المؤلفون: Turnbaugh, Peter, Haiser, HJ, Seim, KL, Balskus, EP, Turnbaugh, PJ

URL الوصول: https://escholarship.org/uc/item/3bv8b60w

المؤلفون: Ke X; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Novartis Institute for Biomedical Research Inc., Cambridge, MA, 02139, USA., You K; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Pichaud M; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Novartis Institute for Biomedical Research Inc., Cambridge, MA, 02139, USA., Haiser HJ; Novartis Institute for Biomedical Research Inc., Cambridge, MA, 02139, USA., Graham DB; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital, Harvard School of Medicine, Boston, Massachusetts, 02114, USA., Vlamakis H; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Porter JA; Novartis Institute for Biomedical Research Inc., Cambridge, MA, 02139, USA., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. xavier@molbio.mgh.harvard.edu.; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital, Harvard School of Medicine, Boston, Massachusetts, 02114, USA. xavier@molbio.mgh.harvard.edu.; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. xavier@molbio.mgh.harvard.edu.

المصدر: Genome biology [Genome Biol] 2021 Oct 15; Vol. 22 (1), pp. 292. Date of Electronic Publication: 2021 Oct 15.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100960660 Publication Model: Electronic Cited Medium: Internet ISSN: 1474-760X (Electronic) Linking ISSN: 14747596 NLM ISO Abbreviation: Genome Biol Subsets: MEDLINE

مواضيع طبية MeSH: Endoplasmic Reticulum Stress*/drug effects , Gastrointestinal Microbiome* , Unfolded Protein Response*/drug effects, Bacteria/*metabolism, Aldehydes/pharmacology ; Apoptosis ; Dipeptides/pharmacology ; HT29 Cells ; Humans ; Indoles/pharmacology ; Macrolides/pharmacology ; Tunicamycin/pharmacology

المؤلفون: Bisanz JE; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA., Soto-Perez P; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA., Noecker C; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA., Aksenov AA; Collaborative Mass Spectrometry Innovation Center, Department of Pediatrics, Center for Microbiome Innovation, Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, CA 92093, USA., Lam KN; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA., Kenney GE; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA., Bess EN; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA., Haiser HJ; Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA., Kyaw TS; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA., Yu FB; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA., Rekdal VM; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA., Ha CWY; Department of Medicine, Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Devkota S; Department of Medicine, Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA., Balskus EP; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA., Dorrestein PC; Collaborative Mass Spectrometry Innovation Center, Department of Pediatrics, Center for Microbiome Innovation, Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, CA 92093, USA., Allen-Vercoe E; Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada., Turnbaugh PJ; Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA. Electronic address: peter.turnbaugh@ucsf.edu.

المصدر: Cell host & microbe [Cell Host Microbe] 2020 Jun 10; Vol. 27 (6), pp. 1001-1013.e9. Date of Electronic Publication: 2020 Apr 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101302316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1934-6069 (Electronic) Linking ISSN: 19313128 NLM ISO Abbreviation: Cell Host Microbe Subsets: MEDLINE

مواضيع طبية MeSH: Genomics*, Bacteria/*genetics , Bacteria/*isolation & purification , Dissection/*methods , Gastrointestinal Microbiome/*genetics, Actinobacteria/classification ; Actinobacteria/drug effects ; Actinobacteria/genetics ; Actinobacteria/isolation & purification ; Animals ; Anti-Bacterial Agents/pharmacology ; Bacteria/classification ; Bacteria/drug effects ; Gastrointestinal Microbiome/physiology ; Gastrointestinal Tract/microbiology ; Genes, Bacterial/genetics ; Germ-Free Life ; Humans ; Metagenome ; Metagenomics ; Mice ; Microbial Sensitivity Tests ; Multigene Family ; Phenotype ; Polymorphism, Genetic

SCR Organism: Eggerthella lenta

المؤلفون: Fornelos N; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Franzosa EA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Bishai J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Annand JW; Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research Inc., Cambridge, MA, USA., Oka A; Departments of Medicine, Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Lloyd-Price J; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Arthur TD; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Garner A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Avila-Pacheco J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Haiser HJ; Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research Inc., Cambridge, MA, USA., Tolonen AC; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Porter JA; Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research Inc., Cambridge, MA, USA., Clish CB; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sartor RB; Departments of Medicine, Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Huttenhower C; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Vlamakis H; Broad Institute of MIT and Harvard, Cambridge, MA, USA. hera@broadinstitute.org., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA. xavier@molbio.mgh.harvard.edu.; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA, USA. xavier@molbio.mgh.harvard.edu.; Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. xavier@molbio.mgh.harvard.edu.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. xavier@molbio.mgh.harvard.edu.

المصدر: Nature microbiology [Nat Microbiol] 2020 Mar; Vol. 5 (3), pp. 486-497. Date of Electronic Publication: 2020 Jan 20.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE

مواضيع طبية MeSH: Bacteria/*drug effects , Bacteria/*growth & development , Ethanolamines/*pharmacology , Gastrointestinal Microbiome/*drug effects , Inflammatory Bowel Diseases/*drug therapy, Animals ; Bacteria/genetics ; Bacteroidetes/drug effects ; Bacteroidetes/isolation & purification ; Cohort Studies ; Disease Models, Animal ; Dysbiosis ; Feces/microbiology ; Female ; Gastrointestinal Microbiome/genetics ; Gastrointestinal Microbiome/physiology ; Gene Expression Profiling ; Humans ; Inflammatory Bowel Diseases/microbiology ; Male ; Metagenome ; Mice ; Mice, Inbred C57BL ; Microbiota/drug effects ; Proteobacteria/drug effects ; Proteobacteria/isolation & purification ; Tandem Mass Spectrometry ; Whole Genome Sequencing

المؤلفون: Brown EM; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Ke X; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Novartis Institute for Biomedical Research Inc., Cambridge, MA 02139, USA., Hitchcock D; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Jeanfavre S; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Avila-Pacheco J; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Nakata T; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Arthur TD; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Fornelos N; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Heim C; Novartis Institute for Biomedical Research Inc., Cambridge, MA 02139, USA., Franzosa EA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Watson N; W. M. Keck Microscopy Facility, The Whitehead Institute, Cambridge, MA 02142, USA., Huttenhower C; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Haiser HJ; Novartis Institute for Biomedical Research Inc., Cambridge, MA 02139, USA., Dillow G; Novartis Institute for Biomedical Research Inc., Cambridge, MA 02139, USA., Graham DB; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Finlay BB; Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Kostic AD; Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA; Department of Microbiology and Immunology, Harvard Medical School, Boston, MA 02115, USA., Porter JA; Novartis Institute for Biomedical Research Inc., Cambridge, MA 02139, USA., Vlamakis H; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Clish CB; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Computational and Integrative Biology and Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: xavier@molbio.mgh.harvard.edu.

المصدر: Cell host & microbe [Cell Host Microbe] 2019 May 08; Vol. 25 (5), pp. 668-680.e7.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101302316 Publication Model: Print Cited Medium: Internet ISSN: 1934-6069 (Electronic) Linking ISSN: 19313128 NLM ISO Abbreviation: Cell Host Microbe Subsets: MEDLINE

مواضيع طبية MeSH: Host Microbial Interactions*, Bacteroides thetaiotaomicron/*growth & development , Bacteroides thetaiotaomicron/*metabolism , Intestines/*microbiology , Intestines/*physiology , Sphingolipids/*metabolism , Symbiosis/*drug effects, Animals ; Germ-Free Life ; Homeostasis/drug effects ; Inflammatory Bowel Diseases/prevention & control ; Intestines/drug effects ; Mice

المؤلفون: Franzosa EA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA., Sirota-Madi A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Avila-Pacheco J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fornelos N; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Haiser HJ; Novartis Institute for Biomedical Research Inc, Cambridge, MA, USA., Reinker S; Novartis Institute for Biomedical Research Inc, Cambridge, MA, USA., Vatanen T; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hall AB; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mallick H; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA., McIver LJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA., Sauk JS; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Wilson RG; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Stevens BW; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Scott JM; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Pierce K; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Deik AA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bullock K; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Imhann F; Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.; Department of Genetics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands., Porter JA; Novartis Institute for Biomedical Research Inc, Basel, Switzerland., Zhernakova A; Department of Genetics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands., Fu J; Department of Genetics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.; Department of Pediatrics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands., Weersma RK; Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands., Wijmenga C; Department of Genetics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.; Department of Immunology, K.G. Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway., Clish CB; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Vlamakis H; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Huttenhower C; Broad Institute of MIT and Harvard, Cambridge, MA, USA. chuttenh@hsph.harvard.edu.; Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA. chuttenh@hsph.harvard.edu., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA. xavier@molbio.mgh.harvard.edu.; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. xavier@molbio.mgh.harvard.edu.; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA, USA. xavier@molbio.mgh.harvard.edu.

المصدر: Nature microbiology [Nat Microbiol] 2019 May; Vol. 4 (5), pp. 898.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: PubMed not MEDLINE

المؤلفون: Vatanen T; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Plichta DR; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Somani J; Department of Computer Science, Aalto University, Espoo, Finland., Münch PC; Department for Computational Biology of Infection Research, Helmholtz Center for Infection Research, Brunswick, Germany.; Max von Pettenkofer-Institute for Hygiene and Clinical Microbiology, Ludwig-Maximilian University of Munich, Munich, Germany., Arthur TD; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hall AB; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rudolf S; Analytical Sciences and Imaging, Novartis Institutes for BioMedical Research, Basel, Switzerland., Oakeley EJ; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Ke X; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Young RA; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Haiser HJ; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Kolde R; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Yassour M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Luopajärvi K; Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland., Siljander H; Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.; Department of Pediatrics, Tampere University Hospital, Tampere, Finland., Virtanen SM; Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.; Faculty of Social Sciences/Health Sciences, University of Tampere, Tampere, Finland.; Science Centre, Pirkanmaa Hospital District and Research Center for Child Health, University Hospital, Tampere, Finland., Ilonen J; Immunogenetics Laboratory, University of Turku, Turku, Finland.; Clinical Microbiology, Turku University Hospital, Turku, Finland., Uibo R; Department of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia., Tillmann V; Department of Pediatrics, University of Tartu and Tartu University Hospital, Tartu, Estonia., Mokurov S; Ministry of Health and Social Development, Karelian Republic of the Russian Federation, Petrozavodsk, Russia., Dorshakova N; Petrozavodsk State University, Department of Family Medicine, Petrozavodsk, Russia., Porter JA; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA, USA., McHardy AC; Department for Computational Biology of Infection Research, Helmholtz Center for Infection Research, Brunswick, Germany., Lähdesmäki H; Department of Computer Science, Aalto University, Espoo, Finland., Vlamakis H; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Huttenhower C; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Knip M; Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.; Department of Pediatrics, Tampere University Hospital, Tampere, Finland.; Folkhälsan Research Center, Helsinki, Finland., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA. xavier@molbio.mgh.harvard.edu.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. xavier@molbio.mgh.harvard.edu.; Gastrointestinal Unit, and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. xavier@molbio.mgh.harvard.edu.; Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA, USA. xavier@molbio.mgh.harvard.edu.

المصدر: Nature microbiology [Nat Microbiol] 2019 Mar; Vol. 4 (3), pp. 545.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: PubMed not MEDLINE

المؤلفون: Vatanen T; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Plichta DR; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Somani J; Department of Computer Science, Aalto University, Espoo, Finland., Münch PC; Department for Computational Biology of Infection Research, Helmholtz Center for Infection Research, Brunswick, Germany.; Max von Pettenkofer-Institute for Hygiene and Clinical Microbiology, Ludwig-Maximilian University of Munich, Munich, Germany., Arthur TD; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hall AB; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rudolf S; Analytical Sciences and Imaging, Novartis Institutes for BioMedical Research, Basel, Switzerland., Oakeley EJ; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Ke X; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Young RA; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Haiser HJ; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA, USA., Kolde R; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Yassour M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Luopajärvi K; Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland., Siljander H; Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.; Department of Pediatrics, Tampere University Hospital, Tampere, Finland., Virtanen SM; Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.; Faculty of Social Sciences/Health Sciences, University of Tampere, Tampere, Finland.; Science Centre, Pirkanmaa Hospital District and Research Center for Child Health, University Hospital, Tampere, Finland., Ilonen J; Immunogenetics Laboratory, University of Turku, Turku, Finland.; Clinical Microbiology, Turku University Hospital, Turku, Finland., Uibo R; Department of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia., Tillmann V; Department of Pediatrics, University of Tartu and Tartu University Hospital, Tartu, Estonia., Mokurov S; Ministry of Health and Social Development, Karelian Republic of the Russian Federation, Petrozavodsk, Russia., Dorshakova N; Petrozavodsk State University, Department of Family Medicine, Petrozavodsk, Russia., Porter JA; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA, USA., McHardy AC; Department for Computational Biology of Infection Research, Helmholtz Center for Infection Research, Brunswick, Germany., Lähdesmäki H; Department of Computer Science, Aalto University, Espoo, Finland., Vlamakis H; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Huttenhower C; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Knip M; Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland.; Department of Pediatrics, Tampere University Hospital, Tampere, Finland.; Folkhälsan Research Center, Helsinki, Finland., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA. xavier@molbio.mgh.harvard.edu.; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. xavier@molbio.mgh.harvard.edu.; Gastrointestinal Unit, and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. xavier@molbio.mgh.harvard.edu.; Center for Microbiome Informatics and Therapeutics, MIT, Cambridge, MA, USA. xavier@molbio.mgh.harvard.edu.

المصدر: Nature microbiology [Nat Microbiol] 2019 Mar; Vol. 4 (3), pp. 470-479. Date of Electronic Publication: 2018 Dec 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE

مواضيع طبية MeSH: Adaptation, Physiological* , Genetic Variation* , Genome, Bacterial*, Gastrointestinal Microbiome/*genetics, Age Factors ; Bacteriophages/genetics ; Bacteroides/genetics ; Bacteroides/virology ; Bifidobacterium bifidum/genetics ; Bifidobacterium longum/genetics ; Child Development ; Child, Preschool ; Estonia ; Feces/microbiology ; Female ; Finland ; Humans ; Infant ; Longitudinal Studies ; Male ; Metabolic Networks and Pathways ; Metagenomics ; Polymorphism, Single Nucleotide ; Probiotics ; Russia

المؤلفون: Franzosa EA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA., Sirota-Madi A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Avila-Pacheco J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fornelos N; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Haiser HJ; Novartis Institute for Biomedical Research Inc., Cambridge, MA, USA., Reinker S; Novartis Institute for Biomedical Research Inc., Cambridge, MA, USA., Vatanen T; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hall AB; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mallick H; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA., McIver LJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA., Sauk JS; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Wilson RG; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Stevens BW; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Scott JM; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Pierce K; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Deik AA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bullock K; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Imhann F; Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.; Department of Genetics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands., Porter JA; Novartis Institute for Biomedical Research Inc., Basel, Switzerland., Zhernakova A; Department of Genetics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands., Fu J; Department of Genetics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.; Department of Pediatrics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands., Weersma RK; Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands., Wijmenga C; Department of Genetics, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.; Department of Immunology, K.G. Jebsen Coeliac Disease Research Centre, University of Oslo, Oslo, Norway., Clish CB; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Vlamakis H; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Huttenhower C; Broad Institute of MIT and Harvard, Cambridge, MA, USA. chuttenh@hsph.harvard.edu.; Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA. chuttenh@hsph.harvard.edu., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA. xavier@molbio.mgh.harvard.edu.; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. xavier@molbio.mgh.harvard.edu.; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA, USA. xavier@molbio.mgh.harvard.edu.

المصدر: Nature microbiology [Nat Microbiol] 2019 Feb; Vol. 4 (2), pp. 293-305. Date of Electronic Publication: 2018 Dec 10.

نوع المنشور: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE

مواضيع طبية MeSH: Gastrointestinal Microbiome*/genetics , Gastrointestinal Microbiome*/immunology, Inflammatory Bowel Diseases/*metabolism , Inflammatory Bowel Diseases/*microbiology, Biodiversity ; Biomarkers/metabolism ; Colitis, Ulcerative/immunology ; Colitis, Ulcerative/metabolism ; Colitis, Ulcerative/microbiology ; Crohn Disease/immunology ; Crohn Disease/metabolism ; Crohn Disease/microbiology ; Feces/chemistry ; Feces/microbiology ; Humans ; Inflammation/metabolism ; Inflammation/microbiology ; Inflammatory Bowel Diseases/immunology ; Leukocyte L1 Antigen Complex/analysis ; Metabolome ; Metagenome

المؤلفون: Wlodarska M; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., Luo C; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA., Kolde R; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA., d'Hennezel E; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., Annand JW; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., Heim CE; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., Krastel P; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland., Schmitt EK; Novartis Institutes for BioMedical Research, Novartis Campus, 4056 Basel, Switzerland., Omar AS; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Creasey EA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA., Garner AL; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Mohammadi S; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., O'Connell DJ; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Abubucker S; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., Arthur TD; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Franzosa EA; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Huttenhower C; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Murphy LO; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., Haiser HJ; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., Vlamakis H; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Porter JA; Chemical Biology and Therapeutics, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA., Xavier RJ; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: xavier@molbio.mgh.harvard.edu.

المصدر: Cell host & microbe [Cell Host Microbe] 2017 Jul 12; Vol. 22 (1), pp. 25-37.e6.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101302316 Publication Model: Print Cited Medium: Internet ISSN: 1934-6069 (Electronic) Linking ISSN: 19313128 NLM ISO Abbreviation: Cell Host Microbe Subsets: MEDLINE

مواضيع طبية MeSH: Symbiosis*, Indoles/*metabolism , Indoles/*pharmacology , Inflammation/*metabolism , Intestinal Mucosa/*microbiology , Peptostreptococcus/*metabolism, Animals ; Anti-Inflammatory Agents/pharmacology ; Bacteria/classification ; Bacteria/genetics ; Bacteria/metabolism ; Bacteroides/genetics ; Bacteroides/metabolism ; Clostridiales/genetics ; Clostridiales/metabolism ; Colon/microbiology ; Colon/pathology ; Cytokines/metabolism ; Dysbiosis/metabolism ; Humans ; Inflammatory Bowel Diseases ; Intestinal Mucosa/injuries ; Intestinal Mucosa/metabolism ; Intestines/microbiology ; Mice ; Mucin-2/genetics ; Mucin-2/metabolism ; Mucins/genetics ; Mucins/metabolism ; Organoids