المؤلفون: Somayah S. Elsayed, Helga U. van der Heul, Xiansha Xiao, Aleksi Nuutila, Laura R. Baars, Changsheng Wu, Mikko Metsä-Ketelä, Gilles P. van Wezel

المصدر: Communications Chemistry, Vol 6, Iss 1, Pp 1-16 (2023)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2399-3669

URL الوصول: https://doaj.org/article/552e4cdb804544a5861a5f3671f524ed

المؤلفون: Mandy B. Hulst, Le Zhang, Helga U. van der Heul, Chao Du, Somayah S. Elsayed, Arina Koroleva, Thadee Grocholski, Dennis P. A. Wander, Mikko Metsä-Ketelä, Jacques J. C. Neefjes, Gilles P. van Wezel

المصدر: Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)

مصطلحات موضوعية: doxorubicin, anthracyclines, anticancer, metabolic engineering, biosynthesis, Streptomyces, Biotechnology, TP248.13-248.65

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fbioe.2024.1363803/full; https://doaj.org/toc/2296-4185

URL الوصول: https://doaj.org/article/4df9c2d97b6a46d0a40d7261af1249f7

المؤلفون: Changsheng Wu, Gilles P. van Wezel, Pieter C. Dorrestein, Jens Lübben, Helga U. van der Heul, Adriaan J. Minnaard, Young Hae Choi, Alexey V. Melnik

المساهمون: Chemical Biology 2

المصدر: Angewandte Chemie (International ed. in English), 58(9), 2809-2814
Angewandte Chemie-International Edition, 58(9), 2809-2814. WILEY-V C H VERLAG GMBH
Angewandte Chemie (International Ed. in English)

مصطلحات موضوعية: Models, Molecular, natural product, Stereochemistry, Molecular Conformation, Microbial Sensitivity Tests, 010402 general chemistry, 01 natural sciences, Streptomyces, Catalysis, Stereocenter, Baeyer–Villiger oxidation, 03 medical and health sciences, Polyketide, chemistry.chemical_compound, polyketide, NATURAL-PRODUCTS, Escherichia coli, Metabolomics, Molecule, BIOSYNTHESIS, Natural Products, EXPLORE, 0303 health sciences, molecular networking, Natural product, biology, 030306 microbiology, 010405 organic chemistry, Drug discovery, Communication, General Medicine, General Chemistry, biology.organism_classification, Baeyer-Villiger oxidation, Communications, Anti-Bacterial Agents, 0104 chemical sciences, Propellane, chemistry, Polyketides, Molecular networking, angucycline, ANTIBIOTICS, Bacillus subtilis

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a8aab88b03fe6cc6cd98dd3b53a838
https://doi.org/10.1002/anie.201814581

المؤلفون: Gilles P. van Wezel, Helga U. van der Heul, Michiel T. Uiterweerd, Isabel Nunez Santiago, Adriaan J. Minnaard

المساهمون: Chemical Biology 2

المصدر: European Journal of Organic Chemistry, 2020(32), 5145-5152. WILEY-V C H VERLAG GMBH
European Journal of Organic Chemistry, 5145-5152
ISSUE=32;STARTPAGE=5145;ENDPAGE=5152;TITLE=European Journal of Organic Chemistry

مصطلحات موضوعية: Stereochemistry, NITROSPOREUSINES, 010402 general chemistry, Mass spectrometry, 01 natural sciences, Chemical synthesis, Streptomyces, SHOWDOMYCIN, Minimum inhibitory concentration, Antibiotics, NATURAL-PRODUCTS, Actinomycetes, Structural isomer, BIOSYNTHESIS, Physical and Theoretical Chemistry, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, biology.organism_classification, 0104 chemical sciences, Streptomyces sp, Maleimycin, ALKALOIDS, Yield (chemistry), Gas chromatography, Gas chromatography–mass spectrometry, GC-MS

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe4335cfca18729e85f8ea54c543698
https://research.rug.nl/en/publications/6f4b5a7d-1aab-48d5-b950-6c176ebd3f52

المؤلفون: Changsheng Wu, Andrea E. Prota, Helga U. van der Heul, Chao Du, Xiansha Xiao, Weidong Liu, Mikko Metsä-Ketelä, Chun-Chi Chen, Rey-Ting Guo, Somayah S. Elsayed, Jan Pieter Abrahams, Gilles P. van Wezel

المصدر: ACS Chemical Biology, 15(9), 2529-2538
ACS Chemical Biology

مصطلحات موضوعية: 0301 basic medicine, Rossmann fold, Conformational change, Stereochemistry, Plasma protein binding, Reductase, Cleavage (embryo), Crystallography, X-Ray, 01 natural sciences, Biochemistry, Enzyme catalysis, Substrate Specificity, 03 medical and health sciences, Polyketide, Bacterial Proteins, Catalytic Domain, chemistry.chemical_classification, 010405 organic chemistry, Chemistry, General Medicine, Articles, Streptomyces, 0104 chemical sciences, Anti-Bacterial Agents, Alcohol Oxidoreductases, 030104 developmental biology, Enzyme, Polyketides, Mutation, Biocatalysis, Mutagenesis, Site-Directed, Molecular Medicine, Oxidation-Reduction, Protein Binding

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8fee26a0f5dd1336b75ddf16474bfb
http://hdl.handle.net/1887/3134616

المؤلفون: Silvia Estevão, Helga U van der Heul, Marcel Sluijter, Theo Hoogenboezem, Nico G Hartwig, Annemarie M C van Rossum, Cornelis Vink

المصدر: PLoS ONE, Vol 8, Iss 7, p e70870 (2013)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC3720892?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/ef180c4eb0e748388851a9de4cef3f35

المؤلفون: Gilles P. van Wezel, Bohdan Bilyk, Ryan F. Seipke, Helga U. van der Heul, Kenneth J. McDowall

مصطلحات موضوعية: 0301 basic medicine, Emerging technologies, Nitrogen, 030106 microbiology, Secondary Metabolism, Genomics, Anthraquinones, Computational biology, Biochemistry, Natural (archaeology), Actinobacteria, 03 medical and health sciences, Industrial Microbiology, 4-Butyrolactone, Bacterial Proteins, Drug Discovery, Secondary metabolism, Comparative genomics, biology, Organic Chemistry, Competitor analysis, Gene Expression Regulation, Bacterial, Antibiotic production, biology.organism_classification, Carbon, Anti-Bacterial Agents, 030104 developmental biology, Multigene Family, Streptomycin

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272327463965bb9308189ca43ce0188a
https://eprints.whiterose.ac.uk/130173/1/NaturalProductsReports_April.pdf