المؤلفون: Ak, Dawson, Sb, Reele, Aj, Wood, Hj, Duff, Raymond L. Woosley, Rf, Smith

المصدر: Europe PubMed Central

مصطلحات موضوعية: Electrophysiology, Male, Dogs, Isomerism, Receptors, Adrenergic, beta, Isoproterenol, Action Potentials, Animals, Female, Heart, Propranolol

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d65d78058d719627af2e0b317cfa2116
https://pubmed.ncbi.nlm.nih.gov/6323694

المؤلفون: Dm, Roden, Hj, Duff, Altenbern D, Raymond L. Woosley

المصدر: Europe PubMed Central

مصطلحات موضوعية: Male, Aconitine, Encainide, Rats, Inbred Strains, Procainamide, Rats, Liver, Dealkylation, Digestive System Physiological Phenomena, Heart Conduction System, Heart Rate, Animals, Anilides, Anti-Arrhythmia Agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::92193cdd0d95ab73f33a06c929c2aaa5
https://pubmed.ncbi.nlm.nih.gov/6806461

المؤلفون: Mohammed Taouis, Rs, Sheldon, Rj, Hill, Hj, Duff

المصدر: Europe PubMed Central

مصطلحات موضوعية: Male, Cholera Toxin, Binding Sites, Myocardium, Colforsin, Neurotoxins, Isoproterenol, 8-Bromo Cyclic Adenosine Monophosphate, Heart, Rats, Inbred Strains, In Vitro Techniques, Sodium Channels, Rats, Pertussis Toxin, Cyclic AMP, Animals, Virulence Factors, Bordetella, Alprostadil, Batrachotoxins, Protein Kinase Inhibitors, Protein Kinases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::06fada0d01a1ada740116949789f7978
http://europepmc.org/abstract/med/1645346

المؤلفون: Ku TC; Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States., Cao J; Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States., Won SJ; Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States., Guo J; Faculty of Medicine, Libin Institute, Calgary T2N 4N1, Canada., Camacho-Hernandez GA; Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States., Okorom AV; Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States., Salomon KW; Laboratory for Membrane Protein Dynamics, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark., Lee KH; Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States., Loland CJ; Laboratory for Membrane Protein Dynamics, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark., Duff HJ; Laboratory for Membrane Protein Dynamics, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2200 Copenhagen, Denmark., Shi L; Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States., Newman AH; Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 333 Cassell Drive, Baltimore, Maryland 21224, United States.

المصدر: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2024 Jan 05; Vol. 7 (2), pp. 515-532. Date of Electronic Publication: 2024 Jan 05 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101721411 Publication Model: eCollection Cited Medium: Internet ISSN: 2575-9108 (Electronic) Linking ISSN: 25759108 NLM ISO Abbreviation: ACS Pharmacol Transl Sci Subsets: PubMed not MEDLINE

المؤلفون: Janz A; Comprehensive Heart Failure Center, Department of Cardiovascular Genetics, University Hospital Würzburg, Würzburg, Germany., Walz K; Comprehensive Heart Failure Center, Department of Cardiovascular Genetics, University Hospital Würzburg, Würzburg, Germany., Cirnu A; Comprehensive Heart Failure Center, Department of Cardiovascular Genetics, University Hospital Würzburg, Würzburg, Germany., Surjanto J; Comprehensive Heart Failure Center, Department of Cardiovascular Genetics, University Hospital Würzburg, Würzburg, Germany., Urlaub D; Comprehensive Heart Failure Center, Department of Cardiovascular Genetics, University Hospital Würzburg, Würzburg, Germany., Leskien M; Comprehensive Heart Failure Center, Department of Cardiovascular Genetics, University Hospital Würzburg, Würzburg, Germany., Kohlhaas M; Comprehensive Heart Failure Center, Department of Translational Research, University Hospital Würzburg, Würzburg, Germany., Nickel A; Comprehensive Heart Failure Center, Department of Translational Research, University Hospital Würzburg, Würzburg, Germany., Brand T; Institute of Pharmacology and Toxicology, University of Würzburg, Würzburg, Germany., Nose N; Comprehensive Heart Failure Center, Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany., Wörsdörfer P; Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany., Wagner N; Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany., Higuchi T; Comprehensive Heart Failure Center, Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany., Maack C; Comprehensive Heart Failure Center, Department of Translational Research, University Hospital Würzburg, Würzburg, Germany; Department of Medicine I, University Hospital Würzburg, Würzburg, Germany., Dudek J; Comprehensive Heart Failure Center, Department of Translational Research, University Hospital Würzburg, Würzburg, Germany., Lorenz K; Institute of Pharmacology and Toxicology, University of Würzburg, Würzburg, Germany; Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V., Dortmund, Germany., Klopocki E; Institute for Human Genetics, Biocenter, Julius-Maximilians-University Würzburg, Würzburg, Germany., Ergün S; Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany., Duff HJ; Department of Cardiac Sciences and Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, Canada., Gerull B; Comprehensive Heart Failure Center, Department of Cardiovascular Genetics, University Hospital Würzburg, Würzburg, Germany; Department of Medicine I, University Hospital Würzburg, Würzburg, Germany; Department of Cardiac Sciences and Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, Canada. Electronic address: Gerull_B@ukw.de.

المصدر: Molecular metabolism [Mol Metab] 2024 Jan; Vol. 79, pp. 101859. Date of Electronic Publication: 2023 Dec 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE

مواضيع طبية MeSH: Cardiomyopathy, Dilated*/genetics , Cardiomyopathy, Dilated*/metabolism , Cardiomyopathy, Dilated*/pathology , Cerebellar Ataxia* , Induced Pluripotent Stem Cells*/metabolism , Maleates* , Metabolism, Inborn Errors*, Humans ; Adenosine Triphosphate/metabolism ; HeLa Cells ; Mutation/genetics ; Myocytes, Cardiac/metabolism ; Reactive Oxygen Species/metabolism ; Respiration

SCR Disease Name: 3-Methylglutaconic Aciduria, Type V

المؤلفون: Kudaibergenova M; Centre for Molecular Simulation and Department of Biological Sciences, University of Calgary, Calgary, AB, Canada., Guo J; Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, AB, Canada., Khan HM; Centre for Molecular Simulation and Department of Biological Sciences, University of Calgary, Calgary, AB, Canada., Lees-Miller J; Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, AB, Canada., Mousaei M; Centre for Molecular Simulation and Department of Biological Sciences, University of Calgary, Calgary, AB, Canada., Miranda W; Centre for Molecular Simulation and Department of Biological Sciences, University of Calgary, Calgary, AB, Canada., Ngo VA; Centre for Molecular Simulation and Department of Biological Sciences, University of Calgary, Calgary, AB, Canada., Noskov SY; Centre for Molecular Simulation and Department of Biological Sciences, University of Calgary, Calgary, AB, Canada., Tieleman DP; Centre for Molecular Simulation and Department of Biological Sciences, University of Calgary, Calgary, AB, Canada. Electronic address: tieleman@ucalgary.ca., Duff HJ; Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, AB, Canada. Electronic address: hduff@ucalgary.ca.

المصدر: Biophysical journal [Biophys J] 2022 Dec 06; Vol. 121 (23), pp. 4585-4599. Date of Electronic Publication: 2022 Oct 29.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0370626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-0086 (Electronic) Linking ISSN: 00063495 NLM ISO Abbreviation: Biophys J Subsets: MEDLINE

مواضيع طبية MeSH: ERG1 Potassium Channel*/chemistry , ERG1 Potassium Channel*/genetics, Humans ; Cations ; Molecular Dynamics Simulation ; Mutation

المؤلفون: Lee KH; Computational Chemistry and Molecular Biophysics Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, United States., Fant AD; Computational Chemistry and Molecular Biophysics Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, United States., Guo J; Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada., Guan A; Computational Chemistry and Molecular Biophysics Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, United States., Jung J; Computational Chemistry and Molecular Biophysics Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, United States., Kudaibergenova M; Centre for Molecular Simulation, Department of Biological Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada., Miranda WE; Centre for Molecular Simulation, Department of Biological Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada., Ku T; Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, United States., Cao J; Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, United States., Wacker S; Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada.; Centre for Molecular Simulation, Department of Biological Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada.; Achlys Inc., 7-126 Li Ka Shing Center for Health and Innovation, Edmonton, Alberta T6G 2E1, Canada., Duff HJ; Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada., Newman AH; Medicinal Chemistry Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, United States., Noskov SY; Centre for Molecular Simulation, Department of Biological Sciences, University of Calgary, Calgary, Alberta T2N 1N4, Canada., Shi L; Computational Chemistry and Molecular Biophysics Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, United States.

المصدر: Journal of chemical information and modeling [J Chem Inf Model] 2021 Sep 27; Vol. 61 (9), pp. 4266-4279. Date of Electronic Publication: 2021 Aug 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101230060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-960X (Electronic) Linking ISSN: 15499596 NLM ISO Abbreviation: J Chem Inf Model Subsets: MEDLINE

مواضيع طبية MeSH: Cocaine* , Dopamine Plasma Membrane Transport Proteins*, Ether ; Humans ; Machine Learning ; Models, Molecular

المؤلفون: Miranda WE; Centre for Molecular Simulation and Department of Biological Sciences, 507 Campus Drive, University of Calgary, Calgary, AB, Canada., Guo J; Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, 3280 Hospital Dr., University of Calgary, Calgary, AB, Canada., Mesa-Galloso H; Centre for Molecular Simulation and Department of Biological Sciences, 507 Campus Drive, University of Calgary, Calgary, AB, Canada., Corradi V; Centre for Molecular Simulation and Department of Biological Sciences, 507 Campus Drive, University of Calgary, Calgary, AB, Canada., Lees-Miller JP; Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, 3280 Hospital Dr., University of Calgary, Calgary, AB, Canada., Tieleman DP; Centre for Molecular Simulation and Department of Biological Sciences, 507 Campus Drive, University of Calgary, Calgary, AB, Canada. tieleman@ucalgary.ca., Duff HJ; Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, 3280 Hospital Dr., University of Calgary, Calgary, AB, Canada. hduff@ucalgary.ca., Noskov SY; Centre for Molecular Simulation and Department of Biological Sciences, 507 Campus Drive, University of Calgary, Calgary, AB, Canada. snoskov@ucalgary.ca.

المصدر: Nature communications [Nat Commun] 2021 Mar 03; Vol. 12 (1), pp. 1409. Date of Electronic Publication: 2021 Mar 03.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Ceramides/*metabolism , Ether-A-Go-Go Potassium Channels/*chemistry , Ether-A-Go-Go Potassium Channels/*metabolism, Ceramides/chemistry ; Ceramides/pharmacology ; Electrophysiology/methods ; Ether-A-Go-Go Potassium Channels/antagonists & inhibitors ; Ether-A-Go-Go Potassium Channels/genetics ; HEK293 Cells ; Humans ; Molecular Dynamics Simulation ; Mutagenesis, Site-Directed

المؤلفون: Khan HM; Centre for Molecular Simulation, Department of Biological Sciences, Faculty of Science, University of Calgary, Calgary, Alberta, Canada., Guo J; Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Duff HJ; Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Tieleman DP; Centre for Molecular Simulation, Department of Biological Sciences, Faculty of Science, University of Calgary, Calgary, Alberta, Canada., Noskov SY; Centre for Molecular Simulation, Department of Biological Sciences, Faculty of Science, University of Calgary, Calgary, Alberta, Canada. Electronic address: snoskov@ucalgary.ca.

المصدر: Biophysical journal [Biophys J] 2021 Feb 16; Vol. 120 (4), pp. 738-748. Date of Electronic Publication: 2021 Jan 19.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0370626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-0086 (Electronic) Linking ISSN: 00063495 NLM ISO Abbreviation: Biophys J Subsets: MEDLINE

مواضيع طبية MeSH: Ether-A-Go-Go Potassium Channels*/metabolism , Molecular Dynamics Simulation*, Action Potentials ; Cryoelectron Microscopy ; ERG1 Potassium Channel/metabolism ; Humans

المؤلفون: Janz A; Comprehensive Heart Failure Center (CHFC) and Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany., Chen R; Comprehensive Heart Failure Center (CHFC) and Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany., Regensburger M; Comprehensive Heart Failure Center (CHFC) and Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany., Ueda Y; Institute of Anatomy and Cell Biology II, University of Würzburg, Würzburg, Germany., Rost S; Institute of Human Genetics, Biocentre, University of Würzburg, Würzburg, Germany., Klopocki E; Institute of Human Genetics, Biocentre, University of Würzburg, Würzburg, Germany., Günther K; Institute of Molecular Biology & CMBI, University of Innsbruck, Innsbruck, Austria; Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, Salzburg, Austria., Edenhofer F; Institute of Molecular Biology & CMBI, University of Innsbruck, Innsbruck, Austria., Duff HJ; Libin Cardiovascular Institute of Alberta, Department of Cardiac Sciences, University of Calgary, Calgary, Canada., Ergün S; Institute of Anatomy and Cell Biology II, University of Würzburg, Würzburg, Germany., Gerull B; Comprehensive Heart Failure Center (CHFC) and Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany; Libin Cardiovascular Institute of Alberta, Department of Cardiac Sciences, University of Calgary, Calgary, Canada. Electronic address: gerull_b@ukw.de.

المصدر: Stem cell research [Stem Cell Res] 2020 Jul; Vol. 46, pp. 101856. Date of Electronic Publication: 2020 Jun 02.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 101316957 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-7753 (Electronic) Linking ISSN: 18735061 NLM ISO Abbreviation: Stem Cell Res Subsets: MEDLINE

مواضيع طبية MeSH: Cardiomyopathy, Dilated* , Induced Pluripotent Stem Cells*, Ataxia ; Humans ; Mutation ; Siblings