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المؤلفون: Mengtong Xia, Yu Yan, Haiyan Pu, Xuening Du, Jingyi Liang, Yaning Sun, Jiani Zheng, Yue Yuan

المصدر: Chemical Engineering Journal. 442:136295

مصطلحات موضوعية: General Chemical Engineering, Environmental Chemistry, General Chemistry, Industrial and Manufacturing Engineering

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a4dcb00a1f80c0debb18f75571609d00
https://doi.org/10.1016/j.cej.2022.136295

المؤلفون: Yuhua Huang, Wang Lingyan, Ann E. Weber, Ian W. Davies, Hsueh-Cheng Huang, Mary Senior, Frank Bennett, Quang T. Truong, Stephane L. Bogen, Asra Malikzay, Rebecca Osterman, Eric Ferrari, Paul Tawa, Elizabeth Smith, Haiyan Pu, Vinay Girijavallabhan, Angela Kerekes, Jun Wang, Alexei V. Buevich

المصدر: Bioorganicmedicinal chemistry letters. 27(23)

مصطلحات موضوعية: 0301 basic medicine, Sofosbuvir, Stereochemistry, Propynyl, 030106 microbiology, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Hepacivirus, Microbial Sensitivity Tests, Viral Nonstructural Proteins, Biochemistry, Antiviral Agents, Ns5b polymerase, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Column chromatography, Drug Discovery, medicine, Potency, Nucleotide, Molecular Biology, Uridine, chemistry.chemical_classification, 030102 biochemistry & molecular biology, Dose-Response Relationship, Drug, Organic Chemistry, Nucleosides, chemistry, Molecular Medicine, Nucleoside, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e4b5ff6ec093c3be10484d16116fae
https://pubmed.ncbi.nlm.nih.gov/29056248

المؤلفون: Jun Wang, Weidong Pan, F. George Njoroge, Vinay Girijavallabhan, Ying Huang, Ping Chen, Latha G. Nair, Frank Bennett, Angela Kerekes, Ashok Arasappan, Qun Dang, Qingmei Hong, Stephane L. Bogen, Zhidan Liu, Quang Truong, Sara Esposite, Yuhua Huang, Bancha Vibulbhan, Haiyan Pu, Andrew Stamford, Dmitri A. Pissarnitski, Kevin X. Chen, David B. Olsen, Vishal Verma, David Cole, Zhiqiang Zhao, Randall R. Rossman, Alvarez Carmen S

المصدر: Nucleosides, nucleotidesnucleic acids. 35(6)

مصطلحات موضوعية: Olefin fiber, Azides, 010405 organic chemistry, Guanosine, General Medicine, Hepacivirus, Alkenes, Viral Nonstructural Proteins, 010402 general chemistry, Bioinformatics, 01 natural sciences, Biochemistry, Combinatorial chemistry, Antiviral Agents, Ns5b polymerase, Guanine Nucleotides, 0104 chemical sciences, chemistry.chemical_compound, chemistry, Genetics, Hydrocyanation, Molecular Medicine, Nucleic Acid Synthesis Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a12e0b1f99db43b830f93b2c1a155d
https://pubmed.ncbi.nlm.nih.gov/27104963

المؤلفون: Oleg Selyutin, F. George Njoroge, Qingbei Zeng, Stuart B. Rosenblum, Joseph A. Kozlowski, Mousumi Sannigrahi, Yueheng Jiang, Frank Bennett, Neng-Yang Shih, Eric Ferrari, Gopinadhan N. Anilkumar, Bancha Vibulbhan, Hsueh-Cheng Huang, Jose S. Duca, Li Wang, Pinto Patrick A, Stephen Gavalas, Haiyan Pu, Sony Agrawal, Kevin X. Chen, Charles A. Lesburg, Yuhua Huang, Tin-Yau Chan, Chuan-kui Jiang, Francisco Velazquez, Srikanth Venkatraman

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:713-717

مصطلحات موضوعية: Models, Molecular, Indoles, Isostere, Chemistry, Pharmaceutical, viruses, Carboxylic acid, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Viral Nonstructural Proteins, Crystallography, X-Ray, Antiviral Agents, Biochemistry, Ns5b polymerase, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Moiety, Replicon, Molecular Biology, NS5B, chemistry.chemical_classification, Indole test, Sulfonamides, Organic Chemistry, virus diseases, Hydrogen Bonding, biochemical phenomena, metabolism, and nutrition, digestive system diseases, Sulfonamide, Models, Chemical, chemistry, Drug Design, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f74a4343432a940d8f437e79028a4cd
https://doi.org/10.1016/j.bmcl.2011.10.041

المؤلفون: Bart Cronin, Christopher W. Boyce, Mike Berlin, Birendra N. Pramanik, Peter L. Bartner, Mccormick Kevin D, Larry Heimark, Mahesh Patel, Tze-Ming Chan, Vincent P. Gullo, Alexei V. Buevich, Haiyan Pu, Guodong Chen, Xiaohong Zhu, Robert G. Aslanian, Vinod R. Hegde

المصدر: Journal of Pharmaceutical and Biomedical Analysis. 49:327-332

مصطلحات موضوعية: Quality Control, Magnetic Resonance Spectroscopy, Time Factors, Chemistry, Pharmaceutical, Clinical Biochemistry, Silicones, Pharmaceutical Science, Buffers, Interferon alpha-2, Chemical synthesis, High-performance liquid chromatography, Mass Spectrometry, Analytical Chemistry, Freeze-drying, chemistry.chemical_compound, Impurity, Phase (matter), Drug Discovery, Humans, Organic Chemicals, Chromatography, High Pressure Liquid, Spectroscopy, Biphenyl, Aqueous solution, Chromatography, Molecular Structure, Temperature, Interferon-alpha, Hydrogen-Ion Concentration, Recombinant Proteins, Freeze Drying, chemistry, Powders, Drug Contamination, Quantitative analysis (chemistry)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a93b12bc7cdf01c2267940a26aec6cb
https://doi.org/10.1016/j.jpba.2008.11.038

المؤلفون: Tin-Yau Chan, Frank Bennett, David Hesk, Qingbei Zeng, Li Wang, Pinto Patrick A, Jennifer J. Gesell, Jose S. Duca, Neng-Yang Shih, Kevin X. Chen, Yuhua Huang, Bancha Vibulbhan, Yueheng Jiang, Sony Agrawal, Oleg Selyutin, Steve Sorota, Haiyan Pu, Hsueh-Cheng Huang, Joseph A. Kozlowski, Charles A. Lesburg, Francisco Velazquez, Stephen Gavalas, Cheng Li, Anilkumar G. Nair, Eric Ferrari, F. George Njoroge, Srikanth Venkatraman, Chuan-kui Jiang, Mousumi Sannigrahi, Stuart B. Rosenblum

المصدر: Bioorganicmedicinal chemistry letters. 23(24)

مصطلحات موضوعية: Male, Indoles, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Hepacivirus, Molecular Dynamics Simulation, Viral Nonstructural Proteins, Crystallography, X-Ray, Biochemistry, Rats, Sprague-Dawley, chemistry.chemical_compound, Dogs, Pharmacokinetics, In vivo, Drug Discovery, Distribution (pharmacology), Animals, Humans, Replicon, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Organic Chemistry, Metabolism, Haplorhini, Molecular biology, In vitro, Protein Structure, Tertiary, Rats, Enzyme Activation, Enzyme, chemistry, Quinolines, Molecular Medicine, Lead compound, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04eb82ee6ce4c43fa35b72c72cd7bb9
https://pubmed.ncbi.nlm.nih.gov/24252545

المؤلفون: Mahesh Patel, Adrian Jachens, Tze-Ming Chan, Haiyan Pu, Vincent P. Gullo, Vinod R. Hegde

المصدر: Bioorganic & Medicinal Chemistry Letters. 15:4907-4909

مصطلحات موضوعية: VEGF receptor binding, Magnetic Resonance Spectroscopy, Diene, Stereochemistry, VEGF receptors, Carboxylic acid, Clinical Biochemistry, Alpha (ethology), Pharmaceutical Science, Antineoplastic Agents, Pharmacognosy, Biochemistry, chemistry.chemical_compound, Inhibitory Concentration 50, Growth factor receptor, Drug Discovery, Molecular Biology, IC50, chemistry.chemical_classification, Aqueous solution, Oryctanthus, Molecular Structure, biology, Organic Chemistry, General Medicine, Nuclear magnetic resonance spectroscopy, In vitro, Receptors, Vascular Endothelial Growth Factor, Enzyme, chemistry, Magnolia, Enzyme inhibitor, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e27ed8c7268a9d770d21588631aed9
https://doi.org/10.1016/j.bmcl.2005.08.022

المؤلفون: Stephen Gavalas, Boris Feld, K.-C. Cheng, Weiying Yang, Frank Bennett, Cheng Li, Gopinadhan N. Anilkumar, Qingbei Zeng, Jose S. Duca, Oleg Selyutin, Bancha Vibulbhan, Neng-Yang Shih, Yuhua Huang, Li Wang, Pinto Patrick A, Kevin X. Chen, Joseph A. Kozlowski, F. George Njoroge, Srikanth Venkatraman, Charles A. Lesburg, Hsueh-Cheng Huang, Stuart B. Rosenblum, Haiyan Pu, Francisco Velazquez, Tin-Yau Chan, Sony Agrawal, Yueheng Jiang

المصدر: Journal of medicinal chemistry. 55(5)

مصطلحات موضوعية: Models, Molecular, Indoles, Stereochemistry, Pyridones, Carboxylic acid, Hepacivirus, Viral Nonstructural Proteins, Crystallography, X-Ray, Antiviral Agents, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, Drug Discovery, Moiety, Structure–activity relationship, Animals, Sulfones, Indole test, chemistry.chemical_classification, Molecular Structure, Mutagenicity Tests, Haplorhini, Nitro Compounds, In vitro, Rats, chemistry, Covalent bond, Thiol, Molecular Medicine, Derivative (chemistry)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf86bc03c5325879522fa91b8c41fa0c
https://pubmed.ncbi.nlm.nih.gov/22247956

المؤلفون: Neng Yang Shih, Hsueh-Cheng Huang, Jose S. Duca, Bancha Vibulbhan, Frank Bennett, Kevin X. Chen, Stephen Gavalas, Yueheng Jiang, Robert E. Palermo, Charles A. Lesburg, Srikanth Venkatraman, Zhiqing He, Francisco Velazquez, Nancy Butkiewicz, Li Wang, Boris Feld, Pinto Patrick A, Gopinadhan N. Anilkumar, Yuhua Huang, Stuart B. Rosenblum, Chuan Kui Jiang, Haiyan Pu, Tin Yau Chan, Eric Ferrari, George F Njoroge, Joseph A. Kozlowski, Sony Agrawal, Henry M. Vaccaro, Mousumi Sannigrahi, Qingbei Zeng, Patricia McMonagle, Oleg Selyutin

المصدر: Bioorganicmedicinal chemistry letters. 21(18)

مصطلحات موضوعية: Models, Molecular, Indoles, Stereochemistry, viruses, Clinical Biochemistry, Carboxylic Acids, Pharmaceutical Science, Viral Nonstructural Proteins, Crystallography, X-Ray, Biochemistry, Ns5b polymerase, chemistry.chemical_compound, Structure-Activity Relationship, Heterocyclic Compounds, Catalytic Domain, Drug Discovery, Peptide bond, Replicon, Enzyme Inhibitors, Molecular Biology, NS5B, Polymerase, Indole test, chemistry.chemical_classification, biology, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, virus diseases, Stereoisomerism, biochemical phenomena, metabolism, and nutrition, digestive system diseases, Enzyme, chemistry, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbcde4c34dd48082f61c28f48aee1b2
https://pubmed.ncbi.nlm.nih.gov/21840715