المؤلفون: Koehler MFT; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California 94080, United States., Chen YC; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California 94080, United States., Chen Y; Department of Chemistry, WuXi AppTec, Shanghai 200131, China., Chen Y; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California 94080, United States., Crawford JJ; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California 94080, United States., Durk MR; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California 94080, United States., Garland K; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California 94080, United States., Hanan EJ; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California 94080, United States., Higuchi RI; RQx Pharmaceuticals, La Jolla, California 92037, United States., Hu H; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California 94080, United States., Ly CQ; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California 94080, United States., Paraselli PG; RQx Pharmaceuticals, La Jolla, California 92037, United States., Roberts TC; RQx Pharmaceuticals, La Jolla, California 92037, United States., Schwarz JB; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California 94080, United States., Smith PA; Department of Infectious Disease, Genentech, Inc., South San Francisco, California 94080, United States., Yu Z; Department of Chemistry, WuXi AppTec, Shanghai 200131, China., Heise CE; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Oct 11; Vol. 14 (11), pp. 1524-1530. Date of Electronic Publication: 2023 Oct 11 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Püspök JF; Department of Environmental Sciences, University of California, Riverside, California, USA., Zhao S; Department of Environmental Sciences, University of California, Riverside, California, USA., Calma AD; Department of Environmental Sciences, University of California, Riverside, California, USA., Vourlitis GL; Department of Biological Sciences, California State University, San Marcos, California, USA., Allison SD; Department of Ecology and Evolutionary Biology, University of California, Irvine, California, USA.; Department of Earth System Science, University of California, Irvine, California, USA., Aronson EL; Department of Microbiology and Plant Pathology, University of California, Riverside, California, USA., Schimel JP; Department of Ecology, Evolution, and Marine Biology and Earth Research Institute, University of California, Santa Barbara, California, USA., Hanan EJ; Department of Natural Resources and Environmental Science, University of Nevada, Reno, Nevada, USA., Homyak PM; Department of Environmental Sciences, University of California, Riverside, California, USA.

المصدر: Global change biology [Glob Chang Biol] 2023 Mar; Vol. 29 (6), pp. 1660-1679. Date of Electronic Publication: 2022 Dec 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Blackwell Pub Country of Publication: England NLM ID: 9888746 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2486 (Electronic) Linking ISSN: 13541013 NLM ISO Abbreviation: Glob Chang Biol Subsets: MEDLINE

مواضيع طبية MeSH: Carbon* , Soil*, Nitrogen/analysis ; Ecosystem ; Biomass ; Minerals ; Calcium ; Soil Microbiology

المؤلفون: Hanan EJ; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Braun MG; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Heald RA; Early Discovery Charles River, 7/8 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, U.K., MacLeod C; Early Discovery Charles River, 7/8 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, U.K., Chan C; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Clausen S; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Edgar KA; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Eigenbrot C; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Elliott R; Early Discovery Charles River, 7/8 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, U.K., Endres N; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Friedman LS; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Gogol E; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Gu XH; Pharmaron Beijing Co., Ltd, No. 6 Taihe Road, BDA, Beijing 100176, P. R. China., Thibodeau RH; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Jackson PS; Early Discovery Charles River, 7/8 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, U.K., Kiefer JR; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Knight JD; Early Discovery Charles River, 7/8 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, U.K., Nannini M; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Narukulla R; Early Discovery Charles River, 7/8 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, U.K., Pace A; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Pang J; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Purkey HE; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Salphati L; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Sampath D; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Schmidt S; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Sideris S; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Song K; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Sujatha-Bhaskar S; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Ultsch M; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Wallweber H; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Xin J; Pharmaron Beijing Co., Ltd, No. 6 Taihe Road, BDA, Beijing 100176, P. R. China., Yeap S; Early Discovery Charles River, 7/8 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, U.K., Young A; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Zhong Y; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Staben ST; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2022 Dec 22; Vol. 65 (24), pp. 16589-16621. Date of Electronic Publication: 2022 Dec 01.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Phosphatidylinositol 3-Kinases*/metabolism , Breast Neoplasms*/drug therapy, Humans ; Female ; Phosphoinositide-3 Kinase Inhibitors/pharmacology ; Phosphoinositide-3 Kinase Inhibitors/therapeutic use ; Class I Phosphatidylinositol 3-Kinases/therapeutic use ; Cell Line, Tumor ; Mutation

المؤلفون: Brady MK; Department of Natural Resources & Environmental Science, University of Nevada - Reno, Reno, Nevada, USA., Dickinson MB; US Forest Service, Northern Research Station, Delaware, Ohio, USA., Miesel JR; Department of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, Michigan, USA., Wonkka CL; USDA, ARS, Northern Plains Agricultural Research Laboratory, Sidney, Montana, USA., Kavanagh KL; College of Forestry, Oregon State University, Corvallis, Oregon, USA., Lodge AG; Department of Ecosystem Science and Management, Texas A&M University, College Station, Texas, USA., Rogers WE; Department of Ecosystem Science and Management, Texas A&M University, College Station, Texas, USA., Starns HD; Department of Ecosystem Science and Management, Texas A&M AgriLife Research, Sonora, Texas, USA., Tolleson DR; Department of Ecosystem Science and Management, Texas A&M AgriLife Research, Sonora, Texas, USA., Treadwell ML; Department of Rangeland, Wildlife and Fisheries Management Ecosystem Science and Management, Texas A&M AgriLife Extension Service, San Angelo, Texas, USA., Twidwell D; Department of Agronomy and Horticulture, University of Nebraska at Lincoln, Lincoln, Nebraska, USA., Hanan EJ; Department of Natural Resources & Environmental Science, University of Nevada - Reno, Reno, Nevada, USA.

المصدر: Ecological applications : a publication of the Ecological Society of America [Ecol Appl] 2022 Sep; Vol. 32 (6), pp. e2627. Date of Electronic Publication: 2022 Jun 13.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Ecological Society of America Country of Publication: United States NLM ID: 9889808 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1051-0761 (Print) Linking ISSN: 10510761 NLM ISO Abbreviation: Ecol Appl Subsets: MEDLINE

مواضيع طبية MeSH: Fires* , Wildfires*, Ecosystem ; Heating ; Humans ; Soil/chemistry

المؤلفون: Shuman JK; Terrestrial Sciences Section, Climate and Global Dynamics Laboratory, National Center for Atmospheric Research, P.O. Box 3000, Boulder, CO 80307-3000, USA., Balch JK; Earth Lab, Cooperative Institute for Research in Environmental Sciences (CIRES), University of Colorado Boulder,4001 Discovery Drive, Suite S348 611 UCB, Boulder, CO, 80303, USA., Barnes RT; Environmental Studies Program, Colorado College, 14 East Cache la Poudre, Colorado Springs, CO, 80903, USA., Higuera PE; Department of Ecosystem and Conservation Sciences, University of Montana, 32 Campus Dr., Missoula, MT, 59812, USA., Roos CI; Department of Anthropology, Southern Methodist University, P.O. Box 750336, Dallas, TX, 75275-0336, USA., Schwilk DW; Department of Biological Sciences, Texas Tech University, 2901 Main St. Lubbock, TX, 79409-43131, USA., Stavros EN; Earth Lab, Cooperative Institute for Research in Environmental Sciences (CIRES), University of Colorado Boulder,4001 Discovery Drive, Suite S348 611 UCB, Boulder, CO, 80303, USA., Banerjee T; Samueli School of Engineering, University of California, 3084 Interdisciplinary Science and Engineering Building, UC Irvine, CA 92697, USA., Bela MM; Cooperative Institute for Research in Environmental Sciences (CIRES), University of Colorado at Boulder, 216 UCB, Boulder CO, 80309, USA.; NOAA Chemical Sciences Laboratory, Boulder, CO, USA., Bendix J; Department of Geography and the Environment, Syracuse University, 144 Eggers Hall, Syracuse NY 13244, USA., Bertolino S; Department of Life Sciences and Systems Biology, University of Turin, Via Accademia Albertina 13, 10123 Torino, Italy., Bililign S; Department of Physics, North Carolina A&T State University, 1601 E Market Street, Greensboro, NC 27411, USA., Bladon KD; Department of Forest Engineering, Resources, and Management, Oregon State University, 244 Peavy Forest Science Center; Corvallis, OR, 97331, USA., Brando P; Earth System Science, University of California Irvine, 3215 Croul Hall Irvine, CA 92697, USA., Breidenthal RE; Department of Aeronautics and Astronautics, University of Washington, Box 352400, Seattle, WA 98195-2400, USA., Buma B; Integrative Biology, University of Colorado Denver, Campus Box 171, P.O. Box 173364, Denver, CO 80217-3364, USA., Calhoun D; Department of Mathematics, Boise State University, 1910 University Drive, Boise, ID 83725-1135, USA., Carvalho LMV; Department of Geography, University of California Santa Barbara, 1832 Ellison Hall, Santa Barbara, CA, 93106, USA., Cattau ME; Human-Environment Systems, Boise State University, Boise State Environmental Research Building, 1295 W University Dr, Boise, ID 83706, USA., Cawley KM; National Ecological Observatory Network, Battelle, 1685 38th St., Suite 100, Boulder, CO 80301, USA., Chandra S; Global Water Center, University of Nevada, 1664 N. Virginia, Reno, NV, 89509, USA., Chipman ML; Department of Earth and Environmental Sciences, Syracuse University, 317 Heroy Geology Building, 141 Crouse Dr, Syracuse, NY 13210, USA., Cobian-Iñiguez J; Department of Mechanical Engineering, University of California Merced, Sustainability Research and Engineering, SRE 366, 5200 Lake Rd, Merced, CA 95343, USA., Conlisk E; Point Blue Conservation Science, 3820 Cypress Dr, Petaluma, CA 94954, USA., Coop JD; Clark School of Environment and Sustainability, Western Colorado University, 1 Western Way, Gunnison CO 81231, USA., Cullen A; Evans School of Public Policy and Governance, University of Washington, Parrington Hall, Mailbox 353055, Seattle, WA 98195-3055, USA., Davis KT; Department of Ecosystem and Conservation Sciences, University of Montana, 32 Campus Dr., Missoula, MT, 59812, USA., Dayalu A; Atmospheric and Environmental Research, 131 Hartwell Ave, Lexington MA 02421, USA., De Sales F; Department of Geography, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182-4493, USA., Dolman M; Human-Environment Systems, Boise State University, Boise State Environmental Research Building, 1295 W University Dr, Boise, ID 83706, USA., Ellsworth LM; Department of Fisheries, Wildlife, and Conservation Sciences, Oregon State University, 104 Nash Hall, Corvallis, OR 97330, USA., Franklin S; School of Biological Sciences, University of Northern Colorado, 501 20th Street, Greeley, CO 80639, USA., Guiterman CH; Cooperative Institute for Research in Environmental Sciences (CIRES), University of Colorado at Boulder, 216 UCB, Boulder CO, 80309, USA.; NOAA's National Centers for Environmental Information (NCEI), 325 Broadway, NOAA E/GC3, Boulder, Colorado 80305-3337, USA., Hamilton M; School of Environment and Natural Resources, The Ohio State University, 2021 Coffey Road, Columbus, OH 43210, USA., Hanan EJ; Department of Natural Resources and Environmental Science, University of Nevada, 1664 N. Virginia St. Mail Stop 0186. Reno, NV 89509, USA., Hansen WD; Cary Institute of Ecosystem Studies, PO Box AB, Millbrook, NY 12545, USA., Hantson S; Earth System Science Program, Faculty of Natural Sciences, Max Planck Tandem Group in Earth System Science, Universidad del Rosario, Carrera 26 # 63b-48, Bogota, DC 111221, Colombia., Harvey BJ; School of Environmental and Forest Sciences, University of Washington, UW-SEFS, Box 352100, Seattle, WA 98195, USA., Holz A; Department of Geography, Portland State University, 1721 SW Broadway, Portland, OR 97201, USA., Huang T; Human-Environment Systems, Boise State University, Boise State Environmental Research Building, 1295 W University Dr, Boise, ID 83706, USA., Hurteau MD; Department of Biology, University of New Mexico, MSC03 2020, Albuquerque, NM 87131, USA., Ilangakoon NT; Earth Lab, Cooperative Institute for Research in Environmental Sciences (CIRES), University of Colorado Boulder,4001 Discovery Drive, Suite S348 611 UCB, Boulder, CO, 80303, USA., Jennings M; Institute for Ecological Monitoring and Management, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182-4614, USA., Jones C; Department of Geography, University of California Santa Barbara, 1832 Ellison Hall, Santa Barbara, CA, 93106, USA., Klimaszewski-Patterson A; Department of Geography, California State University Sacramento, 6000 J St, Sacramento, CA 95819, USA., Kobziar LN; College of Natural Resources, University of Idaho, 1031 N. Academic Way Coeur d'Alene, ID 83844, USA., Kominoski J; Institute of Environment and Department of Biological Sciences, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA., Kosovic B; Weather Systems and Assessment Program, National Center for Atmospheric Research, P.O. Box 3000, Boulder, CO 80307-3000, USA., Krawchuk MA; Department of Forest Ecosystems and Society, Oregon State University, Richardson Hall, Corvallis, OR 97331, USA., Laris P; Department of Geography, California State University Long Beach, Long Beach, 1250 Bellflower Blvd, Long Beach, CA 90840, USA., Leonard J; Rocky Mountain Research Station, U.S.D.A. Forest Service, 2500 S. Pine Knoll Dr. Flagstaff, Arizona 86001, USA., Loria-Salazar SM; School of Meteorology, University of Oklahoma, 20 David L Boren Blvd, Norman, OK 73072, USA., Lucash M; Department of Geography, University of Oregon, 1251 University of Oregon, Eugene OR 97403-1251, USA., Mahmoud H; Department of Civil and Environmental Engineering, Colorado State University, 1372 Campus Delivery, Fort Collins, CO, 80523, USA., Margolis E; U.S. Geological Survey, Fort Collins Science Center, New Mexico Landscapes Field Station, 15 Entrance Rd., Los Alamos, NM 87544, USA., Maxwell T; Department of Biological Sciences, Boise State University, 1910 University Dr. Boise ID 83725, USA., McCarty JL; Department of Geography and Geospatial Analysis Center, Miami University, 217 Shideler Hall, Oxford, OH 45056, USA., McWethy DB; Department of Earth Sciences, Montana State University, 226 Traphagen Hall, Bozeman, MT 59717, USA., Meyer RS; Department of Ecology and Evolutionary Biology, University of California Santa Cruz, 130 McAllister Way, Santa Cruz, CA 95060, USA., Miesel JR; Department of Plant, Soil and Microbial Sciences, Michigan State University, 1066 Bogue Street Rm A286, East Lansing, MI 48823, USA., Moser WK; Rocky Mountain Research Station, U.S.D.A. Forest Service, 2500 S. Pine Knoll Dr. Flagstaff, Arizona 86001, USA., Nagy RC; Earth Lab, Cooperative Institute for Research in Environmental Sciences (CIRES), University of Colorado Boulder,4001 Discovery Drive, Suite S348 611 UCB, Boulder, CO, 80303, USA., Niyogi D; Jackson School of Geosciences, and Cockrell School of Engineering, University of Texas at Austin, 2305 Speedway Stop C1160, Austin, TX 78712-1692, USA., Palmer HM; Department of Life and Environmental Sciences, University of California Merced, Merced, 5200 Lake Rd, Merced, CA 95343, USA., Pellegrini A; Department of Plant Sciences, University of Cambridge, Downing St, Cambridge, CB2 3EA, UK., Poulter B; NASA Goddard Space Flight Center, Greenbelt Road, Greenbelt, MD 20771, USA., Robertson K; Tall Timbers Research Station and Land Conservancy, 13093 Henry Beadel Drive, Tallahassee, FL 32312, USA., Rocha AV; Department of Biological Sciences, University of Notre Dame, 100 Campus Dr., Notre Dame, IN 46556, USA., Sadegh M; Department of Civil Engineering, Boise State University, 1910 University Drive, Boise, ID, 83725, USA., Santos F; Environmental Sciences Division, Oak Ridge National Laboratory, One Bethel Valley Road, P.O. Box 2008, MS-6038, Oak Ridge, TN 37831-6038, USA., Scordo F; Global Water Center and the Department of Biology, University of Nevada, 1664 N. Virginia, Reno, NV, 89509, USA.; Instituto Argentino de Oceanografía (IADO-CONICET-UNS), Florida 8000, Bahía Blanca, B8000BFW Buenos Aires, Argentina., Sexton JO; terraPulse, Inc., 13201 Squires Ct., North Potomac, MD 20878, USA., Sharma AS; Department of Astronomy, University of Maryland, 4296 Stadium Dr., Astronomy Dept Room 1113, College Park, MD 20742, USA., Smith AMS; Department of Earth and Spatial Sciences, College of Science, University of Idaho, 875 Perimeter Drive MS 3021, Moscow ID, 83843-3021, USA.; Department of Forest, Rangeland, and Fire Science, College of Natural Resources, University of Idaho, 875 Perimeter Drive MS 1133, Moscow, ID 83844-1133, USA., Soja AJ; NASA Langley Research Center, NASA, 2 Langley Blvd, Hampton, VA 23681, USA.; National Institute of Aerospace, NASA, 100 Exploration Way, Hampton, VA 23666, USA., Still C; Department of Forest Ecosystems and Society, Oregon State University, Richardson Hall, Corvallis, OR 97331, USA., Swetnam T; Data Science Institute, University of Arizona, 1657 E Helen St, Tucson, AZ 85721, USA., Syphard AD; Conservation Biology Institute, 10423 Sierra Vista Ave., La Mesa, CA, 91941, USA., Tingley MW; Ecology and Evolutionary Biology, University of California Los Angeles, 621 Charles E Young Dr S #951606, Los Angeles, CA 90095, USA., Tohidi A; Department of Mechanical Engineering, San Jose State University, Room 310-K, ENG Building, 1 Washington Square, San Jose, CA 95112, USA., Trugman AT; Department of Geography, University of California Santa Barbara, 1832 Ellison Hall, Santa Barbara, CA, 93106, USA., Turetsky M; Institute of Arctic and Alpine Research, University of Colorado Boulder, Campus Box 450, Boulder, CO 80309-0450, USA., Varner JM; Tall Timbers Research Station and Land Conservancy, 13093 Henry Beadel Drive, Tallahassee, FL 32312, USA., Wang Y; School of Earth and Atmospheric Sciences, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332, USA., Whitman T; Department of Soil Science, University of Wisconsin-Madison, 1525 Observatory Dr., Madison, WI 53711, USA., Yelenik S; Rocky Mountain Research Station, U.S.D.A. Forest Service, 920 Valley Road, Reno NV, 89512, USA., Zhang X; Department of Life and Environmental Sciences, University of California Merced, Merced, 5200 Lake Rd, Merced, CA 95343, USA.

المصدر: PNAS nexus [PNAS Nexus] 2022 Aug 04; Vol. 1 (3), pp. pgac115. Date of Electronic Publication: 2022 Aug 04 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press on behalf of the National Academy of Sciences Country of Publication: England NLM ID: 9918367777906676 Publication Model: eCollection Cited Medium: Internet ISSN: 2752-6542 (Electronic) Linking ISSN: 27526542 NLM ISO Abbreviation: PNAS Nexus Subsets: PubMed not MEDLINE

المؤلفون: Song KW; Department of Discovery Oncology, Genentech, Inc., South San Francisco, California., Edgar KA; Department of Discovery Oncology, Genentech, Inc., South San Francisco, California., Hanan EJ; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California., Hafner M; Department of Oncology Bioinformatics, Genentech, Inc., South San Francisco, California., Oeh J; Department of Translational Oncology, Genentech, Inc., South San Francisco, California., Merchant M; Department of Translational Oncology, Genentech, Inc., South San Francisco, California., Sampath D; Department of Translational Oncology, Genentech, Inc., South San Francisco, California., Nannini MA; Department of Translational Oncology, Genentech, Inc., South San Francisco, California., Hong R; Department of Translational Oncology, Genentech, Inc., South San Francisco, California., Phu L; Department of Microchemistry, Proteomics & Lipidomics, Genentech, Inc., South San Francisco, California., Forrest WF; Department of Oncology Bioinformatics, Genentech, Inc., South San Francisco, California., Stawiski E; Department of Oncology Bioinformatics, Genentech, Inc., South San Francisco, California., Schmidt S; Department of Biochemical and Cell Pharmacology, Genentech, Inc., South San Francisco, California., Endres N; Department of Biochemical and Cell Pharmacology, Genentech, Inc., South San Francisco, California., Guan J; Department of Discovery Oncology, Genentech, Inc., South San Francisco, California., Wallin JJ; Department of Translational Oncology, Genentech, Inc., South San Francisco, California., Cheong J; Department of Translational Oncology, Genentech, Inc., South San Francisco, California., Plise EG; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California., Lewis Phillips GD; Department of Discovery Oncology, Genentech, Inc., South San Francisco, California., Salphati L; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California., Heffron TP; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California., Olivero AG; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California., Malek S; Department of Discovery Oncology, Genentech, Inc., South San Francisco, California., Staben ST; Department of Discovery Chemistry, Genentech, Inc., South San Francisco, California., Kirkpatrick DS; Department of Microchemistry, Proteomics & Lipidomics, Genentech, Inc., South San Francisco, California., Dey A; Department of Discovery Oncology, Genentech, Inc., South San Francisco, California. dey.anwesha@gene.com lorisfriedman123@gmail.com., Friedman LS; Department of Translational Oncology, Genentech, Inc., South San Francisco, California. dey.anwesha@gene.com lorisfriedman123@gmail.com.

المصدر: Cancer discovery [Cancer Discov] 2022 Jan; Vol. 12 (1), pp. 204-219. Date of Electronic Publication: 2021 Sep 20.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use , Breast Neoplasms*/drug therapy , Breast Neoplasms*/genetics , Class I Phosphatidylinositol 3-Kinases*/genetics , Imidazoles*/pharmacology , Imidazoles*/therapeutic use , Oxazepines*/pharmacology , Oxazepines*/therapeutic use , Phosphoinositide-3 Kinase Inhibitors*/pharmacology , Phosphoinositide-3 Kinase Inhibitors*/therapeutic use , Receptor, ErbB-2*/genetics, Female ; Humans ; Cell Line, Tumor/drug effects

المؤلفون: Hanan EJ, Liang J, Wang X, Blake RA, Blaquiere N, Staben ST

المصدر: Journal of medicinal chemistry [J Med Chem] 2020 Oct 22; Vol. 63 (20), pp. 11330-11361. Date of Electronic Publication: 2020 Jun 15.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Small Molecule Libraries*/chemistry , Small Molecule Libraries*/pharmacology, Drug Discovery/*methods , Proteolysis/*drug effects, Binding Sites ; Cell Line, Tumor ; Humans ; Molecular Structure ; Protein Binding ; Proteins/antagonists & inhibitors ; Ubiquitin-Protein Ligases

المؤلفون: Garland K; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Pantua H; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Braun MG; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Burdick DJ; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Castanedo GM; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Chen YC; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Cheng YX; Pharmaron Beijing Co., Ltd, No. 6 Taihe Road, BDA, Beijing 100176, PR China., Cheong J; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Daniels B; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Deshmukh G; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Fu Y; Pharmaron Beijing Co., Ltd, No. 6 Taihe Road, BDA, Beijing 100176, PR China., Gibbons P; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Gloor SL; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Hua R; Pharmaron Beijing Co., Ltd, No. 6 Taihe Road, BDA, Beijing 100176, PR China., Labadie S; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Liu X; Pharmaron Beijing Co., Ltd, No. 6 Taihe Road, BDA, Beijing 100176, PR China., Pastor R; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Stivala C; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Xu M; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Xu Y; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Zheng H; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Kapadia SB; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Hanan EJ; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: hanan.emily@gene.com.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2020 Oct 15; Vol. 30 (20), pp. 127419. Date of Electronic Publication: 2020 Aug 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents/*pharmacology , Escherichia coli/*drug effects , Peptides/*pharmacology, Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Dose-Response Relationship, Drug ; Microbial Sensitivity Tests ; Molecular Structure ; Peptides/chemical synthesis ; Peptides/chemistry ; Structure-Activity Relationship

المؤلفون: Pantua H; Department of Infectious Diseases, Genentech, South San Francisco, California, USA pantua.homer@gene.com kapadia.sharookh@gene.com., Skippington E; Department of OMNI Bioinformatics, Genentech, South San Francisco, California, USA., Braun MG; Department of Chemistry, Genentech, South San Francisco, California, USA., Noland CL; Department of Structural Biology, Genentech, South San Francisco, California, USA., Diao J; Department of Infectious Diseases, Genentech, South San Francisco, California, USA., Peng Y; Department of Infectious Diseases, Genentech, South San Francisco, California, USA., Gloor SL; Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, California, USA., Yan D; Department of Translational Immunology, Genentech, South San Francisco, California, USA., Kang J; Department of Translational Immunology, Genentech, South San Francisco, California, USA., Katakam AK; Department of OMNI Bioinformatics, Genentech, South San Francisco, California, USA.; Department of Pathology, Genentech, South San Francisco, California, USA., Reeder J; Department of OMNI Bioinformatics, Genentech, South San Francisco, California, USA., Castanedo GM; Department of Chemistry, Genentech, South San Francisco, California, USA., Garland K; Department of Chemistry, Genentech, South San Francisco, California, USA., Komuves L; Department of OMNI Bioinformatics, Genentech, South San Francisco, California, USA.; Department of Pathology, Genentech, South San Francisco, California, USA., Sagolla M; Department of OMNI Bioinformatics, Genentech, South San Francisco, California, USA.; Department of Pathology, Genentech, South San Francisco, California, USA., Austin CD; Department of OMNI Bioinformatics, Genentech, South San Francisco, California, USA.; Department of Pathology, Genentech, South San Francisco, California, USA., Murray J; Department of Structural Biology, Genentech, South San Francisco, California, USA., Xu Y; Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, California, USA., Modrusan Z; Department of Molecular Biology, Genentech, South San Francisco, California, USA., Xu M; Department of Translational Immunology, Genentech, South San Francisco, California, USA., Hanan EJ; Department of Chemistry, Genentech, South San Francisco, California, USA., Kapadia SB; Department of Infectious Diseases, Genentech, South San Francisco, California, USA pantua.homer@gene.com kapadia.sharookh@gene.com.

المصدر: MBio [mBio] 2020 Sep 08; Vol. 11 (5). Date of Electronic Publication: 2020 Sep 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents/*pharmacology , Aspartic Acid Endopeptidases/*antagonists & inhibitors , Bacterial Proteins/*antagonists & inhibitors , Drug Resistance, Bacterial/*genetics , Lipoproteins/*metabolism , Uropathogenic Escherichia coli/*drug effects , Uropathogenic Escherichia coli/*enzymology, Animals ; Aspartic Acid Endopeptidases/genetics ; Bacterial Proteins/genetics ; Enterobacteriaceae/classification ; Enterobacteriaceae/drug effects ; Escherichia coli/drug effects ; Escherichia coli/enzymology ; Escherichia coli/genetics ; Escherichia coli Infections/microbiology ; Female ; Humans ; Mice ; Mice, Inbred C57BL ; Peptides/chemistry ; Peptides/pharmacology ; Uropathogenic Escherichia coli/genetics ; Uropathogenic Escherichia coli/pathogenicity

المؤلفون: Clairfeuille T; Structural Biology, Genentech Inc., South San Francisco, CA, USA., Buchholz KR; Infectious Diseases, Genentech Inc., South San Francisco, CA, USA., Li Q; Microchemistry, Proteomics & Lipidomics, Genentech Inc., South San Francisco, CA, USA., Verschueren E; Microchemistry, Proteomics & Lipidomics, Genentech Inc., South San Francisco, CA, USA., Liu P; Microchemistry, Proteomics & Lipidomics, Genentech Inc., South San Francisco, CA, USA., Sangaraju D; Drug Metabolism & Pharmacokinetics, Genentech Inc., South San Francisco, CA, USA., Park S; Translational Immunology, Genentech Inc., South San Francisco, CA, USA., Noland CL; Structural Biology, Genentech Inc., South San Francisco, CA, USA., Storek KM; Infectious Diseases, Genentech Inc., South San Francisco, CA, USA., Nickerson NN; Infectious Diseases, Genentech Inc., South San Francisco, CA, USA., Martin L; BioMolecular Resources, Genentech Inc., South San Francisco, CA, USA., Dela Vega T; BioMolecular Resources, Genentech Inc., South San Francisco, CA, USA., Miu A; Biochemical & Cellular Pharmacology, Genentech Inc., South San Francisco, CA, USA., Reeder J; Bioinformatics & Computational Biology, Genentech Inc., South San Francisco, CA, USA., Ruiz-Gonzalez M; Discovery Chemistry Departments, Genentech Inc., South San Francisco, CA, USA., Swem D; Infectious Diseases, Genentech Inc., South San Francisco, CA, USA., Han G; Microchemistry, Proteomics & Lipidomics, Genentech Inc., South San Francisco, CA, USA., DePonte DP; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, USA., Hunter MS; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, USA., Gati C; Bioscience Division, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.; Stanford University, Department of Structural Biology, Stanford, CA, USA., Shahidi-Latham S; Drug Metabolism & Pharmacokinetics, Genentech Inc., South San Francisco, CA, USA., Xu M; Translational Immunology, Genentech Inc., South San Francisco, CA, USA., Skelton N; Discovery Chemistry Departments, Genentech Inc., South San Francisco, CA, USA., Sellers BD; Discovery Chemistry Departments, Genentech Inc., South San Francisco, CA, USA., Skippington E; Bioinformatics & Computational Biology, Genentech Inc., South San Francisco, CA, USA., Sandoval W; Microchemistry, Proteomics & Lipidomics, Genentech Inc., South San Francisco, CA, USA., Hanan EJ; Discovery Chemistry Departments, Genentech Inc., South San Francisco, CA, USA. hanan.emily@gene.com., Payandeh J; Structural Biology, Genentech Inc., South San Francisco, CA, USA. payandeh.jian@gene.com.; Infectious Diseases, Genentech Inc., South San Francisco, CA, USA. payandeh.jian@gene.com., Rutherford ST; Infectious Diseases, Genentech Inc., South San Francisco, CA, USA. rutherford.steven@gene.com.

المصدر: Nature [Nature] 2020 Aug; Vol. 584 (7821), pp. 479-483. Date of Electronic Publication: 2020 Aug 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Cell Membrane/*chemistry , Escherichia coli/*chemistry , Escherichia coli/*pathogenicity , Escherichia coli Proteins/*chemistry , Escherichia coli Proteins/*metabolism , Lipopolysaccharides/*chemistry , Lipopolysaccharides/*metabolism, Amidohydrolases/chemistry ; Amidohydrolases/metabolism ; Amino Acid Motifs ; Bacterial Outer Membrane/chemistry ; Bacterial Outer Membrane/metabolism ; Binding Sites ; Cell Membrane/metabolism ; Enzyme Stability ; Escherichia coli/cytology ; Escherichia coli/drug effects ; Genes, Essential ; Hydrolases/chemistry ; Hydrolases/metabolism ; Lipid A/chemistry ; Lipid A/metabolism ; Lipopolysaccharides/biosynthesis ; Microbial Sensitivity Tests ; Microbial Viability/drug effects ; Models, Molecular ; Peptide Fragments/chemistry ; Peptide Fragments/metabolism ; Peptide Fragments/pharmacology ; Periplasm/chemistry ; Periplasm/metabolism ; Protein Binding ; Virulence