المؤلفون: Wang X; Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau of Ministry of Agriculture and Rural Affairs, College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, China., Dai W; Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau of Ministry of Agriculture and Rural Affairs, College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, China., Zhang C; Key Laboratory of Plant Protection Resources and Pest Management of Ministry of Education, Key Laboratory of Integrated Pest Management on Crops in Northwestern Loess Plateau of Ministry of Agriculture and Rural Affairs, College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, China.

المصدر: Journal of agricultural and food chemistry [J Agric Food Chem] 2024 May 15; Vol. 72 (19), pp. 10805-10813. Date of Electronic Publication: 2024 May 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5118 (Electronic) Linking ISSN: 00218561 NLM ISO Abbreviation: J Agric Food Chem Subsets: MEDLINE

مواضيع طبية MeSH: Insecticides*/pharmacology , Larva*/metabolism , Larva*/genetics , Larva*/growth & development , Larva*/drug effects , Nitro Compounds*/pharmacology , Nitro Compounds*/metabolism , Neonicotinoids*/pharmacology , Neonicotinoids*/metabolism , Insect Proteins*/metabolism , Insect Proteins*/genetics , Receptors, Aryl Hydrocarbon*/metabolism , Receptors, Aryl Hydrocarbon*/genetics, Animals ; Diptera/metabolism ; Diptera/genetics ; Diptera/drug effects ; Diptera/growth & development ; Aryl Hydrocarbon Receptor Nuclear Translocator/metabolism ; Aryl Hydrocarbon Receptor Nuclear Translocator/genetics ; Cytochrome P-450 Enzyme System/metabolism ; Cytochrome P-450 Enzyme System/genetics ; Inactivation, Metabolic ; Transcription Factors/genetics ; Transcription Factors/metabolism

المؤلفون: Abduh MS; Immune Responses in Different Diseases Research Group, Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: mabdoh@kau.edu.sa., Alwassil OI; Department of Pharmaceutical Sciences, College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh 11451, Saudi Arabia. Electronic address: wassilo@ksau-hs.edu.sa., Aldaqal SM; Immune Responses in Different Diseases Research Group, Department of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia. Electronic address: saldaqal@kau.edu.sa., Alfwuaires MA; Department of Biological Sciences, College of Science, King Faisal University, Hofuf 31982, Saudi Arabia. Electronic address: malfwuaires@kfu.edu.sa., Farhan M; International Medical Research Center (iMReC), Aqaba 77110, Jordan; Drug Development Department, UniTechPharma, Fribourg 1700, Switzerland. Electronic address: mf@unitechpharma.swiss., Hanieh H; International Medical Research Center (iMReC), Aqaba 77110, Jordan; Basic Medical Sciences Department, Faculty of Medicine, Aqaba Medical Sciences University, Aqaba 77110, Jordan. Electronic address: h.hanieh@amsu.edu.jo.

المصدر: Biochemical pharmacology [Biochem Pharmacol] 2024 Apr; Vol. 222, pp. 116079. Date of Electronic Publication: 2024 Feb 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, Aryl Hydrocarbon*/metabolism , Breast Neoplasms*/genetics , Pyrazoles*, Animals ; Mice ; Female ; Humans ; Ligands ; Quality of Life ; Cytochrome P-450 CYP1A1/metabolism ; Pyridines/pharmacology ; Pyridines/therapeutic use ; Aryl Hydrocarbon Receptor Nuclear Translocator/genetics ; SOXC Transcription Factors/metabolism

المؤلفون: Mosa FES; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2E1, Canada., AlRawashdeh S; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2E1, Canada., El-Kadi AOS; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2E1, Canada., Barakat K; Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2E1, Canada.

المصدر: Journal of chemical information and modeling [J Chem Inf Model] 2024 Mar 25; Vol. 64 (6), pp. 2021-2034. Date of Electronic Publication: 2024 Mar 08.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101230060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-960X (Electronic) Linking ISSN: 15499596 NLM ISO Abbreviation: J Chem Inf Model Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, Aryl Hydrocarbon*/metabolism , Artificial Intelligence*, Humans ; Ligands ; Aryl Hydrocarbon Receptor Nuclear Translocator/chemistry ; Aryl Hydrocarbon Receptor Nuclear Translocator/genetics ; Aryl Hydrocarbon Receptor Nuclear Translocator/metabolism

المؤلفون: Opitz CA; German Cancer Research Center (DKFZ), Heidelberg, Division of Metabolic Crosstalk in Cancer and the German Cancer Consortium (DKTK), DKFZ Core Center Heidelberg, 69120 Heidelberg, Germany; Neurology Clinic and National Center for Tumor Diseases, 69120 Heidelberg, Germany. Electronic address: c.opitz@dkfz.de., Holfelder P; German Cancer Research Center (DKFZ), Heidelberg, Division of Metabolic Crosstalk in Cancer and the German Cancer Consortium (DKTK), DKFZ Core Center Heidelberg, 69120 Heidelberg, Germany; Faculty of Bioscience, Heidelberg University, 69120 Heidelberg, Germany., Prentzell MT; German Cancer Research Center (DKFZ), Heidelberg, Division of Metabolic Crosstalk in Cancer and the German Cancer Consortium (DKTK), DKFZ Core Center Heidelberg, 69120 Heidelberg, Germany; Faculty of Bioscience, Heidelberg University, 69120 Heidelberg, Germany., Trump S; Molecular Epidemiology Unit, Berlin Institute of Health at Charité and the German Cancer Consortium (DKTK), Partner Site Berlin, a partnership between DKFZ and Charité -Universitätsmedizin Berlin, 10117 Berlin, Germany.

المصدر: Biochemical pharmacology [Biochem Pharmacol] 2023 Oct; Vol. 216, pp. 115798. Date of Electronic Publication: 2023 Sep 09.

نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Neoplasms*/genetics , Receptors, Aryl Hydrocarbon*/genetics , Receptors, Aryl Hydrocarbon*/metabolism, Humans ; Aryl Hydrocarbon Receptor Nuclear Translocator/genetics ; Aryl Hydrocarbon Receptor Nuclear Translocator/metabolism ; Epigenesis, Genetic

المؤلفون: Park K; Department of Food Science and Nutrition, and Convergence Program of Material Science for Medicine and Pharmaceutics, Hallym University, Chuncheon, Republic of Korea., Uchida Y; Department of Food Science and Nutrition, and Convergence Program of Material Science for Medicine and Pharmaceutics, Hallym University, Chuncheon, Republic of Korea. Electronic address: Uchida@ucsf.edu.

المصدر: The Journal of investigative dermatology [J Invest Dermatol] 2023 Oct; Vol. 143 (10), pp. 1862-1864. Date of Electronic Publication: 2023 Jul 10.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Comment

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1747 (Electronic) Linking ISSN: 0022202X NLM ISO Abbreviation: J Invest Dermatol Subsets: MEDLINE

مواضيع طبية MeSH: Aryl Hydrocarbon Receptor Nuclear Translocator*/metabolism, Epidermis/metabolism ; Glucosylceramides/metabolism ; Receptors, Aryl Hydrocarbon/genetics ; Receptors, Aryl Hydrocarbon/metabolism

المؤلفون: Wang S; Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, People's Republic of China., Xu Y; Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, People's Republic of China., Wang L; Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, People's Republic of China., Lin J; Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, People's Republic of China., Xu C; Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, People's Republic of China., Zhao X; Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, People's Republic of China., Zhang H; Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, People's Republic of China.

المصدر: Inflammatory bowel diseases [Inflamm Bowel Dis] 2024 Sep 03; Vol. 30 (9), pp. 1546-1555.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 9508162 Publication Model: Print Cited Medium: Internet ISSN: 1536-4844 (Electronic) Linking ISSN: 10780998 NLM ISO Abbreviation: Inflamm Bowel Dis Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, Aryl Hydrocarbon*/metabolism , Receptors, Aryl Hydrocarbon*/genetics , Th17 Cells*/immunology , T-Lymphocytes, Regulatory*/immunology , Colitis*/immunology , Colitis*/chemically induced , Dendritic Cells*/immunology , Mice, Knockout* , Mice, Inbred C57BL*, Animals ; Mice ; Humans ; Female ; Male ; Crohn Disease/immunology ; Adult ; Cell Differentiation ; Case-Control Studies ; Middle Aged ; Dextran Sulfate ; Disease Models, Animal ; Carbazoles ; Basic Helix-Loop-Helix Transcription Factors

المؤلفون: Jia Q; Department of Dermatology, Peking University People's Hospital, No.11 Xizhimen South Street, Xicheng District, Beijing, 100044, China., Liu P; Department of Dermatology, Peking University People's Hospital, No.11 Xizhimen South Street, Xicheng District, Beijing, 100044, China., Wang X; Department of Dermatology, Peking University People's Hospital, No.11 Xizhimen South Street, Xicheng District, Beijing, 100044, China., Hu J; Department of Dermatology, Peking University People's Hospital, No.11 Xizhimen South Street, Xicheng District, Beijing, 100044, China., Jia J; Department of Dermatology, Peking University People's Hospital, No.11 Xizhimen South Street, Xicheng District, Beijing, 100044, China., Zhang J; Department of Dermatology, Peking University People's Hospital, No.11 Xizhimen South Street, Xicheng District, Beijing, 100044, China. rmzjz@126.com., Li H; Department of Dermatology, Peking University People's Hospital, No.11 Xizhimen South Street, Xicheng District, Beijing, 100044, China. lhoumin@sina.cn.

المصدر: Archives of dermatological research [Arch Dermatol Res] 2024 Aug 29; Vol. 316 (8), pp. 585. Date of Electronic Publication: 2024 Aug 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8000462 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-069X (Electronic) Linking ISSN: 03403696 NLM ISO Abbreviation: Arch Dermatol Res Subsets: MEDLINE

مواضيع طبية MeSH: Filaggrin Proteins*/metabolism , Protein Precursors*/metabolism , Protein Precursors*/genetics , Keratinocytes*/metabolism , Keratinocytes*/drug effects , Intermediate Filament Proteins*/metabolism , Intermediate Filament Proteins*/genetics , Dermatitis, Atopic*/metabolism , Dermatitis, Atopic*/drug therapy , Dermatitis, Atopic*/pathology , Disease Models, Animal* , Up-Regulation*/drug effects , Receptors, Aryl Hydrocarbon*/metabolism , Receptors, Aryl Hydrocarbon*/genetics, Animals ; Mice ; Humans ; Membrane Proteins/metabolism ; Membrane Proteins/genetics ; Cells, Cultured ; Skin/pathology ; Skin/metabolism ; Skin/drug effects ; Mice, Inbred BALB C ; Signal Transduction/drug effects ; DNA-Binding Proteins ; Transcription Factors

المؤلفون: Cholico GN; Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, USA.; Institute for Integrative Toxicology, Michigan State University, East Lansing, Michigan, USA., Nault R; Institute for Integrative Toxicology, Michigan State University, East Lansing, Michigan, USA.; Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan, USA., Zacharewski T; Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, USA. tzachare@msu.edu.; Institute for Integrative Toxicology, Michigan State University, East Lansing, Michigan, USA. tzachare@msu.edu.

المصدر: BMC genomics [BMC Genomics] 2024 Aug 28; Vol. 25 (1), pp. 809. Date of Electronic Publication: 2024 Aug 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100965258 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2164 (Electronic) Linking ISSN: 14712164 NLM ISO Abbreviation: BMC Genomics Subsets: MEDLINE

مواضيع طبية MeSH: Polychlorinated Dibenzodioxins*/toxicity , Receptors, Aryl Hydrocarbon*/metabolism , Receptors, Aryl Hydrocarbon*/genetics , Mice, Inbred C57BL* , Liver*/metabolism , Liver*/drug effects , Liver*/pathology, Animals ; Mice ; Male ; Hepatocytes/metabolism ; Hepatocytes/drug effects ; Gene Expression Regulation/drug effects ; Oxidative Stress/drug effects ; Lipid Metabolism/drug effects ; Lipid Metabolism/genetics ; Hepatic Stellate Cells/metabolism ; Hepatic Stellate Cells/drug effects ; Gene Expression Profiling

المؤلفون: Mitchell C; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States., Staley S; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States., Williams MC; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States., Saxena A; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States., Bogdon R; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States., Roark K; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States., Hailey M; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States., Miranda K; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States., Becker W; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States., Dopkins N; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States., Pena MM; Department of Biological Sciences, College of Arts and Sciences, University of South Carolina, Columbia, SC, United States., Hogan KM; Department of Biological Sciences, College of Arts and Sciences, University of South Carolina, Columbia, SC, United States., Baird M; Department of Biological Sciences, College of Arts and Sciences, University of South Carolina, Columbia, SC, United States., Wilson K; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States., Nagarkatti P; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States., Nagarkatti M; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States., Busbee PB; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, SC, United States.

المصدر: Frontiers in immunology [Front Immunol] 2024 Aug 20; Vol. 15, pp. 1444045. Date of Electronic Publication: 2024 Aug 20 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, Aryl Hydrocarbon*/metabolism , Receptors, Aryl Hydrocarbon*/genetics , Interleukin-22* , Interleukins*/metabolism , Colitis*/immunology , Colitis*/microbiology , Bacteroides*/immunology, Animals ; Female ; Mice ; Male ; Gastrointestinal Microbiome/immunology ; Dysbiosis/immunology ; Mice, Inbred C57BL ; Indoles/pharmacology ; Disease Models, Animal ; Sex Factors ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Mice, Knockout

المؤلفون: Hsieh CW; Division of Nephrology, Department of Internal Medicine, Pingtung Christian Hospital, Pingtung 900, Taiwan.; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan., Chang LH; Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan., Wang YH; Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan., Li WT; Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan., Chang JK; Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Department of Orthopaedics, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Department of Orthopedics, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung 801, Taiwan., Chen CH; Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Department of Orthopaedics, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Department of Orthopedics, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung 801, Taiwan.; Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan.; School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Ph.D. Program in Biomedical Engineering, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Graduate Institute of Materials Engineering, College of Engineering, National Pingtung University of Science and Technology, Pingtung 912, Taiwan., Ho ML; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Orthopaedic Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Ph.D. Program in Biomedical Engineering, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Graduate Institute of Materials Engineering, College of Engineering, National Pingtung University of Science and Technology, Pingtung 912, Taiwan.; Department of Physiology, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.; Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.; College of Professional Studies, National Pingtung University of Science and Technology, Pingtung 912, Taiwan.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Aug 12; Vol. 25 (16). Date of Electronic Publication: 2024 Aug 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, Aryl Hydrocarbon*/metabolism , Receptors, Aryl Hydrocarbon*/genetics , Indican* , Mesenchymal Stem Cells*/metabolism , Mesenchymal Stem Cells*/drug effects , Osteogenesis*/drug effects , Transcription Factor HES-1*/metabolism , Transcription Factor HES-1*/genetics , Signal Transduction*/drug effects, Animals ; Mice ; Cell Differentiation/drug effects ; Core Binding Factor Alpha 1 Subunit/metabolism ; Core Binding Factor Alpha 1 Subunit/genetics ; Bone Morphogenetic Protein 2/metabolism ; Bone Morphogenetic Protein 2/genetics ; Basic Helix-Loop-Helix Transcription Factors