المؤلفون: Stephanie E Hesselson, Pär Matsson, James E Shima, Hisayo Fukushima, Sook Wah Yee, Yuya Kobayashi, Jason M Gow, Connie Ha, Benjamin Ma, Annie Poon, Susan J Johns, Doug Stryke, Richard A Castro, Harunobu Tahara, Ji Ha Choi, Ligong Chen, Nicolas Picard, Elin Sjödin, Maarke J E Roelofs, Thomas E Ferrin, Richard Myers, Deanna L Kroetz, Pui-Yan Kwok, Kathleen M Giacomini

المصدر: PLoS ONE, Vol 4, Iss 9, p e6942 (2009)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC2735003?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/09fb7e921026438cb6a8f93630163930

المؤلفون: Harunobu Tahara, Kazuhiro Kobayashi, Yoshiyuki Kagawa

المصدر: Journal of pharmaceutical and biomedical analysis. 186

مصطلحات موضوعية: Bioanalysis, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Antigen-Antibody Complex, Monoclonal antibody, Humanized antibody, 01 natural sciences, Antibodies, Analytical Chemistry, Mice, Pharmacokinetics, Liquid chromatography–mass spectrometry, In vivo, Tandem Mass Spectrometry, Drug Discovery, medicine, Animals, Humans, Spectroscopy, Chromatography, biology, 010405 organic chemistry, Chemistry, 010401 analytical chemistry, Native Polyacrylamide Gel Electrophoresis, Antibodies, Monoclonal, Haplorhini, 0104 chemical sciences, Immunoglobulin G, biology.protein, Female, Antibody, Peptides, Chromatography, Liquid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5517fc7b892e1e93b964d3443f3403
https://pubmed.ncbi.nlm.nih.gov/32371323

المؤلفون: Maki Hasegawa, Harunobu Tahara, Miwa Watanabe

المصدر: Biopharmaceuticsdrug disposition. 40(2)

مصطلحات موضوعية: Male, Triazolam, Hydrocortisone, CYP3A, Urinary system, Midazolam, Pharmaceutical Science, Endogeny, Pharmacology, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, Oral administration, medicine, Animals, Cytochrome P-450 CYP3A, Pharmacology (medical), Drug Interactions, Alprazolam, Dose-Response Relationship, Drug, business.industry, Cytochrome P-450 CYP3A Inducers, General Medicine, Hydroxycholesterols, Macaca fascicularis, 030220 oncology & carcinogenesis, Area Under Curve, sense organs, Rifampin, business, Rifampicin, Biomarkers, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407e8aa9584a6e01d2586116bcc4ce83
https://pubmed.ncbi.nlm.nih.gov/30724384

المؤلفون: Sook Wah Yee, Stephanie Hesselson, Susan J. Johns, Pui-Yan Kwok, Richard A. Castro, Harunobu Tahara, Doug Stryke, Thomas E. Ferrin, Michiko Kawamoto, Thomas J. Urban, Kathleen M. Giacomini

المصدر: Journal of Pharmacology and Experimental Therapeutics. 329:262-271

مصطلحات موضوعية: Organic Cation Transport Proteins, Biology, SLC22A5, Polymorphism, Single Nucleotide, Metabolism, Transport, and Pharmacogenomics, Carnitine, Cell Line, Tumor, Genetic variation, Gene expression, Ethnicity, medicine, Humans, SNP, Tissue Distribution, RNA, Messenger, Cloning, Molecular, Luciferases, Promoter Regions, Genetic, Solute Carrier Family 22 Member 5, Allele frequency, Cells, Cultured, Pharmacology, Genetics, Symporters, Haplotype, Genetic Variation, Transporter, Molecular biology, Haplotypes, biology.protein, Molecular Medicine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb9f6632c4bb1cf4784b8561f867b39
https://doi.org/10.1124/jpet.108.146449

المؤلفون: Sreenath V. Sharma, Junichi Kurebayashi, Shiro Akinaga, Yoji Ikuina, Leonard M. Neckers, Tatsuya Tamaoki, Yukimasa Shiotsu, Chikara Murakata, Harunobu Tahara, Theodor W. Schulte, Shiro Soga, Makiko Shimizu, Kazuo Yamaguchi

المصدر: Cancer Chemotherapy and Pharmacology. 48:435-445

مصطلحات موضوعية: Cancer Research, Mice, Nude, Apoptosis, Breast Neoplasms, Toxicology, Lactones, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Oximes, Tumor Cells, Cultured, polycyclic compounds, Animals, Humans, Pharmacology (medical), HSP90 Heat-Shock Proteins, Enzyme Inhibitors, Pharmacology, Mice, Inbred BALB C, biology, Ansamycin, Stereoisomerism, Biological activity, Genes, erbB-2, Geldanamycin, Hsp90, In vitro, Radicicol, Gene Expression Regulation, Oncology, chemistry, Biochemistry, Herbimycin, Injections, Intravenous, biology.protein, Cancer research, Female, Macrolides

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83cd4cf140fc0b917ce62e04cf32c49
https://doi.org/10.1007/s002800100373

المؤلفون: Youcai Zhang, Chaline Brown, Sophie L. Stocker, Anh Nguyet Nguyen, Richard A. Castro, Claire M. Brett, Cheryl D. Cropp, Ji Ha Choi, Yong Huang, Harunobu Tahara, Radojka M. Savic, Sook Wah Yee, Diment Singh, Kathleen M. Giacomini

المصدر: Journal of pharmaceutical sciences, vol 102, iss 9

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, pharmacogenomic, Kidney Disease, Cefotaxime, Organic anion transporter 1, Adolescent, cefotaxime, organic anion transporter, Organic Anion Transporters, Pharmaceutical Science, Pharmacology, Organic Anion Transporters, Sodium-Independent, OAT3, Kidney, Article, Young Adult, Genetic, Pharmacokinetics, Asian People, Gene Frequency, Clinical Research, In vivo, Internal medicine, medicine, Humans, Pharmacology & Pharmacy, Polymorphism, Allele frequency, Sodium-Independent, Polymorphism, Genetic, biology, renal clearance, Kidney metabolism, Pharmacology and Pharmaceutical Sciences, tubular secretion, Anti-Bacterial Agents, medicine.anatomical_structure, Endocrinology, HEK293 Cells, Renal physiology, biology.protein, Female, polymorphisms, pharmacokinetics, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d262ac1a5867ee94b526d08216e6838f
https://pubmed.ncbi.nlm.nih.gov/23649425

المؤلفون: Makoto Kiso, Guiyun Xu, Akira Hasegawa, Yasuo Suzuki, Takashi Suzuki, Harunobu Tahara

المصدر: The Journal of Biochemistry. 115:202-207

مصطلحات موضوعية: Ganglioside, biology, Ligand binding assay, Hemagglutinin (influenza), Alpha (ethology), General Medicine, Biochemistry, H5N1 genetic structure, Virology, Virus, biology.protein, lipids (amino acids, peptides, and proteins), Hemoglobin, Receptor, Molecular Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::77b08ede0e1f35ff4924db7381211a69
https://doi.org/10.1093/oxfordjournals.jbchem.a124318

المؤلفون: Harunobu Tahara, Ryo Inoue, Masakazu Kakuni, Chise Tateno, Maki Hasegawa, Junko Ushiki

المصدر: Drug metabolism and disposition: the biological fate of chemicals. 40(3)

مصطلحات موضوعية: Male, Receptors, Steroid, Pharmaceutical Science, Pharmacology, Mice, Cytochrome P-450 Enzyme System, In vivo, Animals, Cytochrome P-450 CYP3A, Humans, Drug Interactions, RNA, Messenger, CYP2C8, Receptor, CYP2C9, Biotransformation, Pregnane X receptor, CYP3A4, biology, Pioglitazone, Chimera, Pregnane X Receptor, Cytochrome P450, Biological Transport, Triazolam, In vitro, Liver, Inactivation, Metabolic, Models, Animal, biology.protein, Microsomes, Liver, Mephenytoin, Thiazolidinediones, Warfarin, Rifampin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4a86e5721e95835043ae001e16f555
https://pubmed.ncbi.nlm.nih.gov/22126990

المؤلفون: Nico Scheer, Maki Hasegawa, Dongtao N. Lee, Harunobu Tahara, C. Roland Wolf, Sylvia Krueger, Yury Kapelyukh, Jost Seibler, Anja Rode

المصدر: Molecular pharmacology. 80(3)

مصطلحات موضوعية: Pharmacology, Pregnane X receptor, Receptors, Steroid, CYP3A4, CYP3A, Pregnane X Receptor, Cytochrome P450, Mice, Transgenic, Biology, Cell biology, Mice, Inbred C57BL, Mice, Humanized mouse, Constitutive androstane receptor, biology.protein, Molecular Medicine, Animals, Cytochrome P-450 CYP3A, Humans, Drug Interactions, Receptor, CYP3A7

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f5a01280f897381f8368663dd31011
https://pubmed.ncbi.nlm.nih.gov/21628639

المؤلفون: Yuya Kobayashi, Benjamin Ma, Deanna L. Kroetz, Maarke J.E. Roelofs, Sook Wah Yee, Ji Ha Choi, Stephanie Hesselson, Ligong Chen, Connie Ha, Hisayo Fukushima, Pui-Yan Kwok, Harunobu Tahara, Kathleen M. Giacomini, Pär Matsson, Richard M. Myers, Nicolas Picard, James E. Shima, Doug Stryke, Susan J. Johns, Elin Sjödin, Annie Poon, Jason M. Gow, Richard A. Castro, Thomas E. Ferrin

المساهمون: Zanger, Ulrich

المصدر: PloS one, vol 4, iss 9
PLoS ONE, Vol 4, Iss 9, p e6942 (2009)
PLoS ONE

مصطلحات موضوعية: Adult, Male, Adolescent, General Science & Technology, Genetics and Genomics/Pharmacogenomics, lcsh:Medicine, ATP-binding cassette transporter, Single-nucleotide polymorphism, Biology, Kidney, 030226 pharmacology & pharmacy, Nucleotide diversity, Promoter Regions, 03 medical and health sciences, 0302 clinical medicine, Gene Frequency, Genetic, Genetics and Genomics/Population Genetics, Genetics, Humans, Polymorphism, Promoter Regions, Genetic, lcsh:Science, Gene, 030304 developmental biology, 0303 health sciences, Multidisciplinary, Polymorphism, Genetic, lcsh:R, Cell Membrane, Kidney metabolism, Genetic Variation, Promoter, Solute carrier family, Pharmacology/Adverse Reactions, Liver, Gene Expression Regulation, Multigene Family, lcsh:Q, ATP-Binding Cassette Transporters, Female, Efflux, Pharmacology/Personalized Medicine, Carrier Proteins, Research Article

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d723da0a968f5281896b4ddea40a7a
https://escholarship.org/uc/item/1m1186zr