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المؤلفون: Zhang Y; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037 USA., Liu Z; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037 USA., Hirschi M; Medicine Design, Pfizer Research and Development, Pfizer Inc., La Jolla, CA 92121, USA., Brodsky O; Medicine Design, Pfizer Research and Development, Pfizer Inc., La Jolla, CA 92121, USA., Johnson E; Medicine Design, Pfizer Research and Development, Pfizer Inc., La Jolla, CA 92121, USA., Won SJ; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037 USA., Nagata A; Medicine Design, Pfizer Research and Development, Pfizer Inc., La Jolla, CA 92121, USA., Petroski MD; Oncology Research and Development, Pfizer Inc., La Jolla, CA 92121, USA., Majmudar JD; Discovery Sciences, Pfizer Research and Development, Pfizer Inc., Cambridge, MA 02139, USA., Niessen S; Oncology Research and Development, Pfizer Inc., La Jolla, CA 92121, USA.; Current address: Belharra Therapeutics, 3985 Sorrento Valley Blvd suite c, San Diego, CA 92121., VanArsdale T; Oncology Research and Development, Pfizer Inc., La Jolla, CA 92121, USA., Gilbert AM; Discovery Sciences, Pfizer Research and Development, Pfizer Inc., Groton, CT 06340, USA., Hayward MM; Discovery Sciences, Pfizer Research and Development, Pfizer Inc., Groton, CT 06340, USA.; Current address: Magnet Biomedicine, 321 Harrison Ave., Suite 600, Boston, MA 02118, USA., Stewart AE; Medicine Design, Pfizer Research and Development, Pfizer Inc., La Jolla, CA 92121, USA., Nager AR; Oncology Research and Development, Pfizer Inc., La Jolla, CA 92121, USA., Melillo B; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037 USA., Cravatt B; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037 USA.

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jan 19. Date of Electronic Publication: 2024 Jan 19.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Abbasov ME; Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA. mikail.abbasov@cornell.edu.; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA. mikail.abbasov@cornell.edu., Kavanagh ME; Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA., Ichu TA; Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA., Lazear MR; Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA., Tao Y; Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA., Crowley VM; Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA., Am Ende CW; Medicine Design, Pfizer Worldwide Research and Development, Groton, CT, USA., Hacker SM; Department of Chemistry, Technische Universität München, Garching, Germany., Ho J; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Dix MM; Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA., Suciu R; Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA., Hayward MM; Medicine Design, Pfizer Worldwide Research and Development, Groton, CT, USA., Kiessling LL; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Cravatt BF; Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA. cravatt@scripps.edu.

المصدر: Nature chemistry [Nat Chem] 2021 Nov; Vol. 13 (11), pp. 1081-1092. Date of Electronic Publication: 2021 Sep 09.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101499734 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1755-4349 (Electronic) Linking ISSN: 17554330 NLM ISO Abbreviation: Nat Chem Subsets: MEDLINE

مواضيع طبية MeSH: Lysine/*chemistry , Proteome/*chemistry, HEK293 Cells ; Humans ; Ligands ; Proteomics/methods ; Structure-Activity Relationship

المؤلفون: Abbasov ME; Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA. mikail.abbasov@cornell.edu.; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA. mikail.abbasov@cornell.edu., Kavanagh ME; Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA., Ichu TA; Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA., Lazear MR; Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA., Tao Y; Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA., Crowley VM; Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA., Am Ende CW; Medicine Design, Pfizer Worldwide Research and Development, Groton, CT, USA., Hacker SM; Department of Chemistry, Technische Universität München, Garching, Germany., Ho J; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Dix MM; Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA., Suciu R; Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA., Hayward MM; Medicine Design, Pfizer Worldwide Research and Development, Groton, CT, USA., Kiessling LL; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA., Cravatt BF; Department of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA. cravatt@scripps.edu.

المصدر: Nature chemistry [Nat Chem] 2021 Nov; Vol. 13 (11), pp. 1151.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101499734 Publication Model: Print Cited Medium: Internet ISSN: 1755-4349 (Electronic) Linking ISSN: 17554330 NLM ISO Abbreviation: Nat Chem Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Schiemer J; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT, USA., Horst R; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT, USA., Meng Y; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT, USA., Montgomery JI; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT, USA., Xu Y; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT, USA., Feng X; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT, USA., Borzilleri K; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT, USA., Uccello DP; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT, USA., Leverett C; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT, USA., Brown S; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT, USA., Che Y; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT, USA., Brown MF; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT, USA., Hayward MM; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT, USA., Gilbert AM; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT, USA., Noe MC; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT, USA., Calabrese MF; Discovery Sciences, Pfizer Worldwide Research and Development, Groton, CT, USA. matthew.calabrese@pfizer.com.

المصدر: Nature chemical biology [Nat Chem Biol] 2021 Feb; Vol. 17 (2), pp. 152-160. Date of Electronic Publication: 2020 Nov 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Agammaglobulinaemia Tyrosine Kinase/*genetics , Inhibitor of Apoptosis Proteins/*genetics, Chromatography, Gel ; Cross-Linking Reagents ; Humans ; Kinetics ; Models, Molecular ; Nuclear Magnetic Resonance, Biomolecular ; Protein Conformation ; Proteolysis ; Spectrometry, Mass, Electrospray Ionization ; Ubiquitin-Protein Ligases ; Ubiquitination ; X-Ray Diffraction

المؤلفون: Gerstenberger BS; Pfizer Inc., Cambridge, Massachusetts 02139, United States., Ambler C; Pfizer Inc., Groton, Connecticut 06340, United States., Arnold EP; Pfizer Inc., Groton, Connecticut 06340, United States., Banker ME; Pfizer Inc., Groton, Connecticut 06340, United States., Brown MF; Pfizer Inc., Groton, Connecticut 06340, United States., Clark JD; Pfizer Inc., Cambridge, Massachusetts 02139, United States., Dermenci A; Pfizer Inc., Groton, Connecticut 06340, United States., Dowty ME; Pfizer Inc., Cambridge, Massachusetts 02139, United States., Fensome A; Pfizer Inc., Cambridge, Massachusetts 02139, United States., Fish S; Pfizer Inc., Cambridge, Massachusetts 02139, United States., Hayward MM; Pfizer Inc., Groton, Connecticut 06340, United States., Hegen M; Pfizer Inc., Cambridge, Massachusetts 02139, United States., Hollingshead BD; Pfizer Inc., Cambridge, Massachusetts 02139, United States., Knafels JD; Pfizer Inc., Groton, Connecticut 06340, United States., Lin DW; Pfizer Inc., Groton, Connecticut 06340, United States., Lin TH; Pfizer Inc., Cambridge, Massachusetts 02139, United States., Owen DR; Pfizer Inc., Cambridge, Massachusetts 02139, United States., Saiah E; Pfizer Inc., Cambridge, Massachusetts 02139, United States., Sharma R; Pfizer Inc., Groton, Connecticut 06340, United States., Vajdos FF; Pfizer Inc., Groton, Connecticut 06340, United States., Xing L; Pfizer Inc., Cambridge, Massachusetts 02139, United States., Yang X; Pfizer Inc., Groton, Connecticut 06340, United States., Yang X; Pfizer Inc., Groton, Connecticut 06340, United States., Wright SW; Pfizer Inc., Groton, Connecticut 06340, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2020 Nov 25; Vol. 63 (22), pp. 13561-13577. Date of Electronic Publication: 2020 Aug 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Autoimmune Diseases/*enzymology , Drug Discovery/*methods , Protein Kinase Inhibitors/*chemistry , Protein Kinase Inhibitors/*pharmacology , TYK2 Kinase/*antagonists & inhibitors, Animals ; Autoimmune Diseases/drug therapy ; Humans ; Mice ; Mice, Transgenic ; Microsomes, Liver/drug effects ; Microsomes, Liver/enzymology ; Protein Kinase Inhibitors/therapeutic use ; Protein Structure, Secondary ; TYK2 Kinase/chemistry ; TYK2 Kinase/metabolism

المؤلفون: Fensome A; Medicine Design, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States., Ambler CM; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States., Arnold E; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States., Banker ME; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States., Brown MF; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States., Chrencik J; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States., Clark JD; Inflammation and Immunology, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States., Dowty ME; Medicine Design, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States., Efremov IV; Medicine Design, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States., Flick A; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States., Gerstenberger BS; Medicine Design, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States., Gopalsamy A; Medicine Design, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States., Hayward MM; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States., Hegen M; Inflammation and Immunology, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States., Hollingshead BD; Drug Safety Research and Development, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States., Jussif J; Inflammation and Immunology, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States., Knafels JD; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States., Limburg DC; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States., Lin D; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States., Lin TH; Inflammation and Immunology, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States., Pierce BS; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States., Saiah E; Medicine Design, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States., Sharma R; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States., Symanowicz PT; Inflammation and Immunology, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States., Telliez JB; Inflammation and Immunology, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States., Trujillo JI; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States., Vajdos FF; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States., Vincent F; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States., Wan ZK; Medicine Design, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States., Xing L; Medicine Design, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States., Yang X; Medicine Design, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States., Yang X; Medicine Design, Pfizer Inc., Eastern Point Road , Groton , Connecticut 06340 , United States., Zhang L; Medicine Design, Pfizer Inc., 1 Portland Street , Cambridge , Massachusetts 02139 , United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2018 Oct 11; Vol. 61 (19), pp. 8597-8612. Date of Electronic Publication: 2018 Aug 16.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antitubercular Agents/*pharmacology , Arthritis, Experimental/*prevention & control , Janus Kinase 1/*antagonists & inhibitors , Mycobacterium tuberculosis/*drug effects , Protein Kinase Inhibitors/*pharmacology , Pyrazoles/*pharmacology , Pyrimidines/*pharmacology , TYK2 Kinase/*antagonists & inhibitors , Tuberculosis/*complications, Animals ; Arthritis, Experimental/chemically induced ; Arthritis, Experimental/microbiology ; Female ; Molecular Structure ; Rats ; Rats, Inbred Lew ; Tuberculosis/microbiology