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المؤلفون: Veronica V. Rezelj, Audrey Fischer, Francesca Moretti, Romel Rosales, Olivier Schwartz, Jiankun Lyu, Francois Pognan, Andrew C. Kruse, Kris M. White, Marco Vignuzzi, Heiko Schadt, Ziyang Zhang, Henry R. O’Donnell, Michael Schotsaert, Kevan M. Shokat, Tia A. Tummino, Adolfo García-Sastre, Nevan J. Krogan, Jean-Rene Galarneau, Raveen Rathnasinghe, Blandine Monel, Benoit Fischer, Briana L. McGovern, Assaf Alon, Matthew J. O’Meara, Thomas Vallet, Brian K. Shoichet, Sonia Jangra, Laszlo Urban
المساهمون: University of California [San Francisco] (UC San Francisco), University of California (UC), Populations virales et Pathogenèse - Viral Populations and Pathogenesis, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Novartis Institutes for BioMedical Research (NIBR), University of Michigan [Ann Arbor], University of Michigan System, Virus et Immunité - Virus and immunity (CNRS-UMR3569), Icahn School of Medicine at Mount Sinai [New York] (MSSM), Harvard Medical School [Boston] (HMS), This work was supported by grants from the Defense Advanced Research Projects Agency (HR0011-19-2-0020 to B.K.S., N.J.K., A.G.-S., and K.M.S.), NIGMS R35GM122481 (to B.K.S.), National Institutes of Health (P50AI150476, U19AI135990, U19AI135972, R01AI143292, R01AI120694, P01AI063302, and R01AI122747 to N.J.K.), Excellence in Research Award (ERA) from the Laboratory for Genomics Research (LGR) (to N.J.K.), a collaboration between UCSF, UCB, and GSK (no. 133122P to N.J.K.), a Fast Grant for COVID-19 from the Emergent Ventures program at the Mercatus Center of George Mason University (to N.J.K.), funding from the Roddenberry Foundation (to N.J.K.), funding from F. Hoffmann–La Roche and Vir Biotechnology (to N.J.K.), gifts from QCRG philanthropic donors (to N.J.K.), funding from Institut Pasteur (to O.S. and M.V.), Urgence COVID-19 Fundraising Campaign of Institut Pasteur (to O.S. and M.V.), Labex IBEID (ANR-10-LABX-62-IBEID to O.S. and M.V.), ANR/FRM Flash Covid PROTEO-SARS-CoV-2 (to O.S.), IDISCOVR (to O.S.), National Institutes of Health (R01GM119185 to A.C.K.), partly supported by the Center for Research for Influenza Pathogenesis, a Center of Excellence for Influenza Research and Surveillance supported by the National Institute of Allergy and Infectious Diseases (contract no. HHSN272201400008C to A.G.-S.), a supplement to NIAID grant U19AI135972 and to DoD grant W81XWH-20-1-0270 (to A.G.-S.), a Fast Grant from the Mercatus Center (to A.G.-S.), the generous support of the JPB Foundation and the Open Philanthropy Project [research grant 2020-215611 (5384) to A.G.-S.], and anonymous donors (to A.G.-S.). Z.Z. is a Damon Runyon fellow supported by the Damon Runyon Cancer Research Foundation (DRG-2281-17)., We gratefully acknowledge the Région Ile-de-France (program DIM1Health) for the use of the Institut Pasteur imaging facility. We thank N. Aulner for assistance with image requisition and A. Danckaert for assistance with image analysis at Institut Pasteur, Paris. We thank R. Albrecht for support with the BSL3 facility and procedures at the Icahn School of Medicine at Mount Sinai, New York. We thank C. Hayden for the work with the transmission electron microscopy at Novartis. We thank T. R. O’Meara for reading the manuscript. We thank K. Obernier, M. Bouhaddou, and J. M. Fabius for contributions to the overall COVID-19 effort at QCRG., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-20-COVI-0059,PROTEO-SARS-CoV-2,Protéomique du SARS-CoV-2(2020)
المصدر: Science (New York, N.Y.)
Science (New York, N.Y.), vol 373, iss 6554
Science
Science, 2021, 373 (6554), pp.541-547. ⟨10.1126/science.abi4708⟩مصطلحات موضوعية: Drug, General Science & Technology, media_common.quotation_subject, Microbial Sensitivity Tests, Pharmacology, Lipidoses, Virus Replication, Amiodarone, Antiviral Agents, Article, Dose-Response Relationship, Mice, Surface-Active Agents, Cations, Chlorocebus aethiops, Animals, Humans, Medicine, Lung, Vero Cells, Phospholipids, Repurposing, media_common, Phospholipidosis, Multidisciplinary, Dose-Response Relationship, Drug, SARS-CoV-2, Drug discovery, business.industry, Drug Repositioning, COVID-19, Hydroxychloroquine, Molecular Pharmacology, COVID-19 Drug Treatment, Drug repositioning, Infectious Diseases, Good Health and Well Being, 5.1 Pharmaceuticals, A549 Cells, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Female, Development of treatments and therapeutic interventions, business, medicine.drug
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82c7138db547cd2c3c9cdbd9634a67d
https://doi.org/10.1126/science.abi4708 -
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المؤلفون: Christelle Stamm, Pierre Nimsgern, Thomas Knoepfel, Jasmin Wirth, Michel Niklaus, Diana Graus-Porta, Alberto Del Rio Espinola, Dario Sterker, Michael Kiffe, Nicolas Warin, Van Huy Luu, Mario Madoerin, Robert Mah, Jacqueline Kinyamu-Akunda, Robin Alec Fairhurst, Milen Todorov, Nicole Buschmann, Sebastien Ripoche, Nils Ostermann, Inga Galuba, Philippe Couttet, Catherine Leblanc, Alexandra Buhles, Jutta Blank, Flavia Adler, Wolfgang Jahnke, Chao Zou, Joerg Berghausen, Andreas Weiss, Pascal Furet, Heiko Schadt, Johannes Voshol, Markus Wartmann, Joerg Trappe
المصدر: Journal of Medicinal Chemistry. 63:12542-12573
مصطلحات موضوعية: Receptor complex, Pyridines, Sequence alignment, Molecular Dynamics Simulation, Piperazines, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Cell Line, Tumor, Drug Discovery, Animals, Structure–activity relationship, Receptor, Fibroblast Growth Factor, Type 4, Amino Acid Sequence, Cysteine, Kinase activity, Binding site, Protein Kinase Inhibitors, Cell Proliferation, Binding Sites, Liver Neoplasms, Hemithioacetal, Fibroblast growth factor receptor 4, Xenograft Model Antitumor Assays, Rats, chemistry, Biochemistry, Drug Design, Hepatocytes, Microsomes, Liver, Molecular Medicine, Half-Life
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المؤلفون: Francois Pognan, Laszlo Urban, Heiko Schadt, Veronica V. Rezelj, Adolfo Garcia-Sastre, Olivier Schwartz, Blandine Monel, Nevan J. Krogan, Audrey Fischer, Ziyang Zhang, Brian K. Shoichet, Assaf Alon, Matthew J. O’Meara, Benoit Fischer, Kevan M. Shokat, Tia A. Tummino, Kris M. White, Marco Vignuzzi, Francesca Moretti, Jiankun Lyu, Thomas Vallet, Henry R. O’Donnell, Andrew C. Kruse
المصدر: bioRxiv
article-version (status) pre
article-version (number) 1مصطلحات موضوعية: Phospholipidosis, Coronavirus disease 2019 (COVID-19), Drug discovery, business.industry, Mechanism (biology), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Medicine, Drug side effects, Pharmacology, business, Article, Repurposing, In vitro
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9022a1070b6eea488945070d6619e143
https://doi.org/10.1101/2021.03.23.436648 -
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المؤلفون: Armin Wolf, Andreas Weiss, Markus Wartmann, Pascal Furet, William R. Sellers, Alexandra Buhles, Patrizia Barzaghi-Rinaudo, Heiko Schadt, Catherine Leblanc, Robin Alec Fairhurst, Robert Mah, Mario Centeleghe, Jacqueline Kinyamu-Akunda, Philippe Couttet, Jutta Blank, Michael Kiffe, Nicole Buschmann, Dario Sterker, Audrey Kauffmann, Masato Murakami, Youzhen Wang, Diana Graus Porta, Flavia Adler, Thomas Knoepfel, Francesco Hofmann, Christelle Stamm
المصدر: Molecular cancer therapeutics. 18(12)
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Mice, Nude, 03 medical and health sciences, Mice, 0302 clinical medicine, medicine, Animals, Humans, Kinome, Receptor, Fibroblast Growth Factor, Type 4, Kinase activity, Receptor, Kinase, business.industry, Liver Neoplasms, FGF19, Fibroblast growth factor receptor 4, medicine.disease, Fibroblast Growth Factors, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Cancer research, Signal transduction, business, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ddb66996e7002e1cf057f14bbb2a55
https://pubmed.ncbi.nlm.nih.gov/31409633 -
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المؤلفون: Terrilyn A. Richardson, Chi-Hse Teng, Audrey Fischer, Marianne Schwald, William Kluwe, Joerg Andreas Mahl, Robin Alec Fairhurst, Luigi Manenti, Francois Pognan, Armin Wolf, Gerd A. Kullak-Ublick, Mathilde Lienard, Jacqueline Kinyamu-Akunda, Elizabeth Skuba, Salah-Dine Chibout, Andreas Weiss, Kuno Wuersch, Philippe Couttet, Heiko Schadt, Diana Graus Porta, Corinne Emotte
المساهمون: University of Zurich, Kinyamu-Akunda, Jacqueline
المصدر: Toxicological sciences : an official journal of the Society of Toxicology. 163(1)
مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, medicine.drug_class, Pyridines, Cholestyramine Resin, 610 Medicine & health, Toxicology, Cholesterol 7 alpha-hydroxylase, Piperazines, Bile Acids and Salts, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Dogs, Internal medicine, Toxicity Tests, medicine, Animals, Receptor, Fibroblast Growth Factor, Type 4, Protein Kinase Inhibitors, Cholestyramine, biology, Bile acid, Dose-Response Relationship, Drug, 3005 Toxicology, FGF19, Alanine Transaminase, Toxicokinetics, Dose–response relationship, 030104 developmental biology, Endocrinology, Alanine transaminase, chemistry, Liver, 10199 Clinic for Clinical Pharmacology and Toxicology, 030220 oncology & carcinogenesis, biology.protein, Female, Taurolithocholic acid, Taurodeoxycholic acid, medicine.drug
وصف الملف: Cholestyramine in dogs paper_v8_Nov22_gku.pdf - application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d746446e070550903c7f77a79f7ce1e
https://pubmed.ncbi.nlm.nih.gov/29432567 -
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المؤلفون: Hong Lu, James N. VerHoeve, Suzanne T. Wolford, Terrilyn A. Richardson, Ursula Junker Walker, Wei Zhou, Paul E. Miller, Mikhail Akimov, William Kluwe, Axel Vicart, Danielle Roman, Heiko Schadt, Oliver C. Turner
المصدر: Toxicology and applied pharmacology. 309
مصطلحات موضوعية: 0301 basic medicine, Pathology, medicine.medical_specialty, genetic structures, Cmax, Biology, Toxicology, Eye, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, Electroretinography, Animals, Rats, Wistar, Adverse effect, Pharmacology, medicine.diagnostic_test, Retinal, Isoxazoles, Resorcinols, Rats, 030104 developmental biology, Endocrinology, chemistry, RPE65, 030220 oncology & carcinogenesis, Serum iron, Histopathology, sense organs, Erg
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المؤلفون: Heiko Schadt, Salah-Dine Chibout, Michael Merz, Armin Wolf, Gerd A. Kullak-Ublick, Francois Pognan
المساهمون: University of Zurich, Kullak-Ublick, Gerd A
المصدر: Clinics and Research in Hepatology and Gastroenterology
مصطلحات موضوعية: 0301 basic medicine, medicine.drug_class, Context (language use), 610 Medicine & health, Cholestasis, Intrahepatic, Pharmacology, digestive system, Bile Acids and Salts, 03 medical and health sciences, Cholestasis, Enterohepatic Circulation, medicine, Homeostasis, Humans, 2715 Gastroenterology, Enterohepatic circulation, Liver injury, Hepatology, Bile acid, business.industry, Gastroenterology, Lipid metabolism, Biological Transport, medicine.disease, 3. Good health, Diarrhea, 030104 developmental biology, Biochemistry, 10199 Clinic for Clinical Pharmacology and Toxicology, 2721 Hepatology, Bile Ducts, medicine.symptom, Chemical and Drug Induced Liver Injury, business, Biomarkers
وصف الملف: Schadt et al_Clin Res Hepatol Gastroenterol_revised.pdf - application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf44f288c32bcad595dbf8d18198212
https://www.zora.uzh.ch/id/eprint/128518/ -
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المؤلفون: Heiko Schadt, Francois Pognan, Armin Wolf, Daniel P. Stiehl, Salah-Dine Chibout, Audrey Dietz, Carlos A. Penno, Catia Vicente Vieira, Pierre Moulin, Marianne Schwald
المصدر: Toxicology Letters. 229:S82
مصطلحات موضوعية: Chemistry, Cyclosporin a, General Medicine, Pharmacology, Toxicology, After treatment
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المؤلفون: Heiko, Schadt, Zuhal, Dincer, Marianne, Schwald, Audrey, Dietz, David, Ledieu, Andre, Cordier, Maria, Papoutsi, Ursula, Junker Walker, Fiona, Spence, Salah-Dine, Chibout, Armin, Wolf, Francois, Pognan
المصدر: In Toxicology Letters 28 August 2013 221 Supplement:S172-S172