المؤلفون: Kavanagh ME; Department of Chemistry, Scripps Research, La Jolla, CA, USA., Horning BD; Vividion Therapeutics, San Diego, CA, USA., Khattri R; Vividion Therapeutics, San Diego, CA, USA., Roy N; Vividion Therapeutics, San Diego, CA, USA., Lu JP; Vividion Therapeutics, San Diego, CA, USA., Whitby LR; Vividion Therapeutics, San Diego, CA, USA., Ye E; Department of Chemistry, Scripps Research, La Jolla, CA, USA., Brannon JC; Vividion Therapeutics, San Diego, CA, USA., Parker A; Vividion Therapeutics, San Diego, CA, USA., Chick JM; Vividion Therapeutics, San Diego, CA, USA., Eissler CL; Vividion Therapeutics, San Diego, CA, USA., Wong AJ; Vividion Therapeutics, San Diego, CA, USA., Rodriguez JL; Vividion Therapeutics, San Diego, CA, USA., Rodiles S; Vividion Therapeutics, San Diego, CA, USA., Masuda K; Department of Chemistry, Scripps Research, La Jolla, CA, USA., Teijaro JR; Department of Immunology and Microbial Science, Scripps Research, La Jolla, CA, USA., Simon GM; Vividion Therapeutics, San Diego, CA, USA., Patricelli MP; Vividion Therapeutics, San Diego, CA, USA. mattp@vividion.com., Cravatt BF; Department of Chemistry, Scripps Research, La Jolla, CA, USA. cravatt@scripps.edu.

المصدر: Nature chemical biology [Nat Chem Biol] 2022 Dec; Vol. 18 (12), pp. 1388-1398. Date of Electronic Publication: 2022 Sep 12.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Cysteine* , Proteomics*, Signal Transduction ; Cytokines ; Protein Isoforms

المؤلفون: Kavanagh ME; Department of Chemistry, Scripps Research, La Jolla, CA, USA., Horning BD; Vividion Therapeutics, San Diego, CA, USA., Khattri R; Vividion Therapeutics, San Diego, CA, USA., Roy N; Vividion Therapeutics, San Diego, CA, USA., Lu JP; Vividion Therapeutics, San Diego, CA, USA., Whitby LR; Vividion Therapeutics, San Diego, CA, USA., Ye E; Department of Chemistry, Scripps Research, La Jolla, CA, USA., Brannon JC; Vividion Therapeutics, San Diego, CA, USA., Parker A; Vividion Therapeutics, San Diego, CA, USA., Chick JM; Vividion Therapeutics, San Diego, CA, USA., Eissler CL; Vividion Therapeutics, San Diego, CA, USA., Wong AJ; Vividion Therapeutics, San Diego, CA, USA., Rodriguez JL; Vividion Therapeutics, San Diego, CA, USA., Rodiles S; Vividion Therapeutics, San Diego, CA, USA., Masuda K; Department of Chemistry, Scripps Research, La Jolla, CA, USA., Teijaro JR; Department of Immunology and Microbial Science, Scripps Research, La Jolla, CA, USA., Simon GM; Vividion Therapeutics, San Diego, CA, USA., Patricelli MP; Vividion Therapeutics, San Diego, CA, USA. mattp@vividion.com., Cravatt BF; Department of Chemistry, Scripps Research, La Jolla, CA, USA. cravatt@scripps.edu.

المصدر: Nature chemical biology [Nat Chem Biol] 2022 Nov; Vol. 18 (11), pp. 1288.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Lee HY; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92307, United States., Suciu RM; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92307, United States., Horning BD; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92307, United States., Vinogradova EV; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92307, United States., Ulanovskaya OA; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92307, United States., Cravatt BF; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92307, United States. Electronic address: cravatt@scripps.edu.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Sep 01; Vol. 28 (16), pp. 2682-2687. Date of Electronic Publication: 2018 Apr 10.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Acetamides/*pharmacology , Enzyme Inhibitors/*pharmacology , Nicotinamide N-Methyltransferase/*antagonists & inhibitors, Acetamides/chemical synthesis ; Catalytic Domain ; Cell Line, Tumor ; Cysteine/chemistry ; Enzyme Inhibitors/chemical synthesis ; Humans ; Nicotinamide N-Methyltransferase/chemistry

المؤلفون: Bar-Peled L; The Skaggs Institute for Chemical Biology and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: lironbp@scripps.edu., Kemper EK; The Skaggs Institute for Chemical Biology and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA., Suciu RM; The Skaggs Institute for Chemical Biology and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA., Vinogradova EV; The Skaggs Institute for Chemical Biology and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA., Backus KM; The Skaggs Institute for Chemical Biology and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA., Horning BD; The Skaggs Institute for Chemical Biology and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA., Paul TA; Oncology Research Unit, Pfizer Worldwide Research and Development, La Jolla, CA 92121, USA., Ichu TA; The Skaggs Institute for Chemical Biology and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA., Svensson RU; Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Olucha J; The Skaggs Institute for Chemical Biology and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA., Chang MW; Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Kok BP; The Skaggs Institute for Chemical Biology and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA., Zhu Z; Oncology Research Unit, Pfizer Worldwide Research and Development, La Jolla, CA 92121, USA., Ihle NT; Oncology Research Unit, Pfizer Worldwide Research and Development, La Jolla, CA 92121, USA., Dix MM; The Skaggs Institute for Chemical Biology and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA., Jiang P; Oncology Research Unit, Pfizer Worldwide Research and Development, La Jolla, CA 92121, USA., Hayward MM; Oncology Research Unit, Pfizer Worldwide Research and Development, La Jolla, CA 92121, USA., Saez E; The Skaggs Institute for Chemical Biology and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA., Shaw RJ; Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Cravatt BF; The Skaggs Institute for Chemical Biology and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: cravatt@scripps.edu.

المصدر: Cell [Cell] 2017 Oct 19; Vol. 171 (3), pp. 696-709.e23. Date of Electronic Publication: 2017 Sep 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Transcriptome*, Carcinoma, Non-Small-Cell Lung/*chemistry , Carcinoma, Non-Small-Cell Lung/*genetics , Lung Neoplasms/*chemistry , Lung Neoplasms/*genetics , Proteome/*analysis, Carcinoma, Non-Small-Cell Lung/metabolism ; Cell Line, Tumor ; Cysteine/metabolism ; DAX-1 Orphan Nuclear Receptor/metabolism ; Gene Regulatory Networks ; Humans ; Kelch-Like ECH-Associated Protein 1/genetics ; Kelch-Like ECH-Associated Protein 1/metabolism ; Ligands ; Lung Neoplasms/metabolism

المؤلفون: Matthews ML; Chemical Physiology, The Scripps Research Institute, La Jolla, California 92037, USA., He L; Chemical Physiology, The Scripps Research Institute, La Jolla, California 92037, USA.; Bioinformatics Solutions Inc., Waterloo, Ontario N2L 6J2, Canada., Horning BD; Chemical Physiology, The Scripps Research Institute, La Jolla, California 92037, USA., Olson EJ; Chemistry and Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA., Correia BE; Chemical Physiology, The Scripps Research Institute, La Jolla, California 92037, USA.; École polytechnique fédérale de Lausanne, CH-1015 Lausanne, Switzerland., Yates JR 3rd; Chemical Physiology, The Scripps Research Institute, La Jolla, California 92037, USA., Dawson PE; Chemistry and Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA., Cravatt BF; Chemical Physiology, The Scripps Research Institute, La Jolla, California 92037, USA.

المصدر: Nature chemistry [Nat Chem] 2017 Mar; Vol. 9 (3), pp. 234-243. Date of Electronic Publication: 2016 Oct 31.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101499734 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1755-4349 (Electronic) Linking ISSN: 17554330 NLM ISO Abbreviation: Nat Chem Subsets: MEDLINE

مواضيع طبية MeSH: Proteomics*, Adenosylmethionine Decarboxylase/*chemistry , Nerve Tissue Proteins/*chemistry, Adenosylmethionine Decarboxylase/metabolism ; Amino Acids/chemistry ; Amino Acids/metabolism ; Cell Survival ; Fluorescent Dyes/chemistry ; HEK293 Cells ; Humans ; Hydrazines/chemistry ; Methionine/chemistry ; Methionine/metabolism ; Molecular Structure ; Nerve Tissue Proteins/metabolism

المؤلفون: Horning BD; Departments of Chemical Physiology, The Scripps Research Institute , La Jolla, California 92307, United States., Suciu RM; Departments of Chemical Physiology, The Scripps Research Institute , La Jolla, California 92307, United States., Ghadiri DA; Departments of Chemical Physiology, The Scripps Research Institute , La Jolla, California 92307, United States., Ulanovskaya OA; Departments of Chemical Physiology, The Scripps Research Institute , La Jolla, California 92307, United States., Matthews ML; Departments of Chemical Physiology, The Scripps Research Institute , La Jolla, California 92307, United States., Lum KM; Departments of Chemical Physiology, The Scripps Research Institute , La Jolla, California 92307, United States., Backus KM; Departments of Chemical Physiology, The Scripps Research Institute , La Jolla, California 92307, United States., Brown SJ; Departments of Chemical Physiology, The Scripps Research Institute , La Jolla, California 92307, United States., Rosen H; Departments of Chemical Physiology, The Scripps Research Institute , La Jolla, California 92307, United States., Cravatt BF; Departments of Chemical Physiology, The Scripps Research Institute , La Jolla, California 92307, United States.

المصدر: Journal of the American Chemical Society [J Am Chem Soc] 2016 Oct 12; Vol. 138 (40), pp. 13335-13343. Date of Electronic Publication: 2016 Sep 30.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

مواضيع طبية MeSH: Proteomics*, Methyltransferases/*metabolism, Cell Line, Tumor ; Enzyme Activation ; Humans ; Molecular Probes/metabolism ; S-Adenosylhomocysteine/metabolism ; Ultraviolet Rays

المؤلفون: Backus KM; Department of Chemical Physiology, The Scripps Research Institute. La Jolla, California 92307, USA., Correia BE; Department of Chemical Physiology, The Scripps Research Institute. La Jolla, California 92307, USA., Lum KM; Department of Chemical Physiology, The Scripps Research Institute. La Jolla, California 92307, USA., Forli S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute. La Jolla, California 92307, USA., Horning BD; Department of Chemical Physiology, The Scripps Research Institute. La Jolla, California 92307, USA., González-Páez GE; Department of Molecular and Experimental Medicine, The Scripps Research Institute. La Jolla, California 92307, USA., Chatterjee S; Department of Molecular and Experimental Medicine, The Scripps Research Institute. La Jolla, California 92307, USA., Lanning BR; Department of Chemical Physiology, The Scripps Research Institute. La Jolla, California 92307, USA., Teijaro JR; Department of Immunology and Microbial Science, The Scripps Research Institute. La Jolla, California 92307, USA., Olson AJ; Department of Integrative Structural and Computational Biology, The Scripps Research Institute. La Jolla, California 92307, USA., Wolan DW; Department of Molecular and Experimental Medicine, The Scripps Research Institute. La Jolla, California 92307, USA., Cravatt BF; Department of Chemical Physiology, The Scripps Research Institute. La Jolla, California 92307, USA.

المصدر: Nature [Nature] 2016 Jun 23; Vol. 534 (7608), pp. 570-4. Date of Electronic Publication: 2016 Jun 15.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Cysteine/*metabolism , Drug Evaluation, Preclinical/*methods , Proteome/*chemistry , Proteome/*metabolism , Small Molecule Libraries/*metabolism , Small Molecule Libraries/*pharmacology , T-Lymphocytes/*metabolism, Apoptosis ; Caspase 10/chemistry ; Caspase 10/metabolism ; Caspase 8/chemistry ; Caspase 8/metabolism ; Cells, Cultured ; Enzyme Precursors/chemistry ; Enzyme Precursors/metabolism ; Humans ; Ligands ; Peptide Fragments/chemistry ; Peptide Fragments/metabolism ; T-Lymphocytes/chemistry ; Transcription Factors/chemistry ; Transcription Factors/metabolism

المؤلفون: Horning BD; Merck Center for Catalysis at Princeton University, Princeton, New Jersey 08544, USA., MacMillan DW

المصدر: Journal of the American Chemical Society [J Am Chem Soc] 2013 May 01; Vol. 135 (17), pp. 6442-5. Date of Electronic Publication: 2013 Apr 19.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

مواضيع طبية MeSH: Vinca Alkaloids/*chemical synthesis, Cyclization ; Indicators and Reagents ; Magnetic Resonance Spectroscopy ; Models, Molecular ; Stereoisomerism ; Vinca Alkaloids/chemistry ; X-Ray Diffraction