المؤلفون: Kapil Gadkar, Justin Feigelman, Siddharth Sukumaran, Manoj C. Rodrigo, Tracy Staton, Fang Cai, Rebecca N. Bauer, David F. Choy, Cynthia L. Stokes, Heleen Scheerens, Saroja Ramanujan

المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 9, Pp 1268-1277 (2022)

مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2163-8306

URL الوصول: https://doaj.org/article/d4c73fd7fc9c4dc591d8ab594626b323

المؤلفون: Steve Gallion, Jacob Z. Chen, Kropf Jeffrey E, Joseph W. Lubach, Pat Maciejewski, Heleen Scheerens, Seung H. Lee, Aaron C. Schmitt, Daniel F. Ortwine, Arna Katewa, Jin-Ming Xiong, Huiyong Hu, James J. Crawford, Wei Deng, Karin Reif, Zhongdong Zhao, Julie DiPaolo, Liming Dong, Kevin S. Currie, Fusheng Zhou, Peter Blomgren, Jonathon Hau, Charles Eigenbrot, Meire Bremer, Jen Macaluso, Adam R. Johnson, Scott A. Mitchell, Jianjun Xu, Lichuan Liu, James Barbosa, Wendy B. Young, Harvey Wong, Xiaojing Wang

المصدر: ACS Medicinal Chemistry Letters

مصطلحات موضوعية: 0301 basic medicine, Lupus, Arthritis, Pharmacology, Biochemistry, 03 medical and health sciences, Animal model, immune system diseases, hemic and lymphatic diseases, Drug Discovery, medicine, Bruton's tyrosine kinase, Rheumatoid arthritis, chemistry.chemical_classification, Kinase inhibitor, Systemic lupus erythematosus, G-744, biology, Organic Chemistry, medicine.disease, Featured Letter, 030104 developmental biology, chemistry, Btk, biology.protein, Tyrosine kinase, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc964ccce9164661bfc88c9b1de2df6f
https://doi.org/10.1021/acsmedchemlett.7b00103

المؤلفون: James J. Crawford, Joseph W. Lubach, Peter Blomgren, Pat Maciejewski, Steve Gallion, Jen Macaluso, Julie Di Paolo, Donna Dambach, Adam R. Johnson, Christine Yu, Xiaojing Wang, James Barbosa, Jin-Ming Xiong, Karin Reif, Zhongdong Zhao, Harvey Wong, Aaron C. Schmitt, Kevin S. Currie, Wendy B. Young, Kropf Jeffrey E, Scott A. Mitchell, Heleen Scheerens, Seung H. Lee, Charles Eigenbrot, Meire Bremer, Daniel F. Ortwine, Jianjun Xu, Lichuan Liu

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:575-579

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Pyrimidinones, Thiophenes, Cleavage (embryo), Biochemistry, Mice, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Amide, Drug Discovery, Agammaglobulinaemia Tyrosine Kinase, Animals, Humans, Transferase, Bruton's tyrosine kinase, Peptide bond, Protein Kinase Inhibitors, Molecular Biology, biology, Aryl, Organic Chemistry, Metabolism, Protein-Tyrosine Kinases, Rats, Pyridazines, 030104 developmental biology, chemistry, Microsomes, Liver, biology.protein, Molecular Medicine, Linker

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf6fb1bae7e3532455b3d6860ca9fdb
https://doi.org/10.1016/j.bmcl.2015.11.076

المؤلفون: Shweta G. Kotwal, Ashley M. Smith, John-Paul Oliveria, Gail M. Gauvreau, Heleen Scheerens, Jonathan MacLean, Brittany M. Salter, Jeffrey M. Harris, Roma Sehmi

المصدر: American Journal of Respiratory and Critical Care Medicine. 196:107-109

مصطلحات موضوعية: 0301 basic medicine, Pulmonary and Respiratory Medicine, Sputum Cytology, biology, business.industry, Critical Care and Intensive Care Medicine, Immunoglobulin E, medicine.disease, Palatine tonsil, Allergen challenge, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, 030228 respiratory system, BLOOD/BONE MARROW, Immunology, biology.protein, Medicine, Sputum, Bone marrow, medicine.symptom, business, Asthma

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::916464e32931f0cc70ad35010b310b60
https://doi.org/10.1164/rccm.201611-2274le

المؤلفون: Marcus Maurer, Petra Staubach, Christopher R. Cabanski, Colette Cochran, Heleen Scheerens, Divya Samineni, Mary S. Bradley, Martin Metz, Jeffrey M. Harris, Gordon Sussman

المصدر: Journal of Allergy and Clinical Immunology. 138:1730-1732

مصطلحات موضوعية: medicine.medical_specialty, business.industry, Immunology, Quilizumab, law.invention, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, Randomized controlled trial, Refractory, law, Internal medicine, Immunology and Allergy, Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f6106dc3a83cd35b33906476ba024eea
https://doi.org/10.1016/j.jaci.2016.06.023

المؤلفون: Jonathan Corren, Phillip E. Korenblat, Julie Olsson, Nicola A. Hanania, Dana McClintock, Romeo Maciuca, Wendy S. Putnam, Saloumeh K Fischer, Karl Yen, Elaine Murray, Ramona Doyle, Sarah Gray, Melissa Cheu, Heleen Scheerens, Michael Noonan, Yanan Zheng, Cecile T.J. Holweg, John G. Matthews

المصدر: Thorax

مصطلحات موضوعية: Adult, Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Time Factors, Adolescent, Injections, Subcutaneous, Cytokine Biology, Placebo, Severity of Illness Index, Lebrikizumab, Young Adult, Double-Blind Method, Forced Expiratory Volume, Internal medicine, Severity of illness, Clinical endpoint, Humans, Medicine, Dosing, Lung, Aged, Retrospective Studies, Asthma, Dose-Response Relationship, Drug, business.industry, Antibodies, Monoclonal, Retrospective cohort study, Middle Aged, medicine.disease, Surgery, Asthma Mechanisms, Treatment Outcome, Respiratory Research, Female, business, Follow-Up Studies, medicine.drug, Tralokinumab

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc4c3a4fdb859df3c351434b88b593a1
https://doi.org/10.1136/thoraxjnl-2014-206719

المؤلفون: Aaron C. Schmitt, Donna Dambach, Jen Macaluso, Kevin S. Currie, Xiaojing Wang, James Barbosa, Sarah G. Hymowitz, Kropf Jeffrey E, Steve Gallion, Peter Blomgren, Lichuan Liu, Scott A. Mitchell, Julie Di Paolo, Jin-Ming Xiong, Joseph W. Lubach, Pat Maciejewski, C. Gregory Sowell, Heleen Scheerens, Seung H. Lee, Karin Reif, Zhongdong Zhao, Wendy B. Young, Jianjun Xu, Harvey Wong, Brigitte Maurer, Daniel F. Ortwine, James J. Crawford, Meire Bremer

المصدر: Bioorganic & Medicinal Chemistry Letters. 25(6):1333-1337

مصطلحات موضوعية: Drug, media_common.quotation_subject, Clinical Biochemistry, Pharmaceutical Science, Pyrimidinones, Thiophenes, Molecular Dynamics Simulation, Pharmacology, Crystallography, X-Ray, Biochemistry, Mice, Structure-Activity Relationship, Dogs, Pharmacokinetics, Healthy volunteers, Drug Discovery, Agammaglobulinaemia Tyrosine Kinase, Animals, Humans, Moiety, Bruton's tyrosine kinase, Potency, Peptide bond, Protein Kinase Inhibitors, Molecular Biology, media_common, Binding Sites, biology, Chemistry, Organic Chemistry, Protein-Tyrosine Kinases, Bridged Bicyclo Compounds, Heterocyclic, In vitro, Protein Structure, Tertiary, Rats, Benzamides, Microsomes, Liver, biology.protein, Molecular Medicine, Half-Life, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c496f050f083aefc72670970299af579

المؤلفون: Claus Bachert, Heleen Scheerens, Jeffrey M. Harris, Gabriele Holtappels, Olga Li, Lee Honigberg, Ashley M. Smith

المصدر: The Journal of allergy and clinical immunology. 143(2)

مصطلحات موضوعية: Immunology, Receptors, Antigen, B-Cell, Polymerase Chain Reaction, Prime (order theory), Text mining, Nasal Polyps, Protein Domains, Paranasal Sinuses, Immunology and Allergy, Medicine, Humans, In patient, Nasal polyps, Sinusitis, Asthma, Rhinitis, B-Lymphocytes, business.industry, Membrane Proteins, Immunoglobulin E, medicine.disease, Immunoglobulin Class Switching, Elevated IgE, Chronic Disease, Disease Progression, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c18e231aaf37397903e1ed08b92a9c1
https://pubmed.ncbi.nlm.nih.gov/30359682

المؤلفون: John-Paul, Oliveria, Brittany M, Salter, Jonathan, MacLean, Shweta, Kotwal, Ashley, Smith, Jeffrey M, Harris, Heleen, Scheerens, Roma, Sehmi, Gail M, Gauvreau

المصدر: American journal of respiratory and critical care medicine. 196(1)

مصطلحات موضوعية: B-Lymphocytes, Palatine Tonsil, Sputum, Bone Marrow Cells, Allergens, Immunoglobulin E, Asthma, Bronchial Provocation Tests, Bronchoconstrictor Agents, Bone Marrow, Forced Expiratory Volume, Humans, Lymphocyte Count, Methacholine Chloride

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::ceb6f92ca09f067894c85564288c456b
https://pubmed.ncbi.nlm.nih.gov/28665197

المؤلفون: June H. Lee, David F. Choy, John G. Matthews, Wendy S. Putnam, Nizar N. Jarjour, Joseph R. Arron, Jeffrey M. Harris, Rich Erickson, Yanan Zheng, Heleen Scheerens

المصدر: Clinical and Experimental Allergy

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Immunology, Periostin, Immunoglobulin E, Placebo, Gastroenterology, Anti-asthmatic Agent, Lebrikizumab, Bronchial Provocation Tests, Young Adult, Th2 Cells, Forced Expiratory Volume, Internal medicine, lebrikizumab, Humans, Immunology and Allergy, Medicine, Anti-Asthmatic Agents, Lung, Asthma, Interleukin-13, biology, business.industry, Area under the curve, biomarkers, Antibodies, Monoclonal, Original Articles, allergen challenge, Middle Aged, asthma, Allergens, medicine.disease, Treatment Outcome, Interleukin 13, biology.protein, Th2 inflammation, Female, IL13, business, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b581f3741b1703714cf48da673177b3a
https://doi.org/10.1111/cea.12220