-
1دورية أكاديمية
لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل. -
2دورية أكاديمية
لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل. -
3دورية أكاديمية
لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل. -
4
-
5دورية أكاديمية
لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل. -
6دورية أكاديمية
لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل. -
7
-
8دورية أكاديمية
لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل. -
9دورية أكاديمية
المؤلفون: Scott JD, Li SW, Brunskill AP, Chen X, Cox K, Cumming JN, Forman M, Gilbert EJ, Hodgson RA, Hyde LA, Jiang Q; Albany Molecular Research Inc. , 26 Corporate Circle, Albany, New York 12203, United States., Iserloh U, Kazakevich I, Kuvelkar R, Mei H, Meredith J, Misiaszek J, Orth P, Rossiter LM; Albany Molecular Research Inc. , 26 Corporate Circle, Albany, New York 12203, United States., Slater M; Albany Molecular Research Inc. , 26 Corporate Circle, Albany, New York 12203, United States., Stone J, Strickland CO, Voigt JH, Wang G, Wang H, Wu Y, Greenlee WJ, Parker EM, Kennedy ME, Stamford AW
المصدر: Journal of medicinal chemistry [J Med Chem] 2016 Dec 08; Vol. 59 (23), pp. 10435-10450. Date of Electronic Publication: 2016 Nov 18.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
مواضيع طبية MeSH: Drug Discovery*, Alzheimer Disease/*drug therapy , Amyloid beta-Protein Precursor/*antagonists & inhibitors , Cyclic S-Oxides/*pharmacology , Thiadiazines/*pharmacology, Alzheimer Disease/metabolism ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Cyclic S-Oxides/chemical synthesis ; Cyclic S-Oxides/chemistry ; Dogs ; Dose-Response Relationship, Drug ; Humans ; Macaca fascicularis ; Models, Molecular ; Molecular Structure ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; Thiadiazines/chemical synthesis ; Thiadiazines/chemistry
-
10دورية أكاديمية
المؤلفون: Kennedy ME; Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA. matthew.kennedy@merck.com andy.stamford1@gmail.com ericmcparker@comcast.net mark.forman@merck.com., Stamford AW; Department of Global Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, USA. matthew.kennedy@merck.com andy.stamford1@gmail.com ericmcparker@comcast.net mark.forman@merck.com., Chen X; Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Cox K; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Cumming JN; Department of Global Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Dockendorf MF; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Egan M; Department of Clinical Research, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Ereshefsky L; PAREXEL, Glendale, CA 91206, USA., Hodgson RA; Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Hyde LA; Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Jhee S; PAREXEL, Glendale, CA 91206, USA., Kleijn HJ; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Kuvelkar R; Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Li W; Department of Global Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Mattson BA; Department of Safety Assessment, Merck Research Laboratories, West Point, PA 19446, USA., Mei H; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Palcza J; Department of Biostatistics, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Scott JD; Department of Global Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Tanen M; Translational Biomarkers Department, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Troyer MD; Department of Translational Medicine, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Tseng JL; Department of Translational Medicine, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Stone JA; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Parker EM; Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA. matthew.kennedy@merck.com andy.stamford1@gmail.com ericmcparker@comcast.net mark.forman@merck.com., Forman MS; Department of Translational Medicine, Merck Research Laboratories, Kenilworth, NJ 07033, USA. matthew.kennedy@merck.com andy.stamford1@gmail.com ericmcparker@comcast.net mark.forman@merck.com.
المصدر: Science translational medicine [Sci Transl Med] 2016 Nov 02; Vol. 8 (363), pp. 363ra150.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
مواضيع طبية MeSH: Alzheimer Disease/*metabolism , Amyloid Precursor Protein Secretases/*antagonists & inhibitors , Amyloid beta-Peptides/*chemistry , Aspartic Acid Endopeptidases/*antagonists & inhibitors , Central Nervous System/*metabolism , Cyclic S-Oxides/*pharmacology , Thiadiazines/*pharmacology, Administration, Oral ; Amyloid Precursor Protein Secretases/metabolism ; Animals ; Aspartic Acid Endopeptidases/metabolism ; Brain/metabolism ; Catalytic Domain ; Crystallography, X-Ray ; Drug Design ; Female ; Glucose/metabolism ; Macaca fascicularis ; Magnetic Resonance Spectroscopy ; Mice ; Myelin Sheath/chemistry ; Peptides/chemistry ; Rabbits ; Rats