المؤلفون: Yan S; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA.; Harvard Medical School, 25 Shattuck St, Boston, MA, 02130, USA., Santoro A; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA.; Harvard Medical School, 25 Shattuck St, Boston, MA, 02130, USA., Niphakis MJ; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA., Pinto AM; The Salk Institute for Biological Studies, 10010 N. Torey Pines Rd, La Jolla, CA, 92037-1002, USA., Jacobs CL; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA.; Harvard Medical School, 25 Shattuck St, Boston, MA, 02130, USA., Ahmad R; Immunology and Microbiology Department, Dasman Diabetes Institute, Jasim Mohamad Al Bahar St., Kuwait City, Kuwait., Suciu RM; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA., Fonslow BR; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA., Herbst-Graham RA; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA., Ngo N; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA., Henry CL; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA., Herbst DM; Lundbeck La Jolla Research Center Inc., 10835 Road To The Cure Dr. #250, San Diego, CA, 92121, USA., Saghatelian A; The Salk Institute for Biological Studies, 10010 N. Torey Pines Rd, La Jolla, CA, 92037-1002, USA., Kahn BB; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA.; Harvard Medical School, 25 Shattuck St, Boston, MA, 02130, USA.; Broad Institute of Harvard and MIT, 320 Charles St., Cambridge, MA, 02141, USA., Rosen ED; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA, 02215, USA. erosen@bidmc.harvard.edu.; Harvard Medical School, 25 Shattuck St, Boston, MA, 02130, USA. erosen@bidmc.harvard.edu.; Broad Institute of Harvard and MIT, 320 Charles St., Cambridge, MA, 02141, USA. erosen@bidmc.harvard.edu.

المصدر: Nature communications [Nat Commun] 2024 May 30; Vol. 15 (1), pp. 4605. Date of Electronic Publication: 2024 May 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Insulin Resistance* , Interferon Regulatory Factor-3*/metabolism , Interferon Regulatory Factor-3*/genetics , Obesity*/metabolism , Diet, High-Fat*/adverse effects , Inflammation*/metabolism , Mice, Knockout* , Adipocytes*/metabolism, Animals ; Male ; Mice ; Mice, Inbred C57BL ; Glucose/metabolism ; 3T3-L1 Cells

المؤلفون: Pang Z; Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA., Schafroth MA; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA., Ogasawara D; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA., Wang Y; Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA., Nudell V; Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA., Lal NK; Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA., Yang D; Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA., Wang K; Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA., Herbst DM; Lundbeck La Jolla Research Center, San Diego, CA 92121, USA., Ha J; Lundbeck La Jolla Research Center, San Diego, CA 92121, USA., Guijas C; Lundbeck La Jolla Research Center, San Diego, CA 92121, USA., Blankman JL; Lundbeck La Jolla Research Center, San Diego, CA 92121, USA., Cravatt BF; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA., Ye L; Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: liye@scripps.edu.

المصدر: Cell [Cell] 2022 May 12; Vol. 185 (10), pp. 1793-1805.e17. Date of Electronic Publication: 2022 Apr 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Click Chemistry* , Optical Imaging*/methods, Animals ; Brain ; Drug Delivery Systems ; Mammals ; Mice

المؤلفون: Jing H; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037., Reed A; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037., Ulanovskaya OA; Lundbeck La Jolla Research Center, La Jolla, CA 92121., Grigoleit JS; Lundbeck La Jolla Research Center, La Jolla, CA 92121., Herbst DM; Lundbeck La Jolla Research Center, La Jolla, CA 92121., Henry CL; Lundbeck La Jolla Research Center, La Jolla, CA 92121., Li H; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037., Barbas S; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037., Germain J; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037., Masuda K; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037., Cravatt BF; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037; cravatt@scripps.edu.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Oct 12; Vol. 118 (41).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Eicosanoids/*metabolism , Endocannabinoids/*metabolism , Immunity, Innate/*immunology , Macrophages/*immunology , Phospholipase C gamma/*metabolism, Animals ; Antigens, CD/biosynthesis ; Antigens, Differentiation, Myelomonocytic/biosynthesis ; COS Cells ; Cell Line ; Chlorocebus aethiops ; Cytokines/immunology ; Diglycerides/metabolism ; Group IV Phospholipases A2/metabolism ; HEK293 Cells ; Humans ; Inflammation/immunology ; Lipopolysaccharides/immunology ; Lipoprotein Lipase/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microglia/immunology ; Monoacylglycerol Lipases/metabolism ; Phospholipase C gamma/genetics ; Prostaglandins/biosynthesis ; Receptors, Fc/immunology ; Signal Transduction/immunology

المؤلفون: Reardon HT; Abide Therapeutics, San Diego, CA, USA., Herbst RA; Abide Therapeutics, San Diego, CA, USA., Henry CL; Abide Therapeutics, San Diego, CA, USA., Herbst DM; Abide Therapeutics, San Diego, CA, USA., Ngo N; Abide Therapeutics, San Diego, CA, USA., Cisar JS; Abide Therapeutics, San Diego, CA, USA.; Janssen Research & Development, Spring House, PA., Weber OD; Abide Therapeutics, San Diego, CA, USA., Niphakis MJ; Abide Therapeutics, San Diego, CA, USA., O'Neill GP; Abide Therapeutics, San Diego, CA, USA.

المصدر: SLAS technology [SLAS Technol] 2019 Oct; Vol. 24 (5), pp. 489-498. Date of Electronic Publication: 2019 Jun 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101697564 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2472-6311 (Electronic) Linking ISSN: 24726303 NLM ISO Abbreviation: SLAS Technol Subsets: MEDLINE

مواضيع طبية MeSH: Microfluidics/*methods , Proteomics/*methods, Algorithms ; Animals ; Biological Assay ; Mice ; Molecular Weight ; Reproducibility of Results

المؤلفون: Clapper JR; Abide Therapeutics, San Diego, California., Henry CL; Abide Therapeutics, San Diego, California., Niphakis MJ; Abide Therapeutics, San Diego, California., Knize AM; Abide Therapeutics, San Diego, California., Coppola AR; Abide Therapeutics, San Diego, California., Simon GM; Abide Therapeutics, San Diego, California., Ngo N; Abide Therapeutics, San Diego, California., Herbst RA; Abide Therapeutics, San Diego, California., Herbst DM; Abide Therapeutics, San Diego, California., Reed AW; Abide Therapeutics, San Diego, California., Cisar JS; Abide Therapeutics, San Diego, California., Weber OD; Abide Therapeutics, San Diego, California., Viader A; Abide Therapeutics, San Diego, California., Alexander JP; Abide Therapeutics, San Diego, California., Cunningham ML; Abide Therapeutics, San Diego, California., Jones TK; Abide Therapeutics, San Diego, California., Fraser IP; Abide Therapeutics, San Diego, California., Grice CA; Abide Therapeutics, San Diego, California., Ezekowitz RAB; Abide Therapeutics, San Diego, California., O'Neill GP; Abide Therapeutics, San Diego, California., Blankman JL; Abide Therapeutics, San Diego, California jackie@abidetx.com.

المصدر: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2018 Dec; Vol. 367 (3), pp. 494-508. Date of Electronic Publication: 2018 Oct 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

مواضيع طبية MeSH: Endocannabinoids/*metabolism , Enzyme Inhibitors/*pharmacology , Monoacylglycerol Lipases/*antagonists & inhibitors, Analgesics/pharmacology ; Animals ; Antipruritics/pharmacology ; Arachidonic Acids/metabolism ; Brain/drug effects ; Brain/metabolism ; Cell Line, Tumor ; Cyclooxygenase Inhibitors/pharmacology ; Glycerides/metabolism ; Humans ; Hydrolysis/drug effects ; Male ; Mice ; Mice, Inbred ICR ; PC-3 Cells ; Pain/drug therapy ; Pain/metabolism ; Piperidines/pharmacology ; Prostaglandins/pharmacology ; Rats ; Rats, Sprague-Dawley ; Rodentia