نتائج البحث - "Hariharan, Saminathan"

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دورية أكاديمية

Perspectives on the use and risk of adverse events associated with cytokine-storm targeting antibodies and challenges associated with development of novel monoclonal antibodies for the treatment of COVID-19 clinical cases

المؤلفون: Aishwarya Mary Johnson, Robert Barigye, Hariharan Saminathan

المصدر: Human Vaccines & Immunotherapeutics, Vol 17, Iss 9, Pp 2824-2840 (2021)

مصطلحات موضوعية: covid-19, immunotherapeutics, adverse effects, monoclonal antibodies, Immunologic diseases. Allergy, RC581-607, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2164-5515; https://doaj.org/toc/2164-554X

URL الوصول: https://doaj.org/article/f1105f37444a4d8dbf392de7d95b4435

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دورية أكاديمية

Fyn Kinase-Mediated PKCδ Y311 Phosphorylation Induces Dopaminergic Degeneration in Cell Culture and Animal Models: Implications for the Identification of a New Pharmacological Target for Parkinson’s Disease

المؤلفون: Hariharan Saminathan, Anamitra Ghosh, Danhui Zhang, Chunjuan Song, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy

المصدر: Frontiers in Pharmacology, Vol 12 (2021)

مصطلحات موضوعية: Fyn, PKCδ, neurodegeneration, phosphorylation, kinase, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2021.631375/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/9bdce804fea34a378593f9a6adaeca78

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Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain

المؤلفون: Guanglin Luo, Ling Chen, Walter A. Kostich, Brian Hamman, Jason Allen, Amy Easton, Clotilde Bourin, Michael Gulianello, Jonathan Lippy, Susheel Nara, Sreenivasulu Naidu Pattipati, Kumaran Dandapani, Manoj Dokania, Pradeep Vattikundala, Vivek Sharma, Saravanan Elavazhagan, Manoj Kumar Verma, Manish Lal Das, Santosh Wagh, Anand Balakrishnan, Benjamin M. Johnson, Kenneth S. Santone, George Thalody, Rex Denton, Hariharan Saminathan, Vinay K. Holenarsipur, Anoop Kumar, Abhijith Rao, Siva Prasad Putlur, Sarat Kumar Sarvasiddhi, Ganesh Shankar, Justin V. Louis, Manjunath Ramarao, Charles M. Conway, Yu-Wen Li, Rick Pieschl, Yuan Tian, Yang Hong, Linda Bristow, Charles F. Albright, Joanne J. Bronson, John E. Macor, Carolyn D. Dzierba

المصدر: Journal of Medicinal Chemistry. 65:4534-4564

مصطلحات موضوعية: Mice, Structure-Activity Relationship, Spinal Cord, Anesthetics, General, Drug Discovery, Animals, Neuralgia, Molecular Medicine, Protein Kinase Inhibitors, Ethers, Rats

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf11be6e3846cab6b37f029b5b93a8d
https://doi.org/10.1021/acs.jmedchem.1c02132

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Discovery of (S)-1-((2′,6-Bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain

المؤلفون: Guanglin Luo, Ling Chen, Walter A. Kostich, Brian Hamman, Jason Allen, Amy Easton, Clotilde Bourin, Michael Gulianello, Jonathan Lippy, Susheel Nara, Tarun Kumar Maishal, Kamalraj Thiyagarajan, Prasadrao Jalagam, Sreenivasulu Naidu Pattipati, Kumaran Dandapani, Manoj Dokania, Pradeep Vattikundala, Vivek Sharma, Saravanan Elavazhagan, Manoj Kumar Verma, Manish Lal Das, Santosh Wagh, Anand Balakrishnan, Benjamin M. Johnson, Kenneth S. Santone, George Thalody, Rex Denton, Hariharan Saminathan, Vinay K. Holenarsipur, Anoop Kumar, Abhijith Rao, Siva Prasad Putlur, Sarat Kumar Sarvasiddhi, Ganesh Shankar, Justin V. Louis, Manjunath Ramarao, Charles M. Conway, Yu-Wen Li, Rick Pieschl, Yuan Tian, Yang Hong, Jonathan Ditta, Arvind Mathur, Jianqing Li, Daniel Smith, Joseph Pawluczyk, Dawn Sun, Shiuhang Yip, Dauh-Rurng Wu, Muthalagu Vetrichelvan, Anuradha Gupta, Alan Wilson, Suma Gopinathan, Suman Wason, Linda Bristow, Charles F. Albright, Joanne J. Bronson, John E. Macor, Carolyn D. Dzierba

المصدر: Journal of Medicinal Chemistry. 65:4457-4480

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::38224dcaf3d9ea2fabc4ac6df4a42a84
https://doi.org/10.1021/acs.jmedchem.1c02131

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5

Pharmacological inhibition of PTEN rescues dopaminergic neurons by attenuating apoptotic and neuroinflammatory signalling events

المؤلفون: Aishwarya Mary Johnson, Sara Jose, Abdul Rasheed Palakkot, Farheen Badrealam Khan, Jaleel Kizhakkayil, Shamma Ali Abdulla AlNaqbi, Mark GH Scott, Mohammed Akhli Ayoub, Richard Gordon, Hariharan Saminathan

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5a89ec3a7f3f6307adf9909b567f93ac
https://doi.org/10.21203/rs.3.rs-1785484/v1

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Discovery of (

المؤلفون: Guanglin, Luo, Ling, Chen, Walter A, Kostich, Brian, Hamman, Jason, Allen, Amy, Easton, Clotilde, Bourin, Michael, Gulianello, Jonathan, Lippy, Susheel, Nara, Tarun Kumar, Maishal, Kamalraj, Thiyagarajan, Prasadrao, Jalagam, Sreenivasulu Naidu, Pattipati, Kumaran, Dandapani, Manoj, Dokania, Pradeep, Vattikundala, Vivek, Sharma, Saravanan, Elavazhagan, Manoj Kumar, Verma, Manish Lal, Das, Santosh, Wagh, Anand, Balakrishnan, Benjamin M, Johnson, Kenneth S, Santone, George, Thalody, Rex, Denton, Hariharan, Saminathan, Vinay K, Holenarsipur, Anoop, Kumar, Abhijith, Rao, Siva Prasad, Putlur, Sarat Kumar, Sarvasiddhi, Ganesh, Shankar, Justin V, Louis, Manjunath, Ramarao, Charles M, Conway, Yu-Wen, Li, Rick, Pieschl, Yuan, Tian, Yang, Hong, Jonathan, Ditta, Arvind, Mathur, Jianqing, Li, Daniel, Smith, Joseph, Pawluczyk, Dawn, Sun, Shiuhang, Yip, Dauh-Rurng, Wu, Muthalagu, Vetrichelvan, Anuradha, Gupta, Alan, Wilson, Suma, Gopinathan, Suman, Wason, Linda, Bristow, Charles F, Albright, Joanne J, Bronson, John E, Macor, Carolyn D, Dzierba

المصدر: Journal of medicinal chemistry. 65(6)

مصطلحات موضوعية: Mice, Spinal Cord, Animals, Brain, Neuralgia, Amines, Protein Kinase Inhibitors, Rats

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::1e41976413f9c4afd18a0630ac9bd2a0
https://pubmed.ncbi.nlm.nih.gov/35257579

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7

Environmental neurotoxicants and inflammasome activation in Parkinson's disease - A focus on the gut-brain axis

المؤلفون: Hariharan Saminathan, Richard D. Gordon, Zhen-Yi Andy Ou, Aishwarya Mary Johnson

المصدر: The international journal of biochemistrycell biology. 142

مصطلحات موضوعية: Parkinson's disease, biology, business.industry, Inflammasomes, Gut–brain axis, Inflammasome, Cell Biology, Disease, Neuropathology, Gut flora, medicine.disease, biology.organism_classification, Biochemistry, Immune system, Synuclein, medicine, business, Neuroscience, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339a44fc4008137a01a49ee3c88def6c
https://pubmed.ncbi.nlm.nih.gov/34737076

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Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia

المؤلفون: Huajun Jin, Hariharan Saminathan, Shivani Ghaisas, Manikandan Samidurai, Nikhil Panicker, Valina L. Dawson, Dharmin Rokad, Tae In Kam, Anumantha G. Kanthasamy, Monica R. Langley, Adhithiya Charli, Dilshan S. Harischandra, Arthi Kanthasamy, Olga Pletnikova, Matthew Neal, Souvarish Sarkar, Ted M. Dawson, Vellareddy Anantharam

المصدر: The Journal of Experimental Medicine

مصطلحات موضوعية: CD36 Antigens, 0301 basic medicine, Protein Folding, Inflammasomes, CD36, Interleukin-1beta, Priming (immunology), Proto-Oncogene Proteins c-fyn, 0302 clinical medicine, Immunology and Allergy, Gliosis, Research Articles, integumentary system, Microglia, biology, Chemistry, NF-kappa B, Parkinson Disease, Inflammasome, Dependovirus, Mitochondria, 3. Good health, Cell biology, Protein Kinase C-delta, medicine.anatomical_structure, alpha-Synuclein, medicine.drug, Immunology, Models, Biological, Article, Protein Aggregates, 03 medical and health sciences, Enzyme activator, FYN, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Animals, Humans, Scavenger receptor, Neuroinflammation, nervous system diseases, Enzyme Activation, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, nervous system, biology.protein, Reactive Oxygen Species, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf9a3ae4bb1a5fe9de8fe5dd35e8d28
https://doi.org/10.1084/jem.20182191

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Fyn Kinase-Mediated PKCδ Y311 Phosphorylation Induces Dopaminergic Degeneration in Cell Culture and Animal Models: Implications for the Identification of a New Pharmacological Target for Parkinson's Disease

المؤلفون: Anamitra Ghosh, Chunjuan Song, Huajun Jin, Hariharan Saminathan, Arthi Kanthasamy, Danhui Zhang, Vellareddy Anantharam, Anumantha G. Kanthasamy

المصدر: Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabca61c3a40c53f1655895544ebdd65
https://pubmed.ncbi.nlm.nih.gov/33995031

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Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: Relevance to translational research

المؤلفون: Vellareddy Anantharam, Anumantha G. Kanthasamy, Nikhil Panicker, Arthi Kanthasamy, Hariharan Saminathan, Jesse M. Hostetter, Adhithiya Charli, Jie Luo, Huajun Jin, Richard D. Gordon

المصدر: Eur J Pharmacol

مصطلحات موضوعية: 0301 basic medicine, Lipopolysaccharides, Male, medicine.medical_specialty, Mice, 129 Strain, Lipopolysaccharide, Anti-Inflammatory Agents, Dasatinib, Nitric Oxide Synthase Type II, Apoptosis, Systemic inflammation, Proto-Oncogene Proteins c-fyn, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, FYN, Internal medicine, medicine, Splenocyte, Animals, Src family kinase, Protein Kinase Inhibitors, Pharmacology, Mice, Knockout, biology, Behavior, Animal, Chemistry, Endotoxemia, Nitric oxide synthase, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Endocrinology, Liver, biology.protein, Cytokines, Tumor necrosis factor alpha, medicine.symptom, Inflammation Mediators, 030217 neurology & neurosurgery, Locomotion, Spleen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::223099099c7f103520a8abc4d25e5132
https://pubmed.ncbi.nlm.nih.gov/32565338

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