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المؤلفون: Jan Skácel, Stefan Djukic, Ondřej Baszczyňski, Filip Kalčic, Tadeáš Bílek, Karel Chalupský, Jaroslav Kozák, Alexandra Dvořáková, Eva Tloušt’ová, Zuzana Král’ová, Markéta Šmídková, Jan Voldřich, Michaela Rumlová, Petr Pachl, Jiří Brynda, Tereza Vučková, Milan Fábry, Jan Snášel, Iva Pichová, Pavlína Řezáčová, Helena Mertlíková-Kaiserová, Zlatko Janeba
المصدر: Journal of Medicinal Chemistry. 66:6652-6681
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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المؤلفون: Milan Vrabel, Veronika Šlachtová, Simona Bellová, Agustina La-Venia, Juraj Galeta, Martin Dračínský, Karel Chalupský, Helena Mertlíková-Kaiserová, Peter Rukovanský, Rastislav Dzijak
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3c1c48644cfc314998d73c80405b0695
https://doi.org/10.26434/chemrxiv-2023-75pjq -
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المؤلفون: Mbilo Misehe, Martin Klima, Marika Matoušová, Dominika Chalupská, Milan Dejmek, Michal Šála, Helena Mertlíková-Kaiserová, Evzen Boura, Radim Nencka
المصدر: Bioorganicmedicinal chemistry letters. 76
مصطلحات موضوعية: Adenine, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Ligands, Biochemistry, Molecular Docking Simulation, Structure-Activity Relationship, Adenosine Triphosphate, Drug Design, Drug Discovery, Molecular Medicine, Molecular Biology, 1-Phosphatidylinositol 4-Kinase
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المؤلفون: Jan Voldřich, Marika Matoušová, Markéta Šmídková, Barbora Slavíková, Hana Chodounská, Eva Kudová, Helena Mertlíková-Kaiserová
المصدر: European journal of pharmacology. 927
مصطلحات موضوعية: Pharmacology, Neurons, Animals, Glutamic Acid, Hippocampus, Receptors, N-Methyl-D-Aspartate, Cells, Cultured, Rats
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المؤلفون: Pavla Perlíková, Marian Hajduch, Blanka Klepetářová, Martina Medvedíková, Nemanja Milisavljevic, Helena Mertlíková-Kaiserová, Petr Džubák, Barbora Lišková, Jana Trylčová, Eva Tloušťová, Radek Pohl, Michal Tichý, Michal Hocek, Ondřej Hodek, Lucia Veselovská, Soňa Gurská, Natálie Kudlová
المصدر: Chemistry – A European Journal. 26:13002-13015
مصطلحات موضوعية: Glycosylation, Pyrimidine, 010405 organic chemistry, Stereochemistry, Organic Chemistry, Total synthesis, Antineoplastic Agents, General Chemistry, 010402 general chemistry, Antiviral Agents, 01 natural sciences, Catalysis, 0104 chemical sciences, Structure-Activity Relationship, chemistry.chemical_compound, chemistry, Nucleophile, Purines, Pyridine, Ribonucleosides, Derivatization, Selectivity, DNA
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المؤلفون: Martin Dračínský, Michala Zgarbová, Filip Kalčic, Helena Mertlíková-Kaiserová, Karel Chalupský, Alexandra Dvořáková, Jan Hodek, Timotej Strmeň, Jaroslav Šebestík, Jan Weber, Zlatko Janeba, Ondřej Baszczyňski
المصدر: Journal of medicinal chemistry. 64(22)
مصطلحات موضوعية: Hepatitis B virus, Phenol, Chemistry, Diastereomer, Protide, Stereoisomerism, Microbial Sensitivity Tests, Prodrug, Tenofovir alafenamide, Combinatorial chemistry, Amides, Antiviral Agents, Chiral column chromatography, Drug Discovery, HIV-1, Hepatocytes, Molecular Medicine, Moiety, Humans, Tyrosine, Epimer, Phosphoric Acids, Prodrugs, Tenofovir
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المؤلفون: Zlatko Janeba, Helena Mertlíková-Kaiserová, Michal Šafránek, Val J. Watts, Michael P. Hayes, Michal Česnek, Martin Dračínský, Eva Tloušťová
المصدر: ChemMedChem
مصطلحات موضوعية: Bordetella pertussis, Stereochemistry, Anthrax toxin, Bacterial Toxins, Organophosphonates, Adenylate kinase, Biochemistry, Article, chemistry.chemical_compound, Structure-Activity Relationship, Halogens, Drug Discovery, General Pharmacology, Toxicology and Pharmaceutics, IC50, Pharmacology, chemistry.chemical_classification, Antigens, Bacterial, biology, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Prodrug, biology.organism_classification, Phosphonate, Thiazoles, Enzyme, chemistry, Adenylate Cyclase Toxin, Bacillus anthracis, Adenylyl Cyclase Inhibitors, Molecular Medicine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbbc62ffa6bf0469bd0dfd346724a5eb
https://europepmc.org/articles/PMC8741643/ -
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المؤلفون: Marcela Krečmerová, Karel Pomeisl, Helena Mertlíková-Kaiserová, Radek Pohl, Jakub Benýšek, Alice Pomeislová, Petra Rubešová, Lenka Poštová Slavětínská, Marika Matousova, Miroslav Otmar
المصدر: Bioorganicmedicinal chemistry. 32
مصطلحات موضوعية: Stereochemistry, Cell Survival, Clinical Biochemistry, Cathepsin K, Organophosphonates, Pharmaceutical Science, Antineoplastic Agents, Cleavage (embryo), 01 natural sciences, Biochemistry, Cell Line, chemistry.chemical_compound, Structure-Activity Relationship, Thiadiazoles, Drug Discovery, Moiety, Humans, Enzyme Inhibitors, Protecting group, Molecular Biology, Cell Proliferation, chemistry.chemical_classification, Glycogen Synthase Kinase 3 beta, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Nucleosides, Phosphonate, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, chemistry, Molecular Medicine, Drug Screening Assays, Antitumor, Cysteine
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المؤلفون: Helena Mertlíková-Kaiserová, Eva Tloušťová, Jan Skácel, Val J. Watts, Ema Chaloupecká, Petra Břehová, Monica Soto-Velasquez, Martin Dračínský, Zlatko Janeba, Michal Česnek
المصدر: Eur J Med Chem
مصطلحات موضوعية: Adenosine monophosphate, Anthrax toxin, Organophosphonates, Adenylate kinase, Microbial Sensitivity Tests, Cyclase, Bordetella pertussis, Article, Cell Line, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Drug Discovery, Animals, Humans, Cytotoxicity, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, General Medicine, Prodrug, Anti-Bacterial Agents, Thiazoles, Biochemistry, chemistry, Bacillus anthracis, Adenylyl Cyclase Inhibitors, Nucleoside triphosphate, Adenylate Cyclase Toxin, Neuralgia, Cyclase activity
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المؤلفون: William R. Roush, Michael Mareš, Pavla Fajtová, Jiří Brynda, Martin Lepšík, Cory D. Emal, Pavlína Řezáčová, Adam R. Renslo, Adéla Jílková, Jindřich Fanfrlík, Martin Horn, Helena Mertlíková-Kaiserová, Conor R. Caffrey, Petra Rubešová
المصدر: ACS Infectious Diseases
مصطلحات موضوعية: 0301 basic medicine, Peptidomimetic, cathepsin B, 030106 microbiology, Druggability, Schistosomiasis, Cathepsin B, Article, drug target, 03 medical and health sciences, medicine, Moiety, Animals, Humans, Sulfones, vinyl sulfone inhibitor, Schistosoma, biology, Chemistry, Rational design, Schistosoma mansoni, biology.organism_classification, medicine.disease, 030104 developmental biology, Infectious Diseases, Biochemistry, parasite, cysteine peptidase