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1دورية أكاديمية
لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل. -
2دورية أكاديمية
لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل. -
3دورية أكاديمية
المؤلفون: Webber SE; Pfizer Global Research and Development, La Jolla, 3565 General Atomics Court, San Diego, CA 92121, USA. swebber@anadyspharma.com, Marakovits JT, Dragovich PS, Prins TJ, Zhou R, Fuhrman SA, Patick AK, Matthews DA, Lee CA, Srinivasan B, Moran T, Ford CE, Brothers MA, Harr JE, Meador JW 3rd, Ferre RA, Worland ST
المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2001 Oct 22; Vol. 11 (20), pp. 2683-6.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
مواضيع طبية MeSH: Peptides/*chemical synthesis , Protease Inhibitors/*chemical synthesis , Viral Proteins/*antagonists & inhibitors, 3C Viral Proteases ; Antiviral Agents/chemical synthesis ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Cysteine Endopeptidases/metabolism ; Microbial Sensitivity Tests ; Models, Molecular ; Peptides/chemistry ; Peptides/pharmacology ; Protease Inhibitors/chemistry ; Protease Inhibitors/pharmacology ; Rhinovirus/drug effects ; Structure-Activity Relationship ; Viral Proteins/metabolism
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4دورية أكاديمية
المؤلفون: Dragovich PS; Agouron Pharmaceuticals, Inc., 3565 General Atomics Court, San Diego, California 92121, USA., Prins TJ, Zhou R, Webber SE, Marakovits JT, Fuhrman SA, Patick AK, Matthews DA, Lee CA, Ford CE, Burke BJ, Rejto PA, Hendrickson TF, Tuntland T, Brown EL, Meador JW 3rd, Ferre RA, Harr JE, Kosa MB, Worland ST
المصدر: Journal of medicinal chemistry [J Med Chem] 1999 Apr 08; Vol. 42 (7), pp. 1213-24.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
مواضيع طبية MeSH: Viral Proteins*, Antiviral Agents/*chemical synthesis , Cysteine Endopeptidases/*metabolism , Cysteine Proteinase Inhibitors/*chemical synthesis , Glutamine/*chemistry , Isoxazoles/*chemical synthesis , Lactams/*chemical synthesis , Oligopeptides/*chemical synthesis , Pyrrolidinones/*chemical synthesis , Rhinovirus/*enzymology, 3C Viral Proteases ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Cell Line ; Crystallography, X-Ray ; Cysteine Proteinase Inhibitors/chemistry ; Cysteine Proteinase Inhibitors/pharmacology ; Drug Design ; Drug Evaluation, Preclinical ; Humans ; Isoxazoles/chemistry ; Isoxazoles/pharmacology ; Lactams/chemistry ; Lactams/pharmacology ; Models, Molecular ; Molecular Mimicry ; Oligopeptides/chemistry ; Oligopeptides/pharmacology ; Phenylalanine/analogs & derivatives ; Pyrrolidinones/chemistry ; Pyrrolidinones/pharmacology ; Rhinovirus/drug effects ; Structure-Activity Relationship ; Valine/analogs & derivatives
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5دورية أكاديمية
المؤلفون: Dragovich PS; Agouron Pharmaceuticals, Inc., 3565 General Atomics Court, San Diego, California 92121, USA., Webber SE, Babine RE, Fuhrman SA, Patick AK, Matthews DA, Lee CA, Reich SH, Prins TJ, Marakovits JT, Littlefield ES, Zhou R, Tikhe J, Ford CE, Wallace MB, Meador JW 3rd, Ferre RA, Brown EL, Binford SL, Harr JE, DeLisle DM, Worland ST
المصدر: Journal of medicinal chemistry [J Med Chem] 1998 Jul 16; Vol. 41 (15), pp. 2806-18.
نوع المنشور: Comparative Study; Journal Article
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
مواضيع طبية MeSH: Antiviral Agents*/chemical synthesis , Antiviral Agents*/chemistry , Antiviral Agents*/metabolism , Antiviral Agents*/pharmacology , Cysteine Proteinase Inhibitors*/chemical synthesis , Cysteine Proteinase Inhibitors*/chemistry , Cysteine Proteinase Inhibitors*/metabolism , Cysteine Proteinase Inhibitors*/pharmacology , Drug Design* , Oligopeptides*/chemical synthesis , Oligopeptides*/chemistry , Oligopeptides*/metabolism , Oligopeptides*/pharmacology , Viral Proteins*, Cysteine Endopeptidases/*metabolism , Rhinovirus/*drug effects, 3C Viral Proteases ; Animals ; Binding Sites ; Cell Line, Transformed ; Crystallography, X-Ray ; Cysteine Endopeptidases/chemistry ; Drug Stability ; HeLa Cells ; Humans ; Protein Conformation ; Rats ; Rats, Sprague-Dawley ; Rhinovirus/enzymology ; Structure-Activity Relationship