المؤلفون: Palucki Brenda, Patrick G. Pollard, Liangqin Guo, Tung M. Fong, Matthew J. Wyvratt, Randy R. Miller, Shuwen He, Constantin Tamvakopoulos, Iyassu K. Sebhat, Qianping Peng, Ravi P. Nargund, Zhixiong Ye, Airu S. Chen, Doreen E. Cashen, David H. Weinberg, Min K. Park, Raman K. Bakshi, D. Euan MacIntyre, Howard Y. Chen, Rui Tang, Tanya MacNeil, Qingmei Hong, Alison M. Strack, Ralph A. Stearns, Jian Liu, William J. Martin

المصدر: Bioorganic & Medicinal Chemistry Letters. 21:2330-2334

مصطلحات موضوعية: medicine.drug_class, Clinical Biochemistry, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Pharmaceutical Science, Carboxamide, Pharmacology, Biochemistry, Partial agonist, Piperazines, Rats, Sprague-Dawley, Eating, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Oral administration, In vivo, Drug Discovery, medicine, Animals, Urea, Obesity, Receptor, Molecular Biology, Organic Chemistry, Haplorhini, Rats, Disease Models, Animal, Piperazine, chemistry, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99aea0aa624d82cc9bc8f3cfa4bdb369
https://doi.org/10.1016/j.bmcl.2011.02.090

المؤلفون: Yingjie Lai, Ralph A. Stearns, Qianping Peng, Ravi P. Nargund, Qingmei Hong, Jian Liu, Rui Tang, Matthew J. Wyvratt, Raman K. Bakshi, Randy R. Miller, Tianying Jian, Alison M. Strack, Tanya MacNeil, Liangqin Guo, Howard Y. Chen, James Dellureficio, Iyassu K. Sebhat, Peter H. Dobbelaar, Airu S. Chen, Constantin Tamvakopoulos, David H. Weinberg, Tung M. Fong, Christopher L. Franklin, Shuwen He, Zhixiong Ye

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:4399-4405

مصطلحات موضوعية: Agonist, medicine.medical_specialty, Pyrrolidines, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Anti-Obesity Agents, Internal medicine, Drug Discovery, medicine, Animals, Humans, Potency, Structure–activity relationship, Spiro Compounds, Obesity, Molecular Biology, Mice, Knockout, Chemistry, Body Weight, Organic Chemistry, Amides, Rats, Endocrinology, Drug development, Anorectic, Receptor, Melanocortin, Type 4, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04db1e6e6855a321002bb787613d21e
https://doi.org/10.1016/j.bmcl.2010.06.062

المؤلفون: Howard Y. Chen, William J. Martin, D. Euan MacIntyre, Zhixiong Ye, Raman K. Bakshi, Alison M. Strack, Doreen E. Cashen, Jian Liu, Yingjie Lai, Tianying Jian, Constantin Tamvakopoulos, Nancy N. Tsou, Shuwen He, James Dellureficio, Tung M. Fong, Peter H. Dobbelaar, David H. Weinberg, Airu S. Chen, Qingmei Hong, Iyassu K. Sebhat, Tanya MacNeil, Christopher L. Franklin, Ravi P. Nargund, Ralph A. Stearns, Rui Tang, Richard G. Ball, Matthew J. Wyvratt, Randy R. Miller, Liangqin Guo, Qianping Peng

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:2106-2110

مصطلحات موضوعية: Male, Agonist, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, CHO Cells, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, Cricetulus, Dogs, Erectile Dysfunction, Cricetinae, Drug Discovery, medicine, Animals, Humans, Spiro Compounds, Receptor, Molecular Biology, Molecular Structure, Chemistry, Organic Chemistry, Haplorhini, Rats, Bioavailability, Indans, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ecb491322cadefd63c62faedffb60b8
https://doi.org/10.1016/j.bmcl.2010.02.058

المؤلفون: Marc L. Reitman, Cheng Guo, Theresa M. Kelly, Constantin Tamvakopoulos, Joseph M. Metzger, Tianying Jian, Howard Y. Chen, Arthur A. Patchett, Oksana C. Palyha, Alison M. Strack, Allan J. Goodman, Ravi P. Nargund, Peter H. Dobbelaar, Yanqing Kan, Mark Hadden, Larry Yet, Peter R. Guzzo, Qianping Peng, Linus S. Lin, Shuwen He, Lauren P. Shearman, Alan J. Henderson, Carina P. Tan, Sargent Bruce J, Xiao-Ming Guan, Scott D. Feighner, Iyassu K. Sebhat, Jie Pan, Jian Liu, Donald J. Marsh, Matthew J. Wyvratt, Andrew D. Howard, Megan Ruenz

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:1913-1917

مصطلحات موضوعية: Agonist, medicine.drug_class, Clinical Biochemistry, Biological Availability, Pharmaceutical Science, Pharmacology, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Humans, Potency, Structure–activity relationship, Molecular Biology, Biphenyl, Chemistry, Drug discovery, fungi, Organic Chemistry, Imidazoles, Rats, Bombesin receptor, Bioavailability, Receptors, Bombesin, Molecular Medicine, Bombesin Receptor Subtype-3

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9388422b542c24893358d41aa77156
https://doi.org/10.1016/j.bmcl.2010.01.154

المؤلفون: Doreen E. Cashen, Constantin Tamvakopoulos, Qianping Peng, William J. Martin, David H. Weinberg, Charles Rosenblum, Arthur A. Patchett, Tanya MacNeil, Patrick G. Pollard, Zhixiong Ye, Raman K. Bakshi, Ralph A. Stearns, Rubana N. Kalyani, Palucki Brenda, Joseph M. Metzger, Alison M. Strack, Lex H.T. Van der Ploeg, D. Euan MacIntyre, Iyassu K. Sebhat, Aurawan Vongs, Airu S. Chen, Ravi P. Nargund, Liangqin Guo, Matthew J. Wyvratt, Randy R. Miller, Rui Tang, Howard Y. Chen, Khaled J. Barakat

المصدر: Bioorganic & Medicinal Chemistry Letters. 15:3501-3505

مصطلحات موضوعية: Male, Agonist, Quinuclidines, Time Factors, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Rodentia, Carboxamide, Biochemistry, Chemical synthesis, Piperazines, Rats, Sprague-Dawley, Eating, Structure-Activity Relationship, Piperidines, In vivo, Drug Discovery, medicine, Animals, Humans, Receptor, Molecular Biology, Aza Compounds, Bicyclic molecule, Chemistry, Penile Erection, digestive, oral, and skin physiology, Organic Chemistry, Small molecule, Rats, Microsomes, Liver, Receptor, Melanocortin, Type 4, Molecular Medicine, Melanocortin, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec96b03aa1e5f2ba3d3c429b0a51544
https://doi.org/10.1016/j.bmcl.2005.05.109

المؤلفون: Howard Y. Chen, Marc L. Reitman, Hongyue Dai, Sheena Mumick, John S. Mudgett, Airu Chen, John Lamb, Su Qian, Drew T. Weingarth, Chunsheng Zhang, Douglas J. MacNeil

المصدر: Obesity Research. 13:1311-1320

مصطلحات موضوعية: Male, medicine.medical_specialty, CCR2, Chemokine, Carboxypeptidases A, Receptors, CCR2, Endocrinology, Diabetes and Metabolism, Adipose tissue macrophages, Antigens, Differentiation, Myelomonocytic, Medicine (miscellaneous), Adipose tissue, Inflammation, White adipose tissue, Biology, Mice, Endocrinology, Antigens, CD, Internal medicine, Adipocytes, medicine, Animals, Obesity, RNA, Messenger, Chemokine CCL2, Mice, Knockout, Tumor Necrosis Factor-alpha, Gene Expression Profiling, Macrophages, Public Health, Environmental and Occupational Health, Dietary Fats, Mice, Inbred C57BL, Knockout mouse, biology.protein, Receptors, Chemokine, Tumor necrosis factor alpha, Inflammation Mediators, medicine.symptom, Signal Transduction, Food Science

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc9216faffb2ed5f0c90296c62ec4ef
https://doi.org/10.1038/oby.2005.159

المؤلفون: George R. Breese, Donald J. Marsh, Montserrat Navarro, Todd E. Thiele, Darin J. Knapp, Airu S. Chen, Inmaculada Cubero, Howard Y. Chen

المصدر: Alcoholism: Clinical & Experimental Research. 29:949-957

مصطلحات موضوعية: Male, Agonist, medicine.medical_specialty, Alcohol Drinking, Genotype, medicine.drug_class, Medicine (miscellaneous), Toxicology, Peptides, Cyclic, Article, Eating, Mice, Dopamine receptor D1, Dopamine, Internal medicine, Dopamine receptor D2, medicine, Animals, Agouti-Related Protein, Ethanol metabolism, Behavior, Animal, Ethanol, Chemistry, Receptors, Melanocortin, digestive, oral, and skin physiology, Melanotan II, Peptide Fragments, Ventral tegmental area, Psychiatry and Mental health, medicine.anatomical_structure, Endocrinology, alpha-MSH, Receptor, Melanocortin, Type 4, Female, Melanocortin, hormones, hormone substitutes, and hormone antagonists, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83888f6e3360c76c3b4fc9c92accbb69
https://doi.org/10.1097/01.alc.0000167740.19702.8c

المؤلفون: Kang Cheng, Matthias Strowski, Jianying Xiao, Tsuei-Ju Wu, Ning Ren, Nancy Robertson, Martin S. Springer, Kenneth K. Wu, Zhihua Li, James M. Balkovec, Melba Hernandez, Howard Y. Chen, Cheryl B. Le Grand, Bill Pikounis, Anne Hermanowski-Vosatka, Joseph M. Metzger, Samuel D. Wright, Steven H. Olson, Alison M. Strack, Gloria C. Koo, Steven S. Mundt, Rolf Thieringer, Heather Noonan, Kashmira Shah, James M. Schaeffer, Christian N. Nunes, Bei B. Zhang

المصدر: The Journal of Experimental Medicine

مصطلحات موضوعية: Apolipoprotein E, Blood Glucose, Male, medicine.medical_specialty, Hydrocortisone, Arteriosclerosis, medicine.medical_treatment, Immunology, Adamantane, Type 2 diabetes, Glucagon, Article, chemistry.chemical_compound, Mice, Insulin resistance, 11β-hydroxysteroid dehydrogenase type 1, Internal medicine, 11-beta-Hydroxysteroid Dehydrogenase Type 1, medicine, Immunology and Allergy, Animals, Insulin, Enzyme Inhibitors, Aorta, Triglycerides, Mice, Knockout, Mice, Inbred ICR, biology, Cholesterol, Fatty Acids, Azepines, Syndrome, Triazoles, medicine.disease, Cortisone, Enzyme Activation, Disease Models, Animal, Endocrinology, chemistry, biology.protein, Diet, Atherogenic, Metabolic syndrome, Insulin Resistance, hormones, hormone substitutes, and hormone antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2100c617c4f08e8bc6b622a8ee436ebe
http://europepmc.org/articles/PMC2212859

المؤلفون: Mathias Z. Strowski, Jill K. Fisher, Bei B. Zhang, Howard Y. Chen, Myrna E. Trumbauer, Martin Köhler, Hilary A. Wilkinson, Shobhna Gopal-Truter, Zhihua Li, James M. Schaeffer, Allan D. Blake, Deborah Szalkowski

المصدر: Molecular Endocrinology. 17:93-106

مصطلحات موضوعية: Male, endocrine system, medicine.medical_specialty, medicine.medical_treatment, CHO Cells, Biology, Transfection, Glucagon, Islets of Langerhans, Mice, Organ Culture Techniques, Endocrinology, Cricetinae, Internal medicine, Insulin Secretion, medicine, Animals, Homeostasis, Insulin, Glucose homeostasis, Receptors, Somatostatin, Cloning, Molecular, Molecular Biology, Mice, Knockout, Somatostatin receptor, Pancreatic islets, Glucagon secretion, General Medicine, Insulin oscillation, Glucose, medicine.anatomical_structure, Somatostatin, Gene Targeting, Female, Somatostatin-28, Insulin Resistance

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc641e4f68bb4fcbf99e2337aab64484
https://doi.org/10.1210/me.2001-0035

المؤلفون: Xiao-Ming Guan, Douglas J. MacNeil, Myrna E. Trumbauer, Dawn E. Novi, Howard Y. Chen, Drew T. Weingarth, Yue Feng, Hong Yu, Airu Chen, Easter G. Frazier, Donald J. Marsh, Ramon E. Camacho, Shobhna Gopal-Truter, Lauren P. Shearman, Lex H.T. Van der Ploeg, Su Qian, Zhu Shen

المصدر: Molecular and Cellular Biology. 22:5027-5035

مصطلحات موضوعية: Central Nervous System, medicine.medical_specialty, Pro-Opiomelanocortin, Receptors, Peptide, Neuropeptide, Energy homeostasis, Mice, Proopiomelanocortin, Internal medicine, Orexigenic, mental disorders, Mammalian Genetic Models with Minimal or Complex Phenotypes, medicine, Animals, Homeostasis, Agouti-Related Protein, Neuropeptide Y, RNA, Messenger, Molecular Biology, Mice, Knockout, biology, Leptin, digestive, oral, and skin physiology, Proteins, Cell Biology, Neuropeptide Y receptor, humanities, Phenotype, Endocrinology, Receptors, Corticotropin, nervous system, Hypothalamus, biology.protein, Intercellular Signaling Peptides and Proteins, Receptor, Melanocortin, Type 4, Melanocortin, Energy Metabolism, hormones, hormone substitutes, and hormone antagonists, Receptor, Melanocortin, Type 3, Signal Transduction, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0152c7c06258272c0f0e426c1391cc9
https://doi.org/10.1128/mcb.22.14.5027-5035.2002