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المؤلفون: Anthone W. Dunah, Thierry Bussiere, Kenneth J. Rhodes, Hairuo Peng, Lin Xu, Mahin Arastu, Gnanasambandam Kumaravel, Joy Wang, Melanie S. Brennan, Pamela A. Snodgrass-Belt, Arthur G. Taveras, Mi-young Jung, Tina Talreja, Sowmya Chollate, Zhili Xin, Diana Fahrer, Robert Dunstan, Robert H. Scannevin, Ellen Rohde, H. Moore Arnold
المصدر: Neuropharmacology. 103:57-68
مصطلحات موضوعية: Male, 0301 basic medicine, Gene isoform, Pathology, medicine.medical_specialty, Central nervous system, BACE1-AS, Plaque, Amyloid, Cleavage (embryo), Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Alzheimer Disease, Amyloid precursor protein, medicine, Animals, Protein Isoforms, Pharmacology, Aldehydes, Amyloid beta-Peptides, Dose-Response Relationship, Drug, biology, P3 peptide, Brain, medicine.disease, Rats, Inbred F344, Rats, Disease Models, Animal, Macaca fascicularis, 030104 developmental biology, medicine.anatomical_structure, biology.protein, Amyloid Precursor Protein Secretases, Alzheimer's disease, Amyloid precursor protein secretase, 030217 neurology & neurosurgery
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المؤلفون: Linda C. Burkly, Tricia L. May-Dracka, Jason D. Fontenot, Joe Lyssikatos, Timothy D. McKee, Douglas Marcotte, Laura Silvian, Thomas Hesson, Istvan J. Enyedy, Zhili Xin, Thomas A. Patterson, Margot Brickelmaier, Ping Wu, Mia Rushe, Govinda Bhisetti, Robert M. Arduini, Andrea Bertolotti-Ciarlet, Ellen Cahir-McFarland, Paramasivam Murugan, Kerri Spilker, Hairuo Peng, Kevin Little
المصدر: Bioorganicmedicinal chemistry letters. 28(10)
مصطلحات موضوعية: 0301 basic medicine, Pyridines, T cell, T-Lymphocytes, Clinical Biochemistry, Pharmaceutical Science, Protein Serine-Threonine Kinases, Biochemistry, Cell Line, 03 medical and health sciences, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Phosphorylation, Protein kinase A, Molecular Biology, Protein Kinase Inhibitors, Mice, Knockout, Binding Sites, Chemistry, Kinase, Organic Chemistry, Germinal center, T helper cell, Cell biology, Protein Structure, Tertiary, Molecular Docking Simulation, 030104 developmental biology, medicine.anatomical_structure, Cell culture, Protein Kinase C-theta, Molecular Medicine, Interleukin-2
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المؤلفون: Robert H. Scannevin, Tina Talreja, Lin Xu, Gnanasambandam Kumaravel, David Kocisko, Arthur G. Taveras, Anthone W. Dunah, Hairuo Peng, Kenneth J. Rhodes, Ellen Rohde, H. Moore Arnold, Sowmya Chollate, Pamela A. Snodgrass-Belt, Mi-yong Jung, Andrew Zhang, Zhili Xin, Melanie N. Shackett
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:7277-7280
مصطلحات موضوعية: Scaffold, Carboxylic acid, Clinical Biochemistry, Drug Evaluation, Preclinical, Administration, Oral, Pharmaceutical Science, Pharmacology, Biochemistry, Mice, chemistry.chemical_compound, Piperidines, Oral administration, Drug Discovery, Animals, γ secretase, Enzyme Inhibitors, Molecular Biology, Phenylacetates, chemistry.chemical_classification, Amyloid beta-Peptides, Nonsteroidal, Anti-Inflammatory Agents, Non-Steroidal, Organic Chemistry, Brain, Combinatorial chemistry, Peptide Fragments, Rats, chemistry, Drug Design, Molecular Medicine, Amyloid Precursor Protein Secretases
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المؤلفون: Tina Talreja, Arthur G. Taveras, Michael Humora, Lawrence Gan, J. Hernan Cuervo, Kenneth J. Rhodes, Hairuo Peng, Lin Xu, Anthone W. Dunah, Gnanasambandam Kumaravel, Pamela A. Snodgrass-Belt, Mi-young Jung, Zhili Xin, Sowmya Chollate, Melanie N. Shackett, Ellen Rohde, H. Moore Arnold, Robert H. Scannevin
المصدر: ACS Medicinal Chemistry Letters. 2:786-791
مصطلحات موضوعية: biology, business.industry, Organic Chemistry, Notch signaling pathway, Pharmacology, Biochemistry, In vitro, Pharmacokinetics, In vivo, Oral administration, Pharmacodynamics, Drug Discovery, biology.protein, Medicine, Potency, business, Amyloid precursor protein secretase
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المصدر: Bioorganic & Medicinal Chemistry. 11:3165-3170
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, MAP Kinase Kinase 1, Pharmaceutical Science, Imides, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Cyclic AMP, Humans, Structure–activity relationship, Enzyme Inhibitors, Imide, Molecular Biology, Protein Kinase C, Mitogen-Activated Protein Kinase Kinases, chemistry.chemical_classification, Molecular Structure, biology, Kinase, Organic Chemistry, Cyclic AMP-Dependent Protein Kinases, Quinone, Enzyme, chemistry, Enzyme inhibitor, Drug Design, Mitogen-activated protein kinase, biology.protein, Molecular Medicine, Drug Screening Assays, Antitumor, Naphthoquinones
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المؤلفون: Leon H. Zalkow, Diane M. Otterness, Robert T. Abraham, Hairuo Peng
المصدر: Tetrahedron. 57:1891-1896
مصطلحات موضوعية: chemistry.chemical_classification, Ozonolysis, Stereochemistry, Organic Chemistry, Phosphatase, Ethyl acetate, Biochemistry, chemistry.chemical_compound, Acetic acid, chemistry, Drug Discovery, Moiety, Ozonide, Piperidine, Lactone
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7
المؤلفون: Deog Il Kim, Robert T. Abraham, Hairuo Peng, Leon H. Zalkow, Wenge Xie, Diane M. Otterness, Garth Powis
المصدر: Bioorganic & Medicinal Chemistry. 8:299-306
مصطلحات موضوعية: Stereochemistry, Carboxylic acid, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Steroid, chemistry.chemical_compound, Menadione, Drug Discovery, Tumor Cells, Cultured, medicine, Humans, cdc25 Phosphatases, Enzyme Inhibitors, Molecular Biology, IC50, chemistry.chemical_classification, biology, Spectrum Analysis, Organic Chemistry, Recombinant Proteins, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Steroids, Drug Screening Assays, Antitumor, Pharmacophore, Growth inhibition, Acids
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المؤلفون: Dominique Hebrault, Hairuo Peng, Xianglin Shi, Michael Humora, Zhili Xin, William F. Kiesman, Tina Talreja, Zezhou Wang
المصدر: ChemInform. 43
مصطلحات موضوعية: Reaction rate, Reaction conditions, chemistry.chemical_compound, Salicylaldehyde, Chemistry, Organic chemistry, General Medicine, Molecular sieve, Stereocenter
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المؤلفون: William F. Kiesman, Tina Talreja, Michael Humora, Hairuo Peng, Xianglin Shi, Dominique Hebrault, Zhili Xin, Zezhou Wang
المصدر: The Journal of organic chemistry. 77(2)
مصطلحات موضوعية: Reaction conditions, Aldehydes, Magnetic Resonance Spectroscopy, Molecular Structure, Chemistry, Organic Chemistry, Stereoisomerism, Chemistry Techniques, Synthetic, Molecular sieve, Stereocenter, Reaction rate, chemistry.chemical_compound, Salicylaldehyde, Organic chemistry, Amines, Amyloid Precursor Protein Secretases, Chromatography, High Pressure Liquid
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المؤلفون: Yu Zhao, Zhongjian Jia, Hairuo Peng
المصدر: ChemInform. 27
مصطلحات موضوعية: biology, Chemistry, Stereochemistry, Nanotechnology, Epimer, General Medicine, biology.organism_classification, Noreremophilane, Ligularia przewalskii
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