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المؤلفون: Lutgarde Serneels, Rajeshwar Narlawar, Laura Perez Benito, Marti Municoy, Victor Guallar, Dries T’Syen, Maarten Dewilde, François Bischoff, Erwin Fraiponts, Gary Tresadern, Peter W.M. Roevens, Harrie J.M. Gijsen, Bart De Strooper
مصطلحات موضوعية: therapy, medicinal chemistry, inhibitors, selectivity, Cell Biology, ƴ-secretase, Molecular Biology, Biochemistry
وصف الملف: Print-Electronic
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34173e9b72a677f8f8c9ec51792ad684
https://lirias.kuleuven.be/handle/20.500.12942/719766 -
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المؤلفون: Ann Vos, Frederik Jan Rita Rombouts, Andrés A. Trabanco, Daniel Oehlrich, Harrie J.M. Gijsen, Diederik Moechars, Sven Franciscus Anna Van Brandt, Aldo Peschiulli, Gregor James Macdonald, Michel Surkyn, Gary Tresadern, Michiel Van Gool, Nigel E. Austin, Michel Anna Jozef De Cleyn
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: animal structures, Amyloid β, biology, Chemistry, Organic Chemistry, hERG, Pharmacology, Biochemistry, Bioavailability, Piperazine, chemistry.chemical_compound, In vivo, mental disorders, Drug Discovery, biology.protein, Potency, Efflux, Penetrant (biochemical)
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المؤلفون: Naoya Asada, Tatsuhiko Ueno, Shiho Yamamoto, Ken-ichi Kusakabe, Diederik Moechars, Naoki Kanegawa, Harrie J.M. Gijsen, Frederik J. R. Rombouts, Mana Ito, Eriko Matsuoka, Hisanori Ito
المصدر: Journal of Medicinal Chemistry. 64:14165-14174
مصطلحات موضوعية: chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Amyloid, biology, Pyridines, Chemistry, Cocrystal, Loop (topology), Structure-Activity Relationship, chemistry.chemical_compound, Enzyme, In vivo, mental disorders, Drug Discovery, Pyridine, Amyloid precursor protein, biology.protein, Biophysics, Aspartic Acid Endopeptidases, Humans, Molecular Medicine, Amyloid Precursor Protein Secretases, Enzyme Inhibitors, Selectivity
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المؤلفون: Ann Vos, Lieve Lammens, Richard Alexander, Frederik J. R. Rombouts, Michel Surkyn, Kenji Morimoto, Laurent Leclercq, Nigel Austin, Koichi Tsubone, Tatsuhiko Ueno, Michel Anna Jozef De Cleyn, Deborah Dhuyvetter, Ken-ichi Kusakabe, Ard Teisman, Diederik Moechars, Tom Jacobs, An Van Den Bergh, Hirokazu Sumiyoshi, Herman Borghys, Shunsuke Einaru, Soufyan Jerhaoui, Brian Joel Hrupka, Harrie J.M. Gijsen
المصدر: Journal of Medicinal Chemistry. 64:14175-14191
مصطلحات موضوعية: Models, Molecular, Sulfonyl, chemistry.chemical_classification, Pyrrolidines, Cardiovascular safety, Dose-Response Relationship, Drug, Molecular Structure, Bicyclic molecule, Amyloid β, Chemistry, Pharmacology, Crystallography, X-Ray, Highly selective, Cns toxicity, Structure-Activity Relationship, mental disorders, Drug Discovery, Reactive metabolite, Lipophilicity, Aspartic Acid Endopeptidases, Humans, Molecular Medicine, Amyloid Precursor Protein Secretases
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المصدر: Expert Opinion on Therapeutic Patents. 31:25-52
مصطلحات موضوعية: Amyloid, Patent literature, 01 natural sciences, Patents as Topic, 03 medical and health sciences, 0302 clinical medicine, Drug Development, Alzheimer Disease, mental disorders, Drug Discovery, Amyloid precursor protein, Animals, Aspartic Acid Endopeptidases, Humans, Protease Inhibitors, Pharmacology, chemistry.chemical_classification, biology, Chemistry, General Medicine, Small molecule, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, Biochemistry, 030220 oncology & carcinogenesis, β secretase, biology.protein, Amyloid Precursor Protein Secretases
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المؤلفون: Yasuyoshi Iso, Shigeru Ando, Harrie J.M. Gijsen, Yasuto Kido, Shinji Suzuki, Herman Borghys, Kenji Morimoto, Vijay Urmaliya, Deborah Dhuyvetter, Takahiko Yamamoto, Ard Teisman, Gaku Sakaguchi, Naoki Kanegawa, Nigel Austin, Eriko Matsuoka, An Van Den Bergh, Hisanori Ito, Takuya Oguma, Francois Paul Bischoff, Tamio Fukushima, Peter Verboven, Tomoyuki Kawachi, Kenji Nakahara, Yoshinori Yamano, Kosuke Anan, Ken-ichi Kusakabe
المصدر: ChemMedChem. 14:1894-1910
مصطلحات موضوعية: Male, Models, Molecular, hERG, Thiazines, Pharmacology, 01 natural sciences, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Oral administration, Oxazines, Drug Discovery, Hydrolase, Amyloid precursor protein, Animals, Aspartic Acid Endopeptidases, Humans, General Pharmacology, Toxicology and Pharmaceutics, Mice, Knockout, chemistry.chemical_classification, Mice, Inbred ICR, Amyloid beta-Peptides, Trifluoromethyl, Dose-Response Relationship, Drug, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Rats, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Enzyme, Drug Design, Hepatocytes, Microsomes, Liver, biology.protein, Microsome, Molecular Medicine, Efflux, Amyloid Precursor Protein Secretases
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المؤلفون: Ann Vos, Aldo Peschiulli, Frederik J. R. Rombouts, Sven Franciscus Anna Van Brandt, Pauline Heckmann, Michel Anna Jozef De Cleyn, Solène Bache, Carolina Martinez-Lamenca, Jos Leenaerts, Harrie J.M. Gijsen, Chien-Chi Hsiao
المصدر: European journal of medicinal chemistry. 228
مصطلحات موضوعية: Pyrrolidines, hERG, Amidines, Electrons, Amidine, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, Drug Discovery, Animals, Aspartic Acid Endopeptidases, Humans, Solubility, Enzyme Inhibitors, Pharmacology, chemistry.chemical_classification, biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Physical, Organic Chemistry, General Medicine, Permeation, Combinatorial chemistry, Enzyme, Membrane, chemistry, biology.protein, Amine gas treating, Amyloid Precursor Protein Secretases, Conjugate
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المؤلفون: Kazuki Fujimoto, Shigeru Ando, Yutaka Tonomura, Shuhei Yoshida, Harrie J.M. Gijsen, Shiho Yamamoto, Diederik Moechars, Naoki Kanegawa, Frederik J. R. Rombouts, Hisanori Ito, Kouki Fuchino, Shinji Suzuki, Takahiko Yamamoto, Eriko Matsuoka, Genta Tadano, Naoya Asada, Ken-ichi Kusakabe
المصدر: Journal of medicinal chemistry. 64(6)
مصطلحات موضوعية: Propynyl, 01 natural sciences, Cocrystal, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Alzheimer Disease, Drug Discovery, Oxazines, Molecule, Aspartic Acid Endopeptidases, Humans, Enzyme Inhibitors, 030304 developmental biology, 0303 health sciences, Chemistry, Water, Combinatorial chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Drug Design, β secretase, Molecular Medicine, Verubecestat, Structure based, Amyloid Precursor Protein Secretases, Selectivity, High homology
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المؤلفون: Sergio A. Alonso de Diego, Daniel Oehlrich, Harrie J.M. Gijsen, Andrés A. Trabanco, Hana Prokopcová, Nigel Austin, Michel Surkyn, Dries Van den Bossche, Frederik J. R. Rombouts, Deborah Dhuyvetter, Gregor James Macdonald, Sven Franciscus Anna Van Brandt, Herman Borghys, Michiel Van Gool, Diederik Moechars, Aránzazu García-Molina, Michel Anna Jozef De Cleyn, Carolina Martinez-Lamenca
المصدر: Journal of Medicinal Chemistry. 61:5292-5303
مصطلحات موضوعية: Male, 0301 basic medicine, ERG1 Potassium Channel, Guinea Pigs, hERG, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Mice, Inbred Strains, Pharmacology, Rats, Sprague-Dawley, Amidine, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dogs, 0302 clinical medicine, Drug Stability, In vivo, Oxazines, Drug Discovery, Animals, Aspartic Acid Endopeptidases, Humans, Structure–activity relationship, Protease Inhibitors, Amyloid beta-Peptides, Cardiovascular safety, biology, Peptide Fragments, Clinical trial, 030104 developmental biology, chemistry, Cardiovascular Diseases, Toxicity, β secretase, biology.protein, Molecular Medicine, Administration, Intravenous, Amyloid Precursor Protein Secretases, Chemical and Drug Induced Liver Injury, 030217 neurology & neurosurgery
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المؤلفون: Takahiko Yamamoto, Yasuyoshi Iso, Harrie J.M. Gijsen, Tsuyoshi Hasegawa, Tamio Fukushima, Hisanori Ito, Yoshinori Yamano, Ken-ichi Kusakabe, Yasuto Kido, Herman Borghys, Motoko Hosono, Kenji Nakahara, Kouki Fuchino, Yusuke Sako, Shigeru Ando, Naoya Asada, Kazuo Komano, Gaku Sakaguchi, Masayoshi Ogawa, Genta Tadano, Chie Unemura, Deborah Dhuyvetter, Shuichi Ohnishi
المصدر: Journal of Medicinal Chemistry. 61:5525-5546
مصطلحات موضوعية: 0301 basic medicine, Pyrazine, Protein Conformation, Stereochemistry, hERG, 01 natural sciences, Rats, Sprague-Dawley, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Protein structure, In vivo, Oxazines, Drug Discovery, Animals, Humans, Structure–activity relationship, Potency, Tissue Distribution, Enzyme Inhibitors, Dose-Response Relationship, Drug, biology, 010405 organic chemistry, Drug discovery, Brain, Rats, 0104 chemical sciences, Molecular Docking Simulation, 030104 developmental biology, chemistry, biology.protein, Molecular Medicine, Efflux, Amyloid Precursor Protein Secretases