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1
المؤلفون: Hejuan Cheng, Changjun Sun, Wenbao Li, Gang Li, Jianchun Zhao, Yanyan Chu, Zhenhua Tian, Yang-yang Chu
المصدر: Chemical Biology & Drug Design. 90:609-617
مصطلحات موضوعية: Niacinamide, 0301 basic medicine, Drug, Sorafenib, Indazoles, media_common.quotation_subject, Drug design, Antineoplastic Agents, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Neoplasms, Drug Discovery, medicine, Humans, Urea, IC50, Cell Proliferation, media_common, Pharmacology, Indazole, Improved solubility, Chemistry, Phenylurea Compounds, Organic Chemistry, HCT116 Cells, Combinatorial chemistry, Molecular Docking Simulation, Human colon cancer, Proto-Oncogene Proteins c-kit, 030104 developmental biology, Drug Design, 030220 oncology & carcinogenesis, Computer-Aided Design, Molecular Medicine, Drug Screening Assays, Antitumor, medicine.drug
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2
المؤلفون: Huashi Guan, Hejuan Cheng, Zhongpeng Ding, Wenbao Li, Wang Shixiao, Zhiyun Meng, Guifang Dou, Jianchun Zhao, Sun Tianwen
المصدر: Journal of Ocean University of China. 16:305-310
مصطلحات موضوعية: 0301 basic medicine, Chemistry, Ocean Engineering, Total body, Pharmacology, Oceanography, Combinatorial chemistry, In vitro, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Deuterium, Pharmacokinetics, In vivo, 030220 oncology & carcinogenesis, Blood circulation, Derivative (chemistry), Plinabulin
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3
المؤلفون: Mengyan Deng, Zhongpeng Ding, Wenbao Li, Feng Li, Hejuan Cheng, Hou Yingwei, Jianchun Zhao, Guifang Dou, Mingxu Ma
المصدر: Bioorganicmedicinal chemistry. 26(16)
مصطلحات موضوعية: 0301 basic medicine, Male, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Diketopiperazines, Pharmacology, Biochemistry, Excretion, 03 medical and health sciences, chemistry.chemical_compound, Inhibitory Concentration 50, Mice, 0302 clinical medicine, Gefitinib, Pharmacokinetics, Cytochrome P-450 Enzyme System, In vivo, Cell Line, Tumor, Neoplasms, Drug Discovery, medicine, Animals, Humans, Tissue Distribution, Rats, Wistar, Molecular Biology, Mice, Inbred BALB C, Chemistry, Organic Chemistry, Cancer, Blood Proteins, medicine.disease, Deuterium, In vitro, Rats, 030104 developmental biology, 030220 oncology & carcinogenesis, Pharmacodynamics, Microsomes, Liver, Molecular Medicine, Female, medicine.drug, Plinabulin, Half-Life, Protein Binding
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4Development of MBRI-001, a deuterium-substituted plinabulin derivative as a potent anti-cancer agent
المؤلفون: Wenbao Li, Hejuan Cheng, Huashi Guan, Jianchun Zhao, Wang Shixiao, Zhongpeng Ding, Hou Yingwei
المصدر: Bioorganicmedicinal chemistry letters. 27(6)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Isostere, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Diketopiperazines, Pharmacology, Biochemistry, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Pharmacokinetics, Drug Discovery, medicine, Animals, Humans, Molecular Biology, Chemistry, Organic Chemistry, Cancer, medicine.disease, Deuterium, Xenograft Model Antitumor Assays, Rats, 030104 developmental biology, Targeted drug delivery, Docetaxel, 030220 oncology & carcinogenesis, Area Under Curve, Toxicity, Cancer cell, Molecular Medicine, medicine.drug, Plinabulin