-
1دورية أكاديمية
المؤلفون: Léa Mélin, Emily Gesner, Sarah Attwell, Olesya A. Kharenko, Edward H. van der Horst, Henrik C. Hansen, Alexandre Gagnon
المصدر: ACS Omega, Vol 6, Iss 33, Pp 21327-21338 (2021)
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2470-1343
-
2
المؤلفون: Emily M. Gesner, Sarah Attwell, Henrik C. Hansen, Alexandre Gagnon, Olesya A. Kharenko, Edward H. van der Horst, Léa Mélin
المصدر: ACS Omega, Vol 6, Iss 33, Pp 21327-21338 (2021)
ACS Omegaمصطلحات موضوعية: 0303 health sciences, animal structures, 010405 organic chemistry, Chemistry, Stereochemistry, viruses, General Chemical Engineering, Protein subunit, virus diseases, General Chemistry, biochemical phenomena, metabolism, and nutrition, 01 natural sciences, Article, Chromatin remodeling, 0104 chemical sciences, Bromodomain, 03 medical and health sciences, chemistry.chemical_compound, PBAF complex, Selectivity, Lead compound, QD1-999, Function (biology), 030304 developmental biology
-
3
المصدر: Bioorganicmedicinal chemistry letters. 47
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Nerve Tissue Proteins, 01 natural sciences, Biochemistry, Chromatin remodeling, Structure-Activity Relationship, Drug Discovery, Transcriptional regulation, Nucleosome, Humans, Epigenetics, Molecular Biology, Transcription factor, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Antigen processing, Chemistry, Organic Chemistry, Antigens, Nuclear, 0104 chemical sciences, Bromodomain, Cell biology, 010404 medicinal & biomolecular chemistry, PHD finger, Molecular Medicine, Transcription Factors
-
4
المؤلفون: Eric Campeau, Sanjay Lakhotia, Laura Tsujikawa, Sarah Attwell, Olesya A. Kharenko, Reena G. Patel, Cyrus Calosing, Ravi Jahagirdar, Henrik C. Hansen
المصدر: Cancer Research. 78:P3-06
مصطلحات موضوعية: Cancer Research, BRD4, Fulvestrant, business.industry, Estrogen receptor, medicine.disease, BET inhibitor, Prostate cancer, Breast cancer, Oncology, Cancer stem cell, Cancer research, Medicine, business, Tamoxifen, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::dda7f9b895d5e54b4b0e42616287a470
https://doi.org/10.1158/1538-7445.sabcs17-p3-06-07 -
5
المؤلفون: Henrik C. Hansen, Olesya A. Kharenko
المصدر: Drug Discovery Today: Technologies. 24:19-24
مصطلحات موضوعية: 0301 basic medicine, BRD4, Irreversible binding, Nuclear Proteins, Proteins, Cell Cycle Proteins, Computational biology, Biology, Bioinformatics, Small molecule, Bromodomain, 03 medical and health sciences, 030104 developmental biology, Drug Discovery, Animals, Humans, Molecular Medicine, DECIPHER, Epigenetics, Transcription Factors
-
6
المؤلفون: Robert K. Suto, Karen Norek, Emily M. Gesner, Kevin G. McLure, Reena G. Patel, André O. White, Olesya A. Kharenko, Henrik C. Hansen, Eric Fontano, Peter Young
المصدر: Biochemical and Biophysical Research Communications. 477:62-67
مصطلحات موضوعية: 0301 basic medicine, BRD4, Stereochemistry, Lysine, Biophysics, Calorimetry, Crystallography, X-Ray, 01 natural sciences, Biochemistry, BET inhibitor, 03 medical and health sciences, Molecular Biology, Transcription factor, Quinazolinones, Binding Sites, biology, 010405 organic chemistry, Chemistry, hemic and immune systems, Isothermal titration calorimetry, Cell Biology, Small molecule, 0104 chemical sciences, Bromodomain, 030104 developmental biology, Histone, biology.protein, Thermodynamics, Transcription Factors
-
7
المؤلفون: Kevin G. McLure, Reena G. Patel, Edward H. van der Horst, Henrik C. Hansen, S. David Brown, Olesya A. Kharenko, Damodharan Lakshminarasimhan, Bryan Cordell Duffy, Cyrus Calosing, Douglas B. Kitchen, Peter Young, André O. White, Robert K. Suto
المصدر: Journal of medicinal chemistry. 61(18)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, BRD4, Protein Conformation, Antineoplastic Agents, Cell Cycle Proteins, Crystallography, X-Ray, 01 natural sciences, 03 medical and health sciences, Structure-Activity Relationship, Protein structure, Methionine, Drug Discovery, Tumor Cells, Cultured, Humans, Transcription factor, Molecular Structure, 010405 organic chemistry, Drug discovery, Chemistry, Nuclear Proteins, Small molecule, 0104 chemical sciences, Bromodomain, 030104 developmental biology, Biochemistry, Acetylation, Covalent bond, Drug Design, Hematologic Neoplasms, Molecular Medicine, Transcription Factors
-
8
المؤلفون: Alison Bendele, Narmada Shenoy, Suzana Marusic, Raymond Yu, Gregory S. Wagner, Ravi Jahagirdar, Karen Norek, Dean Gilham, Jennifer Tobin, Kevin G. McLure, Henrik C. Hansen, Ewelina Kulikowski, Peter Young, Sarah Attwell, Norman C.W. Wong
المصدر: Molecular pharmacology. 92(6)
مصطلحات موضوعية: 0301 basic medicine, Lipopolysaccharides, Male, Encephalomyelitis, Autoimmune, Experimental, Anti-Inflammatory Agents, Inflammation, Biology, medicine.disease_cause, Antibodies, Autoimmunity, Proinflammatory cytokine, Autoimmune Diseases, Arthritis, Rheumatoid, 03 medical and health sciences, 0302 clinical medicine, Gene expression, medicine, Animals, Humans, Cells, Cultured, Quinazolinones, Pharmacology, Autoimmune disease, B-Lymphocytes, Arthritis, Experimental autoimmune encephalomyelitis, Proteins, U937 Cells, Fibroblasts, medicine.disease, Bromodomain, Mice, Inbred C57BL, 030104 developmental biology, Rats, Inbred Lew, Immunology, Acute Disease, Cancer research, Molecular Medicine, Experimental pathology, Cytokines, Female, Collagen, medicine.symptom, Spleen, 030215 immunology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13938f005c87ac17258bfce31797ed78
https://pubmed.ncbi.nlm.nih.gov/28974538 -
9
المؤلفون: Jennifer Tobin, Salman Azhar, Kevin G. McLure, Rai Ajit K. Srivastava, Jin Wu, Jan Johansson, Haiyan Zhang, Peter Young, Henrik C. Hansen, Raymond Yu, Norman C. W. Wong, Gregory S. Wagner, Ravi Jahagirdar, Sarah Attwell
المصدر: Atherosclerosis. 236:91-100
مصطلحات موضوعية: Male, Apolipoprotein E, medicine.medical_specialty, Aortic Diseases, Drug Evaluation, Preclinical, Hyperlipidemias, RVX 208, Biology, Cell Line, Proinflammatory cytokine, BET inhibitor, Mice, chemistry.chemical_compound, Apolipoproteins E, High-density lipoprotein, Internal medicine, medicine, Animals, Humans, RNA, Messenger, Diet, Fat-Restricted, Aorta, Quinazolinones, Inflammation, Mice, Knockout, Apolipoprotein A-I, Cholesterol, Gene Expression Profiling, Cholesterol, HDL, Endothelial Cells, Cholesterol, LDL, U937 Cells, Atherosclerosis, Mice, Inbred C57BL, Endocrinology, Betaine-Homocysteine S-Methyltransferase, Liver, chemistry, Diet, Western, Low-density lipoprotein, HMG-CoA reductase, Immunology, Quinazolines, biology.protein, Cytokines, lipids (amino acids, peptides, and proteins), Cardiology and Cardiovascular Medicine
-
10
المؤلفون: M. Madhava Reddy, Peter C. Michels, Vadim V. Mozhaev, Yuri L. Khmelnitsky, Gregory S. Wagner, Sihem Boudjabi, Ian C. Cotterill, Henrik C. Hansen, Vladimir Khlebnikov
المصدر: European Journal of Medicinal Chemistry. 64:121-128
مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, Chromatography, Molecular Structure, Carboxylic acid, Metabolite, Organic Chemistry, Glucuronidation, Glycosidic bond, General Medicine, Glucuronic acid, chemistry.chemical_compound, chemistry, S9 fraction, Drug Discovery, Microsomes, Liver, Quinazolines, Proton NMR, Animals, Humans, Rabbits, Carboxylate, Quinazolinones