المؤلفون: Fraz A. Ismat, Helen H. Usansky, Raul Villa, Jun Zou, Ariel Teper

المصدر: Advances in Therapy.

مصطلحات موضوعية: Adult, Dose-Response Relationship, Drug, Hypertension, Pulmonary, Vasodilator Agents, Esters, General Medicine, Dizziness, Epoprostenol, Cough, Double-Blind Method, Delayed-Action Preparations, Humans, Prodrugs, Pharmacology (medical), Powders

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7538e7281b4b59aad4d2d9e3467b6b7c
https://doi.org/10.1007/s12325-022-02296-x

المؤلفون: Patrick J. Sinko, Helen H. Usansky, Peidi Hu

المصدر: Drug Metabolism and Disposition. 36:863-869

مصطلحات موضوعية: Male, Administration, Oral, Biological Availability, Pharmaceutical Science, Absorption (skin), Pharmacology, Biology, Intestinal absorption, Rats, Sprague-Dawley, Pharmacokinetics, Oral administration, medicine, Animals, Cytochrome P-450 CYP3A, Saquinavir, Multidrug resistance-associated protein 2, Area under the curve, HIV Protease Inhibitors, Multidrug Resistance-Associated Protein 2, Rats, Bioavailability, Intestinal Absorption, Multidrug Resistance-Associated Proteins, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7630e07100c7f2bb0d4beb231b0f8f12
https://doi.org/10.1124/dmd.107.017483

المؤلفون: Helen H. Usansky, Patrick J. Sinko

المصدر: Journal of Pharmacology and Experimental Therapeutics. 314:391-399

مصطلحات موضوعية: Drug, Cell Membrane Permeability, media_common.quotation_subject, Kinetics, Analytical chemistry, Biological Availability, Models, Biological, Pharmacokinetics, Predictive Value of Tests, Mass transfer, Humans, A value, Computer Simulation, Transcellular, media_common, Pharmacology, Models, Statistical, Dose-Response Relationship, Drug, Chemistry, In vitro, Permeability (earth sciences), Intestinal Absorption, Pharmaceutical Preparations, Molecular Medicine, Caco-2 Cells, Algorithms

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a1715f4f51355f6fb908dcd545f31e
https://doi.org/10.1124/jpet.104.076182

المؤلفون: Jeevan R. Kunta, Barbara A. Perry, Patrick J. Sinko, Helen H. Usansky

المصدر: Journal of Pharmacology and Experimental Therapeutics. 310:359-366

مصطلحات موضوعية: medicine.medical_specialty, CYP3A, Biology, Pharmacology, Intestinal absorption, First pass effect, Internal medicine, medicine, Animals, Secretion, ATP Binding Cassette Transporter, Subfamily B, Member 1, Saquinavir, HIV Protease Inhibitors, Metabolism, Small intestine, Bioavailability, Endocrinology, medicine.anatomical_structure, Liver, Molecular Medicine, Female, Rabbits, Digestive System, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bfbd4fef4b10ae1b13f7702fe2e8f56
https://doi.org/10.1124/jpet.103.064394

المؤلفون: Helen H. Usansky, Patrick J. Sinko

المصدر: Pharmaceutical Research. 20:390-396

مصطلحات موضوعية: Pharmacology, biology, Endothelium, Chemistry, Stereochemistry, Organic Chemistry, Pharmaceutical Science, Blood–brain barrier, In vitro, Endothelial stem cell, medicine.anatomical_structure, Permeability (electromagnetism), In vivo, cardiovascular system, biology.protein, medicine, Biophysics, Molecular Medicine, Pharmacology (medical), Microvessel, Biotechnology, P-glycoprotein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e3e38f3d3833ae75bba3d0ca162e9cb4
https://doi.org/10.1023/a:1022647903205

المؤلفون: Chalmers JD; Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK. jchalmers@dundee.ac.uk., Usansky H; Insmed Incorporated, Bridgewater, NJ, USA., Rubino CM; Institute for Clinical Pharmacodynamics, Inc, Schenectady, NY, USA., Teper A; Insmed Incorporated, Bridgewater, NJ, USA., Fernandez C; Insmed Incorporated, Bridgewater, NJ, USA., Zou J; Insmed Incorporated, Bridgewater, NJ, USA., Mange KC; Insmed Incorporated, Bridgewater, NJ, USA.

المصدر: Clinical pharmacokinetics [Clin Pharmacokinet] 2022 Oct; Vol. 61 (10), pp. 1457-1469. Date of Electronic Publication: 2022 Jul 25.

نوع المنشور: Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Country of Publication: Switzerland NLM ID: 7606849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1926 (Electronic) Linking ISSN: 03125963 NLM ISO Abbreviation: Clin Pharmacokinet Subsets: MEDLINE

مواضيع طبية MeSH: Bronchiectasis*/drug therapy , Cystic Fibrosis*, Adult ; Benzoxazoles ; Cathepsin G ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/therapeutic use ; Fibrosis ; Humans ; Leukocyte Elastase/therapeutic use ; Myeloblastin ; Oxazepines ; Serine Proteases/therapeutic use

المؤلفون: Usansky H; Insmed Incorporated, Bridgewater, New Jersey, USA., Yoon E; Adventist Health Glendale, USC Verdugo Hills Hospital, Glendale Memorial Hospital and Health Center, Glendale, California, USA., Teper A; Insmed Incorporated, Bridgewater, New Jersey, USA., Zou J; Insmed Incorporated, Bridgewater, New Jersey, USA., Fernandez C; Insmed Incorporated, Bridgewater, New Jersey, USA.

المصدر: Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2022 Jul; Vol. 11 (7), pp. 832-842. Date of Electronic Publication: 2022 Apr 11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101572899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2160-7648 (Electronic) Linking ISSN: 2160763X NLM ISO Abbreviation: Clin Pharmacol Drug Dev Subsets: MEDLINE

مواضيع طبية MeSH: Benzoxazoles*/administration & dosage , Benzoxazoles*/adverse effects , Benzoxazoles*/pharmacokinetics , Oxazepines*/administration & dosage , Oxazepines*/adverse effects , Oxazepines*/pharmacokinetics, Adult ; Asian People ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/antagonists & inhibitors ; Dose-Response Relationship, Drug ; Humans ; White People

المؤلفون: Smith RA; Asana BioSciences, Princeton Pike Corporate Center, Lawrenceville, New Jersey. roger.smith@asanabio.com., Zammit DJ; Asana BioSciences, Princeton Pike Corporate Center, Lawrenceville, New Jersey., Damle NK; Asana BioSciences, Princeton Pike Corporate Center, Lawrenceville, New Jersey., Usansky H; Asana BioSciences, Princeton Pike Corporate Center, Lawrenceville, New Jersey., Reddy SP; Asana BioSciences, Princeton Pike Corporate Center, Lawrenceville, New Jersey., Lin JH; Asana BioSciences, Princeton Pike Corporate Center, Lawrenceville, New Jersey., Mistry M; Asana BioSciences, Princeton Pike Corporate Center, Lawrenceville, New Jersey., Rao NS; Asana BioSciences, Princeton Pike Corporate Center, Lawrenceville, New Jersey., Denis LJ; Asana BioSciences, Princeton Pike Corporate Center, Lawrenceville, New Jersey., Gupta S; Asana BioSciences, Princeton Pike Corporate Center, Lawrenceville, New Jersey.

المصدر: Molecular cancer therapeutics [Mol Cancer Ther] 2021 Aug; Vol. 20 (8), pp. 1327-1337. Date of Electronic Publication: 2021 May 27.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal, Humanized/*chemistry , Antineoplastic Agents/*pharmacology , Breast Neoplasms/*drug therapy , Immunoconjugates/*pharmacology , Lung Neoplasms/*drug therapy , Membrane Glycoproteins/*antagonists & inhibitors , Single-Chain Antibodies/*chemistry, Animals ; Apoptosis ; Breast Neoplasms/immunology ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Proliferation ; Female ; Humans ; Lung Neoplasms/immunology ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Mice ; Mice, Nude ; Mice, SCID ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays

المؤلفون: Dellinger RP; Division of Critical Care Medicine, Department of Medicine, Cooper University Hospital, 1 Cooper Plaza, Camden, NJ 08103, USA. dellinger-phil@cooperhealth.edu., Trzeciak SW, Criner GJ, Zimmerman JL, Taylor RW, Usansky H, Young J, Goldstein B

المصدر: Critical care (London, England) [Crit Care] 2012 Dec 12; Vol. 16 (2), pp. R36. Date of Electronic Publication: 2012 Dec 12.

نوع المنشور: Journal Article; Multicenter Study; Randomized Controlled Trial

بيانات الدورية: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 9801902 Publication Model: Electronic Cited Medium: Internet ISSN: 1466-609X (Electronic) Linking ISSN: 13648535 NLM ISO Abbreviation: Crit Care Subsets: MEDLINE

مواضيع طبية MeSH: Nitric Oxide/*administration & dosage , Respiratory Distress Syndrome/*drug therapy, Administration, Inhalation ; Adult ; Area Under Curve ; Chi-Square Distribution ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged ; Placebos ; Prospective Studies ; Respiratory Distress Syndrome/mortality ; Respiratory Distress Syndrome/physiopathology ; Respiratory Function Tests ; Statistics, Nonparametric ; Treatment Outcome

المؤلفون: Toombs CF; Discovery Science, Ikaria, Seattle, WA 98102, USA., Insko MA, Wintner EA, Deckwerth TL, Usansky H, Jamil K, Goldstein B, Cooreman M, Szabo C

المصدر: British journal of clinical pharmacology [Br J Clin Pharmacol] 2010 Jun; Vol. 69 (6), pp. 626-36.

نوع المنشور: Journal Article; Randomized Controlled Trial

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print Cited Medium: Internet ISSN: 1365-2125 (Electronic) Linking ISSN: 03065251 NLM ISO Abbreviation: Br J Clin Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Hydrogen Sulfide/*analysis , Sulfides/*administration & dosage, Breath Tests/methods ; Chromatography, Ion Exchange ; Cohort Studies ; Exhalation ; Humans ; Infusions, Intravenous ; Smell ; Sulfides/blood ; Thiosulfates/blood