المؤلفون: Donovan LK; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Delaidelli A; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada., Joseph SK; Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Centre for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA., Bielamowicz K; Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Centre for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA., Fousek K; Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Centre for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA., Holgado BL; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Manno A; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Srikanthan D; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Gad AZ; Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Centre for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA., Van Ommeren R; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Przelicki D; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Richman C; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Ramaswamy V; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada., Daniels C; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Pallota JG; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Douglas T; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Joynt ACM; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Haapasalo J; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Nor C; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Vladoiu MC; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Kuzan-Fischer CM; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Garzia L; Cancer Research Program, McGill University Health Centre Research Institute, Montreal, Quebec, Canada., Mack SC; Brain Tumour Program, Children's Cancer Centre and Department of Paediatrics, Baylor College of Medicine, Houston, TX, USA., Varadharajan S; Brain Tumour Program, Children's Cancer Centre and Department of Paediatrics, Baylor College of Medicine, Houston, TX, USA., Baker ML; Centre for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA., Hendrikse L; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Ly M; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Kharas K; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Balin P; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Wu X; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Qin L; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Huang N; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Stucklin AG; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Morrissy AS; Department of Biochemistry & Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada., Cavalli FMG; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Luu B; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Suarez R; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., De Antonellis P; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Michealraj A; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Rastan A; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Hegde M; Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Centre for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA., Komosa M; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Sirbu O; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Kumar SA; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Abdullaev Z; Laboratory of Pathology, National Cancer Institute Centre for Cancer Research, Bethesda, MD, USA., Faria CC; Division of Neurosurgery, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria, Lisbon, Portugal., Yip S; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Hukin J; Division of Neurology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada., Tabori U; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Hawkins C; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Aldape K; Laboratory of Pathology, National Cancer Institute Centre for Cancer Research, Bethesda, MD, USA., Daugaard M; Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada., Maris JM; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Centre for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Sorensen PH; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada., Ahmed N; Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA. nmahmed@texaschildrens.org.; Centre for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA. nmahmed@texaschildrens.org., Taylor MD; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. mdt.cns@gmail.com.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada. mdt.cns@gmail.com.; Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada. mdt.cns@gmail.com.; Department of Surgery, Department of Laboratory Medicine and Pathobiology, and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. mdt.cns@gmail.com.

المصدر: Nature medicine [Nat Med] 2021 Jun; Vol. 27 (6), pp. 1117-1120.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Skowron P; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Farooq H; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Cavalli FMG; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Morrissy AS; Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Alberta Children's Hospital Research Institute, Calgary, AB, Canada.; Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada., Ly M; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Hendrikse LD; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Wang EY; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Djambazian H; McGill University Genome Centre, McGill University, Montreal, QC, Canada.; Department of Human Genetics, McGill University, Montreal, QC, Canada., Zhu H; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Mungall KL; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada., Trinh QM; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Zheng T; Department of Neurology, University of California San Francisco, San Francisco, CA, United States., Dai S; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA, United States., Stucklin ASG; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Vladoiu MC; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Fong V; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Holgado BL; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Nor C; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Wu X; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Abd-Rabbo D; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Bérubé P; McGill University Genome Centre, McGill University, Montreal, QC, Canada., Wang YC; McGill University Genome Centre, McGill University, Montreal, QC, Canada., Luu B; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Suarez RA; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Rastan A; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada., Gillmor AH; Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Alberta Children's Hospital Research Institute, Calgary, AB, Canada.; Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada., Lee JJY; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Zhang XY; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada., Daniels C; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Dirks P; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Malkin D; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Division of Haematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada., Bouffet E; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Division of Haematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada., Tabori U; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Institute of Medical Science, University of Toronto, Toronto, ON, Canada.; Division of Haematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada., Loukides J; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Doz FP; SIREDO Center (pediatric, adolescent and young adults oncology), Institut Curie, University of Paris, Paris, France., Bourdeaut F; SIREDO Center (pediatric, adolescent and young adults oncology), Institut Curie, University of Paris, Paris, France., Delattre OO; INSERM U 830, Institut Curie, Paris, France., Masliah-Planchon J; Unit of Somatic Genetics, Institut Curie, Paris, France., Ayrault O; PSL Research University, Université Paris Sud, Université Paris-Saclay, CNRS UMR 3347, INSERM U1021, Institut Curie, Paris, France., Kim SK; Department of Neurosurgery, Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul, South Korea., Meyronet D; Hospices Civils de Lyon, Institute of Pathology, University Lyon 1, Department of Cancer Cell Plasticity-INSERM U1052 Cancer Research Center of Lyon, Lyon, France., Grajkowska WA; Department of Pathology, The Children's Memorial Health Institute, Warsaw, Poland., Carlotti CG; Department of Surgery and Anatomy, Faculty of Medicine of Ribeirão Preto, University of Sao Paulo, São Paulo, Brazil., de Torres C; Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain., Mora J; Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain., Eberhart CG; Departments of Pathology, Ophthalmology and Oncology, John Hopkins University School of Medicine, Baltimore, MD, United States., Van Meir EG; Department of Hematology & Medical Oncology, School of Medicine and Winship Cancer Institute, Emory University, Atlanta, GA, United States., Kumabe T; Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan., French PJ; Department of Neurology, Erasmus University Medical Center, Rotterdam, Netherlands., Kros JM; Department of Pathology, Erasmus University Medical Center, Rotterdam, Netherlands., Jabado N; Division of Experimental Medicine, McGill University, Montreal, QC, Canada., Lach B; Department of Pathology and Molecular Medicine, Division of Anatomical Pathology, McMaster University, Hamilton, ON, Canada.; Department of Pathology and Laboratory Medicine, Hamilton General Hospital, Hamilton, ON, Canada., Pollack IF; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States., Hamilton RL; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States., Rao AAN; Division of Pediatric Hematology/Oncology, Mayo Clinic, Rochester, MN, United States., Giannini C; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States., Olson JM; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States., Bognár L; Department of Neurosurgery, University of Debrecen, Medical and Health Science Centre, Debrecen, Hungary., Klekner A; Department of Neurosurgery, University of Debrecen, Medical and Health Science Centre, Debrecen, Hungary., Zitterbart K; Department of Pediatric Oncology, Masaryk University School of Medicine, Brno, Czech Republic., Phillips JJ; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, United States.; Department of Pathology, University of California San Francisco, San Francisco, CA, United States., Thompson RC; Department of Neurological Surgery, Vanderbilt Medical Center, Nashville, TN, United States., Cooper MK; Department of Neurology, Vanderbilt Medical Center, Nashville, TN, United States., Rubin JB; Departments of Neuroscience, Washington University School of Medicine in St. Louis, St. Louis, MO, United States., Liau LM; Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California, United States., Garami M; 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary., Hauser P; 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary., Li KKW; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong., Ng HK; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong., Poon WS; Department of Surgery, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong., Yancey Gillespie G; Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL, United States., Chan JA; Charbonneau Cancer Institute, University of Calgary, Calgary, AB, Canada., Jung S; Department of Neurosurgery, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hwasun Hospital and Medical School, Hwasun-gun, Jeollanam-do, South Korea., McLendon RE; Department of Pathology, Duke University, Durham, NC, United States.; Department of Neurosurgery, Duke University, Durham, NC, United States., Thompson EM; Department of Neurosurgery, Duke University, Durham, NC, United States., Zagzag D; Department of Pathology and Neurosurgery, NYU Grossman School of Medicine and NYU Langone Health, New York, NY, United States., Vibhakar R; Department of Pediatrics, University of Colorado Denver, Aurora, CO, United States., Ra YS; Department of Neurosurgery, University of Ulsan, Asan Medical Center, Seoul, South Korea., Garre ML; U.O. Neurochirurgia, Istituto Giannina Gaslini, Genova, Italy., Schüller U; Institute of Neuropathology, University Medical Center, Hamburg-Eppendorf, Germany.; Research Institute Children's Cancer Center, Hamburg, Germany.; Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, Germany., Shofuda T; Division of Stem Cell Research, Institute for Clinical Research, Osaka National Hospital, Osaka, Japan., Faria CC; Division of Neurosurgery, Centro Hospitalar Lisboa Norte (CHULN), Hospital de Santa Maria, Lisbon, Portugal.; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., López-Aguilar E; Division of Pediatric Hematology/Oncology, Hospital Pediatría Centro Médico Nacional century XXI, Mexico City, Mexico., Zadeh G; Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.; MacFeeters-Hamilton Center for Neuro-Oncology Research, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Hui CC; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Ramaswamy V; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Division of Haematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada., Bailey SD; Department of Surgery, Division of Thoracic and Upper Gastrointestinal Surgery, Faculty of Medicine, McGill University, Montreal, QC, Canada.; Cancer Research Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada., Jones SJ; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.; Department of Molecular Biology & Biochemistry, Simon Fraser University, Burnaby, BC, Canada., Mungall AJ; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada., Moore RA; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada., Calarco JA; Department of Cell & Systems Biology, University of Toronto, Toronto, ON, Canada., Stein LD; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; Adaptive Oncology, Ontario Institute for Cancer Research, Toronto, ON, Canada., Bader GD; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.; The Donnelly Centre, University of Toronto, Toronto, ON, Canada., Reimand J; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Ragoussis J; McGill University Genome Centre, McGill University, Montreal, QC, Canada.; Department of Human Genetics, McGill University, Montreal, QC, Canada., Weiss WA; Department of Neurology, University of California San Francisco, San Francisco, CA, United States.; Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, United States.; Department of Pediatrics, University of California San Francisco, San Francisco, CA, United States., Marra MA; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada., Suzuki H; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada. hisuzuki-ngy@umin.ac.jp.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada. hisuzuki-ngy@umin.ac.jp., Taylor MD; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada. mdt.cns@gmail.com.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. mdt.cns@gmail.com.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada. mdt.cns@gmail.com.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. mdt.cns@gmail.com.; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada. mdt.cns@gmail.com.; Department of Surgery, University of Toronto, Toronto, ON, Canada. mdt.cns@gmail.com.

المصدر: Nature communications [Nat Commun] 2021 Mar 19; Vol. 12 (1), pp. 1749. Date of Electronic Publication: 2021 Mar 19.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation, Neoplastic* , Transcriptome*, Cerebellar Neoplasms/*genetics , Hedgehog Proteins/*genetics , Medulloblastoma/*genetics, Adolescent ; Adult ; Child ; Child, Preschool ; Female ; Gene Regulatory Networks ; Genetic Variation ; Humans ; Infant ; Male ; Middle Aged ; Signal Transduction/genetics ; Young Adult

المؤلفون: Michealraj KA; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Kumar SA; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G 1L7, Canada., Kim LJY; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA., Cavalli FMG; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Przelicki D; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G 1L7, Canada., Wojcik JB; Department of Biochemistry and Biophysics and Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Delaidelli A; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC V6T 1Z2, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z2, Canada., Bajic A; Department of Human Genetics, McGill University, Montreal, QC H3A 1B1, Canada., Saulnier O; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., MacLeod G; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada., Vellanki RN; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada., Vladoiu MC; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G 1L7, Canada., Guilhamon P; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Ong W; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G 1L7, Canada., Lee JJY; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G 1L7, Canada., Jiang Y; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Holgado BL; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Rasnitsyn A; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Malik AA; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1L7, Canada., Tsai R; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Richman CM; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Juraschka K; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G 1L7, Canada., Haapasalo J; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Wang EY; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., De Antonellis P; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Suzuki H; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Farooq H; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Balin P; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G 1L7, Canada., Kharas K; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G 1L7, Canada., Van Ommeren R; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G 1L7, Canada., Sirbu O; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada., Rastan A; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Krumholtz SL; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Ly M; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G 1L7, Canada., Ahmadi M; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada., Deblois G; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada., Srikanthan D; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G 1L7, Canada., Luu B; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Loukides J; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Wu X; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Garzia L; Cancer Research Program, McGill University Health Centre Research Institute, Montreal, QC H4A 3J1, Canada., Ramaswamy V; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Division of Haematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada., Kanshin E; Institute for Research in Immunology and Cancer (IRIC), Department of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada., Sánchez-Osuna M; Institute for Research in Immunology and Cancer (IRIC), Department of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada., El-Hamamy I; Computational Biology Program, Adaptive Oncology Theme, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1L7, Canada., Coutinho FJ; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Prinos P; Structural Genomics Consortium, University of Toronto, 101 College Street, MaRS Centre, South Tower, Toronto, ON M5G 1L7, Canada., Singh S; Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON L8S 4K1, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada; Department of Surgery, McMaster University, Hamilton, ON L8S 4K1, Canada., Donovan LK; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Daniels C; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Schramek D; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1L7, Canada., Tyers M; Institute for Research in Immunology and Cancer (IRIC), Department of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada., Weiss S; Hotchkiss Brain Institute, Department of Cell Biology and Anatomy, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada., Stein LD; Computational Biology Program, Adaptive Oncology Theme, Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1L7, Canada., Lupien M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada., Wouters BG; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada., Garcia BA; Department of Biochemistry and Biophysics and Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Arrowsmith CH; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Structural Genomics Consortium, University of Toronto, 101 College Street, MaRS Centre, South Tower, Toronto, ON M5G 1L7, Canada., Sorensen PH; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC V6T 1Z2, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 1Z2, Canada., Angers S; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada; Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Jabado N; Department of Human Genetics, McGill University, Montreal, QC H3A 1B1, Canada; Department of Pediatrics, McGill University, The Research Institute of the McGill University Health Center, Montreal, QC H4A 3J1, Canada., Dirks PB; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5G 1L7, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON M5G 1L7, Canada., Mack SC; Texas Children's Hospital Cancer Center, Department of Pediatrics, Baylor College of Medicine, Dan L. Duncan Cancer Center, Houston, TX 77030, USA. Electronic address: stephen.mack@bcm.edu., Agnihotri S; Department of Neurological Surgery, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Electronic address: sameer.agnihotri@gmail.com., Rich JN; Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address: drjeremyrich@gmail.com., Taylor MD; The Arthur and Sonia Labatt Brain Tumor Research Center, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON M5G 1L7, Canada. Electronic address: mdt.cns@gmail.com.

المصدر: Cell [Cell] 2020 Jun 11; Vol. 181 (6), pp. 1329-1345.e24. Date of Electronic Publication: 2020 May 22.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Ependymoma/*genetics , Ependymoma/*metabolism , Epigenome/*genetics , Infratentorial Neoplasms/*genetics , Infratentorial Neoplasms/*metabolism, Animals ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Cell Line ; Cell Proliferation/genetics ; DNA Methylation/genetics ; Epigenomics/methods ; Histones/genetics ; Histones/metabolism ; Humans ; Infant ; Lysine/genetics ; Lysine/metabolism ; Male ; Mice, Inbred C57BL ; Mutation/genetics

المؤلفون: Van Ommeren R; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Garzia L; Department of Surgery, Faculty of Medicine, McGill University, Montreal, QC, Canada., Holgado BL; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Ramaswamy V; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada., Taylor MD; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada.; Senior Author.

المصدر: Brain pathology (Zurich, Switzerland) [Brain Pathol] 2020 May; Vol. 30 (3), pp. 691-702. Date of Electronic Publication: 2020 Jan 15.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: International Society of Neuropathology Country of Publication: Switzerland NLM ID: 9216781 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-3639 (Electronic) Linking ISSN: 10156305 NLM ISO Abbreviation: Brain Pathol Subsets: MEDLINE

مواضيع طبية MeSH: Cerebellar Neoplasms/*genetics , Medulloblastoma/*genetics , Neoplasm Metastasis/*genetics , Tumor Microenvironment/*genetics, Cell Line, Tumor ; Cerebellar Neoplasms/pathology ; Humans ; Medulloblastoma/secondary ; Neoplasm Metastasis/pathology

المؤلفون: Donovan LK; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Delaidelli A; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada., Joseph SK; Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Centre for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA., Bielamowicz K; Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Centre for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA., Fousek K; Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Centre for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA., Holgado BL; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Manno A; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Srikanthan D; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Gad AZ; Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Centre for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA., Van Ommeren R; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Przelicki D; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Richman C; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Ramaswamy V; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada., Daniels C; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Pallota JG; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Douglas T; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Joynt ACM; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Haapasalo J; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Nor C; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Vladoiu MC; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Kuzan-Fischer CM; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Garzia L; Cancer Research Program, McGill University Health Centre Research Institute, Montreal, Quebec, Canada., Mack SC; Brain Tumour Program, Children's Cancer Centre and Department of Paediatrics, Baylor College of Medicine, Houston, TX, USA., Varadharajan S; Brain Tumour Program, Children's Cancer Centre and Department of Paediatrics, Baylor College of Medicine, Houston, TX, USA., Baker ML; Centre for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA., Hendrikse L; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Ly M; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Kharas K; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Balin P; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Wu X; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Qin L; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Huang N; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Stucklin AG; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Morrissy AS; Department of Biochemistry & Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada., Cavalli FMG; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Luu B; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Suarez R; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., De Antonellis P; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Michealraj A; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Rastan A; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Hegde M; Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.; Centre for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA., Komosa M; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Sirbu O; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Kumar SA; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Abdullaev Z; Laboratory of Pathology, National Cancer Institute Centre for Cancer Research, Bethesda, MD, USA., Faria CC; Division of Neurosurgery, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria, Lisbon, Portugal., Yip S; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Hukin J; Division of Neurology, British Columbia Children's Hospital, Vancouver, British Columbia, Canada., Tabori U; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Hawkins C; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada., Aldape K; Laboratory of Pathology, National Cancer Institute Centre for Cancer Research, Bethesda, MD, USA., Daugaard M; Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada.; Vancouver Prostate Centre, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada., Maris JM; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Centre for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Sorensen PH; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada., Ahmed N; Texas Children's Hospital, Baylor College of Medicine, Houston, TX, USA. nmahmed@texaschildrens.org.; Centre for Cell and Gene Therapy, Texas Children's Hospital, Houston Methodist Hospital, Baylor College of Medicine, Houston, TX, USA. nmahmed@texaschildrens.org., Taylor MD; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. mdt.cns@gmail.com.; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada. mdt.cns@gmail.com.; Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada. mdt.cns@gmail.com.; Department of Surgery, Department of Laboratory Medicine and Pathobiology, and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. mdt.cns@gmail.com.

المصدر: Nature medicine [Nat Med] 2020 May; Vol. 26 (5), pp. 720-731. Date of Electronic Publication: 2020 Apr 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Study

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Brain Neoplasms/*therapy , Cancer Vaccines/*administration & dosage , Cerebrospinal Fluid/*drug effects , Ependymoma/*therapy , Immunotherapy, Adoptive/*methods , Medulloblastoma/*therapy, Animals ; Brain Neoplasms/cerebrospinal fluid ; Brain Neoplasms/immunology ; Brain Neoplasms/pathology ; Cerebellar Neoplasms/cerebrospinal fluid ; Cerebellar Neoplasms/immunology ; Cerebellar Neoplasms/pathology ; Cerebellar Neoplasms/therapy ; Cerebrospinal Fluid/immunology ; Child ; Child, Preschool ; Drug Delivery Systems/methods ; Ependymoma/cerebrospinal fluid ; Ependymoma/immunology ; Ependymoma/pathology ; Female ; HEK293 Cells ; Humans ; Infant ; Injections, Intraventricular ; Male ; Medulloblastoma/cerebrospinal fluid ; Medulloblastoma/immunology ; Medulloblastoma/pathology ; Mice ; Neoplasm Metastasis ; Receptors, Chimeric Antigen/administration & dosage ; Receptors, Chimeric Antigen/genetics ; Receptors, Chimeric Antigen/immunology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; T-Lymphocytes/transplantation ; Treatment Outcome ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays

المؤلفون: Vladoiu MC; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., El-Hamamy I; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Donovan LK; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Farooq H; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Holgado BL; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Sundaravadanam Y; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Ramaswamy V; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Division of Haematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada., Hendrikse LD; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Kumar S; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Mack SC; Brain Tumor Program, Children's Cancer Center and Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Lee JJY; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Fong V; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Juraschka K; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Przelicki D; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Michealraj A; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Skowron P; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada., Luu B; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Suzuki H; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Morrissy AS; Department of Biochemistry & Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Cavalli FMG; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Garzia L; Cancer Research Program, McGill University Health Centre Research Institute, Montreal, Quebec, Canada., Daniels C; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Wu X; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada., Qazi MA; Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Singh SK; Stem Cell and Cancer Research Institute, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.; Department of Surgery, McMaster University, Hamilton, Ontario, Canada., Chan JA; Charbonneau Cancer Institute, University of Calgary, Calgary, Alberta, Canada., Marra MA; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada., Malkin D; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Dirks P; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.; Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada., Heisler L; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Pugh T; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Ng K; Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Notta F; Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Thompson EM; Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA., Kleinman CL; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Lady Davis Research Institute, Jewish General Hospital, Montreal, Quebec, Canada., Joyner AL; Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA., Jabado N; Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada. nada.jabado@mcgill.ca., Stein L; Computational Biology Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada. lincoln.stein@oicr.on.ca., Taylor MD; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada. mdt.cns@gmail.com.; The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. mdt.cns@gmail.com.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. mdt.cns@gmail.com.; Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada. mdt.cns@gmail.com.; Department of Surgery and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. mdt.cns@gmail.com.

المصدر: Nature [Nature] 2019 Aug; Vol. 572 (7767), pp. 67-73. Date of Electronic Publication: 2019 May 01.

نوع المنشور: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Evolution, Molecular* , Gene Expression Regulation, Developmental* , Gene Expression Regulation, Neoplastic* , Transcription, Genetic*, Cerebellar Neoplasms/*genetics , Cerebellar Neoplasms/*pathology , Fetus/*metabolism, Animals ; Cerebellar Neoplasms/classification ; Cerebellum/cytology ; Cerebellum/embryology ; Cerebellum/metabolism ; Child ; Female ; Fetus/cytology ; Glioma/classification ; Glioma/genetics ; Glioma/pathology ; Humans ; Medulloblastoma/classification ; Medulloblastoma/genetics ; Medulloblastoma/pathology ; Mice ; Sequence Analysis, RNA ; Single-Cell Analysis ; Time Factors ; Transcriptome/genetics

المؤلفون: Garzia L, Kijima N, Morrissy AS, De Antonellis P, Guerreiro-Stucklin A, Holgado BL, Wu X, Wang X, Parsons M, Zayne K, Manno A, Kuzan-Fischer C, Nor C, Donovan LK, Liu J, Qin L, Garancher A, Liu KW, Mansouri S, Luu B, Thompson YY, Ramaswamy V, Peacock J, Farooq H, Skowron P, Shih DJH, Li A, Ensan S, Robbins CS, Cybulsky M, Mitra S, Ma Y, Moore R, Mungall A, Cho YJ, Weiss WA, Chan JA, Hawkins CE, Massimino M, Jabado N, Zapotocky M, Sumerauer D, Bouffet E, Dirks P, Tabori U, Sorensen PHB, Brastianos PK, Aldape K, Jones SJM, Marra MA, Woodgett JR, Wechsler-Reya RJ, Fults DW, Taylor MD

المصدر: Cell [Cell] 2018 May 31; Vol. 173 (6), pp. 1549. Date of Electronic Publication: 2018 May 31.

نوع المنشور: Journal Article; Published Erratum

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: PubMed not MEDLINE

المؤلفون: Garzia L; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Kijima N; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Morrissy AS; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., De Antonellis P; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Guerreiro-Stucklin A; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Holgado BL; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Wu X; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Wang X; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Parsons M; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Zayne K; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Manno A; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Kuzan-Fischer C; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Nor C; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Donovan LK; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Liu J; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Qin L; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Garancher A; Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Liu KW; Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Mansouri S; MacFeeters-Hamilton Brain Tumour Centre, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Luu B; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Thompson YY; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Ramaswamy V; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada., Peacock J; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Farooq H; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Skowron P; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Shih DJH; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada., Li A; Department of Immunology, University of Toronto, Toronto, ON, Canada., Ensan S; Department of Immunology, University of Toronto, Toronto, ON, Canada., Robbins CS; Department of Immunology, University of Toronto, Toronto, ON, Canada; Peter Munk Cardiac Centre, Toronto General Research Institute, University Health Network, Toronto, ON, Canada., Cybulsky M; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Toronto General Research Institute, University Health Network, Toronto, ON, Canada., Mitra S; Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA., Ma Y; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency and Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada., Moore R; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency and Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada., Mungall A; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency and Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada., Cho YJ; Departments of Pediatrics, Neurological Surgery and Neurology, University of California, San Francisco, San Francisco, CA, USA., Weiss WA; Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada., Chan JA; Division of Pathology, The Hospital for Sick Children, Toronto, ON, Canada., Hawkins CE; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Division of Pathology, The Hospital for Sick Children, Toronto, ON, Canada., Massimino M; Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy., Jabado N; Division of Hematology/Oncology, McGill University, Montreal, QC, Canada., Zapotocky M; Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada; Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, University Hospital Motol, Charles University, Prague, Czech Republic., Sumerauer D; Department of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, University Hospital Motol, Charles University, Prague, Czech Republic., Bouffet E; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada., Dirks P; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada., Tabori U; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada., Sorensen PHB; Department of Molecular Oncology, British Columbia Cancer Research Centre, Vancouver, BC, Canada., Brastianos PK; Division of Neuro-Oncology, Massachusetts General Hospital, Boston, MA, USA., Aldape K; MacFeeters-Hamilton Brain Tumour Centre, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Jones SJM; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency and Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada., Marra MA; Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency and Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada., Woodgett JR; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Wechsler-Reya RJ; Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA; Department of Pediatrics, University of California, San Diego, San Diego, CA, USA., Fults DW; Department of Neurosurgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Taylor MD; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON, Canada; The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada. Electronic address: mdtaylor@sickkids.ca.

المصدر: Cell [Cell] 2018 Feb 22; Vol. 172 (5), pp. 1050-1062.e14.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Medulloblastoma/*blood supply , Medulloblastoma/*pathology , Meningeal Neoplasms/*blood supply , Meningeal Neoplasms/*secondary, Allografts ; Animals ; Cell Line, Tumor ; Chemokine CCL2/metabolism ; Chromosomes, Human, Pair 10/genetics ; Female ; Humans ; Male ; Medulloblastoma/genetics ; Mice, SCID ; Neoplastic Cells, Circulating ; Parabiosis

المؤلفون: Wang X; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Holgado BL; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada., Ramaswamy V; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.; Department of Haematology & Oncology, Hospital for Sick Children, Toronto, Ontario, Canada., Mack S; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada., Zayne K; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada., Remke M; German Cancer Consortium, University of Düsseldorf, Düsseldorf, Germany., Wu X; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada., Garzia L; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada., Daniels C; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada., Kenney AM; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.; Department of Pediatric Oncology, Emory University, Atlanta, Georgia, USA.; Winship Cancer Institute, Atlanta, Georgia, USA., Taylor MD; Developmental & Stem Cell Biology Program, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Division of Neurosurgery, Hospital for Sick Children, Toronto, Ontario, Canada.

المصدر: Neuro-oncology [Neuro Oncol] 2018 Feb 19; Vol. 20 (3), pp. 313-323.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 100887420 Publication Model: Print Cited Medium: Internet ISSN: 1523-5866 (Electronic) Linking ISSN: 15228517 NLM ISO Abbreviation: Neuro Oncol Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation, Neoplastic*, Biomarkers, Tumor/*genetics , Cerebellar Neoplasms/*diagnosis , Medulloblastoma/*diagnosis , MicroRNAs/*genetics, Cerebellar Neoplasms/genetics ; Humans ; Medulloblastoma/genetics ; Prognosis

المؤلفون: Mack SC; Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.; Department of Pediatric Hematolgy and Oncology, Texas Children's Cancer and Hematology Centers, Houston, Texas, USA.; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA., Pajtler KW; Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), 69120 Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.; Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany., Chavez L; Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), 69120 Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.; Department of Medicine, Division of Medical Genetics, University of California - San Diego School of Medicine, La Jolla, California 92093, USA., Okonechnikov K; Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), 69120 Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany., Bertrand KC; Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.; Department of Pediatric Hematolgy and Oncology, Texas Children's Cancer and Hematology Centers, Houston, Texas, USA.; Department of Pediatrics, Cleveland Clinic, Cleveland, Ohio 44195, USA., Wang X; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA.; Department of Medicine, Division of Regenerative Medicine, University of California - San Diego School of Medicine, La Jolla, California, USA., Erkek S; Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), 69120 Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany and German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.; European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany., Federation A; Department of Genomic Sciences, University of Washington, Seattle, Washington 355065, USA., Song A; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA., Lee C; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA., Wang X; Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada., McDonald L; Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada., Morrow JJ; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio 44106, USA., Saiakhova A; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio 44106, USA., Sin-Chan P; Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada., Wu Q; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA.; Department of Medicine, Division of Regenerative Medicine, University of California - San Diego School of Medicine, La Jolla, California, USA., Michaelraj KA; Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada., Miller TE; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA.; Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA., Hubert CG; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA., Ryzhova M; Department of Neuropathology, NN Burdenko Neurosurgical Institute, 4th Tverskaya-Yamskaya 16, Moscow 125047, Russia., Garzia L; Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada., Donovan L; Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada., Dombrowski S; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA.; Rose Ella Burkhardt Brain Tumor & Neuro-Oncology Center, Cleveland Clinic Neurological Institute, Department of Neurosurgery, Cleveland Clinic, Cleveland, Ohio 44195, USA., Factor DC; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, Ohio 44106, USA., Luu B; Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada., Valentim CLL; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA., Gimple RC; Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio 44195, USA.; Department of Medicine, Division of Regenerative Medicine, University of California - San Diego School of Medicine, La Jolla, California, USA.; Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA., Morton A; 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Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada., Singh SK; Department of Surgery, Division of Neurosurgery, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada., Huang A; Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, USA., Dirks PB; Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada., Bouffet E; Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, USA., Bradner JE; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, USA., Ramaswamy V; Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.; Division of Hematology and Oncology, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada., Jabado N; Departments of Paediatrics and Human Genetics, McGill University and the McGill University Health Centre Research Institute, Montreal, Quebec H3Z 2Z3, Canada., Rutka JT; Division of Neurosurgery, Program in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada., Northcott PA; Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, Tennessee, USA., Lupien M; Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada., Lichter P; 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المصدر: Nature [Nature] 2018 Jan 04; Vol. 553 (7686), pp. 101-105. Date of Electronic Publication: 2017 Dec 20.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation, Neoplastic* , Molecular Targeted Therapy*, Enhancer Elements, Genetic/*genetics , Ependymoma/*drug therapy , Ependymoma/*genetics , Gene Regulatory Networks/*genetics , Oncogenes/*genetics , Transcription Factors/*metabolism, Animals ; Base Sequence ; Ependymoma/classification ; Ependymoma/pathology ; Female ; Humans ; Mice ; Precision Medicine ; RNA Interference ; Xenograft Model Antitumor Assays