المؤلفون: Sampaziotis, F, Justin, AW, Tysoe, OC, Sawiak, S, Cardoso-De-Brito, M, Ortmann, D, Yangou, L, Ross, A, Bargher, J, Bertero, A, Zonneveld, MCF, Pawlowski, M, Madrigal, P, Georgakopoulos, N, Pirmadjid, N, Zilbauer, M, Sinha, S, Hannan, NRF, Vallier, L

المساهمون: Sampaziotis, Fotios [0000-0003-0812-7586], Sawiak, Stephen [0000-0003-4210-9816], Madrigal, Pedro [0000-0003-1959-8199], Georgakopoulos, Nikitas [0000-0002-1879-6583], Zilbauer, Matthias [0000-0002-7272-0547], Sinha, Sanjay [0000-0001-5900-1209], Vallier, Ludovic [0000-0002-3848-2602], Apollo - University of Cambridge Repository

مصطلحات موضوعية: tissue engineering, regenerative medicine

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39eba637d9d6c6652e3123ce9bd45371
https://www.repository.cam.ac.uk/handle/1810/264945

المؤلفون: Bertero, A, Pawlowski, M, Ortmann, D, Snijders, K, Yiangou, L, Cardoso de Brito, M, Brown, S, Bernard, WG, Cooper, JD, Giacomelli, E, Gambardella, L, Hannan, NRF, Iyer, D, Sampaziotis, F, Serrano, F, Zonneveld, MCF, Sinha, S, Kotter, M, Vallier, L

المساهمون: Bernard, William [0000-0002-2622-5115], Sampaziotis, Fotios [0000-0003-0812-7586], Sinha, Sanjay [0000-0001-5900-1209], Kotter, Mark [0000-0001-5145-7199], Vallier, Ludovic [0000-0002-3848-2602], Apollo - University of Cambridge Repository

مصطلحات موضوعية: DPY30, shRNA, POU5F1, human pluripotent stem cells, T, brachyury, OCT4, CRISPR/Cas9

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::607a7b72b54cad678fb495068071ad9e

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المؤلفون: Durczak PM; Biodiscovery Institute, Translational Medical Sciences, School of Medicine, University of Nottingham., Fair KL; Biodiscovery Institute, Translational Medical Sciences, School of Medicine, University of Nottingham., Jinks N; Biodiscovery Institute, Translational Medical Sciences, School of Medicine, University of Nottingham., Cuevas Ocaña S; Biodiscovery Institute, Translational Medical Sciences, School of Medicine, University of Nottingham., Sainz Zuñiga CB; Biodiscovery Institute, Translational Medical Sciences, School of Medicine, University of Nottingham., Hannan NRF; Biodiscovery Institute, Translational Medical Sciences, School of Medicine, University of Nottingham; nick.hannan@nottingham.ac.uk.

المصدر: Journal of visualized experiments : JoVE [J Vis Exp] 2024 Mar 08 (205). Date of Electronic Publication: 2024 Mar 08.

نوع المنشور: Journal Article; Video-Audio Media

بيانات الدورية: Publisher: MYJoVE Corporation Country of Publication: United States NLM ID: 101313252 Publication Model: Electronic Cited Medium: Internet ISSN: 1940-087X (Electronic) Linking ISSN: 1940087X NLM ISO Abbreviation: J Vis Exp Subsets: MEDLINE

مواضيع طبية MeSH: Induced Pluripotent Stem Cells* , Inflammatory Bowel Diseases*, Humans ; Intestines ; Intestinal Mucosa ; Cell Differentiation ; Organoids

المؤلفون: Cuevas-Ocaña S; Biosciences Institute, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.; Biodiscovery Institute, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK., Yang JY; Programme in Developmental & Stem Cell Biology, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Aushev M; Wellcome Trust Centre for Mitochondrial Research, Institute of Genetic Medicine, Biomedicine West Wing, Centre for Life, Times Square, Newcastle upon Tyne NE1 3BZ, UK., Schlossmacher G; Biosciences Institute, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Bear CE; Programme in Molecular Medicine, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Hannan NRF; Biodiscovery Institute, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK., Perkins ND; Biosciences Institute, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Rossant J; Programme in Developmental & Stem Cell Biology, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Wong AP; Programme in Developmental & Stem Cell Biology, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Gray MA; Biosciences Institute, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Jun 17; Vol. 24 (12). Date of Electronic Publication: 2023 Jun 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Gene Editing*/methods , Pluripotent Stem Cells*/metabolism, Humans ; CRISPR-Cas Systems/genetics ; Mutation ; Heterozygote

المؤلفون: Grove JI; National Institute of Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust & University of Nottingham, Nottingham, UK.; Nottingham Digestive Diseases Centre, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK., Lo PCK; Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK.; University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, UK., Shrine N; Genetic Epidemiology Group, Department of Population Health Sciences, University of Leicester, Leicester, UK., Barwell J; Clinical Genetics Department, University Hospitals Leicester NHS Trust, Leicester, UK., Wain LV; Genetic Epidemiology Group, Department of Population Health Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Respiratory Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Tobin MD; Genetic Epidemiology Group, Department of Population Health Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Respiratory Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Salter AM; School of Biosciences, University of Nottingham, Nottingham, UK., Borkar AN; School of Veterinary Medicine and Science, University of Nottingham, Nottingham, UK., Cuevas-Ocaña S; Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK.; University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, UK., Bennett N; Genetic Epidemiology Group, Department of Population Health Sciences, University of Leicester, Leicester, UK., John C; Genetic Epidemiology Group, Department of Population Health Sciences, University of Leicester, Leicester, UK., Ntalla I; Clinical Genetics Department, University Hospitals Leicester NHS Trust, Leicester, UK., Jones GE; Clinical Genetics Department, University Hospitals Leicester NHS Trust, Leicester, UK., Neal CP; Leicester Cancer Research Centre, University of Leicester, Leicester, UK., Thomas MG; Ulverscroft Eye Unit, Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, UK., Kuht H; Ulverscroft Eye Unit, Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, UK., Gupta P; Department of Chemical Pathology and Metabolic Diseases, University Hospitals of Leicester NHS Trust, Leicester, UK.; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK., Vemala VM; Department of Gastroenterology, University Hospitals of Leicester NHS Trust, Leicester, UK., Grant A; Department of Gastroenterology, University Hospitals of Leicester NHS Trust, Leicester, UK., Adewoye AB; Department of Genetics and Genome Biology, University of Leicester, Leicester, UK., Shenoy KT; Population Health and Research Institute, Trivandrum, India., Balakumaran LK; Population Health and Research Institute, Trivandrum, India., Hollox EJ; Department of Genetics and Genome Biology, University of Leicester, Leicester, UK., Hannan NRF; Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK.; University of Nottingham Biodiscovery Institute, University of Nottingham, Nottingham, UK., Aithal GP; National Institute of Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust & University of Nottingham, Nottingham, UK.; Nottingham Digestive Diseases Centre, Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, UK.

المصدر: JHEP reports : innovation in hepatology [JHEP Rep] 2023 Apr 23; Vol. 5 (8), pp. 100764. Date of Electronic Publication: 2023 Apr 23 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101761237 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-5559 (Electronic) Linking ISSN: 25895559 NLM ISO Abbreviation: JHEP Rep Subsets: PubMed not MEDLINE

المؤلفون: Gajera KR; Swiss Institute for Experimental Cancer Research (ISREC), École Polytechnique Fédérale de Lausanne-(EPFL-SV), Lausanne, Switzerland.; Translational Medical Sciences Unit, School of Medicine, Centre for Cancer Sciences, Biodiscovery Institute-3, University Park, University of Nottingham, Nottingham, UK., Fair KL; Translational Medical Sciences Unit, School of Medicine, Centre for Cancer Sciences, Biodiscovery Institute-3, University Park, University of Nottingham, Nottingham, UK., Moran GW; Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, UK.; NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK., Hannan NRF; Translational Medical Sciences Unit, School of Medicine, Centre for Cancer Sciences, Biodiscovery Institute-3, University Park, University of Nottingham, Nottingham, UK., Huelsken J; Swiss Institute for Experimental Cancer Research (ISREC), École Polytechnique Fédérale de Lausanne-(EPFL-SV), Lausanne, Switzerland., Ordóñez-Morán P; Translational Medical Sciences Unit, School of Medicine, Centre for Cancer Sciences, Biodiscovery Institute-3, University Park, University of Nottingham, Nottingham, UK. paloma.ordonezmoran@nottingham.ac.uk.

المصدر: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2023; Vol. 2650, pp. 53-61.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis* , Biological Assay*, Cell Differentiation ; Intestines ; Retinoids/pharmacology

المؤلفون: Rimland CA; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Immunopathogenesis Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom.; Medical Scientist Training Program, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC., Tilson SG; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom.; Welcome Trust Sanger Institute, Hinxton, United Kingdom.; Liver Diseases Branch, NIDDK, NIH, Bethesda, MD., Morell CM; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom., Tomaz RA; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom., Lu WY; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, The University of Birmingham, Birmingham, United Kingdom., Adams SE; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Immunopathogenesis Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD.; Department of Biological Sciences, North Carolina State University, Raleigh, NC., Georgakopoulos N; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom., Otaizo-Carrasquero F; Genomic Technologies Section, Research Technologies Branch, NIAID, NIH, Bethesda, MD., Myers TG; Genomic Technologies Section, Research Technologies Branch, NIAID, NIH, Bethesda, MD., Ferdinand JR; Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Gieseck RL 3rd; Immunopathogenesis Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD., Sampaziotis F; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom., Tysoe OC; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom., Ross A; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom., Kraiczy JM; Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom., Wesley B; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom., Muraro D; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom.; Welcome Trust Sanger Institute, Hinxton, United Kingdom., Zilbauer M; Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom., Oniscu GC; Edinburgh Transplant Centre, Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh, United Kingdom., Hannan NRF; Division of Cancer and Stem Cells, School of Medicine, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, United Kingdom.; National Institute for Health Research Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, United Kingdom., Forbes SJ; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom., Saeb-Parsy K; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom., Wynn TA; Immunopathogenesis Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD., Vallier L; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom.

المصدر: Hepatology (Baltimore, Md.) [Hepatology] 2021 Jan; Vol. 73 (1), pp. 247-267.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE

مواضيع طبية MeSH: Bile Ducts, Extrahepatic/*cytology , Bile Ducts, Intrahepatic/*cytology , Epithelial Cells/*cytology , Organoids/*physiology, Animals ; Bile ; Bile Ducts, Extrahepatic/physiology ; Bile Ducts, Intrahepatic/physiology ; Cell Differentiation ; Common Bile Duct/cytology ; Epithelial Cells/physiology ; Gallbladder/cytology ; Gene Expression Regulation ; Humans ; Keratin-19/analysis ; Liver/physiology ; Mice ; RNA-Seq ; Tissue and Organ Procurement

المؤلفون: Segeritz CP; Wellcome Trust and MRC Cambridge Stem Cell Institute, Department of Surgery, University of Cambridge, UK; Cambridge Institute for Medical Research, University of Cambridge, UK., Rashid ST; Wellcome Trust and MRC Cambridge Stem Cell Institute, Department of Surgery, University of Cambridge, UK; Cambridge Institute for Medical Research, University of Cambridge, UK; Centre for Stem Cells and Regenerative Medicine & Institute for Liver Studies, King's College London, UK. Electronic address: tamir.rashid@kcl.ac.uk., de Brito MC; Wellcome Trust and MRC Cambridge Stem Cell Institute, Department of Surgery, University of Cambridge, UK., Serra MP; Centre for Stem Cells and Regenerative Medicine & Institute for Liver Studies, King's College London, UK., Ordonez A; Cambridge Institute for Medical Research, University of Cambridge, UK., Morell CM; Wellcome Trust and MRC Cambridge Stem Cell Institute, Department of Surgery, University of Cambridge, UK., Kaserman JE; Center for Regenerative Medicine (CReM) of Boston University and Boston Medical Center, Boston, MA 02118, USA., Madrigal P; Wellcome Trust and MRC Cambridge Stem Cell Institute, Department of Surgery, University of Cambridge, UK., Hannan NRF; Wellcome Trust and MRC Cambridge Stem Cell Institute, Department of Surgery, University of Cambridge, UK., Gatto L; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Building O, Downing Site, Cambridge CB2 1QW, UK., Tan L; Cambridge Institute for Medical Research, University of Cambridge, UK., Wilson AA; Center for Regenerative Medicine (CReM) of Boston University and Boston Medical Center, Boston, MA 02118, USA., Lilley K; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Building O, Downing Site, Cambridge CB2 1QW, UK., Marciniak SJ; Cambridge Institute for Medical Research, University of Cambridge, UK., Gooptu B; NIHR Leicester BRC-Respiratory and Leicester Institute of Structural & Chemical Biology, University of Leicester, UK; ISMB/Birkbeck & UCL, University of London, UK; Division of Asthma, Allergy and Lung Biology, King's College London, UK., Lomas DA; UCL Respiratory, University College London, UK. Electronic address: d.lomas@ucl.ac.uk., Vallier L; Wellcome Trust and MRC Cambridge Stem Cell Institute, Department of Surgery, University of Cambridge, UK; Wellcome Trust Sanger Institute, Genome Campus Hinxton, UK. Electronic address: lv225@cam.ac.uk.

المصدر: Journal of hepatology [J Hepatol] 2018 Oct; Vol. 69 (4), pp. 851-860. Date of Electronic Publication: 2018 Jun 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE

مواضيع طبية MeSH: Hepatocytes/*cytology , Induced Pluripotent Stem Cells/*physiology , Inflammation/*complications , Unfolded Protein Response/*physiology , alpha 1-Antitrypsin Deficiency/*etiology, Cells, Cultured ; Endoplasmic Reticulum/physiology ; Humans ; alpha 1-Antitrypsin/genetics

المؤلفون: Fair KL; Division of Cancer and Stem Cells, School of Medicine, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK., Colquhoun J; Division of Cancer and Stem Cells, School of Medicine, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK., Hannan NRF; Division of Cancer and Stem Cells, School of Medicine, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK nick.hannan@nottingham.ac.uk.; National Institute for Health Research (NIHR) Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham NG7 2RD, UK.

المصدر: Philosophical transactions of the Royal Society of London. Series B, Biological sciences [Philos Trans R Soc Lond B Biol Sci] 2018 Jul 05; Vol. 373 (1750).

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Royal Society Country of Publication: England NLM ID: 7503623 Publication Model: Print Cited Medium: Internet ISSN: 1471-2970 (Electronic) Linking ISSN: 09628436 NLM ISO Abbreviation: Philos Trans R Soc Lond B Biol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Epithelial Cells/*physiology , Intestines/*growth & development , Organoids/*growth & development , Pluripotent Stem Cells/*physiology, Cell Culture Techniques/methods ; Humans ; In Vitro Techniques ; Intestinal Diseases/physiopathology ; Intestines/physiopathology ; Organoids/physiopathology