-
1
المؤلفون: Nicola Arnold, Julie Christie, Sandra Haberthuer, Roger J. Taylor, Alastair Denholm, Mark Keenan, Julia Hatto, Mark Mercer, Lyndon Nigel Brown, Clive Mccarthy, Neil John Press, Helen Oakman, Andrew R. Tuffnell, Morris Tweed, Alexandre Trifilieff, Robert Cheung, Joseph D. Fullerton, Thomas H. Keller, David Beer, Helene Sahri, Pamela Tranter
المصدر: Journal of Medicinal Chemistry. 58:6747-6752
مصطلحات موضوعية: Drug, Cyclohexanecarboxylic Acids, Vomiting, Nausea, media_common.quotation_subject, Pulmonary disease, Pharmacology, Pulmonary Disease, Chronic Obstructive, Structure-Activity Relationship, Pharmacokinetics, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Dosing, Naphthyridines, PDE4 Inhibitors, media_common, COPD, Dose-Response Relationship, Drug, Chemistry, medicine.disease, Rats, Solubility, Thermodynamics, Molecular Medicine, Phosphodiesterase 4 Inhibitors, medicine.symptom
-
2
المؤلفون: Helene Sahri, Julie Christie, Neil John Press, Mark Keenan, Sandra Haberthuer, Morris Tweed, Andrew R. Tuffnell, Mark Mercer, Joseph D. Fullerton, John R. Fozard, Thomas H. Keller, Nicola Elaine Press, Lyndon Nigel Brown, Roger J. Taylor, Clive Mccarthy, Julia Hatto, Robert Cheung, Pamela Tranter
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:3081-3085
مصطلحات موضوعية: medicine.drug_class, Clinical Biochemistry, Adenosine A3 Receptor Antagonists, Pharmaceutical Science, Pharmacology, Receptor, Adenosine A2B, Adenosine receptor antagonist, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Aminothiazole, Heterocyclic Compounds, Drug Discovery, medicine, Animals, Rats, Wistar, Receptor, Molecular Biology, ADME, Chemistry, Receptor, Adenosine A3, Organic Chemistry, Antagonist, Receptor antagonist, Adenosine, Adenosine receptor, Adenosine A2 Receptor Antagonists, Rats, Thiazoles, Molecular Medicine, medicine.drug
-
3
المؤلفون: Sandra Haberthuer, Trixie Wagner, Lyndon Nigel Brown, Julia Hatto, Nicola Arnold, Clive Mccarthy, Julie Christie, John R. Fozard, Helene Sahri, Helen Oakman, Thomas H. Keller, Roger J. Taylor, Robert Cheung, Mark Keenan, Neil John Press, Joseph D. Fullerton, Andrew R. Tuffnell, Alexandre Trifilieff, John W. Tyler, David Beer, Alastair Denholm, Morris Tweed, Mark Mercer, Pamela Tranter
المصدر: Journal of medicinal chemistry. 55(17)
مصطلحات موضوعية: Models, Molecular, Magnetic Resonance Spectroscopy, Chemistry, Vomiting, Drug Evaluation, Preclinical, Pharmacology, Bioavailability, Rats, Disease Models, Animal, Mice, Phosphodiesterase-4, Pharmacokinetics, Solubility, In vivo, Drug Design, Drug Discovery, Aqueous solubility, Molecular Medicine, Animals, Humans, Phosphodiesterase 4 Inhibitors, Cells, Cultured