxamide, Chimeric antigen receptor, PPi, pyrophosphoric acid, Small molecule modulators, FDA, U.S. Food and Drug Administration, VHL, von Hippel–Lindau, lcsh:Therapeutics. Pharmacology, AMP, adenosine monophosphate, TBK1, TANK-binding kinase 1, Cancer research, cGAMP, cyclic guanosine monophosphate-adenosine monophosphate, business, cGAS, cyclic guanosine monophosphate-adenosine monophosphate synthase, CTLA-4, cytotoxic T lymphocyte associated protein 4, cGAS, STING

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c604607610f05b2d37da5b2cce00382
http://www.sciencedirect.com/science/article/pii/S2211383519316946

المؤلفون: Razvan L. Cornea, Ching-Chieh Tung, Daniel P. Singh, Filip Van Petegem, Donald M. Bers, Bengt Svensson, Kaja Rožman, Levy M. Treinen, Siobhan M. Wong King Yuen, Courtney C. Aldrich, Bradley S. Launikonis, Jingyan Zhang, David D. Thomas, Aleksey V. Zima, Jacob A. Schwarz, Christopher Y. Ko, Roman Nikolaienko

المصدر: The Journal of biological chemistry, vol 298, iss 1
The Journal of Biological Chemistry

مصطلحات موضوعية: Biosensing Techniques, HTS, high-throughput screening, Cardiovascular, HF, heart failure, Biochemistry, Ryanodine receptor 2, Medical and Health Sciences, Mice, 0302 clinical medicine, Fluorescence Resonance Energy Transfer, Myocyte, FWHM, full-width at half-maximum, Pediatric, CaM, calmodulin, 0303 health sciences, Chemistry, Ryanodine receptor, NTR, N-terminal region, Skeletal, Biological Sciences, musculoskeletal system, Cell biology, Heart Disease, FA, fusidic acid, FKBP, FK506 binding protein 12.6, 5.1 Pharmaceuticals, cardiovascular system, CPVT, catecholaminergic polymorphic ventricular tachycardia, Muscle, Development of treatments and therapeutic interventions, tissues, Research Article, myopathy, Biotechnology, Biochemistry & Molecular Biology, High-throughput screening, EC, excitation–contraction, SPR, surface plasmon resonance, high-throughput screening, 03 medical and health sciences, fluorescence lifetime, ryanodine receptor, Animals, Muscle, Skeletal, Enhancer, Molecular Biology, 030304 developmental biology, RYR1, FLT, fluorescence lifetime, Endoplasmic reticulum, N-terminal region, SR, sarcoplasmic reticulum, Ryanodine Receptor Calcium Release Channel, Cell Biology, RyR, ryanodine receptor, WT, wild-type, High-Throughput Screening Assays, Förster resonance energy transfer, Chemical Sciences, FRET, Calcium, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e651b16da8560235f301c406f3eb42
https://escholarship.org/uc/item/1sw1d750