المؤلفون: Delia I. Fernández, Sara Troitiño, Vladimír Sobota, Bibian M. E. Tullemans, Jinmi Zou, Helma van den Hurk, Ángel García, Saman Honarnejad, Marijke J. E. Kuijpers, Johan W. M. Heemskerk

المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)

مصطلحات موضوعية: Collagen, Cytosolic calcium, Glycoprotein VI, Prestwick library, Thrombin, Thrombosis, Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/e0e4cce4e1b944baa6e8d33649209870

المؤلفون: Ming Jiang, Mirjam C. W. Huizenga, Jonah L. Wirt, Janos Paloczi, Avand Amedi, Richard J. B. H. N. van den Berg, Joerg Benz, Ludovic Collin, Hui Deng, Xinyu Di, Wouter F. Driever, Bogdan I. Florea, Uwe Grether, Antonius P. A. Janssen, Thomas Hankemeier, Laura H. Heitman, Tsang-Wai Lam, Florian Mohr, Anto Pavlovic, Iris Ruf, Helma van den Hurk, Anna F. Stevens, Daan van der Vliet, Tom van der Wel, Matthias B. Wittwer, Constant A. A. van Boeckel, Pal Pacher, Andrea G. Hohmann, Mario van der Stelt

المصدر: Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/fdb22352db0b4e3798c8149c29653a5f

المؤلفون: Delia I. Fernández, Isabella Provenzale, Hilaire Y.F. Cheung, Jan van Groningen, Bibian M.E. Tullemans, Alicia Veninga, Joanne L. Dunster, Saman Honarnejad, Helma van den Hurk, Marijke J.E. Kuijpers, Johan W.M. Heemskerk

المصدر: iScience, Vol 25, Iss 1, Pp 103718- (2022)

مصطلحات موضوعية: Cell biology, Functional aspects of cell biology, Methodology in biological sciences, Science

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004221016886; https://doaj.org/toc/2589-0042

URL الوصول: https://doaj.org/article/41f61631ed79476488c1835c6a7c8eef

المؤلفون: Helma van den Hurk, Jan J. M. van Groningen, Jos de Man, Johan Friesen, J.C.M. Uitdehaag, Guido J.R. Zaman, Yvonne Grobben, Nicole Willemsen-Seegers, Rogier C. Buijsman

المصدر: SLAS Discovery. 25:1018-1025

مصطلحات موضوعية: Ornithine, T-Lymphocytes, High-throughput screening, Arginine, 01 natural sciences, Biochemistry, Fluorescence, Analytical Chemistry, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, Humans, Potency, Enzyme Inhibitors, chemistry.chemical_classification, Quenching (fluorescence), Arginase, Receptor–ligand kinetics, High-Throughput Screening Assays, 0104 chemical sciences, Amino acid, 010404 medicinal & biomolecular chemistry, Enzyme, chemistry, 030220 oncology & carcinogenesis, Molecular Medicine, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9196233de65aa40a9f091093779243b6
https://doi.org/10.1177/2472555220919340

المؤلفون: Helma van den Hurk, Stan van Boeckel, Saman Honarnejad, Steven van Helden

المصدر: Slas Discovery

مصطلحات موضوعية: Computer science, High-throughput screening, ultra-high-throughput screening, Biochemistry, Public-Private Sector Partnerships, Analytical Chemistry, drug discovery, Small Molecule Libraries, 03 medical and health sciences, Automation, 0302 clinical medicine, Lead (geology), assay development and miniaturization, European Lead Factory, Humans, 030304 developmental biology, Flexibility (engineering), 0303 health sciences, Drug discovery, business.industry, Research, High-Throughput Screening Assays, Europe, Engineering management, Proof of concept, 030220 oncology & carcinogenesis, Drug Design, Perspective, Molecular Medicine, Factory (object-oriented programming), public-private partnerships, Small and medium-sized enterprises, business, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45332217e07e9b0550f96c77f3af19c
http://europepmc.org/articles/PMC8637381

المؤلفون: Delia I, Fernández, Isabella, Provenzale, Hilaire Y F, Cheung, Jan, van Groningen, Bibian M E, Tullemans, Alicia, Veninga, Joanne L, Dunster, Saman, Honarnejad, Helma, van den Hurk, Marijke J E, Kuijpers, Johan W M, Heemskerk

المصدر: iScience

مصطلحات موضوعية: Cell biology, Functional aspects of cell biology, Methodology in biological sciences, Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::f97c2fe61bab3374cc750d4a5247af7c
https://pubmed.ncbi.nlm.nih.gov/35072010

المؤلفون: Ozge Gunduz-Cinar, Laura I. Castillo, Antonius P A Janssen, Helma van den Hurk, Marjolein Soethoudt, Andrew Holmes, Resat Cinar, Cristina Miliano, Annelot C. M. van Esbroeck, Colleen M Donovan, Pal Pacher, Elliot D. Mock, Aron H. Lichtman, Alexander T Bakker, Jesse Wat, Matthew W. Buczynski, Anouk M F van der Gracht, Tom van der Wel, Ioli Kotsogianni, Vasudev Kantae, Tiemen J Wendel, Xinyu Di, Thomas Hankemeier, Matthias B. Wittwer, Matthew N. Hill, János Pálóczi, Gavin N. Petrie, Uwe Grether, Joshua K. Park, Andrea Martella, Zoltán Varga, Ming Jiang, Daisuke Ogasawara, Giulia Donvito, Benjamin F. Cravatt, Constant A. A. van Boeckel, Bogdan I. Florea, Mario van der Stelt, Mohammed A. Mustafa

المصدر: Nature Chemical Biology, 16(6), 667-675
Nat Chem Biol

مصطلحات موضوعية: Male, Cannabinoid receptor, Nape, medicine.medical_treatment, Drug Evaluation, Preclinical, Article, Amidohydrolases, 03 medical and health sciences, chemistry.chemical_compound, Mice, Fatty acid amide hydrolase, Cell Line, Tumor, Lipidomics, medicine, Phospholipase D, Animals, Humans, Enzyme Inhibitors, Receptors, Cannabinoid, Molecular Biology, Cannabinoid Receptor Antagonists, 030304 developmental biology, 0303 health sciences, Behavior, Animal, Molecular Structure, Chemistry, Phosphatidylethanolamines, 030302 biochemistry & molecular biology, Brain, Cell Biology, Anandamide, Blood Proteins, Fear, Lipid Metabolism, Endocannabinoid system, Cell biology, Mice, Inbred C57BL, medicine.anatomical_structure, lipids (amino acids, peptides, and proteins), Cannabinoid, Signal Transduction

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858eb516053df2c6e71eaf7ba6acceef
https://www.nature.com/articles/s41589-020-0528-7

المؤلفون: Veronique Hamon, Helma van den Hurk, Philip H. Jones, Angus Morrison, Natalia A. Ignatenko, Gemma L. Baillie, Niels Smits, Nikolas Gunkel, Aubry K. Miller, Joanne Hewitt, Andrew Pannifer, Elena De Vita, Elizabeth M. Beck, Emily Russell, Stuart P. McElroy

المصدر: Chemmedchem

مصطلحات موضوعية: PATHOGENESIS, Chemistry, Medicinal, MELANOMA, 01 natural sciences, Biochemistry, 0305 Organic Chemistry, SERINE-PROTEASE NEUROSIN, Cytochrome P-450 Enzyme System, Cell Movement, Drug Discovery, Pharmacology & Pharmacy, General Pharmacology, Toxicology and Pharmaceutics, chemistry.chemical_classification, Full Paper, biology, Chemistry, Drug discovery, High-throughput screening, Stereoisomerism, Full Papers, SUBSTRATE-SPECIFICITY, ALZHEIMERS-DISEASE, Molecular Docking Simulation, Neuroprotective Agents, Molecular Medicine, Kallikreins, SPINAL-CORD, 1115 Pharmacology and Pharmaceutical Sciences, Life Sciences & Biomedicine, Half-Life, EXPRESSION, Medicinal & Biomolecular Chemistry, Inhibitory Concentration 50, Structure-Activity Relationship, TARGETS, Potency, Structure–activity relationship, Humans, Oxazolidinones, Pharmacology, Serine protease, Science & Technology, Binding Sites, 0304 Medicinal and Biomolecular Chemistry, 010405 organic chemistry, Organic Chemistry, Kallikrein, Protease inhibitors, HCT116 Cells, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, Docking (molecular), biology.protein, Tissue Kallikreins, ACTIVATION PROFILES, Medicinal Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028f6971b3491f16f6a912a55eb2fbe7
http://hdl.handle.net/10044/1/93822

المؤلفون: Elena De Vita, Niels Smits, Helma van den Hurk, Elizabeth M. Beck, Joanne Hewitt, Gemma Baillie, Emily Russell, Andrew Pannifer, Véronique Hamon, Angus Morrison, Stuart P. McElroy, Philip Jones, Natalia A. Ignatenko, Nikolas Gunkel, Aubry K. Miller

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977b4da381966adcd88d776530a8130d
https://doi.org/10.26434/chemrxiv.9788276.v1

المؤلفون: Philip S. Jones, Sylviane Boucharens, Stuart P. McElroy, Angus Morrison, Saman Honarnejad, Stan van Boeckel, Helma van den Hurk, Daniel Basting, Jörg Hüser, Stefan Jaroch, Eckhard Ottow, Jorg Benningshof, Rutger H. A. Folmer, Frank Leemhuis, Patricia M. Kramer-Verhulst, Vera J. M. Nies, Kristina M. Orrling, Ton Rijnders, Claudia Pfander, Ola Engkvist, Garry Pairaudeau, Peter B. Simpson, Jean-Yves Ortholand, Didier Roche, Alexander Dömling, Sven M. Kühnert, Peter W. M. Roevens, Herman van Vlijmen, Eva J. A. van Wanrooij, Christophe Verbruggen, Peter Nussbaumer, Huib Ovaa, Mario van der Stelt, Klaus Baek Simonsen, Lena Tagmose, Herbert Waldmann, James Duffy, Dirk Finsinger, Mirek Jurzak, Nicola A. Burgess-Brown, Wen H. Lee, Floris P. J. T. Rutjes, Hubert Haag, Christopher Kallus, Hartmut Mors, Thierry Dorval, Brigitte Lesur, Fernando Ramon Olayo, Daniel Hamza, Geraint Jones, Christopher Pearce, Alexander Piechot, Dimitrios Tzalis, Mads H. Clausen, Jeremy Davis, Daphné Derouane, Céline Vermeiren, Markus Kaiser, Robert A. Stockman, Denise V. Barrault, Andrew D. Pannifer, Jason R. Swedlow, Adam S. Nelson, Romano V. A. Orru, Eelco Ruijter, Steven P. van Helden, Volkhart M. Li, Ton Vries, Jon S. B. de Vlieger

المصدر: Nature Reviews Drug Discovery
Nature Reviews. Drug Discovery, 21, 245-246
Nature Reviews. Drug Discovery, 21, 4, pp. 245-246

مصطلحات موضوعية: Small Molecule Libraries, Pharmacology, Drug Discovery, Humans, Synthetic Organic Chemistry, General Medicine, High-Throughput Screening Assays

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d851dc3fb96708a39839a80c7c53a40