المؤلفون: Elisabeth Speckmeier, Antje Pommereau, Kay-Christoph Grosser, Hartmut Mors, Thomas C. Maier, Thomas Licher, Felix Bärenz

المصدر: SLAS Discovery, Vol 27, Iss 5, Pp 298-305 (2022)

مصطلحات موضوعية: Isocitrate dehydrogenase type 1 (IDH1), IDH1 R132H inhibitors, Acoustic droplet ejection mass spectrometry (ADE-MS), Echo-MS, Open port interface, Label-free high throughput screening, Medicine (General), R5-920, Biotechnology, TP248.13-248.65

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2472555222136610; https://doaj.org/toc/2472-5552

URL الوصول: https://doaj.org/article/3d7dc617e5834613884663dd47a709a9

المؤلفون: Elisabeth Defossa, Matthias Löhn, Matthias Schäfer, Pavel Safar, Dietmar Weitz, Kristin Breitschopf, Matthias Lohmann, María Méndez, David S Thorpe, Jens Riedel, Nils Rackelmann, Hartmut Mors, Hans Matter, Michael Kurz, Ziyu Li, Michael Podeschwa, Sylvain Lebreton

المصدر: Journal of Medicinal Chemistry. 63:2292-2307

مصطلحات موضوعية: Blood Glucose, Male, endocrine system, Allosteric modulator, Allosteric regulation, Pharmacology, 01 natural sciences, Glucagon-Like Peptide-1 Receptor, Rats, Sprague-Dawley, Mice, 03 medical and health sciences, Allosteric Regulation, In vivo, Drug Discovery, Animals, Humans, Hypoglycemic Agents, Receptor, Cells, Cultured, 030304 developmental biology, ADME, 0303 health sciences, Chemistry, HEK 293 cells, Small molecule, In vitro, Rats, 0104 chemical sciences, Mice, Inbred C57BL, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, HEK293 Cells, Diabetes Mellitus, Type 2, Drug Design, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dde87dac749897ba8532f58a4dc0ec6
https://doi.org/10.1021/acs.jmedchem.9b01071

المؤلفون: Philip S. Jones, Sylviane Boucharens, Stuart P. McElroy, Angus Morrison, Saman Honarnejad, Stan van Boeckel, Helma van den Hurk, Daniel Basting, Jörg Hüser, Stefan Jaroch, Eckhard Ottow, Jorg Benningshof, Rutger H. A. Folmer, Frank Leemhuis, Patricia M. Kramer-Verhulst, Vera J. M. Nies, Kristina M. Orrling, Ton Rijnders, Claudia Pfander, Ola Engkvist, Garry Pairaudeau, Peter B. Simpson, Jean-Yves Ortholand, Didier Roche, Alexander Dömling, Sven M. Kühnert, Peter W. M. Roevens, Herman van Vlijmen, Eva J. A. van Wanrooij, Christophe Verbruggen, Peter Nussbaumer, Huib Ovaa, Mario van der Stelt, Klaus Baek Simonsen, Lena Tagmose, Herbert Waldmann, James Duffy, Dirk Finsinger, Mirek Jurzak, Nicola A. Burgess-Brown, Wen H. Lee, Floris P. J. T. Rutjes, Hubert Haag, Christopher Kallus, Hartmut Mors, Thierry Dorval, Brigitte Lesur, Fernando Ramon Olayo, Daniel Hamza, Geraint Jones, Christopher Pearce, Alexander Piechot, Dimitrios Tzalis, Mads H. Clausen, Jeremy Davis, Daphné Derouane, Céline Vermeiren, Markus Kaiser, Robert A. Stockman, Denise V. Barrault, Andrew D. Pannifer, Jason R. Swedlow, Adam S. Nelson, Romano V. A. Orru, Eelco Ruijter, Steven P. van Helden, Volkhart M. Li, Ton Vries, Jon S. B. de Vlieger

المصدر: Nature Reviews Drug Discovery
Nature Reviews. Drug Discovery, 21, 245-246
Nature Reviews. Drug Discovery, 21, 4, pp. 245-246

مصطلحات موضوعية: Small Molecule Libraries, Pharmacology, Drug Discovery, Humans, Synthetic Organic Chemistry, General Medicine, High-Throughput Screening Assays

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d851dc3fb96708a39839a80c7c53a40