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1
المؤلفون: Haiying Bao, Angela M. Lam, Shalini Bansal, Byoung-Kwon Chun, Michael J. Sofia, Holly M. Micolochick Steuer, Jinfa Du, Ying Jiang, Donghui Bao, Eisuke Murakami, Bruce S. Ross, Christine Espiritu, Michael J. Otto, Phillip A. Furman, Hai-Ren Zhang, P. Ganapati Reddy, Congrong Niu
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:5924-5929
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Microbial Sensitivity Tests, Virus Replication, Antiviral Agents, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Stability, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Prodrugs, Nucleotide, Cytotoxicity, Molecular Biology, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, Prodrug, Phosphate, In vitro, Rats, Liver, Molecular Medicine, Nucleotides, Cyclic, Nucleoside
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2
المؤلفون: P. Ganapati Reddy, Darius Babusis, Angela M. Lam, Piyun B. Chao, Hai-Ren Zhang, Shalini Bansal, Yeojin Park, Phillip A. Furman, Eisuke Murakami, Wonsuk Chang, Congrong Niu, Haiying Bao, Michael J. Otto, Joseph Woolley, Adrian S. Ray, Li-Quan Wang, Tatiana Tolstykh, Jinfa Du, Michael J. Sofia
المصدر: Antimicrobial Agents and Chemotherapy. 56:3767-3775
مصطلحات موضوعية: Hepacivirus, Biology, Antiviral Agents, chemistry.chemical_compound, medicine, Cytochrome P-450 CYP3A, Humans, Pharmacology (medical), Nucleotide, NS5B, Cells, Cultured, Pharmacology, chemistry.chemical_classification, Phosphoric Diester Hydrolases, Phosphodiesterase, Nucleosides, Prodrug, Adenosine, Molecular biology, Nucleoside-diphosphate kinase, Cyclic P-Oxides, Infectious Diseases, Enzyme, chemistry, Biochemistry, Nucleoside-Diphosphate Kinase, Hepatocytes, Guanylate Kinases, Nucleoside, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da0bfffe81e52369ac0268db57f2fe8
https://doi.org/10.1128/aac.00530-12 -
3
المصدر: The Journal of Organic Chemistry. 76:8311-8319
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Chemistry, Pharmaceutical, Protide, Electrons, Hepacivirus, Antiviral Agents, Structure-Activity Relationship, Viral Proteins, Phenols, Nucleophile, Humans, Organic chemistry, Phosphoric Acids, Prodrugs, Nucleotide, Amino Acids, Chromatography, High Pressure Liquid, chemistry.chemical_classification, Nucleotides, Chemistry, Organic Chemistry, Diastereomer, Esters, Nucleosides, Stereoisomerism, Phosphoramidate, DNA-Directed RNA Polymerases, Prodrug, Amides, Hepatitis C, Amino acid, Sofosbuvir, Uridine Monophosphate, Nucleoside
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4
المؤلفون: Holly M. Micolochick Steuer, Donghui Bao, Wonsuk Chang, Bruce S. Ross, Angela M. Lam, Shalini Bansal, Dhanapalan Nagarathnam, Michael J. Otto, P. Ganapati Reddy, Meg Keilman, Byoung-Kwon Chun, Congrong Niu, Hai-Ren Zhang, Rachakonda Suguna, Christine Espiritu, Phillip A. Furman, Jinfa Du, Michael J. Sofia
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:7376-7380
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Molecular Conformation, Administration, Oral, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, Crystallography, X-Ray, Antiviral Agents, Biochemistry, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Prodrugs, Nucleotide, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Organic Chemistry, Nucleosides, Prodrug, Nucleotidyltransferase, In vitro, Cyclic P-Oxides, Rats, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Nucleotides, Cyclic, Nucleoside
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5
المؤلفون: Jinfa Du, Angela M. Lam, Shalini Bansal, Rachakonda Suguna, Congrong Niu, Meg Keilman, Michael J. Otto, Donghui Bao, Bruce S. Ross, Peiyuan Wang, Dhanapalan Nagarathnam, Wonsuk Chang, Holly M. Micolochick Steuer, Michael J. Sofia, Hai-Ren Zhang, Phillip A. Furman, P. Ganapati Reddy, Christine Espiritu
المصدر: Journal of Medicinal Chemistry. 53:7202-7218
مصطلحات موضوعية: Hepatitis C virus, Protide, Hepacivirus, In Vitro Techniques, Viral Nonstructural Proteins, Crystallography, X-Ray, medicine.disease_cause, Antiviral Agents, Cell Line, Structure-Activity Relationship, Dogs, In vivo, Drug Resistance, Viral, Drug Discovery, medicine, Animals, Humans, Prodrugs, Nucleotide, chemistry.chemical_classification, virus diseases, Esters, Stereoisomerism, Biological activity, Phosphoramidate, Prodrug, digestive system diseases, Rats, Macaca fascicularis, Liver, Biochemistry, chemistry, Mutation, Hepatocytes, Molecular Medicine, Replicon, Sofosbuvir, Uridine Monophosphate, Nucleoside
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6
المؤلفون: Hai-Ren Zhang, Quan Zhang, Kung K. Wang, Chongsheng Shi
المصدر: The Journal of Organic Chemistry. 65:7977-7983
مصطلحات موضوعية: Ellipticine, Aza Compounds, chemistry.chemical_compound, chemistry, Organic Chemistry, Thermal decomposition, Substituent, Organic chemistry, Antineoplastic Agents, Ellipticines, Naphthyridines
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7
المؤلفون: Kung K. Wang, Hai-Ren Zhang
المصدر: The Journal of Organic Chemistry. 64:7996-7999
مصطلحات موضوعية: chemistry.chemical_classification, Acetylide, Organic Chemistry, chemistry.chemical_element, Alcohol, Chloride, Medicinal chemistry, Adduct, chemistry.chemical_compound, Sodium borohydride, Hydrocarbon, Thionyl chloride, chemistry, medicine, Organic chemistry, Lithium, medicine.drug
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8
المؤلفون: Kung K. Wang, Hai-Ren Zhang, Jeffrey L. Petersen
المصدر: The Journal of Organic Chemistry. 64:1650-1656
مصطلحات موضوعية: chemistry.chemical_compound, Aryl radical, Chemistry, Intramolecular force, Yield (chemistry), Organic Chemistry, Thermal decomposition, Moiety, Ring (chemistry), Photochemistry, Radical cyclization, Adduct
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9
المؤلفون: Ying Jiang, Jinfa Du, Hai-Ren Zhang, Christine Espiritu, Michael J. Sofia, Meg Keilman, Byoung-Kwon Chun, Phillip A. Furman, Wonsuk Chang, Donghui Bao, Bruce S. Ross, Holly M. Micolochick Steuer
المصدر: Nucleosides, nucleotidesnucleic acids. 30(11)
مصطلحات موضوعية: Bioanalysis, Halogenation, Stereochemistry, Hepatitis C virus, Anti hepatitis c virus, Hepacivirus, medicine.disease_cause, Biochemistry, Antiviral Agents, Genetics, medicine, Humans, Nucleotide, Prodrugs, chemistry.chemical_classification, Addition reaction, Stable isotope ratio, Nucleosides, General Medicine, Prodrug, Hepatitis C, Cyclic P-Oxides, chemistry, Isotope Labeling, Molecular Medicine, Sofosbuvir, Uridine Monophosphate
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10
المؤلفون: Michael J. Sofia, Rachakonda Suguna, P. Ganapati Reddy, Byoung-Kwon Chun, Hai-Ren Zhang, Bruce S. Ross
المصدر: The Journal of organic chemistry. 76(10)
مصطلحات موضوعية: Purine, chemistry.chemical_classification, Stereochemistry, Lactol, Organic Chemistry, Nucleosides, Stereoisomerism, Hepacivirus, Prodrug, Chemical synthesis, Antiviral Agents, Cyclic P-Oxides, Substrate Specificity, chemistry.chemical_compound, Cyclic nucleotide, Stereospecificity, chemistry, Cyclization, Nucleotide, Prodrugs, Nucleoside