المؤلفون: Alektiar JM; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America., Shan M; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America., Radyk MD; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America., Zhang L; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America., Halbrook CJ; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America., Lin L; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America., Espinoza C; Department of Surgery, University of Michigan, Ann Arbor, Michigan, United States of America., Mier IF; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States of America., Lavoie BL; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America., Salvatore L; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America., Pasca di Magliano M; Department of Surgery, University of Michigan, Ann Arbor, Michigan, United States of America.; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America., Cantley LC; Department of Cancer Biology, Dana Farber Cancer Center, Boston, Massachusetts, United States of America.; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, United States of America., Mueller JL; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, United States of America., Lyssiotis CA; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States of America.; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan, United States of America.; Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America.

المصدر: PloS one [PLoS One] 2024 Jun 06; Vol. 19 (6), pp. e0303577. Date of Electronic Publication: 2024 Jun 06 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Malate Dehydrogenase*/metabolism , Malate Dehydrogenase*/genetics , Mice, Knockout* , Phenotype*, Animals ; Male ; Mice ; Female ; Germ Cells/metabolism ; Mice, Inbred C57BL

المؤلفون: Alcolea MP, Alonso-Curbelo D, Ambrogio C, Bullman S, Correia AL, Ernst A, Halbrook CJ, Kelly GL, Lund AW, Quail DF, Ruscetti M, Shema E, Stromnes IM, Tam WL

المصدر: Cancer discovery [Cancer Discov] 2024 Apr 04; Vol. 14 (4), pp. 674-682.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: Neoplasms*/epidemiology, Humans

المؤلفون: Radyk MD; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Nelson BS; Doctoral Program in Cancer Biology, University of Michigan, Ann Arbor, USA., Halbrook CJ; Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA.; University of California Irvine Chao Family Comprehensive Cancer Center, Orange, CA, USA., Wood A; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Lavoie B; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Salvatore L; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Corfas G; Kresge Hearing Research Institute and Dept. of Otolaryngology, Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA., Colacino JA; Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Program in the Environment, College of Literature, Sciences, and the Arts, University of Michigan, Ann Arbor, MI, USA.; University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Shah YM; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA., Crawford HC; Department of Surgery, Henry Ford Pancreatic Cancer Center, Henry Ford Health System, Detroit, MI, USA., Lyssiotis CA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA.

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 08. Date of Electronic Publication: 2023 Nov 08.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Nwosu ZC; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Ward MH; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Department of Chemistry, Washington University in St Louis, St Louis, MO, USA.; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; Center for Metabolomics and Isotope Tracing, Washington University in St Louis, St Louis, MO, USA., Sajjakulnukit P; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Poudel P; Division of Molecular Pathology, The Institute of Cancer Research, London, UK., Ragulan C; Division of Molecular Pathology, The Institute of Cancer Research, London, UK., Kasperek S; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Radyk M; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Sutton D; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Menjivar RE; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI, USA., Andren A; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Apiz-Saab JJ; Ben May Department for Cancer Research, University of Chicago, Chicago, IL, USA., Tolstyka Z; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Brown K; Department of Surgery, University of Michigan, Ann Arbor, MI, USA., Lee HJ; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Dzierozynski LN; Ben May Department for Cancer Research, University of Chicago, Chicago, IL, USA., He X; Department of Surgery, University of Michigan, Ann Arbor, MI, USA., Ps H; Division of Molecular Pathology, The Institute of Cancer Research, London, UK., Ugras J; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Nyamundanda G; Division of Molecular Pathology, The Institute of Cancer Research, London, UK., Zhang L; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Halbrook CJ; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Carpenter ES; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA., Shi J; Department of Pathology and Clinical Labs, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Shriver LP; Department of Chemistry, Washington University in St Louis, St Louis, MO, USA.; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; Center for Metabolomics and Isotope Tracing, Washington University in St Louis, St Louis, MO, USA., Patti GJ; Department of Chemistry, Washington University in St Louis, St Louis, MO, USA.; Department of Medicine, Washington University in St Louis, St Louis, MO, USA.; Center for Metabolomics and Isotope Tracing, Washington University in St Louis, St Louis, MO, USA., Muir A; Ben May Department for Cancer Research, University of Chicago, Chicago, IL, USA., Pasca di Magliano M; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Sadanandam A; Division of Molecular Pathology, The Institute of Cancer Research, London, UK. anguraj.sadanandam@icr.ac.uk.; Centre for Global Oncology, Division of Molecular Pathology, The Institute of Cancer Research, London, UK. anguraj.sadanandam@icr.ac.uk., Lyssiotis CA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA. clyssiot@med.umich.edu.; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA. clyssiot@med.umich.edu.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA. clyssiot@med.umich.edu.

المصدر: Nature [Nature] 2023 Jun; Vol. 618 (7963), pp. 151-158. Date of Electronic Publication: 2023 May 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Pancreatic Neoplasms*/metabolism , Pancreatic Neoplasms*/pathology , Ribose*/metabolism , Tumor Microenvironment* , Uridine*/chemistry , Glucose*/deficiency, Animals ; Mice ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Cell Division ; Cell Line, Tumor ; MAP Kinase Signaling System ; Uridine Phosphorylase/deficiency ; Uridine Phosphorylase/genetics ; Uridine Phosphorylase/metabolism ; Humans

المؤلفون: Halbrook CJ; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697, USA; Institute for Immunology, University of California, Irvine, Irvine, CA 92697, USA; Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, CA 92868, USA. Electronic address: chris.halbrook@uci.edu., Lyssiotis CA; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI 48109, USA; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: costas.lyssiotis@umich.edu., Pasca di Magliano M; Rogel Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA; Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: marinapa@umich.edu., Maitra A; Department of Translational Molecular Pathology, Sheikh Ahmed Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: amaitra@mdanderson.org.

المصدر: Cell [Cell] 2023 Apr 13; Vol. 186 (8), pp. 1729-1754.

نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Pancreatic Ductal*/diagnosis , Carcinoma, Pancreatic Ductal*/drug therapy , Carcinoma, Pancreatic Ductal*/pathology , Carcinoma, Pancreatic Ductal*/surgery , Pancreatic Neoplasms*/diagnosis , Pancreatic Neoplasms*/drug therapy , Pancreatic Neoplasms*/pathology , Pancreatic Neoplasms*/surgery, Humans ; Tumor Microenvironment ; Early Diagnosis ; Prognosis

المؤلفون: Menjivar RE; Cellular and Molecular Biology Program, University of Michigan-Ann Arbor, Ann Arbor, United States., Nwosu ZC; Department of Molecular and Integrative Physiology, University of Michigan-Ann Arbor, Ann Arbor, United States., Du W; Department of Surgery, University of Michigan-Ann Arbor, Ann Arbor, United States., Donahue KL; Cancer Biology Program, University of Michigan-Ann Arbor, Ann Arbor, United States., Hong HS; Department of Immunology, University of Michigan-Ann Arbor, Ann Arbor, United States., Espinoza C; Department of Surgery, University of Michigan-Ann Arbor, Ann Arbor, United States., Brown K; Department of Surgery, University of Michigan-Ann Arbor, Ann Arbor, United States., Velez-Delgado A; Department of Cell and Developmental Biology, University of Michigan-Ann Arbor, Ann Arbor, United States., Yan W; Department of Surgery, University of Michigan-Ann Arbor, Ann Arbor, United States., Lima F; Department of Surgery, University of Michigan-Ann Arbor, Ann Arbor, United States., Bischoff A; Cancer Biology Program, University of Michigan-Ann Arbor, Ann Arbor, United States., Kadiyala P; Department of Immunology, University of Michigan-Ann Arbor, Ann Arbor, United States., Salas-Escabillas D; Cancer Biology Program, University of Michigan-Ann Arbor, Ann Arbor, United States., Crawford HC; Henry Ford Pancreatic Cancer Center, Detroit, United States., Bednar F; Department of Surgery, University of Michigan-Ann Arbor, Ann Arbor, United States.; Rogel Cancer Center, Ann Arbor, United States., Carpenter E; Rogel Cancer Center, Ann Arbor, United States.; Department of Internal Medicine, Division of Gastroenterolog, University of Michigan-Ann Arbor, Ann Arbor, United States., Zhang Y; Department of Surgery, University of Michigan-Ann Arbor, Ann Arbor, United States.; Rogel Cancer Center, Ann Arbor, United States., Halbrook CJ; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, United States.; Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, United States., Lyssiotis CA; Department of Molecular and Integrative Physiology, University of Michigan-Ann Arbor, Ann Arbor, United States.; Cancer Biology Program, University of Michigan-Ann Arbor, Ann Arbor, United States.; Rogel Cancer Center, Ann Arbor, United States.; Department of Internal Medicine, Division of Gastroenterolog, University of Michigan-Ann Arbor, Ann Arbor, United States., Pasca di Magliano M; Cellular and Molecular Biology Program, University of Michigan-Ann Arbor, Ann Arbor, United States.; Cancer Biology Program, University of Michigan-Ann Arbor, Ann Arbor, United States.; Department of Cell and Developmental Biology, University of Michigan-Ann Arbor, Ann Arbor, United States.; Henry Ford Pancreatic Cancer Center, Detroit, United States.; Rogel Cancer Center, Ann Arbor, United States.

المصدر: ELife [Elife] 2023 Feb 02; Vol. 12. Date of Electronic Publication: 2023 Feb 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

مواضيع طبية MeSH: Arginase*/genetics , Arginase*/metabolism , Pancreatic Neoplasms*/pathology, Animals ; Humans ; Mice ; Arginine/metabolism ; CD8-Positive T-Lymphocytes ; Macrophages

المؤلفون: Beutel AK; Department of Molecular Biology and Biochemistry, University of California, Irvine, California.; Department of Internal Medicine, University Hospital Ulm, Ulm, Germany., Halbrook CJ; Department of Molecular Biology and Biochemistry, University of California, Irvine, California.; Chao Family Comprehensive Cancer Center, Orange, California.

المصدر: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2023 Feb 01; Vol. 324 (2), pp. C540-C552. Date of Electronic Publication: 2022 Dec 26.

نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901225 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1563 (Electronic) Linking ISSN: 03636143 NLM ISO Abbreviation: Am J Physiol Cell Physiol Subsets: MEDLINE

مواضيع طبية MeSH: Pancreatic Neoplasms*/drug therapy , Pancreatic Neoplasms*/pathology , Carcinoma, Pancreatic Ductal*/drug therapy , Carcinoma, Pancreatic Ductal*/pathology, Humans ; Gemcitabine ; Deoxycytidine/pharmacology ; Deoxycytidine/therapeutic use ; Drug Resistance, Neoplasm ; Cell Line, Tumor ; Pancreatic Neoplasms

المؤلفون: Singha MK; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California 92697, United States., Zimak J; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, California 92697, United States., Levine SR; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, California 92697, United States., Dai N; New England Biolabs, Beverly, Massachusetts 01915, United States., Hong C; Department of Cell and Developmental Biology, University of California, Irvine, Irvine, California 92697, United States., Anaraki C; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California 92697, United States., Gupta M; Department of Chemistry, University of California, Irvine, Irvine, California 92697, United States., Halbrook CJ; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California 92697, United States., Atwood SX; Department of Cell and Developmental Biology, University of California, Irvine, Irvine, California 92697, United States., Spitale RC; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California 92697, United States.; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, California 92697, United States.; Department of Chemistry, University of California, Irvine, Irvine, California 92697, United States.

المصدر: Biochemistry [Biochemistry] 2022 Dec 06; Vol. 61 (23), pp. 2638-2642. Date of Electronic Publication: 2022 Nov 16.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

مواضيع طبية MeSH: RNA*/chemistry , Tandem Mass Spectrometry*, Animals ; Mice ; Humans ; Chromatography, Liquid ; Gene Expression Profiling

المؤلفون: Halbrook CJ; Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA. chris.halbrook@uci.edu.; University of California Irvine Chao Family Comprehensive Cancer Center, Orange, CA, USA. chris.halbrook@uci.edu.; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA. chris.halbrook@uci.edu.; Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA. chris.halbrook@uci.edu., Thurston G; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Boyer S; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Anaraki C; Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA., Jiménez JA; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., McCarthy A; Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK., Steele NG; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.; Department of Surgery, Henry Ford Health System, Detroit, MI, USA., Kerk SA; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Hong HS; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Lin L; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Law FV; Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA., Felton C; Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK., Scipioni L; Department of Biomedical Engineering, University of California Irvine, Irvine, CA, USA., Sajjakulnukit P; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Andren A; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Beutel AK; Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA., Singh R; Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA., Nelson BS; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Van Den Bergh F; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Krall AS; Department of Biological Chemistry, University of California Los Angeles, Los Angeles, CA, USA., Mullen PJ; Department of Biological Chemistry, University of California Los Angeles, Los Angeles, CA, USA., Zhang L; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Batra S; Riley Hospital for Children at Indiana University Health, Indianapolis, IN, USA., Morton JP; Cancer Research UK Beatson Institute and Institute of Cancer Sciences, University of Glasgow, Glasgow, UK., Stanger BZ; Gastroenterology Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Christofk HR; Department of Biological Chemistry, University of California Los Angeles, Los Angeles, CA, USA., Digman MA; Department of Biomedical Engineering, University of California Irvine, Irvine, CA, USA., Beard DA; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Viale A; Department of Genomic Medicine, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Zhang J; Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA., Crawford HC; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Department of Surgery, Henry Ford Health System, Detroit, MI, USA., Pasca di Magliano M; Department of Surgery, University of Michigan, Ann Arbor, MI, USA.; University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Jorgensen C; Cancer Research UK Manchester Institute, University of Manchester, Manchester, UK., Lyssiotis CA; Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, USA. clyssiot@med.umich.edu.; University of Michigan Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA. clyssiot@med.umich.edu.; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA. clyssiot@med.umich.edu.

المصدر: Nature cancer [Nat Cancer] 2022 Nov; Vol. 3 (11), pp. 1386-1403. Date of Electronic Publication: 2022 Nov 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Pancreatic Neoplasms*/drug therapy , Adenocarcinoma*/drug therapy, Animals ; Mice ; Humans ; Asparagine/metabolism ; Symbiosis ; Tumor Microenvironment

المؤلفون: Kerk SA; Doctoral Program in Cancer Biology, University of Michigan-Ann Arbor, Ann Arbor, United States., Lin L; Department of Molecular and Integrative Physiology, University of Michigan-Ann Arbor, Ann Arbor, United States., Myers AL; Department of Molecular and Integrative Physiology, University of Michigan-Ann Arbor, Ann Arbor, United States., Sutton DJ; Department of Molecular and Integrative Physiology, University of Michigan-Ann Arbor, Ann Arbor, United States., Andren A; Department of Molecular and Integrative Physiology, University of Michigan-Ann Arbor, Ann Arbor, United States., Sajjakulnukit P; Doctoral Program in Cancer Biology, University of Michigan-Ann Arbor, Ann Arbor, United States., Zhang L; Department of Molecular and Integrative Physiology, University of Michigan-Ann Arbor, Ann Arbor, United States., Zhang Y; Department of Surgery, University of Michigan-Ann Arbor, Ann Arbor, United States., Jiménez JA; Doctoral Program in Cancer Biology, University of Michigan-Ann Arbor, Ann Arbor, United States., Nelson BS; Doctoral Program in Cancer Biology, University of Michigan-Ann Arbor, Ann Arbor, United States.; Department of Molecular and Integrative Physiology, University of Michigan-Ann Arbor, Ann Arbor, United States., Chen B; Department of Molecular and Integrative Physiology, University of Michigan-Ann Arbor, Ann Arbor, United States., Robinson A; Department of Cell and Developmental Biology, University of Michigan-Ann Arbor, Ann Arbor, United States., Thurston G; Department of Molecular and Integrative Physiology, University of Michigan-Ann Arbor, Ann Arbor, United States., Kemp SB; Molecular and Cellular Pathology Graduate Program, University of Michigan-Ann Arbor, Ann Arbor, United States., Steele NG; Department of Cell and Developmental Biology, University of Michigan-Ann Arbor, Ann Arbor, United States., Hoffman MT; Department of Molecular and Integrative Physiology, University of Michigan-Ann Arbor, Ann Arbor, United States., Wen HJ; Department of Molecular and Integrative Physiology, University of Michigan-Ann Arbor, Ann Arbor, United States., Long D; Department of Molecular and Integrative Physiology, University of Michigan-Ann Arbor, Ann Arbor, United States., Ackenhusen SE; Program in Chemical Biology, University of Michigan-Ann Arbor, Ann Arbor, United States., Ramos J; Department of Molecular and Integrative Physiology, University of Michigan-Ann Arbor, Ann Arbor, United States., Gao X; Department of Molecular and Integrative Physiology, University of Michigan-Ann Arbor, Ann Arbor, United States., Nwosu ZC; Department of Molecular and Integrative Physiology, University of Michigan-Ann Arbor, Ann Arbor, United States., Galban S; Department of Radiology, University of Michigan, Ann Arbor, United States.; Rogel Cancer Center, University of Michigan, Ann Arbor, United States., Halbrook CJ; Department of Molecular and Integrative Physiology, University of Michigan-Ann Arbor, Ann Arbor, United States., Lombard DB; Department of Pathology and Institute of Gerontology, University of Michigan, Ann Arbor, United States., Piwnica-Worms DR; Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, United States., Ying H; Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, United States., Pasca di Magliano M; Department of Surgery, University of Michigan-Ann Arbor, Ann Arbor, United States.; Rogel Cancer Center, University of Michigan, Ann Arbor, United States., Crawford HC; Department of Molecular and Integrative Physiology, University of Michigan-Ann Arbor, Ann Arbor, United States.; Rogel Cancer Center, University of Michigan, Ann Arbor, United States., Shah YM; Department of Molecular and Integrative Physiology, University of Michigan-Ann Arbor, Ann Arbor, United States.; Rogel Cancer Center, University of Michigan, Ann Arbor, United States.; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, United States., Lyssiotis CA; Doctoral Program in Cancer Biology, University of Michigan-Ann Arbor, Ann Arbor, United States.; Department of Molecular and Integrative Physiology, University of Michigan-Ann Arbor, Ann Arbor, United States.; Rogel Cancer Center, University of Michigan, Ann Arbor, United States.; Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, United States.

المصدر: ELife [Elife] 2022 Jul 11; Vol. 11. Date of Electronic Publication: 2022 Jul 11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Pancreatic Ductal*/pathology , Pancreatic Neoplasms*/pathology, Animals ; Aspartate Aminotransferase, Mitochondrial/genetics ; Aspartate Aminotransferase, Mitochondrial/metabolism ; Fatty Acid-Binding Proteins ; Humans ; Mice ; NAD/metabolism ; Proto-Oncogene Proteins p21(ras)/metabolism ; Pyruvic Acid/metabolism ; Tumor Microenvironment