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المؤلفون: Hsiao-Yen Ma, Qingling Li, Weng Ruh Wong, Elsa-Noah N’Diaye, Patrick Caplazi, Hannah Bender, Zhiyu Huang, Alexander Arlantico, Surinder Jeet, Aaron Wong, Claire Emson, Hans Brightbill, Lucinda Tam, Robert Newman, Merone Roose-Girma, Wendy Sandoval, Ning Ding
المصدر: Science Advances. 9
مصطلحات موضوعية: Multidisciplinary
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2015a85d4411ba48474f981a155c8556
https://doi.org/10.1126/sciadv.adf0133 -
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المؤلفون: Donghyun Joo, Zuliang Jie, Jian-hong Shi, Lingyun Zhang, Lele Zhu, Hans Brightbill, Ting Liu, Xuhong Cheng, Yingzi Cong, Jin Young Yang, Daniel Lin, Yanchuan Li, Meidi Gu, Xiaoping Xie, Shao Cong Sun, Xiaofei Zhou, Hui Wang
المصدر: Nature immunology
مصطلحات موضوعية: 0301 basic medicine, Immunoglobulin A, medicine.medical_treatment, Immunology, ILCs, Inflammation, Protein Serine-Threonine Kinases, Article, Mice, 03 medical and health sciences, Immunity, medicine, Animals, Homeostasis, Immunology and Allergy, Intestinal Mucosa, Immunity, Mucosal, Mice, Knockout, NIK, biology, Innate lymphoid cell, Dendritic Cells, Dendritic cell, Colitis, Immunity, Innate, Cell biology, Mice, Inbred C57BL, 030104 developmental biology, Cytokine, Mucosal immunology, TH17 cells, biology.protein, mucosal immunity, medicine.symptom, Polymeric immunoglobulin receptor, IgA, Signal Transduction
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المؤلفون: Paul J. Wolters, Elsa-Noah N’Diaye, Hsiao-Yen Ma, Bushra Husain, Thirumalai R. Ramalingam, Ryan P. Kelly, Alexander Arlantico, Katrina B. Morshead, Si Hyun Kim, Scot A. Marsters, Guiquan Jia, Charles Yu, Claire Emson, Merone Roose-Girma, Daryle Depianto, Ariel E. Feldstein, Lucinda Tam, Ryan LaCanna, Meredith Sagolla, Surinder Jeet, Zhiyu Huang, Hans Brightbill, Jason A. Vander Heiden, Aaron K. Wong, Nadia Martinez Martin, Ying Xi, Patrick Caplazi, Shuang Wu, Laura Lucio, Avi Ashkenazi, Ning Ding, Sarah Gierke
المصدر: SSRN Electronic Journal.
مصطلحات موضوعية: Cirrhosis, WNT1-inducible-signaling pathway protein 1, Fibrosis, business.industry, Myocardin, Cancer research, medicine, Steatohepatitis, Chronic liver disease, medicine.disease, business, Myofibroblast, Transcription factor
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::10945134be7b0fa798d6a8bb270d3693
https://doi.org/10.2139/ssrn.3966644 -
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المؤلفون: Siddharth Sukumaran, Elsa-Noah N’Diaye, Alexander R. Abbas, Wei-Ching Liang, Katrina B. Morshead, Hans Brightbill, Meron Roose-Girma, Daryle Depianto, Claire Emson, Zhiyu Huang, Jean-Michel Vernes, Jianping Yin, Paul J. Wolters, Tiffany Wong, Hua Zhang, Y. Gloria Meng, Manda Wong, Nico Ghilardi, Zora Modrusan, Patrick Caplazi, Dhaya Seshasayee, Min Xu, Surinder Jeet, Tianhe Sun, Yan Wu, Kai-Hui Sun, Jia Wu, Thirumalai R. Ramalingam, Joseph R. Arron, Jeff Lutman, Wei Yu Lin, Rajbharan Yadav, Racquel Corpuz, Patrick J. Lupardus, Jason A. Vander Heiden
المصدر: Science translational medicine, vol 13, iss 605
مصطلحات موضوعية: Gene isoform, Inflammation, Biology, Medical and Health Sciences, Mice, Transforming Growth Factor beta2, Transforming Growth Factor beta3, In vivo, Fibrosis, Conditional gene knockout, medicine, 2.1 Biological and endogenous factors, Animals, Humans, Protein Isoforms, Lung, Animal, Liver Disease, General Medicine, Biological Sciences, medicine.disease, Blockade, Cell biology, Disease Models, Animal, Toxicity, Disease Models, Female, medicine.symptom, Digestive Diseases, Transforming growth factor
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7ab29cadc58a74410be2094c8ca493
https://pubmed.ncbi.nlm.nih.gov/34349032 -
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المؤلفون: Lucinda Tam, Annemarie Lekkerkerker, Jeffrey Eastham-Anderson, Melanie Domeyer, Brent S. McKenzie, Azadeh Hadadianpour, Eugene Varfolomeev, Arna Katewa, Steven Do, A. Francesca Setiadi, Wyne P. Lee, Joy Drobnick, Andres Paler-Martinez, Rajita Pappu, Katherine Bao, Marian C. Bryan, Alfred Wong, James J. Crawford, Cesar A. Corzo, Vida Asghari, Sha Klabunde, Vladimir Ramirez-Carrozi, Jodie Pang, Jason A. Hackney, Hans Brightbill, Christopher Dela Cruz, Ross Francis, Yonglian Sun, Merone Roose-Girma, Claire Emson, Wendy B. Young, Michael J. Townsend, James R. Kiefer, Cary D. Austin, Swathi Sujatha-Bhaskar, Emily Hunley, Nico Ghilardi, Daqi Xu, Søren Warming, Kate Senger, Zhiyu Huang, Vivian W. C. Lau, Domagoj Vucic, Ali A. Zarrin, Eric Suto
المصدر: Science signaling. 13(634)
مصطلحات موضوعية: Plasma Cells, Endosomes, Biochemistry, 03 medical and health sciences, Mice, 0302 clinical medicine, immune system diseases, Interferon, medicine, Agammaglobulinaemia Tyrosine Kinase, Bruton's tyrosine kinase, Animals, Humans, Kinase activity, Molecular Biology, IRGs, 030304 developmental biology, 0303 health sciences, Membrane Glycoproteins, biology, Chemistry, Cell Biology, Dendritic Cells, IRAK4, Immune complex, Cell biology, Interleukin-1 Receptor-Associated Kinases, Toll-Like Receptor 7, biology.protein, Signal transduction, Tyrosine kinase, 030215 immunology, medicine.drug, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df56c99041e31c3d42be9d115b0561d
https://pubmed.ncbi.nlm.nih.gov/32487715 -
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المؤلفون: Zhiyu Huang, Yingqing Ran, Le An, Alberto Gobbi, Jonathan Maher, Claire Emson, Naomi S. Rajapaksa, Edna F. Choo, Yongsheng Chen, Steven Do, Aleksandr Kolesnikov, Ali A. Zarrin, Christine Yu, Marian C. Bryan, Joy Drobnick, Swathi Sujatha-Bhaskar, Hans Brightbill, James R. Kiefer, Jun Liang, Brent S. McKenzie, Ross Francis, John S. Wai, Patrick J. Lupardus, Kevin DeMent
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Chemokine, Systemic lupus erythematosus, High interest, biology, 010405 organic chemistry, business.industry, Organic Chemistry, Pharmacology, IRAK4, medicine.disease, 01 natural sciences, Biochemistry, Pyrazolopyrimidine, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, biology.protein, Medicine, Kinase activity, business, Whole blood
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c741d6c5a8d5445e4411ce0bee8e8c5
https://europepmc.org/articles/PMC7073891/ -
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المؤلفون: Xuhong Cheng, Xiaofei Zhou, Hans Brightbill, Lele Zhu, Jing Wang, Jee Hyung Sohn, Jin Young Yang, Jae Bum Kim, Jie Yang, Xiaofeng Zheng, Shao Cong Sun, Zuliang Jie, Yaoyao Shi, Meidi Gu, Xiaoping Xie
المصدر: Nature immunology
مصطلحات موضوعية: 0301 basic medicine, Cytotoxicity, Immunologic, Male, HK2, Melanoma, Experimental, CD8-Positive T-Lymphocytes, Lymphocyte Activation, Immunotherapy, Adoptive, 0302 clinical medicine, Hexokinase, Enzyme Stability, Tumor Microenvironment, Immunology and Allergy, Cytotoxic T cell, T cell exhaustion, Mice, Knockout, Kinase, Effector, Chemistry, ROS, Cell biology, medicine.anatomical_structure, Phenotype, Colonic Neoplasms, Female, Signal transduction, Glycolysis, Signal Transduction, T cell, antitumor immunity, Immunology, Glucosephosphate Dehydrogenase, Protein Serine-Threonine Kinases, Article, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, Cell Line, Tumor, T cell metabolism, medicine, Animals, Tumor microenvironment, NIK, Mice, Inbred C57BL, 030104 developmental biology, Anaerobic glycolysis, Energy Metabolism, Reactive Oxygen Species, CD8, NADP, 030215 immunology, G6PD
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المؤلفون: Peter W. Fan, Sarah G. Hymowitz, Teresa Dong, Xingyu Lin, Zoe Zhong, Connie Chan, Paul A. McEwan, Wyne P. Lee, Swathi Sujatha-Bhaskar, Baihua Hu, Nicole Blaquiere, Jason Burch, Jianwen Feng, Hans Brightbill, Steven T. Staben, Alison J Hole, James J. Crawford, Guosheng Wu, Suzanne Brown, Moulay Hicham Alaoui Ismaili, Georgette Castanedo, Patrick Lee, Hoa Le, Leonid M. Berezhkovskiy, Po-Chang Chiang, Robert Godemann, Brent S. McKenzie, Emily B. Gogol, Hernani L Silvestre, Ning Liu, Eric Suto, Nico Ghilardi, Yamin Zhang, Lawren C. Wu, Alice Grabbe
المصدر: Journal of Medicinal Chemistry. 61:6801-6813
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Cell Survival, Protein Conformation, Protein Serine-Threonine Kinases, Mice, 03 medical and health sciences, 0302 clinical medicine, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, B-cell activating factor, Protein Kinase Inhibitors, B cell, Dose-Response Relationship, Drug, Chemistry, Kinase, Drug discovery, Dendritic cell, In vitro, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Cell culture, 030220 oncology & carcinogenesis, Molecular Medicine
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المؤلفون: Eric Suto, Lawren C. Wu, Karin Bents, Justin Lesch, Benjamin T. Jackson, Peter W. Fan, Wyne P. Lee, Laura Christian, Nicole Blaquiere, Nandhini Ramamoorthi, Adam R. Johnson, Emily B. Gogol, Steven T. Staben, Susan Haller, Pawan Bir Kohli, Zora Modrusan, Sandra Linge, Jason DeVoss, James J. Crawford, Christine Everett, Kelli Veliz, Leonid M. Berezhkovskiy, Jason A. Hackney, Georgette Castanedo, Allan Jaochico, Cary D. Austin, Nico Ghilardi, Youngsu Kwon, Swathi Sujatha-Bhaskar, Robert Godemann, Hans Brightbill, Michael J. Townsend, Moulay Hicham Alaoui Ismaili, Brent S. McKenzie, Kathy Barrett
المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communicationsمصطلحات موضوعية: 0301 basic medicine, T-Lymphocytes, Gene Expression, General Physics and Astronomy, Kidney, Mice, 0302 clinical medicine, immune system diseases, Lupus Erythematosus, Systemic, Molecular Targeted Therapy, lcsh:Science, skin and connective tissue diseases, B-Lymphocytes, Multidisciplinary, Systemic lupus erythematosus, Mice, Inbred NZB, biology, Interleukin-12 Subunit p40, Kinase, NF-kappa B, Cytokine TWEAK, Lupus Nephritis, Proteinuria, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Signal transduction, Signal Transduction, Cell Survival, T cell, Science, In Vitro Techniques, Protein Serine-Threonine Kinases, Article, General Biochemistry, Genetics and Molecular Biology, Proinflammatory cytokine, 03 medical and health sciences, medicine, Animals, Humans, B-cell activating factor, Protein Kinase Inhibitors, Cell Proliferation, Inflammation, Lupus erythematosus, CD40, business.industry, Dendritic Cells, General Chemistry, Receptors, OX40, medicine.disease, Disease Models, Animal, 030104 developmental biology, biology.protein, Cancer research, lcsh:Q, business, Spleen
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المؤلفون: Robert Godemann, Kathleen Knüppel, Christian A.G.N. Montalbetti, Stefan Steinbacher, Myron Smith, Lawren C. Wu, Swathi Sujatha-Bhaskar, Jianwen Feng, Maureen Beresini, Jacob Z. Chen, Christine Everett, Pawan Bir Kohli, Susan Krüger, Joachim Kraemer, David A. Roberts, Sarah G. Hymowitz, Ryan Takahashi, Hans Brightbill, Paul A. McEwan, Nobuhiko Kayagaki, Yamin Zhang, Pui Loke, Georgette Castanedo, Charles Eigenbrot, Hai-Feng Cui, Nicole Blaquiere, Steven T. Staben, Brandon J. Bravo, Adam R. Johnson, Emily B. Gogol, Xiaolu Wang
المصدر: Journal of Medicinal Chemistry. 60:627-640
مصطلحات موضوعية: 0301 basic medicine, P50, High selectivity, Active Transport, Cell Nucleus, Protein Serine-Threonine Kinases, Heterocyclic Compounds, 4 or More Rings, Nf κb inducing kinase, Mice, 03 medical and health sciences, Dogs, 0302 clinical medicine, NF-kappa B p52 Subunit, Drug Discovery, Animals, Humans, Oxazoles, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Cell Nucleus, chemistry.chemical_classification, Binding Sites, Phosphoinositide 3-kinase, biology, Kinase, Imidazoles, NF-kappa B p50 Subunit, Isoxazoles, Heterocyclic Compounds, Bridged-Ring, Oxazepines, HEK293 Cells, 030104 developmental biology, chemistry, Biochemistry, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, Structure based, HeLa Cells, Signal Transduction, Tricyclic
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