المؤلفون: McGuire, VA, Ruiz-Zorrilla Diez, T, Emmerich, CH, Strickson, S, Ritorto, MS, Sutavani, RV, Weiβ, A, Houslay, KF, Knebel, A, Meakin, PJ, Phair, IR, Ashford, MLJ, Trost, M, Arthur, JSC

المصدر: Scientific Reports

مصطلحات موضوعية: Mice, Knockout, Mice, Mitogen-Activated Protein Kinase 3, RAW 264.7 Cells, MAP Kinase Signaling System, Dimethyl Fumarate, Toll-Like Receptors, NF-kappa B, Animals, Cytokines, Polyubiquitin, Article

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c567a33ec1518e1b1143c526ca5e1460
http://europepmc.org/articles/PMC4976367

المؤلفون: Strickson S; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; These authors contributed equally to this work., Houslay KF; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; These authors contributed equally to this work., Negri VA; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Ohne Y; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Ottosson T; Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Dodd RB; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Huntington CC; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Baker T; Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Li J; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Stephenson KE; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., O'Connor AJ; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Sagawe JS; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Killick H; Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Moore T; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Rees DG; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Koch S; Imaging & Data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK., Sanden C; Experimental Medical Sciences, Lund University, Lund, Sweden.; Medetect AB, Lund, Sweden., Wang Y; Imaging & Data Analytics, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Gubbins E; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Ghaedi M; Bioscience COPD/IPF, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Kolbeck R; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.; Current: Spirovant Sciences, Philadelphia, PA, USA., Saumyaa S; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Erjefält JS; Experimental Medical Sciences, Lund University, Lund, Sweden.; Allergology and Respiratory Medicine, Lund University, Skåne University Hospital, Lund, Sweden., Sims GP; Bioscience Immunology, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Humbles AA; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; Current: Roche Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland., Scott IC; Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Romero Ros X; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; These authors contributed equally to this work., Cohen ES; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK suzanne.cohen@astrazeneca.com.; These authors contributed equally to this work.

المصدر: The European respiratory journal [Eur Respir J] 2023 Sep 28; Vol. 62 (3). Date of Electronic Publication: 2023 Sep 28 (Print Publication: 2023).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: European Respiratory Society Country of Publication: England NLM ID: 8803460 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1399-3003 (Electronic) Linking ISSN: 09031936 NLM ISO Abbreviation: Eur Respir J Subsets: MEDLINE

مواضيع طبية MeSH: Interleukin-33*/genetics , Interleukin-33*/metabolism , Pulmonary Disease, Chronic Obstructive*/genetics , Pulmonary Disease, Chronic Obstructive*/metabolism , Pulmonary Disease, Chronic Obstructive*/pathology, Humans ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; ErbB Receptors ; Interleukin-1 Receptor-Like 1 Protein ; Oxidation-Reduction ; Receptor for Advanced Glycation End Products/metabolism

المؤلفون: England E; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Rees DG; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Scott IC; Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Carmen S; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Chan DTY; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Chaillan Huntington CE; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Houslay KF; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Erngren T; Drug Metabolism and Pharmacokinetics, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Penney M; Early Oncology DMPK, Oncology R&D, AstraZeneca, Cambridge, UK., Majithiya JB; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Rapley L; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Sims DA; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Hollins C; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Hinchy EC; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Strain MD; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Kemp BP; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Corkill DJ; Bioscience In Vivo, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., May RD; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Vousden KA; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Butler RJ; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Mustelin T; Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, USA., Vaughan TJ; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Lowe DC; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Colley C; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Cohen ES; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK. suzanne.cohen@astrazeneca.com.

المصدر: Scientific reports [Sci Rep] 2023 Jun 17; Vol. 13 (1), pp. 9825. Date of Electronic Publication: 2023 Jun 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Interleukin-1 Receptor-Like 1 Protein*/metabolism , Inflammation*/metabolism, Mice ; Humans ; Animals ; Interleukin-33/metabolism ; Cytokines/metabolism ; ErbB Receptors/metabolism ; Signal Transduction

المؤلفون: Houslay KF; Department of Respiratory, Inflammation and Autoimmunity, MedImmune, Granta Park, Cambridge, UK., Fertig BA; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Christian F; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Tibbo AJ; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Ling J; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Findlay JE; Institute of Cancer Studies and Pharmaceutical Science, King's College, 150 Stamford Street, London, UK., Houslay MD; Institute of Cancer Studies and Pharmaceutical Science, King's College, 150 Stamford Street, London, UK., Baillie GS; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.

المصدر: Journal of biochemistry [J Biochem] 2019 Jul 01; Vol. 166 (1), pp. 97-106.

نوع المنشور: Journal Article; Retracted Publication

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0376600 Publication Model: Print Cited Medium: Internet ISSN: 1756-2651 (Electronic) Linking ISSN: 0021924X NLM ISO Abbreviation: J Biochem

مواضيع طبية MeSH: Signal Transduction*, Cyclic Nucleotide Phosphodiesterases, Type 4/*metabolism , Fibrin/*metabolism , Intracellular Signaling Peptides and Proteins/*metabolism , Nerve Tissue Proteins/*metabolism , Protein Serine-Threonine Kinases/*metabolism , Receptors, Nerve Growth Factor/*metabolism, HEK293 Cells ; Humans ; Phosphorylation

المؤلفون: Houslay KF; Institute of Cardiovascular and Medical Science, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, U.K., Christian F; Institute of Cardiovascular and Medical Science, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, U.K., MacLeod R; Institute of Cardiovascular and Medical Science, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, U.K., Adams DR; Institute of Chemical Sciences, Heriott-Watt University, Edinburgh, U.K.; Mironid Ltd, BioCity Scotland, Bo'Ness Road, Newhouse, North Lanarkshire ML1 5UH, U.K., Houslay MD; Mironid Ltd, BioCity Scotland, Bo'Ness Road, Newhouse, North Lanarkshire ML1 5UH, U.K.; Institute of Pharmaceutical Sciences, King's College London, London SE1 9NH, U.K., Baillie GS; Institute of Cardiovascular and Medical Science, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, U.K. george.baillie@glasgow.ac.uk.

المصدر: The Biochemical journal [Biochem J] 2017 Feb 15; Vol. 474 (4), pp. 597-609. Date of Electronic Publication: 2016 Dec 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE

مواضيع طبية MeSH: Catalytic Domain* , Molecular Docking Simulation*, Cyclic Nucleotide Phosphodiesterases, Type 4/*chemistry , Intracellular Signaling Peptides and Proteins/*chemistry , Protein Serine-Threonine Kinases/*chemistry, 1-Alkyl-2-acetylglycerophosphocholine Esterase/chemistry ; 1-Alkyl-2-acetylglycerophosphocholine Esterase/genetics ; 1-Alkyl-2-acetylglycerophosphocholine Esterase/metabolism ; Amino Acid Motifs ; Animals ; COS Cells ; Chlorocebus aethiops ; Cyclic AMP-Dependent Protein Kinases/chemistry ; Cyclic AMP-Dependent Protein Kinases/genetics ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Cyclic Nucleotide Phosphodiesterases, Type 4/genetics ; Cyclic Nucleotide Phosphodiesterases, Type 4/metabolism ; Gene Expression ; HEK293 Cells ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Microtubule-Associated Proteins/chemistry ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Mitogen-Activated Protein Kinase 1/chemistry ; Mitogen-Activated Protein Kinase 1/genetics ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/chemistry ; Mitogen-Activated Protein Kinase 3/genetics ; Mitogen-Activated Protein Kinase 3/metabolism ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Protein Structure, Secondary ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Signal Transduction ; Ubiquitin-Conjugating Enzymes/chemistry ; Ubiquitin-Conjugating Enzymes/genetics ; Ubiquitin-Conjugating Enzymes/metabolism ; beta-Arrestins/chemistry ; beta-Arrestins/genetics ; beta-Arrestins/metabolism ; src-Family Kinases/chemistry ; src-Family Kinases/genetics ; src-Family Kinases/metabolism

المؤلفون: Scott IC; Respiratory, Inflammation and Autoimmunity Research, MedImmune, Cambridge, UK., Houslay KF; Respiratory, Inflammation and Autoimmunity Research, MedImmune, Cambridge, UK., Cohen ES; Respiratory, Inflammation and Autoimmunity Research, MedImmune, Cambridge, UK.

المصدر: Annals of translational medicine [Ann Transl Med] 2016 Dec; Vol. 4 (24), pp. 500.

نوع المنشور: Editorial; Comment

بيانات الدورية: Publisher: AME Publishing Company Country of Publication: China NLM ID: 101617978 Publication Model: Print Cited Medium: Print ISSN: 2305-5839 (Print) Linking ISSN: 23055839 NLM ISO Abbreviation: Ann Transl Med Subsets: PubMed not MEDLINE