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1دورية أكاديمية
المؤلفون: Zhao H; Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, United States., Hartono SR; Department of Molecular and Cellular Biology, University of California, Davis, Davis, United States., de Vera KMF; Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, United States., Yu Z; Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, United States.; Graduate Group in Biostatistics, University of California, Davis, Davis, United States., Satchi K; Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, United States., Zhao T; Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, United States., Sciammas R; Center for Immunology and Infectious Diseases, University of California, Davis, Davis, United States., Sanz L; Department of Molecular and Cellular Biology, University of California, Davis, Davis, United States., Chédin F; Department of Molecular and Cellular Biology, University of California, Davis, Davis, United States., Barlow J; Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, United States.
المصدر: ELife [Elife] 2022 Dec 21; Vol. 11. Date of Electronic Publication: 2022 Dec 21.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
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2دورية أكاديمية
المؤلفون: Miller HE; Department of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX, USA.; Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, TX, USA.; Bioinformatics Research Network, Atlanta, GA, USA., Montemayor D; Department of Medicine, UT Health San Antonio, San Antonio, TX, USA.; Center for Precision Medicine, UT Health San Antonio, San Antonio, TX, USA., Abdul J; Bioinformatics Research Network, Atlanta, GA, USA.; Department of Biology, University of Ottawa, Ottawa, Canada., Vines A; Bioinformatics Research Network, Atlanta, GA, USA.; Faculty of Arts, University of Bristol, Bristol, U.K., Levy SA; Department of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX, USA.; Bioinformatics Research Network, Atlanta, GA, USA.; Sam & Ann Barshop Institute for Longevity & Aging Studies, UT Health San Antonio, San Antonio, TX, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX, USA., Hartono SR; Department of Molecular and Cellular Biology, UC Davis, Davis, CA, USA., Sharma K; Department of Medicine, UT Health San Antonio, San Antonio, TX, USA.; Center for Precision Medicine, UT Health San Antonio, San Antonio, TX, USA., Frost B; Department of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX, USA.; Sam & Ann Barshop Institute for Longevity & Aging Studies, UT Health San Antonio, San Antonio, TX, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX, USA., Chédin F; Department of Molecular and Cellular Biology, UC Davis, Davis, CA, USA., Bishop AJR; Department of Cell Systems and Anatomy, UT Health San Antonio, San Antonio, TX, USA.; Greehey Children's Cancer Research Institute, UT Health San Antonio, San Antonio, TX, USA.; May's Cancer Center, UT Health San Antonio, San Antonio, TX, USA.
المصدر: Nucleic acids research [Nucleic Acids Res] 2022 Jul 22; Vol. 50 (13), pp. 7260-7286.
نوع المنشور: Journal Article; Meta-Analysis; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
مواضيع طبية MeSH: R-Loop Structures* , RNA*/chemistry , RNA*/genetics, Consensus ; DNA/chemistry ; Nucleic Acid Hybridization
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3دورية أكاديمية
المؤلفون: Kumar S; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Immunology, Harvard Medical School, Boston, Massachusetts., Zeng Z; Department of Data Sciences, Dana-Farber Cancer Institute, Harvard T. H. Chan School of Public Health, Boston, Massachusetts., Bagati A; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Immunology, Harvard Medical School, Boston, Massachusetts., Tay RE; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Immunology, Harvard Medical School, Boston, Massachusetts., Sanz LA; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, California., Hartono SR; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, California., Ito Y; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Immunology, Harvard Medical School, Boston, Massachusetts., Abderazzaq F; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Hatchi E; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Jiang P; Department of Data Sciences, Dana-Farber Cancer Institute, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.; Center for Cancer Research, National Cancer Institute, Bethesda, Maryland., Cartwright ANR; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Immunology, Harvard Medical School, Boston, Massachusetts., Olawoyin O; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Yale School of Medicine, New Haven, Connecticut., Mathewson ND; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Immunology, Harvard Medical School, Boston, Massachusetts., Pyrdol JW; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Department of Immunology, Harvard Medical School, Boston, Massachusetts., Li MZ; Department of Genetics, Harvard Medical School and Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, Massachusetts., Doench JG; Broad Institute of Harvard and MIT, Cambridge, Massachusetts., Booker MA; Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, Massachusetts., Tolstorukov MY; Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, Massachusetts., Elledge SJ; Department of Genetics, Harvard Medical School and Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, Massachusetts., Chédin F; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, California., Liu XS; Department of Data Sciences, Dana-Farber Cancer Institute, Harvard T. H. Chan School of Public Health, Boston, Massachusetts. kai_wucherpfennig@dfci.harvard.edu xsliu@ds.dfci.harvard.edu., Wucherpfennig KW; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts. kai_wucherpfennig@dfci.harvard.edu xsliu@ds.dfci.harvard.edu.; Department of Immunology, Harvard Medical School, Boston, Massachusetts.; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
المصدر: Cancer discovery [Cancer Discov] 2021 Aug; Vol. 11 (8), pp. 2050-2071. Date of Electronic Publication: 2021 Mar 11.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
مواضيع طبية MeSH: Immune Checkpoint Inhibitors/*pharmacology , Neoplasms/*therapy , Protein-Arginine N-Methyltransferases/*antagonists & inhibitors, Cell Line, Tumor/drug effects ; Humans ; Immunotherapy ; T-Lymphocytes/drug effects
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4دورية أكاديمية
المؤلفون: Giuliani V; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. VGiuliani@mdanderson.org., Miller MA; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Liu CY; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hartono SR; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, CA, USA., Class CA; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Pharmaceutical Sciences, Butler University, Indianapolis, IN, USA., Bristow CA; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Suzuki E; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Sanz LA; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, CA, USA., Gao G; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gay JP; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Feng N; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Rose JL; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tomihara H; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Surgery, Kindai University Nara Hospital, Nara, JP, USA., Daniele JR; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Peoples MD; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Bardenhagen JP; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Geck Do MK; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chang QE; ORBIT, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Vangamudi B; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Exo Therapeutics, Cambridge, MA, USA., Vellano C; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ying H; Department of Cellular and Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Deem AK; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Do KA; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Genovese G; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Marszalek JR; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kovacs JJ; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kim M; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Fleming JB; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Division of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA., Guccione E; Department of Oncological Sciences and Pharmacological Sciences at Icahn School of Medicine at Mount Sinai, New York, NY, USA., Viale A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Maitra A; Sheikh Ahmed Bin Zayed Al Nahyan Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Emilia Di Francesco M; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Yap TA; Department of Investigational Cancer Therapeutics (Phase I Program), The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Jones P; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Draetta G; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Carugo A; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chedin F; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, CA, USA., Heffernan TP; Traction, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. TPHeffernan@mdanderson.org.
المصدر: Nature communications [Nat Commun] 2021 Jul 30; Vol. 12 (1), pp. 4626. Date of Electronic Publication: 2021 Jul 30.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
مواضيع طبية MeSH: DNA Damage*, Carcinoma, Pancreatic Ductal/*genetics , Pancreatic Neoplasms/*genetics , Protein-Arginine N-Methyltransferases/*genetics , RNA/*genetics , Repressor Proteins/*genetics, Animals ; Biocatalysis/drug effects ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/prevention & control ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Enzyme Inhibitors/pharmacology ; Female ; Humans ; Mice, Inbred NOD ; Mice, Knockout ; Mice, SCID ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/prevention & control ; Protein-Arginine N-Methyltransferases/metabolism ; RNA/metabolism ; RNA Interference ; Repressor Proteins/metabolism ; Tumor Burden/drug effects ; Xenograft Model Antitumor Assays/methods ; Mice
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5دورية أكاديمية
المؤلفون: Smolka JA; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, Davis, CA., Sanz LA; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, Davis, CA., Hartono SR; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, Davis, CA., Chédin F; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, Davis, CA.
المصدر: The Journal of cell biology [J Cell Biol] 2021 Jun 07; Vol. 220 (6).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
بيانات الدورية: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 0375356 Publication Model: Print Cited Medium: Internet ISSN: 1540-8140 (Electronic) Linking ISSN: 00219525 NLM ISO Abbreviation: J Cell Biol Subsets: MEDLINE
مواضيع طبية MeSH: Antibodies, Monoclonal/*metabolism , DNA/*metabolism , Nucleic Acid Heteroduplexes/*metabolism , RNA/*metabolism , Ribonuclease H/*metabolism, Antibodies, Monoclonal/chemistry ; Antibody Affinity ; Artifacts ; DNA/chemistry ; Humans ; Nucleic Acid Heteroduplexes/chemistry ; RNA/chemistry ; Ribonuclease H/chemistry
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6دورية أكاديمية
المؤلفون: Chédin F; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, Davis, CA, USA., Hartono SR; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, Davis, CA, USA., Sanz LA; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, Davis, CA, USA., Vanoosthuyse V; Laboratoire de Biologie et Modélisation de la Cellule, CNRS, UMR 5239, Univ Lyon, École Normale Supérieure de Lyon, Lyon, France.
المصدر: The EMBO journal [EMBO J] 2021 Feb 15; Vol. 40 (4), pp. e106394. Date of Electronic Publication: 2021 Jan 07.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
مواضيع طبية MeSH: Genome, Human* , Genomic Instability* , R-Loop Structures*, DNA/*chemistry , RNA/*chemistry, Humans
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7دورية أكاديمية
المؤلفون: Shah SS; Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, United States., Hartono SR; Department of Molecular and Cellular Biology, University of California, Davis, Davis, United States., Chédin F; Department of Molecular and Cellular Biology, University of California, Davis, Davis, United States., Heyer WD; Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, United States.; Department of Molecular and Cellular Biology, University of California, Davis, Davis, United States.
المصدر: ELife [Elife] 2020 Nov 13; Vol. 9. Date of Electronic Publication: 2020 Nov 13.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
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8دورية أكاديمية
المؤلفون: Malig M; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, Davis, CA 95616, USA; Integrative Genetics and Genomics Graduate Group, University of California Davis, Davis, CA 95616, USA., Hartono SR; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, Davis, CA 95616, USA., Giafaglione JM; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, Davis, CA 95616, USA., Sanz LA; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, Davis, CA 95616, USA., Chedin F; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, Davis, CA 95616, USA. Electronic address: flchedin@ucdavis.edu.
المصدر: Journal of molecular biology [J Mol Biol] 2020 Mar 27; Vol. 432 (7), pp. 2271-2288. Date of Electronic Publication: 2020 Feb 24.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE
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9دورية أكاديمية
المؤلفون: Stolz R; Department of Molecular and Cellular Biology, University of California, Davis, CA 95616.; Integrative Genetics and Genomics Graduate Group, University of California, Davis, CA 95616., Sulthana S; Department of Molecular and Cellular Biology, University of California, Davis, CA 95616., Hartono SR; Department of Molecular and Cellular Biology, University of California, Davis, CA 95616., Malig M; Department of Molecular and Cellular Biology, University of California, Davis, CA 95616.; Integrative Genetics and Genomics Graduate Group, University of California, Davis, CA 95616., Benham CJ; Department of Mathematics, University of California, Davis, CA 95616; cjbenham@ucdavis.edu flchedin@ucdavis.edu.; Department of Biomedical Engineering, University of California, Davis, CA 95616.; Genome Center, University of California, Davis, CA 95616., Chedin F; Department of Molecular and Cellular Biology, University of California, Davis, CA 95616; cjbenham@ucdavis.edu flchedin@ucdavis.edu.; Genome Center, University of California, Davis, CA 95616.
المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Mar 26; Vol. 116 (13), pp. 6260-6269. Date of Electronic Publication: 2019 Mar 08.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
مواضيع طبية MeSH: Base Sequence* , Nucleic Acid Conformation*, DNA/*chemistry , DNA, Superhelical/*chemistry, DNA, Single-Stranded/chemistry ; Models, Genetic ; Nucleic Acid Hybridization ; Plasmids/chemistry ; RNA/chemistry ; Transcription, Genetic
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10دورية أكاديمية
المؤلفون: Manzo SG; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.; Present address: Division of Gene Regulation, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands., Hartono SR; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, USA., Sanz LA; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, USA., Marinello J; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy., De Biasi S; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy., Cossarizza A; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy., Capranico G; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy. giovanni.capranico@unibo.it., Chedin F; Department of Molecular and Cellular Biology and Genome Center, University of California, Davis, USA. flchedin@ucdavis.edu.
المصدر: Genome biology [Genome Biol] 2018 Jul 30; Vol. 19 (1), pp. 100. Date of Electronic Publication: 2018 Jul 30.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100960660 Publication Model: Electronic Cited Medium: Internet ISSN: 1474-760X (Electronic) Linking ISSN: 14747596 NLM ISO Abbreviation: Genome Biol Subsets: MEDLINE
مواضيع طبية MeSH: Genome, Human* , Transcription, Genetic*, DNA/*chemistry , DNA Topoisomerases, Type I/*genetics , Heterochromatin/*chemistry, Chromatin Immunoprecipitation ; DNA/genetics ; DNA/metabolism ; DNA Replication ; DNA Topoisomerases, Type I/metabolism ; G1 Phase Cell Cycle Checkpoints ; Gene Silencing ; HEK293 Cells ; Heterochromatin/metabolism ; Histones/genetics ; Histones/metabolism ; Humans ; Lamin Type B/genetics ; Lamin Type B/metabolism ; Nucleic Acid Conformation ; RNA Polymerase II/genetics ; RNA Polymerase II/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Resting Phase, Cell Cycle