-
1
المؤلفون: Yasunobu Endou, Shota Murata, Kenichi Shizuno, Yoko Akiba, Hiroshi Takahashi, Yoshihito Otsuka, Hideyuki Maruyama, Sachiko Suzuki, Harushige Kanno, Tomomichi Kurosaki
المصدر: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases. 89(4)
مصطلحات موضوعية: Serotype, Adult, Pneumococcal disease, business.industry, Antimicrobial susceptibility, General Medicine, bacterial infections and mycoses, medicine.disease_cause, Serogroup, Virology, Pneumococcal conjugate vaccine, Microbiology, Vaccination, Pneumococcal Vaccines, Streptococcus pneumoniae, Japan, Levofloxacin, medicine, Humans, business, Child, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::722c136fb96c5027b2b79273a6eaa6f3
https://pubmed.ncbi.nlm.nih.gov/26554218 -
2
المؤلفون: Keizo, Yamaguchi, Yoshikazu, Ishii, Kazuhiro, Tateda, Morihiro, Iwata, Naoki, Watanabe, Masaaki, Shinagawa, Hiroyuki, Kayaba, Masahiko, Kimura, Akira, Suwabe, Mitsuo, Kaku, Yuko, Abe, Keiji, Kanemitsu, Nobuyuki, Taniguchi, Masami, Murakami, Shigefumi, Maesaki, Toru, Kawamura, Fumio, Nomura, Masaharu, Watanabe, Harushige, Kanno, Hajime, Horiuchi, Yoko, Tazawa, Shigemi, Kondo, Shigeki, Misawa, Hiromu, Takemura, Hideki, Nakashima, Takayuki, Matsuto, Yoshinori, Fujimoto, Shiomi, Ishigo, Hirokazu, Gotoh, Osamu, Watanabe, Tetsuya, Yagi, Nami, Shimaoka, Hiroshige, Mikamo, Yuka, Yamagishi, Naohisa, Fujita, Toshiaki, Komori, Satoshi, Ichiyama, Seiji, Kawano, Akifumi, Nakayama, Fumihiko, Nakamura, Hisashi, Kohno, Saori, Fukuda, Nobuchika, Kusano, Motoko, Nose, Michiya, Yokozaki, Makoto, Onodera, Koji, Murao, Kiyoshi, Negayama, Tatsuya, Nishimiya, Hitoshi, Miyamoto, Akira, Matsunaga, Hisae, Yoshimura, Shigeru, Kohno, Katsunori, Yanagihara, Kazufumi, Hiramatsu
المصدر: The Japanese journal of antibiotics. 67(2)
مصطلحات موضوعية: Bacteria, Drug Resistance, Bacterial, Humans, Thienamycins, Meropenem, Microbial Sensitivity Tests, Anti-Bacterial Agents
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::dc6535ecadcd25065198c75aad42055b
https://pubmed.ncbi.nlm.nih.gov/24956909 -
3
المؤلفون: Takeo Toyoda, Shimeru Kamihira, Kazumi Nishino, Teruo Aoyagi, Yoshiaki Kawamura, Toshiharu Matsushima, Hironobu Koga, Takayuki Ezaki, Yoichi Hirakata, Mitsuhiko Osumi, Hiroshi Yonemitsu, Kazunori Tomono, Harushige Kanno, Kazuyuki Sugawara, Shigeru Kohno, Kazuo Nohda, Naoyuki Miyashita, Soichiro Yokota, Masaharu Watanabe
المصدر: Journal of the Japanese Association for Infectious Diseases. 71:1246-1251
مصطلحات موضوعية: Adult, DNA, Bacterial, Male, Tuberculosis, Adolescent, urologic and male genital diseases, Mycobacterium tuberculosis, medicine, Humans, Ligase chain reaction, Aged, Aged, 80 and over, chemistry.chemical_classification, DNA ligase, biology, Chemistry, General Medicine, Nucleic acid amplification technique, Middle Aged, bacterial infections and mycoses, biology.organism_classification, medicine.disease, Molecular biology, female genital diseases and pregnancy complications, Mycobacterium tuberculosis complex, Reagent, embryonic structures, Nucleic acid, Female, Indicators and Reagents, Nucleic Acid Amplification Techniques, human activities
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a1d39b3ef9f165417783587a2b9c48
https://doi.org/10.11150/kansenshogakuzasshi1970.71.1246 -
4
المؤلفون: Keizo, Yamaguchi, Yoshikazu, Ishii, Morihiro, Iwata, Naoki, Watanabe, Masaaki, Shinagawa, Minoru, Yasujima, Akira, Suwabe, Makiko, Kuroda, Mitsuo, Kaku, Miho, Kitagawa, Keiji, Kanemitsu, Yuji, Imafuku, Masami, Murakami, Sachie, Yomodu, Nobuyuki, Taniguchi, Toshiyuki, Yamada, Fumio, Nomura, Harushige, Kanno, Shiegefumi, Maesaki, Giichi, Hashikita, Shigemi, Kondo, Shigeki, Misawa, Hajime, Horiuchi, Yoko, Tazawa, Hideki, Nakashima, Hiromu, Takemura, Masahiko, Okada, Yoshinori, Horikawa, Masato, Maekawa, Osanori, Nagura, Tetsuya, Yagi, Hisashi, Baba, Shiomi, Ishigo, Naohisa, Fujita, Toshiaki, Komori, Satoshi, Ichiyama, Kiyoharu, Yamanaka, Yoko, Murata, Shuji, Matsuo, Hisashi, Kohno, Seiji, Kawano, Shohiro, Kinoshita, Tomohiko, Taminato, Kiyoshi, Negayama, Mitsuharu, Murase, Hitoshi, Miyamoto, Nobuchika, Kusano, Motoko, Nose, Michiya, Yokozaki, Hideyuki, Itaha, Akira, Matsunaga, Hisae, Yoshimura, Shigeru, Kohno, Katsunori, Yanagihara, Junichi, Matsuda, Tetsunori, Saikawa, Kazufumi, Hiramatsu
المصدر: The Japanese journal of antibiotics. 64(2)
مصطلحات موضوعية: Adult, Aged, 80 and over, Dosage Forms, Time Factors, Adolescent, Respiratory System, Infant, Newborn, Infant, Bacterial Infections, Meropenem, Middle Aged, Urine, Gram-Positive Bacteria, Anti-Bacterial Agents, Bacteria, Anaerobic, Young Adult, Japan, Child, Preschool, Drug Resistance, Bacterial, Gram-Negative Bacteria, Humans, Thienamycins, Child, Aged
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::08920b540684369034db80657c70a18d
https://pubmed.ncbi.nlm.nih.gov/21721247 -
5
المؤلفون: Keizo, Yamaguchi, Akira, Ohno, Yoshikazu, Ishii, Kazuhiro, Tateda, Morihiro, Iwata, Makoto, Kanda, Kouji, Akizawa, Chikara, Shimizu, Shinichirou, Kon, Kastushi, Nakamura, Keiko, Matsuda, Makoto, Tominaga, Takuo, Nakagawa, Akihiro, Sugita, Tatsumi, Ito, Jun, Kato, Akira, Suwabe, Kumiko, Yamahata, Chizuko, Kawamura, Hiromi, Tashiro, Hiroko, Horiuchi, Yosei, Katayama, Shigemi, Kondou, Shigeki, Misawa, Misturu, Murata, Yoshio, Kobayashi, Hideyuki, Okamoto, Kenichiro, Yamazaki, Motoi, Okada, Kosuke, Haruki, Harushige, Kanno, Masanori, Aihara, Shigefumi, Maesaki, Giichi, Hashikita, Eiji, Miyajima, Midori, Sumitomo, Takefumi, Saito, Nobuo, Yamane, Chieko, Kawashima, Takahisa, Akiyama, Tamio, Ieiri, Yoshitaka, Yamamoto, Yuki, Okamoto, Hidetoshi, Okabe, Kunihiko, Moro, Masayo, Shigeta, Haruyoshi, Yoshida, Masanobu, Yamashita, Yukio, Hida, Takayuki, Takubo, Tadashi, Kusakabe, Hiroya, Masaki, Hitoshi, Heijyou, Hideo, Nakaya, Kunimitsu, Kawahara, Reiko, Sano, Syuji, Matsuo, Hisashi, Kono, Yosuke, Yuzuki, Norio, Ikeda, Masayo, Idomuki, Masayuki, Soma, Go, Yamamoto, Syohiro, Kinoshita, Seiji, Kawano, Mikio, Oka, Nobuchika, Kusano, Dongchon, Kang, Junko, Ono, Minoru, Yasujima, Makoto, Miki, Masato, Hayashi, Syunji, Okubo, Syunkou, Toyoshima, Mitsuo, Kaku, Imao, Sekine, Joji, Shiotani, Hajime, Horiuchi, Yoko, Tazawa, Akiko, Yoneyama, Kazunari, Kumasaka, Kazuhiko, Koike, Nobuyuki, Taniguchi, Yukio, Ozaki, Takashi, Uchida, Masami, Murakami, Kazuhisa, Inuzuka, Hideo, Gonda, Ikuo, Yamaguchi, Yoshinori, fujimoto, Junji, Iriyama, Yuko, Asano, Hitoshi, Genma, Masato, Maekawa, Hitoshi, Yoshimura, Kaname, Nakatani, Hisashi, Baba, Satoshi, Ichiyama, Shinichi, Fujita, Masao, Kuwabara, Toshiro, Okazaki, Hiromitsu, Fujiwara, Hiromi, Ota, Astushi, Nagai, Jun, Fujita, Kiyoshi, Negayama, Tetsuro, Sugiura, Mikio, Kamioka, Mitsuharu, Murase, Nobuhisa, Yamane, Isamu, Nakasone, Akihiko, Okayama, Yosuke, Aoki, Koji, Kusaba, Yukari, Nakashima, Hiroaki, Miyanohara, Kazufumi, Hiramatsu, Tetsunori, Saikawa, Katsunori, Yanagihara, Junichi, Matsuda, Shigeru, Kohno, Koichi, Mashiba
المصدر: The Japanese journal of antibiotics. 62(4)
مصطلحات موضوعية: Ofloxacin, Time Factors, Bacteria, Japan, Gastrointestinal Diseases, Drug Resistance, Multiple, Bacterial, Drug Resistance, Bacterial, Urinary Tract Infections, Humans, Levofloxacin, Respiratory Tract Infections, Anti-Bacterial Agents
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::4da830b5b78d340116fa42826a6ec4d4
https://pubmed.ncbi.nlm.nih.gov/19860322 -
6
المؤلفون: Keizo, Yamaguchi, Yoshikazu, Ishii, Morihiro, Iwata, Naoki, Watanabe, Nobuyuki, Uehara, Minoru, Yasujima, Takeshi, Kasai, Akira, Suwabe, Kumiko, Yamahata, Mitsuo, Kaku, Keiji, Kanemitsu, Yuji, Imafuku, Kyouko, Nishiyama, Masami, Murakami, Sachie, Yomoda, Nobuyuki, Taniguchi, Toshiyuki, Yamada, Fumio, Nomura, Masaharu, Watanabe, Harushige, Kanno, Masanori, Aihara, Shigefumi, Maesaki, Giichi, Hashikita, Shigemi, Kondo, Shigeki, Misawa, Hajime, Horiuchi, Yoko, Tazawa, Hideki, Nakashima, Hiromu, Takemura, Masahiko, Okada, Fusako, Yamazaki, Toshinobu, Horii, Masato, Maekawa, Hisashi, Baba, Shiomi, Ishigo, Naohisa, Fujita, Toshiaki, Komori, Satoshi, Ichiyama, Yoshitsugu, Iinuma, Shigetaka, Maeda, Kiyoharu, Yamanaka, Yoko, Murata, Shuji, Matsuo, Hisashi, Kohno, Shohiro, Kinoshita, Jun, Fujita, Kiyoshi, Negayama, Mitsuharu, Murase, Hitoshi, Miyamoto, Nobuchika, Kusano, Eiichirou, Mihara, Hideyuki, Itaha, Junko, Ono, Hisae, Yoshimura, Katsunori, Yanagihara, Junichi, Matsuda, Tetsunori, Saikawa, Kazufumi, Hiramatsu
المصدر: The Japanese journal of antibiotics. 60(6)
مصطلحات موضوعية: Time Factors, Japan, Drug Resistance, Bacterial, Gram-Negative Bacteria, Injections, Intravenous, Humans, Thienamycins, Meropenem, Gram-Negative Bacterial Infections, Gram-Positive Bacteria, Gram-Positive Bacterial Infections, beta-Lactamases, Anti-Bacterial Agents
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::a942ccea2fa6b984e8ba58c1f8bc1ab0
https://pubmed.ncbi.nlm.nih.gov/18447206 -
7
المؤلفون: Keizo, Yamaguchi, Akira, Ohno, Yoshikazu, Ishii, Kazuhiro, Tateda, Morihiro, Iwata, Makoto, Kanda, Yoshiko, Tsujio, Hiroya, Kimoto, Mitsuomi, Kaimori, Toshihiko, Nakamura, Chizuko, Kawamura, Masaharu, Nishimura, Koji, Akizawa, Yosei, Katayama, Keiko, Matsuda, Tasuku, Hayashi, Minoru, Yasujima, Takeshi, Kasai, Masahiko, Kimura, Makoto, Tominaga, Makoto, Miki, Susumu, Nakanowatari, Takuo, Nakagawa, Mitsuo, Kaku, Keiji, Kanemitsu, Hiroyuki, Kunishima, Shunkoh, Toyoshima, Masanori, Sakurai, Joji, Shiotani, Akihiro, Sugita, Tatsumi, Ito, Jun, Okada, Akira, Suwabe, Kumiko, Yamahata, Akiko, Yoneyama, Kazunari, Kumasaka, Nobuo, Yamane, Kazuhiko, Koike, Tamio, Ieiri, Hidenori, Kominami, Toshiyuki, Yamada, Toyoko, Oguri, Kouichi, Itoh, Kiyoaki, Watanabe, Yoshio, Kobayashi, Teruko, Ohtake, Takashi, Uchida, Kyoichi, Totsuka, Masami, Murakami, Sachie, Yomoda, Ayako, Takahashi, Hideyuki, Okamoto, Kazuhisa, Inuzuka, Kenichiro, Yamazaki, Hideo, Gonda, Takanori, Yamashita, Ikuo, Yamaguchi, Motoi, Okada, Hiromi, Ikari, Naomi, Kurosawa, Yoshinori, Fujimoto, Shiomi, Ishigo, Yuko, Asano, Mori, Mikio, Ichino, Kano, Eiko, Nagano, Fumio, Kageyama, Etsuko, Shaku, Harushige, Kanno, Masanori, Aihara, Hitoshi, Gemma, Keiichi, Uemura, Eiji, Miyajima, Shighefumi, Maesaki, Giichi, Hashikita, Toshinobu, Horii, Midori, Sumitomo, Hitoshi, Yoshimura, Minoru, Hiraoka, Hideo, Wada, Yosuke, Yuzuki, Norio, Ikeda, Hisashi, Baba, Masayuki, Soma, Tsuyoshi, Yamamoto, Satoshi, Ichiyama, Syohiro, Kinosita, Seiji, Kawano, Shinichi, Fujita, Takeshi, Kageoka, Toshiharu, Hongo, Hidetoshi, Okabe, Kenichi, Tatewaki, Kunihiko, Moro, Mikio, Oka, Yoshihito, Niki, Haruyoshi, Yoshida, Masanobu, Yamashita, Nobuchika, Kusano, Eiichiro, Mihara, Motoko, Nose, Takeshi, Fushiwaki, Masao, Kuwabara, Yoshihiro, Fujiue, Akira, Shimuzu, Takayuki, Takubo, Tadashi, Kusakabe, Yuji, Hinoda, Nobuaki, Tanaka, Hakuo, Takahashi, Hitoshi, Heijyou, Toshiro, Okazaki, Koji, Asai, Kunimitsu, Kawahara, Junichi, Masuda, Reiko, Sano, Tomohiko, Taminato, Kiyoshi, Negayama, Syuji, Matsuo, Masaru, Komatsu, Tetsuro, Sugiura, Mitsuharu, Murase, Kazufumi, Hiramatsu, Nobuhisa, Yamane, Isao, Nakasone, Yoichi, Hirakata, Shigeru, Kohno, Hisamichi, Aizawa, Junichi, Honda, Naotaka, Hamazaki, Akihiko, Okayama, Junko, Ono, Yosuke, Aoki, Kaoru, Okada, Hiroaki, Miyanohara
المصدر: The Japanese journal of antibiotics. 59(6)
مصطلحات موضوعية: Gram-Positive Cocci, Gram-Positive Rods, Time Factors, Japan, Gram-Negative Bacteria, Humans, Drug Resistance, Microbial, Bacterial Infections, Anti-Bacterial Agents, Fluoroquinolones
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::43bfe17d2302e66641bd17b7bc8825ef
https://pubmed.ncbi.nlm.nih.gov/17334061 -
8
المؤلفون: Keizo, Yamaguchi, Masami, Murakami, Ayako, Takahashi, Yoshikazu, Ishii, Morihiro, Iwata, Kouichi, Itoh, Tomoko, Oohara, Naoki, Watanabe, Nobuyuki, Uehara, Fumio, Nomura, Masaharu, Watanabe, Minoru, Yasujima, Takeshi, Kasai, Harushige, Kanno, Masanori, Aihara, Akira, Suwabe, Kumiko, Yamahata, Shigefumi, Maesaki, Giichi, Hashikita, Mitsuo, Kaku, Keiji, Kanemitsu, Kazunori, Miyake, Toyoko, Oguri, Hiroshi, Yoshida, Kyouko, Nishiyama, Jun, Okada, Yoko, Tazawa, Masaru, Komatsu, Hideki, Nakashima, Hiromu, Takemura, Shohiro, Kinoshita, Masahiko, Okada, Sugako, Kobayashi, Tomohiko, Taminato, Kiyoshi, Negayama, Toshinobu, Horii, Mitsuharu, Murase, Hitoshi, Miyamoto, Hisashi, Baba, Nobuchika, Kusano, Eiichiro, Mihara, Shiomi, Ishigo, Masayuki, Kambe, Hideyuki, Itaha, Naohisa, Fujita, Toshiaki, Komori, Junko, Ono, Hisae, Yoshimura, Satoshi, Ichiyama, Shigetaka, Maeda, Yoichi, Hirakata, Junichi, Matsuda, Kiyoharu, Yamanaka, Yoko, Mutara, Tetsunori, Saikawa, Kazufumi, Hiramatsu, Shohiro, Taminato
المصدر: The Japanese journal of antibiotics. 58(6)
مصطلحات موضوعية: Bacteria, Anaerobic, Anti-Infective Agents, Carbapenems, Drug Resistance, Multiple, Bacterial, Drug Resistance, Bacterial, Gram-Negative Bacteria, Injections, Intravenous, Thienamycins, Meropenem, Gram-Positive Bacteria
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::f4fa85370eb313c700c9413aeeac208a
https://pubmed.ncbi.nlm.nih.gov/16521347 -
9
المؤلفون: Keizo, Yamaguchi, Akira, Ohno, Fusako, Kashitani, Morihiro, Iwata, Makoto, Kanda, Yoshiko, Tsujio, Norihiko, Shimoyama, Hidetoshi, Okujima, Minoru, Ito, Hideaki, Kawaguchi, Hitoshi, Chiba, Koji, Akizawa, Yosei, Katayama, Kumiko, Sugimoto, Hiromi, Tashiro, Mitsuomi, Kaimori, Akira, Suwabe, Ritsuko, Obata, Tatsuro, Sugiyama, Shunkoh, Toyoshima, Jun, Kato, Mitsuo, Kaku, Keiji, Kanemitsu, Hiroyuki, Kunishima, Jun, Okada, Yoko, Tazawa, Jun, Igari, Toyoko, Oguri, Kiyoaki, Watanabe, Yoshio, Kobayashi, Hiroshi, Uchida, Kyoichi, Totsuka, Shinichiro, Kon, Katsuji, Nakamura, Keiko, Matsuda, Izumi, Hayashi, Joji, Shiotani, Harushige, Kanno, Akira, Itoh, Midori, Sumitomo, Takashi, Uchida, Atushi, Kawabata, Chikashi, Oiwa, Masamitsu, Iwata, Toshinobu, Horii, Shiomi, Ishigo, Taira, Yoshimura, Satoshi, Ichiyama, Yasunao, Wada, Satoshi, Kimura, Shigefumi, Maesaki, Kouichi, Itoh, Yasunobu, Noda, Takanori, Yamashita, Ikuo, Yamaguchi, Fumio, Kageyama, Etsuko, Shaku, Hisashi, Baba, Kazuhisa, Inuzuka, Hidetoshi, Okabe, Kenichi, Tatewaki, Kunihiko, Moro, Masanori, Aihara, Toshiharu, Matsushima, Yoshihito, Niki, Masao, Kuw Abara, Siro, Ikawa, Mobuaki, Tanaka, Yasuharu, Hinoda, Tetsuro, Sugiura, Mikio, Kamioka, Junko, Ono, Tohru, Takata, Hideichi, Makino, Mitsuharu, Murase, Hisashi, Miyamoto, Hisamichi, Aizawa, Junichi, Honda, Masahide, Takii, Zenzo, Nagasawa, Yosuke, Aoki, Naotaka, Hamazaki, Toshiharu, Tsutsui, Keiichi, Nakagawa, Kazufumi, Hiramatsu, Tetsunori, Saikawa, Nobuhisa, Yamane, Hiroya, Kimoto, Tomio, Kotani, Takeshi, Kageoka, Toshiharu, Hongo, Junichi, Masuda, Hiroaki, Miyanohara, Masayuki, Tsujimura, Minoru, Yasujima
المصدر: The Japanese journal of antibiotics. 58(1)
مصطلحات موضوعية: Ofloxacin, Staphylococcus aureus, Drug Resistance, Bacterial, Gram-Negative Bacteria, Escherichia coli, Humans, Methicillin Resistance, Levofloxacin, Microbial Sensitivity Tests, Gram-Positive Bacteria, Anti-Bacterial Agents
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::137cb80e92ae70ac685413d5d5b2f18c
https://pubmed.ncbi.nlm.nih.gov/15849869 -
10
المؤلفون: Keizo, Yamaguchi, Yoshikazu, Ishii, Morihiro, Iwata, Hiroshi, Yoshida, Toshio, Satoh, Naoki, Watanabe, Nobuyuki, Uehara, Masami, Murakami, Ayako, Takahashi, Minoru, Yasujima, Takeshi, Kasai, Kouichi, Itoh, Yasuhiro, Shibuya, Akira, Suwabe, Ritsuko, Obata, Harushige, Kanno, Setsuko, Kubo, Mitsuo, Kaku, Keiji, Kanemitsu, Shigefumi, Maesaki, Giichi, Hashikita, Jun, Igari, Toyoko, Oguri, Masanori, Aihara, Shohiro, Kinoshita, Jun, Okada, Yoko, Tazawa, Tomohiko, Taminato, Kiyoshi, Negayama, Hideki, Nakashima, Hiromu, Takemura, Mitsuharu, Murase, Hitoshi, Miyamoto, Toshinobu, Horii, Nobuchika, Kusano, Eiichirou, Mihara, Hisashi, Baba, Shiomi, Ishigo, Masayuki, Kambe, Hideyuki, Itaha, Naohisa, Fujita, Toshiaki, Komori, Junko, Ono, Hisae, Yoshimura, Satoshi, Ichiyama, Shigetaka, Maeda, Yoichi, Hirakata, Junichi, Matsuda, Kiyoharu, Yamanaka, Yoko, Murata, Tetsunori, Saikawa, Kazufumi, Hiramatsu
المصدر: The Japanese journal of antibiotics. 57(1)
مصطلحات موضوعية: Time Factors, Bacteria, Carbapenems, Japan, Drug Resistance, Bacterial, Product Surveillance, Postmarketing, Humans, Thienamycins, Bacterial Infections, Meropenem
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::d6127347148e0241c1d207c8c151c3ed
https://pubmed.ncbi.nlm.nih.gov/15116574