المؤلفون: Jo Vandesompele, Peter Nürnberg, Shantanu Banerji, Lukas C. Heukamp, Stefanie Heynck, Matthias Fischer, Daniel Rauh, Sylvie Lantuejoul, Ingelore Baessmann, Holger Moch, Matthew Meyerson, Reinhard Büttner, Kwon-Sik Park, Ines Wilkening, Steinar Solberg, Stefan A. Haas, Egber Smit, Dennis Plenker, Zoe Wainer, Prudence A. Russell, Ilona Dahmen, William Pao, Erik Thunnissen, C. Ligorio, Bram De Wilde, Paul K. Brindle, Diana Böhm, Vito Michele Fazio, Vincenzo Di Cerbo, Benjamin Solomon, Stefania Damiani, Walburga Engel-Riedel, Erich Stoelben, Corinna Ludwig, Hannie Sietsma, Daniëlle A M Heideman, Jürgen Wolf, Thomas Muley, Elisabeth Brambilla, Ruping Sun, Wim Timens, Jay Shendure, Laura Pasqualucci, Kristian Cibulskis, Julien Sage, Gavin M. Wright, Mirjam Koker, Pierre Validire, Danila Seidel, Johannes M. Heuckmann, Harry J.M. Groen, Christian Becker, Philippe Lorimier, Peter J.F. Snijders, Sven Perner, Michael Brockmann, Xin Lu, Franziska Gabler, Scott L. Carter, Marius Lund-Iversen, Lucia Anna Muscarella, Jörg Sänger, Benjamin Besse, Hans Ulrich Schildhaus, Frauke Leenders, John K. Field, Odd Terje Brustugun, Christian Brambilla, Philipp A. Schnabel, Sascha Ansén, Christian Grütter, Michael Hallek, Gad Getz, Yuan Chen, Roopika Menon, Roman K. Thomas, Joachim H. Clement, Janine Altmüller, Martin L. Sos, Hans Hoffmann, Peter M. Schneider, Julie George, Christian Müller, Iver Petersen, Federico Cappuzzo, Lawryn H. Kasper, Robert Schneider, Martin Peifer, Lynnette Fernandez-Cuesta, Jean-Charles Soria, Alex Soltermann, Thomas Zander, Walter Weder

المساهمون: Pathology, Pulmonary medicine, CCA - Oncogenesis, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Groningen Research Institute for Asthma and COPD (GRIAC), Peifer M, Fernández-Cuesta L, Sos ML, George J, Seidel D, Kasper LH, Plenker D, Leenders F, Sun R, Zander T, Menon R, Koker M, Dahmen I, Müller C, Di Cerbo V, Schildhaus HU, Altmüller J, Baessmann I, Becker C, de Wilde B, Vandesompele J, Böhm D, Ansén S, Gabler F, Wilkening I, Heynck S, Heuckmann JM, Lu X, Carter SL, Cibulskis K, Banerji S, Getz G, Park KS, Rauh D, Grütter C, Fischer M, Pasqualucci L, Wright G, Wainer Z, Russell P, Petersen I, Chen Y, Stoelben E, Ludwig C, Schnabel P, Hoffmann H, Muley T, Brockmann M, Engel-Riedel W, Muscarella LA, Fazio VM, Groen H, Timens W, Sietsma H, Thunnissen E, Smit E, Heideman DA, Snijders PJ, Cappuzzo F, Ligorio C, Damiani S, Field J, Solberg S, Brustugun OT, Lund-Iversen M, Sänger J, Clement JH, Soltermann A, Moch H, Weder W, Solomon B, Soria JC, Validire P, Besse B, Brambilla E, Brambilla C, Lantuejoul S, Lorimier P, Schneider PM, Hallek M, Pao W, Meyerson M, Sage J, Shendure J, Schneider R, Büttner R, Wolf J, Nürnberg P, Perner S, Heukamp LC, Brindle PK, Haas S, Thomas RK.

المصدر: Nature Genetics
Nature Genetics, 44(10), 1104-1110. Nature Publishing Group
Peifer, M, Fernandez-Cuesta, L, Sos, M L, George, J, Seidel, D, Kasper, L H, Plenker, D, Leenders, F, Sun, R, Zander, T, Menon, R, Koker, M, Dahmen, I, Muller, C, Di Cerbo, V, Schildhaus, H U, Altmuller, J, Baessmann, I, Becker, C, de Wilde, B, Vandesompele, J, Bohm, D, Ansen, S, Gabler, F, Wilkening, I, Heynck, S, Heuckmann, J M, Lu, X, Carter, S L, Cibulskis, K, Banerji, S, Getz, G, Park, K S, Rauh, D, Grutter, C, Fischer, M, Pasqualucci, L, Wright, G, Wainer, Z, Russell, P, Petersen, I, Chen, Y, Stoelben, E, Ludwig, C, Schnabel, P, Hoffmann, H, Muley, T, Brockmann, M, Engel-Riedel, W, Muscarella, L A, Fazio, V M, Groen, H, Timens, W, Sietsma, H, Thunnissen, F B J M, Smit, E F, Heideman, D A M, Snijders, P J F, Cappuzzo, F, Ligorio, C, Damiani, S, Field, J, Solberg, S, Brustugun, O T, Lund-Iversen, M, Sanger, J, Clement, J H, Soltermann, A, Moch, H, Weder, W, Solomon, B, Soria, J C, Validire, P, Besse, B, Brambilla, E, Brambilla, C, Lantuejoul, S, Lorimier, P, Schneider, P M, Hallek, M, Pao, W, Meyerson, M, Sage, J, Shendure, J, Schneider, R, Buttner, R, Wolf, J, Nurnberg, P, Perner, S, Heukamp, L C, Brindle, P K, de Haas, S & Thomas, R K 2012, ' Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer ', Nature Genetics, vol. 44, no. 10, pp. 1104-1110 . https://doi.org/10.1038/ng.2396
Nature Genetics, 44(10), 1104-+. Nature Publishing Group
Nature Genetics; Vol 44

مصطلحات موضوعية: Mutation rate, EPH-RECEPTOR, Genome, Article, lung, 03 medical and health sciences, 0302 clinical medicine, E-CADHERIN, Genetics, PTEN, EP300, small cell carcinoma, neoplasms, Exome sequencing, ACUTE LYMPHOBLASTIC-LEUKEMIA, 030304 developmental biology, P53 REGULATION, 0303 health sciences, biology, EGFR MUTATIONS, MOUSE MODEL, GENE, humanities, PROSTATE-CANCER, respiratory tract diseases, 3. Good health, FREQUENT MUTATION, Gene expression profiling, Histone, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Human genome, NEUROENDOCRINE TUMORS

وصف الملف: application/pdf; STAMPA

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0d1e6a51b124adf71538e70086efc8
https://doi.org/10.1038/ng.2396

المؤلفون: Martin Termathe, René P. Zahedi, Johannes M. Heuckmann, Matthäus Getlik, Daniel Rauh, Stefano Tomassi, Franziska Hoffgaard, Niklas Schaumann, Julian Engel, Verena Tinnefeld, Carsten Schultz-Fademrecht, Jasmin Krüll, Christian Grütter, Martin L. Sos, Simone Eppmann, Stefan M. Kast, Patrick Kibies, Marina Keul, Sascha Menninger, Svenja C. Mayer-Wrangowski, Sandra Ortiz-Cuaran, Roman K. Thomas, Jonas Lategahn, André Richters, Niklas Uhlenbrock, Christian Becker, Jochen Heil

المساهمون: Engel, J, Richters, A, Getlik, M, Tomassi, S, Keul, M, Termathe, M, Lategahn, J, Becker, C, Mayer-Wrangowski, S, Grütter, C, Uhlenbrock, N, Krüll, J, Schaumann, N, Eppmann, S, Kibies, P, Hoffgaard, F, Heil, J, Menninger, S, Ortiz-Cuaran, S, Heuckmann, Jm, Tinnefeld, V, Zahedi, Rp, Sos, Ml, Schultz-Fademrecht, C, Thomas, Rk, Kast, Sm, Rauh

المصدر: Journal of medicinal chemistry. 58(17)

مصطلحات موضوعية: Models, Molecular, Cell Membrane Permeability, Lung Neoplasms, EGFR, Molecular Conformation, Antineoplastic Agents, Crystallography, X-Ray, Receptor tyrosine kinase, Small Molecule Libraries, T790M, Structure-Activity Relationship, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Drug Discovery, Structure–activity relationship, Humans, Epidermal growth factor receptor, EGFR inhibitors, biology, Chemistry, Rational design, Proteolytic enzymes, Ligand (biochemistry), structure-based design, respiratory tract diseases, ErbB Receptors, Kinetics, Pyrimidines, src-Family Kinases, Biochemistry, Solubility, Drug Resistance, Neoplasm, Drug Design, Mutation, biology.protein, Quinazolines, Molecular Medicine, covalent inhibitor, Pyrazoles, Databases, Chemical

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed290f49315f3c786973b95298a35753
https://pubmed.ncbi.nlm.nih.gov/26275028

المؤلفون: Malchers F; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany Germany., Nogova L; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn, Cologne Duesseldorf, Cologne, Germany., van Attekum MH; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany Germany., Maas L; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany Germany., Brägelmann J; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany Germany.; Mildred Scheel School of Oncology, Cologne, University Hospital Cologne, Medical Faculty, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Cologne, Germany., Bartenhagen C; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, University Hospital Cologne, Medical Faculty, Cologne, Germany., Girard L; University of Texas Southwestern Medical Center, Dallas, Texas, USA., Bosco G; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany Germany., Dahmen I; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany Germany., Michels S; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn, Cologne Duesseldorf, Cologne, Germany., Weeden CE; Personalized Oncology Division, Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, The University of Melbourne, Parkville, Australia., Scheel AH; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Cologne, Germany., Meder L; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn, Cologne Duesseldorf, Cologne, Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Cologne, Germany., Golfmann K; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn, Cologne Duesseldorf, Cologne, Germany., Schuldt P; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn, Cologne Duesseldorf, Cologne, Germany., Siemanowski J; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Cologne, Germany., Rehker J; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Cologne, Germany., Merkelbach-Bruse S; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Cologne, Germany., Menon R; DISCO Pharmaceuticals GmbH, Cologne, Germany., Gautschi O; University of Berne and Cantonal Hospital of Lucerne, Cantonal Hospital of Lucerne, Lucerne, Switzerland., Heuckmann JM; DISCO Pharmaceuticals GmbH, Cologne, Germany., Brambilla E; Département d'Anatomie et Cytologie Pathologiques, Grenoble, France., Asselin-Labat ML; Personalized Oncology Division, Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, The University of Melbourne, Parkville, Australia., Persigehl T; Institute for Diagnostic and Interventional Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Minna JD; University of Texas Southwestern Medical Center, Dallas, Texas, USA., Walczak H; Institute of Biochemistry I, Medical Faculty, University of Cologne, Cologne, Germany.; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Centre for Cell Death, Cancer, and Inflammation (CCCI), UCL Cancer Institute, University College London, London, United Kingdom., Ullrich RT; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn, Cologne Duesseldorf, Cologne, Germany., Fischer M; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, University Hospital Cologne, Medical Faculty, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany., Reinhardt HC; Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, Essen, Germany., Wolf J; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn, Cologne Duesseldorf, Cologne, Germany., Büttner R; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Cologne, Germany., Peifer M; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany Germany.; Center for Molecular Medicine Cologne (CMMC), Cologne, Germany., George J; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany Germany.; Department of Head and Neck Surgery, Medical Faculty, University Hospital Cologne, Cologne, Germany., Thomas RK; University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany Germany.; University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Pathology, Cologne, Germany.; German Cancer Consortium (DKTK), partner site Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany.

المصدر: The Journal of clinical investigation [J Clin Invest] 2023 Nov 01; Vol. 133 (21). Date of Electronic Publication: 2023 Nov 01.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

مواضيع طبية MeSH: Lung Neoplasms*/drug therapy , Lung Neoplasms*/genetics , Lung Neoplasms*/pathology , Carcinoma, Non-Small-Cell Lung*/drug therapy , Carcinoma, Non-Small-Cell Lung*/genetics , Carcinoma, Squamous Cell*/genetics , Carcinoma, Squamous Cell*/pathology, Humans ; Gene Amplification ; Receptor, Fibroblast Growth Factor, Type 1/genetics ; Receptor, Fibroblast Growth Factor, Type 1/metabolism ; Protein Kinase Inhibitors/pharmacology ; Epithelial Cells/metabolism

المؤلفون: Lategahn J; PearlRiver Bio GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany.; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany., Tumbrink HL; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany., Schultz-Fademrecht C; PearlRiver Bio GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany.; Lead Discovery Center GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany., Heimsoeth A; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany., Werr L; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany., Niggenaber J; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany., Keul M; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany., Parmaksiz F; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany., Baumann M; Lead Discovery Center GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany., Menninger S; Lead Discovery Center GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany., Zent E; Lead Discovery Center GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany., Landel I; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany., Weisner J; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany., Jeyakumar K; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany., Heyden L; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany., Russ N; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany., Müller F; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany., Lorenz C; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany., Brägelmann J; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.; Mildred Scheel School of Oncology Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.; Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany., Spille I; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany., Grabe T; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany., Müller MP; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany., Heuckmann JM; PearlRiver Bio GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany., Klebl BM; Lead Discovery Center GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany.; The Norwegian College of Fishery Science, UiT The Arctic University of Norway, PO Box 6050 Langnes, N-9037 Tromsø, Norway., Nussbaumer P; Lead Discovery Center GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany., Sos ML; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.; Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany., Rauh D; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.

المصدر: Journal of medicinal chemistry [J Med Chem] 2022 May 12; Vol. 65 (9), pp. 6643-6655. Date of Electronic Publication: 2022 Apr 29.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Non-Small-Cell Lung*/drug therapy , Lung Neoplasms*/drug therapy , Lung Neoplasms*/genetics , Lung Neoplasms*/pathology, Animals ; Humans ; Mice ; Mutagenesis, Insertional ; Mutation ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use

المؤلفون: Heitz F; Evangelische Kliniken Essen-Mitte Klinik für Gynäkologie und gynäkologische Onkologie, Essen, Germany.; Department for Gynecology with the Center for Oncologic Surgery Charité Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Corporate member of Freie Universität Berlin, Berlin, Germany.; Berlin Institute of Health, Humboldt-Universität zu Berlin, Berlin, Germany., Lakis S; NEO New Oncology GmbH, Cologne, Germany.; ULTIVUE, Segrate Milan, Italy., Harter P; Evangelische Kliniken Essen-Mitte Klinik für Gynäkologie und gynäkologische Onkologie, Essen, Germany., Heikaus S; Evangelische Kliniken Essen-Mitte, Center for Pathology, Essen, Germany., Sehouli J; Department for Gynecology with the Center for Oncologic Surgery Charité Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Corporate member of Freie Universität Berlin, Berlin, Germany.; Berlin Institute of Health, Humboldt-Universität zu Berlin, Berlin, Germany., Talwar J; NEO New Oncology GmbH, Cologne, Germany., Menon R; NEO New Oncology GmbH, Cologne, Germany., Ataseven B; Evangelische Kliniken Essen-Mitte Klinik für Gynäkologie und gynäkologische Onkologie, Essen, Germany.; Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Munich, Germany., Bertrand M; NEO New Oncology GmbH, Cologne, Germany.; Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany., Schneider S; Evangelische Kliniken Essen-Mitte Klinik für Gynäkologie und gynäkologische Onkologie, Essen, Germany., Mariotti E; NEO New Oncology GmbH, Cologne, Germany., Bommert M; Evangelische Kliniken Essen-Mitte Klinik für Gynäkologie und gynäkologische Onkologie, Essen, Germany., Müller JN; NEO New Oncology GmbH, Cologne, Germany., Prader S; Evangelische Kliniken Essen-Mitte Klinik für Gynäkologie und gynäkologische Onkologie, Essen, Germany.; Department of Obstetrics and Gynecology, General Hospital (SABES-ASDAA), Brixen-Bres-sanone, Italy.; Department of Obstetrics and Gynecology, Innsbruck Medical University, Inns-bruck, Austria., Leenders F; NEO New Oncology GmbH, Cologne, Germany., Hengsbach A; Evangelische Kliniken Essen-Mitte Klinik für Gynäkologie und gynäkologische Onkologie, Essen, Germany., Gloeckner C; NEO New Oncology GmbH, Cologne, Germany., Braicu EI; Evangelische Kliniken Essen-Mitte, Center for Pathology, Essen, Germany., Heukamp LC; NEO New Oncology GmbH, Cologne, Germany., du Bois A; Evangelische Kliniken Essen-Mitte Klinik für Gynäkologie und gynäkologische Onkologie, Essen, Germany., Heuckmann JM; NEO New Oncology GmbH, Cologne, Germany.; PearlRiver Bio GmbH, Dortmund, Germany.

المصدر: PloS one [PLoS One] 2022 Feb 07; Vol. 17 (2), pp. e0262770. Date of Electronic Publication: 2022 Feb 07 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One

مواضيع طبية MeSH: CA-125 Antigen*/blood , Ovarian Neoplasms*/genetics , Ovarian Neoplasms*/blood , Ovarian Neoplasms*/pathology , WAP Four-Disulfide Core Domain Protein 2*/analysis , WAP Four-Disulfide Core Domain Protein 2*/metabolism, Humans ; Female ; Middle Aged ; Aged ; Prospective Studies ; Tumor Burden ; Circulating Tumor DNA/blood ; Circulating Tumor DNA/genetics ; Proteins/genetics ; Tumor Suppressor Protein p53/genetics ; Adult ; Mutation ; Biomarkers, Tumor/blood ; Biomarkers, Tumor/genetics ; Membrane Proteins/genetics ; Membrane Proteins/blood ; Neoplasm Grading ; Cystadenocarcinoma, Serous/genetics ; Cystadenocarcinoma, Serous/pathology ; Cystadenocarcinoma, Serous/blood ; Ascites/genetics ; Ascites/pathology ; Ascites/blood ; Carcinoma, Ovarian Epithelial/blood ; Carcinoma, Ovarian Epithelial/genetics ; Carcinoma, Ovarian Epithelial/pathology ; Cell-Free Nucleic Acids/blood ; Cell-Free Nucleic Acids/genetics

المؤلفون: Majewska H; Department of Pathomorphology, Medical University of Gdańsk, ul. Smoluchowskiego, 17 80-211, Gdańsk, Poland., Gorczyński A; Department of Pathomorphology, Medical University of Gdańsk, ul. Smoluchowskiego, 17 80-211, Gdańsk, Poland., Czapiewski P; Department of Pathomorphology, Medical University of Gdańsk, ul. Smoluchowskiego, 17 80-211, Gdańsk, Poland., Menon R; NEO New Oncology GmbH, Cologne, Germany., Mueller J; NEO New Oncology GmbH, Cologne, Germany., Lakis S; NEO New Oncology GmbH, Cologne, Germany., Heuckmann JM; NEO New Oncology GmbH, Cologne, Germany., Laco J; The Fingerland Department of Pathology, Charles University Faculty of Medicine in Hradec Kralove and University Hospital Hradec Kralove, Hradec Kralove, Czech Republic., Gupta R; Department of Tissue Pathology and Diagnostic Oncology, University of Sydney, Sydney, Australia., Andreasen S; Department of Otorhinolaryngology and Maxillofacial Surgery, Køge University Hospital, Køge, Denmark., Stodulski D; Department of Otolaryngology, Medical University of Gdańsk, Gdańsk, Poland., Iliszko M; Department of Biology and Medical Genetics, Medical University of Gdańsk, Gdańsk, Poland., Dziadziuszko R; Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk, Poland., Jassem J; Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk, Poland., Heukamp LC; Institute of Hematopathology Hamburg, Hamburg, Germany., Biernat W; Department of Pathomorphology, Medical University of Gdańsk, ul. Smoluchowskiego, 17 80-211, Gdańsk, Poland. biernat@gumed.edu.pl.

المصدر: Virchows Archiv : an international journal of pathology [Virchows Arch] 2021 May; Vol. 478 (5), pp. 933-941. Date of Electronic Publication: 2020 Nov 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 9423843 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2307 (Electronic) Linking ISSN: 09456317 NLM ISO Abbreviation: Virchows Arch Subsets: MEDLINE

مواضيع طبية MeSH: Anaplastic Lymphoma Kinase/*genetics , Biomarkers, Tumor/*genetics , Carcinoma/*genetics , Salivary Gland Neoplasms/*genetics, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma/enzymology ; Carcinoma/pathology ; Carcinoma, Intraductal, Noninfiltrating/enzymology ; Carcinoma, Intraductal, Noninfiltrating/genetics ; Carcinoma, Intraductal, Noninfiltrating/pathology ; Child ; Female ; Gene Amplification ; Gene Fusion ; High-Throughput Nucleotide Sequencing ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Male ; Middle Aged ; Salivary Gland Neoplasms/enzymology ; Salivary Gland Neoplasms/pathology ; Young Adult

المؤلفون: Ackermann S; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Cartolano M; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany., Hero B; Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany., Welte A; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Kahlert Y; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Roderwieser A; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Bartenhagen C; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Walter E; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Gecht J; Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany., Kerschke L; Institute of Biostatistics and Clinical Research, University of Münster, Münster, Germany., Volland R; Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany., Menon R; NEO New Oncology GmbH, Cologne, Germany., Heuckmann JM; NEO New Oncology GmbH, Cologne, Germany., Gartlgruber M; Division of Neuroblastoma Genomics (B087), German Cancer Research Center, and Hopp Children's Cancer Center at NCT Heidelberg (KiTZ), Heidelberg, Germany., Hartlieb S; Division of Neuroblastoma Genomics (B087), German Cancer Research Center, and Hopp Children's Cancer Center at NCT Heidelberg (KiTZ), Heidelberg, Germany., Henrich KO; Division of Neuroblastoma Genomics (B087), German Cancer Research Center, and Hopp Children's Cancer Center at NCT Heidelberg (KiTZ), Heidelberg, Germany., Okonechnikov K; Division of Pediatric Neurooncology, German Cancer Research Center, and Hopp Children's Cancer Center at NCT Heidelberg (KiTZ), Heidelberg, Germany., Altmüller J; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Center for Genomics, University of Cologne, Cologne, Germany., Nürnberg P; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Center for Genomics, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Lefever S; Center for Medical Genetics, Ghent University, Ghent, Belgium., de Wilde B; Center for Medical Genetics, Ghent University, Ghent, Belgium., Sand F; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Ikram F; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Interdisciplinary Research Centre in Biomedical Materials (IRCBM), COMSATS University Islamabad, Lahore Campus, Lahore, Pakistan., Rosswog C; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Fischer J; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany., Theissen J; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.; Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany., Hertwig F; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Berlin Institute of Health, Berlin, Germany., Singhi AD; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Simon T; Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany., Vogel W; Pathology of the University Medical Center Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.; Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany., Perner S; Pathology of the University Medical Center Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.; Research Center Borstel, Leibniz Center for Medicine and Biosciences, Borstel, Germany., Krug B; Department of Diagnostic and Interventional Radiology, University Hospital of Cologne, Cologne, Germany., Schmidt M; Department of Nuclear Medicine, University of Cologne, Cologne, Germany., Rahmann S; Genome Informatics, Institute of Human Genetics, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.; Computer Science, TU Dortmund, Dortmund, Germany., Achter V; Computing Center, University of Cologne, Cologne, Germany., Lang U; Computing Center, University of Cologne, Cologne, Germany.; Department of Informatics, University of Cologne, Cologne, Germany., Vokuhl C; Kiel Pediatric Tumor Registry, Department of Pediatric Pathology, University of Kiel, Kiel, Germany., Ortmann M; Department of Pathology, University of Cologne, Cologne, Germany., Büttner R; Department of Pathology, University of Cologne, Cologne, Germany., Eggert A; Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Berlin Institute of Health, Berlin, Germany., Speleman F; Center for Medical Genetics, Ghent University, Ghent, Belgium., O'Sullivan RJ; Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute (UPCI), Hillman Cancer Center, Pittsburgh, PA, USA., Thomas RK; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Department of Pathology, University of Cologne, Cologne, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Berthold F; Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany., Vandesompele J; Center for Medical Genetics, Ghent University, Ghent, Belgium., Schramm A; Department of Medical Oncology, West German Cancer Center Essen, University of Duisburg-Essen, Essen, Germany., Westermann F; Division of Neuroblastoma Genomics (B087), German Cancer Research Center, and Hopp Children's Cancer Center at NCT Heidelberg (KiTZ), Heidelberg, Germany., Schulte JH; Department of Pediatric Oncology and Hematology, Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Cancer Consortium (DKTK), Heidelberg, Germany.; Berlin Institute of Health, Berlin, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Peifer M; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Cologne, Germany., Fischer M; Department of Experimental Pediatric Oncology, University Children's Hospital of Cologne, Medical Faculty, Cologne, Germany. matthias.fischer@uk-koeln.de.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.

المصدر: Science (New York, N.Y.) [Science] 2018 Dec 07; Vol. 362 (6419), pp. 1165-1170.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Neuroblastoma/*classification , Neuroblastoma/*mortality , Telomere Homeostasis/*genetics, Child ; Child, Preschool ; Disease-Free Survival ; Exome/genetics ; Genome, Human ; Humans ; Metabolic Networks and Pathways/genetics ; Mutation ; Neuroblastoma/drug therapy ; Neuroblastoma/genetics ; Prognosis ; Sequence Analysis, DNA ; Tumor Suppressor Protein p53/genetics ; ras Proteins/genetics

المؤلفون: Plenker D; Molecular Pathology, Institute of Pathology, University of Cologne, Cologne, Germany.; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany., Bertrand M; NEO New Oncology GmbH, Köln, Germany., de Langen AJ; Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, the Netherlands., Riedel R; Department of Internal Medicine, Center for Integrated Oncology Köln Bonn, University Hospital Cologne, Cologne, Germany., Lorenz C; Molecular Pathology, Institute of Pathology, University of Cologne, Cologne, Germany.; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany., Scheel AH; Institute of Pathology, Center of Integrated Oncology, University Hospital Cologne, Cologne, Germany., Müller J; NEO New Oncology GmbH, Köln, Germany., Brägelmann J; Molecular Pathology, Institute of Pathology, University of Cologne, Cologne, Germany.; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany., Daßler-Plenker J; Department of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany., Kobe C; Department of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany., Persigehl T; Department of Radiology, University Hospital of Cologne, Cologne, Germany., Kluge A; Institute for Diagnostic and Interventional Radiology, Pius-Hospital, Medical Campus University of Oldenburg, Oldenburg, Germany., Wurdinger T; Department of Neurosurgery, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands.; Brain Tumor Center Amsterdam, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands.; Department of Neurology, Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, Charlestown, Massachusetts., Schellen P; Department of Neurosurgery, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands.; Brain Tumor Center Amsterdam, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands., Hartmann G; Department of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany., Zacherle T; NEO New Oncology GmbH, Köln, Germany., Menon R; NEO New Oncology GmbH, Köln, Germany., Thunnissen E; Department of Pathology, VU University Medical Center, Amsterdam, the Netherlands., Büttner R; Institute of Pathology, Center of Integrated Oncology, University Hospital Cologne, Cologne, Germany., Griesinger F; Lung Cancer Network NOWEL, Oldenburg, Germany.; Department of Hematology and Oncology, Pius-Hospital, University Department Internal Medicine-Oncology, Medical Campus University of Oldenburg, Oldenburg, Germany., Wolf J; Department of Internal Medicine, Center for Integrated Oncology Köln Bonn, University Hospital Cologne, Cologne, Germany., Heukamp L; NEO New Oncology GmbH, Köln, Germany.; Lung Cancer Network NOWEL, Oldenburg, Germany.; Institute for Hematopathology, Hamburg, Germany., Sos ML; Molecular Pathology, Institute of Pathology, University of Cologne, Cologne, Germany. msos1@uni-koeln.de heuckmann@newoncology.de.; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany., Heuckmann JM; NEO New Oncology GmbH, Köln, Germany. msos1@uni-koeln.de heuckmann@newoncology.de.

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2018 Mar 15; Vol. 24 (6), pp. 1337-1343. Date of Electronic Publication: 2017 Dec 28.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Adenocarcinoma of Lung/*genetics , Protein Kinase Inhibitors/*pharmacology , Proto-Oncogene Proteins c-met/*antagonists & inhibitors , Proto-Oncogene Proteins c-met/*genetics, Adenocarcinoma of Lung/diagnosis ; Adenocarcinoma of Lung/drug therapy ; Adenocarcinoma of Lung/metabolism ; Adult ; Anaplastic Lymphoma Kinase/antagonists & inhibitors ; Crizotinib/pharmacology ; Crizotinib/therapeutic use ; Female ; Gene Duplication ; Gene Rearrangement ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Molecular Targeted Therapy ; Neoplasm Staging ; Oncogene Proteins, Fusion/chemistry ; Oncogene Proteins, Fusion/genetics ; Oncogene Proteins, Fusion/metabolism ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins c-met/chemistry ; Tomography, X-Ray Computed

المؤلفون: Müller JN; NEO New Oncology GmbH, Köln, Germany., Falk M; Institute for Hematopathology, Hamburg, Germany; Lung Cancer Network NOWEL, Oldenburg, Germany., Talwar J; NEO New Oncology GmbH, Köln, Germany., Neemann N; NEO New Oncology GmbH, Köln, Germany., Mariotti E; NEO New Oncology GmbH, Köln, Germany., Bertrand M; NEO New Oncology GmbH, Köln, Germany., Zacherle T; NEO New Oncology GmbH, Köln, Germany., Lakis S; NEO New Oncology GmbH, Köln, Germany., Menon R; NEO New Oncology GmbH, Köln, Germany., Gloeckner C; NEO New Oncology GmbH, Köln, Germany., Tiemann M; Institute for Hematopathology, Hamburg, Germany; Lung Cancer Network NOWEL, Oldenburg, Germany., Heukamp LC; NEO New Oncology GmbH, Köln, Germany; Institute for Hematopathology, Hamburg, Germany; Lung Cancer Network NOWEL, Oldenburg, Germany., Thomas RK; Department of Translational Genomics, Medical Faculty, University of Köln, Köln, Germany., Griesinger F; Lung Cancer Network NOWEL, Oldenburg, Germany; Department of Hematology and Oncology, Pius-Hospital, University Department Internal Medicine-Oncology, Medical Campus University of Oldenburg, Oldenburg, Germany., Heuckmann JM; NEO New Oncology GmbH, Köln, Germany.

المصدر: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer [J Thorac Oncol] 2017 Oct; Vol. 12 (10), pp. 1503-1511. Date of Electronic Publication: 2017 Jul 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101274235 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-1380 (Electronic) Linking ISSN: 15560864 NLM ISO Abbreviation: J Thorac Oncol Subsets: MEDLINE

مواضيع طبية MeSH: Genomics/*methods , Liquid Biopsy/*methods , Neoplasms/*blood , Neoplasms/*diagnosis, Female ; Humans ; Male ; Neoplasms/genetics ; Proto-Oncogene Mas

المؤلفون: Brägelmann J; Molecular Pathology, Institute of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany; Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany., Dammert MA; Molecular Pathology, Institute of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany; Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany., Dietlein F; Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany., Heuckmann JM; NEO New Oncology GmbH, Gottfried-Hagen-Str. 20, 51105 Cologne, Germany., Choidas A; Lead Discovery Center (LDC) GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany., Böhm S; Molecular Pathology, Institute of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany; Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany., Richters A; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44221 Dortmund, Germany., Basu D; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44221 Dortmund, Germany., Tischler V; Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany., Lorenz C; Molecular Pathology, Institute of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany; Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany., Habenberger P; Lead Discovery Center (LDC) GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany., Fang Z; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44221 Dortmund, Germany., Ortiz-Cuaran S; Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany., Leenders F; Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany., Eickhoff J; Lead Discovery Center (LDC) GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany., Koch U; Lead Discovery Center (LDC) GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany., Getlik M; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44221 Dortmund, Germany., Termathe M; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44221 Dortmund, Germany., Sallouh M; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44221 Dortmund, Germany., Greff Z; Vichem Chemie Research Ltd., Herman Ottó u. 15, Budapest, Hungary., Varga Z; Vichem Chemie Research Ltd., Herman Ottó u. 15, Budapest, Hungary., Balke-Want H; Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany; Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany., French CA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Peifer M; Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany., Reinhardt HC; Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany; Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany., Örfi L; Vichem Chemie Research Ltd., Herman Ottó u. 15, Budapest, Hungary; Department of Pharmaceutical Chemistry, Semmelweis University, Hőgyes E. U.9, Budapest, Hungary., Kéri G; Vichem Chemie Research Ltd., Herman Ottó u. 15, Budapest, Hungary., Ansén S; Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany., Heukamp LC; Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany; Institute of Pathology, Medical Faculty, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany., Büttner R; Institute of Pathology, Medical Faculty, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany., Rauh D; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44221 Dortmund, Germany., Klebl BM; Lead Discovery Center (LDC) GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany., Thomas RK; Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany; Institute of Pathology, Medical Faculty, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany; German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address: roman.thomas@uni-koeln.de., Sos ML; Molecular Pathology, Institute of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany; Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany; Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany. Electronic address: martin.sos@uni-koeln.de.

المصدر: Cell reports [Cell Rep] 2017 Sep 19; Vol. 20 (12), pp. 2833-2845.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Molecular Targeted Therapy*, Neoplasms/*enzymology , Neoplasms/*pathology , Protein Kinase Inhibitors/*pharmacology, Cell Cycle Proteins ; Cell Line, Tumor ; Cyclin T/metabolism ; Cyclin-Dependent Kinase 9/antagonists & inhibitors ; Cyclin-Dependent Kinase 9/metabolism ; HEK293 Cells ; High-Throughput Screening Assays ; Humans ; Neoplasms/genetics ; Nuclear Proteins/antagonists & inhibitors ; Nuclear Proteins/metabolism ; Protein Kinase Inhibitors/chemistry ; RNA Polymerase II/metabolism ; Transcription Elongation, Genetic/drug effects ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/metabolism ; Transcription, Genetic/drug effects