المؤلفون: Zhang Z; Laboratory of Molecular and Chemical Biology of Neurodegeneration, School of Life Sciences, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland.; Laboratory for Biomolecular Modeling, School of Life Sciences, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland., Gehin C; Laboratory of Molecular and Chemical Biology of Neurodegeneration, School of Life Sciences, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland., Abriata LA; Laboratory for Biomolecular Modeling, School of Life Sciences, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland., Dal Peraro M; Laboratory for Biomolecular Modeling, School of Life Sciences, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland., Lashuel H; Laboratory of Molecular and Chemical Biology of Neurodegeneration, School of Life Sciences, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland.

المصدر: ACS chemical neuroscience [ACS Chem Neurosci] 2024 Jun 19; Vol. 15 (12), pp. 2408-2419. Date of Electronic Publication: 2024 May 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE

مواضيع طبية MeSH: Protein Processing, Post-Translational*/physiology , Huntingtin Protein*/metabolism , Huntingtin Protein*/genetics, Humans ; Phosphorylation/physiology ; Acetylation ; Cell Membrane/metabolism ; Molecular Dynamics Simulation ; Membrane Lipids/metabolism ; Huntington Disease/metabolism

المؤلفون: Dickmann CGF; Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom., Milicevic Sephton S; Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom., Barker RA; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom., Aigbirhio FI; Molecular Imaging Chemistry Laboratory, Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

المصدر: Chembiochem : a European journal of chemical biology [Chembiochem] 2024 Jun 03; Vol. 25 (11), pp. e202400152. Date of Electronic Publication: 2024 May 02.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE

مواضيع طبية MeSH: Huntingtin Protein*/genetics , Huntingtin Protein*/metabolism , Huntingtin Protein*/chemistry , Positron-Emission Tomography*, Ligands ; Humans ; Protein Aggregates/drug effects ; Mutation ; Huntington Disease/diagnostic imaging ; Huntington Disease/metabolism ; Huntington Disease/genetics ; Radiopharmaceuticals/chemistry

المؤلفون: Neueder A; Department of Neurology, Ulm University, 89081 Ulm, Germany., Kojer K; Department of Neurology, Ulm University, 89081 Ulm, Germany., Gu Z; Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA., Wang Y; Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA., Hering T; Department of Neurology, Ulm University, 89081 Ulm, Germany., Tabrizi S; UCL Huntington's Disease Centre, UCL Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK.; Dementia Research Institute at UCL, London WC1N 3BG, UK., Taanman JW; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London NW3 2PF, UK., Orth M; Department of Neurology, Ulm University, 89081 Ulm, Germany.; Swiss Huntington Centre, Siloah AG, 3073 Gümligen, Switzerland.; University Hospital of Old Age Psychiatry and Psychotherapy, Bern University, CH-3000 Bern 60, Switzerland.

المصدر: Brain : a journal of neurology [Brain] 2024 Jun 03; Vol. 147 (6), pp. 2009-2022.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE

مواضيع طبية MeSH: Huntington Disease*/genetics , Huntington Disease*/metabolism , Huntington Disease*/pathology , DNA, Mitochondrial*/genetics , Mutation* , Huntingtin Protein*/genetics , Huntingtin Protein*/metabolism , Mitochondrial Dynamics*/genetics, Humans ; Male ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Female ; Oxidative Phosphorylation ; Middle Aged ; Mitochondria/metabolism ; Mitochondria/genetics ; Adult ; Mitophagy/genetics

المؤلفون: Brady ST; Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.; Marine Biological Laboratory, Woods Hole, MA 02543, USA., Mesnard-Hoaglin NA; Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA., Mays S; Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.; Marine Biological Laboratory, Woods Hole, MA 02543, USA., Priego M; Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA., Dziechciowska J; Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA., Morris S; Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.; Marine Biological Laboratory, Woods Hole, MA 02543, USA., Kang M; Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.; Marine Biological Laboratory, Woods Hole, MA 02543, USA., Tsai MY; Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA., Purks JL; Marine Biological Laboratory, Woods Hole, MA 02543, USA., Klein A; Marine Biological Laboratory, Woods Hole, MA 02543, USA., Gaona A; Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA., Melloni A; Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA., Connors T; Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA., Hyman B; Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA.; Department of Neurology, Harvard Medical School, Boston, MA 02129, USA., Song Y; Marine Biological Laboratory, Woods Hole, MA 02543, USA.; Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA.; Department of Neurology, Harvard Medical School, Boston, MA 02129, USA., Morfini GA; Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL 60612, USA.; Marine Biological Laboratory, Woods Hole, MA 02543, USA.

المصدر: Brain : a journal of neurology [Brain] 2024 Jun 03; Vol. 147 (6), pp. 2098-2113.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE

مواضيع طبية MeSH: Huntingtin Protein*/genetics , Huntingtin Protein*/metabolism , Axons*/pathology , Axons*/metabolism , Huntington Disease*/metabolism , Huntington Disease*/genetics , Huntington Disease*/pathology, Animals ; Mice ; Humans ; Mice, Transgenic ; Cells, Cultured ; Mutation/genetics ; Axonal Transport ; Nerve Tissue Proteins/metabolism ; Nerve Tissue Proteins/genetics ; Male ; Peptides/metabolism ; Proline/genetics ; Proline/metabolism ; Proline-Rich Protein Domains ; Female ; Disease Models, Animal ; Neurons/metabolism ; Neurons/pathology

المؤلفون: Torricella F; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892-0520, USA., Tugarinov V; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892-0520, USA., Clore GM; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892-0520, USA.

المصدر: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Jun; Vol. 11 (24), pp. e2309217. Date of Electronic Publication: 2024 Mar 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE

مواضيع طبية MeSH: Huntingtin Protein*/genetics , Huntingtin Protein*/chemistry , Huntingtin Protein*/metabolism , Huntington Disease*/metabolism , Huntington Disease*/genetics, Humans ; Kinetics ; Protein Conformation ; Protein Aggregates ; Magnetic Resonance Spectroscopy/methods ; Peptides/chemistry ; Peptides/metabolism ; Peptides/genetics

المؤلفون: Davis GH; Department of Biological and Biomedical Sciences, Rowan University, Glassboro, New Jersey 08028.; Department of Biology, Saint Joseph's University, Philadelphia, Pennsylvania 19131.; Department of Biological Sciences, University of the Sciences, Philadelphia, Pennsylvania 19104., Zaya A; Department of Biological Sciences, University of the Sciences, Philadelphia, Pennsylvania 19104., Pearce MMP; Department of Biological and Biomedical Sciences, Rowan University, Glassboro, New Jersey 08028 pearcem@rowan.edu.; Department of Biology, Saint Joseph's University, Philadelphia, Pennsylvania 19131.; Department of Biological Sciences, University of the Sciences, Philadelphia, Pennsylvania 19104.

المصدر: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2024 May 15; Vol. 44 (20). Date of Electronic Publication: 2024 May 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Electronic Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE

مواضيع طبية MeSH: Huntington Disease*/metabolism , Huntington Disease*/pathology , Huntington Disease*/genetics , Neuroglia*/metabolism , Neuroglia*/pathology , Drosophila Proteins*/metabolism , Drosophila Proteins*/genetics , Huntingtin Protein*/genetics , Huntingtin Protein*/metabolism , Disease Models, Animal* , Drosophila*, Animals ; Female ; Male ; Phagocytosis/physiology ; Lysosomes/metabolism ; Phagosomes/metabolism ; Animals, Genetically Modified ; Prions/metabolism ; Prions/genetics ; Neurons/metabolism

المؤلفون: Martin DDO; NeurdyPhagy Lab, Department of Biology, Faculty of Science, University of Waterloo, Waterloo, Ontario, Canada., Sanders SS; NeuroPalm Lab, Department of Molecular and Cellular Biology, College of Biological Sciences, University of Guelph, Guelph, Ontario, Canada.

المصدر: Biochemical Society transactions [Biochem Soc Trans] 2024 Jun 26; Vol. 52 (3), pp. 1385-1392.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Portland Press On The Behalf Of The Biochemical Society Country of Publication: England NLM ID: 7506897 Publication Model: Print Cited Medium: Internet ISSN: 1470-8752 (Electronic) Linking ISSN: 03005127 NLM ISO Abbreviation: Biochem Soc Trans Subsets: MEDLINE

مواضيع طبية MeSH: Huntington Disease*/metabolism , Huntington Disease*/drug therapy , Huntingtin Protein*/metabolism , Huntingtin Protein*/genetics, Humans ; Acylation ; Animals ; Fatty Acids/metabolism

المؤلفون: Torricella F; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520, United States., Tugarinov V; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520, United States., Clore GM; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520, United States.

المصدر: The journal of physical chemistry letters [J Phys Chem Lett] 2024 Jun 20; Vol. 15 (24), pp. 6375-6382. Date of Electronic Publication: 2024 Jun 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101526034 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7185 (Electronic) Linking ISSN: 19487185 NLM ISO Abbreviation: J Phys Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Huntingtin Protein*/chemistry , Huntingtin Protein*/genetics , Huntingtin Protein*/metabolism , Muramidase*/chemistry , Muramidase*/metabolism, Kinetics ; Humans ; Dextrans/chemistry ; Peptides/chemistry ; Nuclear Magnetic Resonance, Biomolecular ; Protein Aggregates/drug effects ; Macromolecular Substances/chemistry ; Protein Multimerization/drug effects ; Magnetic Resonance Spectroscopy

المؤلفون: Mishra R; Department Structural Biology, University of Pittsburgh School of Medicine Pittsburgh, PA 15260, USA. Electronic address: rakeshm2014@email.iimcal.ac.in., Gerlach GJ; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine Pittsburgh, PA 15260, USA., Sahoo B; Department Structural Biology, University of Pittsburgh School of Medicine Pittsburgh, PA 15260, USA. Electronic address: bankanidhi@gmail.com., Camacho CJ; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine Pittsburgh, PA 15260, USA. Electronic address: ccamacho@pitt.edu., Wetzel R; Department Structural Biology, University of Pittsburgh School of Medicine Pittsburgh, PA 15260, USA. Electronic address: rwetzel@pitt.edu.

المصدر: Journal of molecular biology [J Mol Biol] 2024 Jun 15; Vol. 436 (12), pp. 168607. Date of Electronic Publication: 2024 May 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Amyloid*/chemistry , Amyloid*/metabolism , Exons* , Huntingtin Protein*/chemistry , Huntingtin Protein*/metabolism , Huntingtin Protein*/genetics , Protein Multimerization*, Humans ; Huntington Disease/metabolism ; Huntington Disease/genetics ; Hydrophobic and Hydrophilic Interactions ; Kinetics ; Models, Molecular ; Peptides/chemistry ; Peptides/metabolism ; Protein Aggregates

المؤلفون: Choi DE; Center for Genomic Medicine, Massachusetts General Hospital, Boston, United States.; Department of Neurology, Harvard Medical School, Boston, United States., Shin JW; Center for Genomic Medicine, Massachusetts General Hospital, Boston, United States.; Department of Neurology, Harvard Medical School, Boston, United States., Zeng S; Center for Genomic Medicine, Massachusetts General Hospital, Boston, United States., Hong EP; Center for Genomic Medicine, Massachusetts General Hospital, Boston, United States.; Department of Neurology, Harvard Medical School, Boston, United States.; Medical and Population Genetics Program, The Broad Institute of MIT and Harvard, Cambridge, United States., Jang JH; Center for Genomic Medicine, Massachusetts General Hospital, Boston, United States.; Department of Neurology, Harvard Medical School, Boston, United States., Loupe JM; Center for Genomic Medicine, Massachusetts General Hospital, Boston, United States.; Department of Neurology, Harvard Medical School, Boston, United States., Wheeler VC; Center for Genomic Medicine, Massachusetts General Hospital, Boston, United States.; Department of Neurology, Harvard Medical School, Boston, United States., Stutzman HE; Center for Genomic Medicine, Massachusetts General Hospital, Boston, United States.; Department of Pathology, Massachusetts General Hospital, Boston, United States., Kleinstiver B; Center for Genomic Medicine, Massachusetts General Hospital, Boston, United States.; Department of Pathology, Massachusetts General Hospital, Boston, United States.; Department of Pathology, Harvard Medical School, Boston, United States., Lee JM; Center for Genomic Medicine, Massachusetts General Hospital, Boston, United States.; Department of Neurology, Harvard Medical School, Boston, United States.; Medical and Population Genetics Program, The Broad Institute of MIT and Harvard, Cambridge, United States.

المصدر: ELife [Elife] 2024 Jun 13; Vol. 12. Date of Electronic Publication: 2024 Jun 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

مواضيع طبية MeSH: Huntington Disease*/genetics , Huntington Disease*/therapy , Gene Editing*/methods , Huntingtin Protein*/genetics , Huntingtin Protein*/metabolism , Trinucleotide Repeat Expansion*/genetics, Animals ; Mice ; Disease Models, Animal ; Humans ; Mutation ; Gene Knock-In Techniques