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المؤلفون: Monje M; Departments of Neurology & Neurological Sciences, Pediatrics, Pathology, Neurosurgery, and Psychiatry & Behavioral Sciences, Stanford University, Stanford, CA 94305, USA. Electronic address: mmonje@stanford.edu., Borniger JC; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., D'Silva NJ; Department of Periodontics and Oral Medicine, School of Dentistry, Department of Pathology, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA., Deneen B; Center for Cell and Gene Therapy, Department of Neurosurgery, Baylor College of Medicine, Houston, TX 77030, USA., Dirks PB; Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Center, Departments of Surgery and Molecular Genetics, Hospital for Sick Children, Toronto, ON M5G1X8, Canada., Fattahi F; Department of Biochemistry and Biophysics, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94115, USA., Frenette PS; Departments of Medicine and Cell Biology, Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA., Garzia L; Cancer Research Program, Research Institute of the McGill University Health Center and Department of Surgery, McGill University, Montreal, QC, Canada., Gutmann DH; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA., Hanahan D; Swiss Institute for Experimental Cancer Research, Swiss Federal Institute of Technology Lausanne, Ludwig Institute for Cancer Research, Swiss Cancer Center Leman, Lausanne, Switzerland., Hervey-Jumper SL; Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94115, USA., Hondermarck H; School of Biomedical Sciences and Pharmacy, Hunter Medical Research Institute, University of Newcastle, Callaghan, NSW 2308, Australia., Hurov JB; Cygnal Therapeutics, Cambridge, MA 02139, USA., Kepecs A; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Knox SM; Program in Craniofacial Biology, Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA., Lloyd AC; MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK., Magnon C; UMR1274 (Equipe Cancer et Microenvironnement-INSERM-CEA), Institut de Radiobiologie Cellulaire et Moléculaire, Institut de Biologie François Jacob, Direction de la Recherche Fondamentale, Paris, France., Saloman JL; Departments of Medicine and Neurobiology, University of Pittsburgh, Pittsburgh, PA 15260, USA., Segal RA; Department of Neurobiology, Harvard Medical School and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA., Sloan EK; Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC 3052, Australia., Sun X; Departments of Pediatrics and Biological Sciences, University of California at San Diego, La Jolla, CA 92093, USA., Taylor MD; Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Center, Developmental and Stem Cell Biology Program, Departments of Surgery, Laboratory Medicine & Pathology and Medical Biophysics, Hospital for Sick Children, Toronto, ON M5G1X8, Canada., Tracey KJ; The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY 11030, USA., Trotman LC; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Tuveson DA; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Wang TC; Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA., White RA; Division of Hematology and Oncology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA., Winkler F; Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, DKTK & Clinical Cooperation Unit Neurooncology, German Cancer Research Center, Heidelberg, Germany.

المصدر: Cell [Cell] 2020 Apr 16; Vol. 181 (2), pp. 219-222.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Neoplasms/*metabolism , Nervous System/*metabolism, Humans ; Neurosciences

المؤلفون: Ulanet DB; Agios Pharmaceuticals, Cambridge, Massachusetts, United States of America., Couto K; Agios Pharmaceuticals, Cambridge, Massachusetts, United States of America., Jha A; Agios Pharmaceuticals, Cambridge, Massachusetts, United States of America., Choe S; Agios Pharmaceuticals, Cambridge, Massachusetts, United States of America., Wang A; Agios Pharmaceuticals, Cambridge, Massachusetts, United States of America., Woo HK; Agios Pharmaceuticals, Cambridge, Massachusetts, United States of America., Steadman M; Agios Pharmaceuticals, Cambridge, Massachusetts, United States of America., DeLaBarre B; Agios Pharmaceuticals, Cambridge, Massachusetts, United States of America., Gross S; Agios Pharmaceuticals, Cambridge, Massachusetts, United States of America., Driggers E; Agios Pharmaceuticals, Cambridge, Massachusetts, United States of America., Dorsch M; Agios Pharmaceuticals, Cambridge, Massachusetts, United States of America., Hurov JB; Agios Pharmaceuticals, Cambridge, Massachusetts, United States of America.

المصدر: PloS one [PLoS One] 2014 Dec 12; Vol. 9 (12), pp. e115144. Date of Electronic Publication: 2014 Dec 12 (Print Publication: 2014).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Non-Small-Cell Lung/*drug therapy , Carcinoma, Non-Small-Cell Lung/*pathology , Glutaminase/*antagonists & inhibitors , Lung Neoplasms/*drug therapy , Lung Neoplasms/*pathology , Oxidative Stress/*drug effects , Sulfides/*pharmacology , Thiadiazoles/*pharmacology, Carcinoma, Non-Small-Cell Lung/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Enzyme Inhibitors/pharmacology ; Epithelial-Mesenchymal Transition ; Genetic Association Studies ; Glutaminase/metabolism ; Humans ; Lung Neoplasms/metabolism ; Molecular Targeted Therapy

المؤلفون: Bobrovnikova-Marjon E; Agios Pharmaceuticals, Cambridge, Massachusetts 02139; email: katya.marjon@agios.com , jonathan.hurov@agios.com., Hurov JB

المصدر: Annual review of medicine [Annu Rev Med] 2014; Vol. 65, pp. 157-70.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Annual Reviews Country of Publication: United States NLM ID: 2985151R Publication Model: Print Cited Medium: Internet ISSN: 1545-326X (Electronic) Linking ISSN: 00664219 NLM ISO Abbreviation: Annu Rev Med Subsets: MEDLINE

مواضيع طبية MeSH: Antimetabolites, Antineoplastic/*therapeutic use , Neoplasms/*drug therapy , Neoplasms/*metabolism, Biomarkers, Tumor/genetics ; DNA-Binding Proteins/genetics ; Fatty Acids/metabolism ; Glutamine/metabolism ; Humans ; Isocitrate Dehydrogenase/genetics ; Methotrexate/therapeutic use ; NAD/metabolism ; Neoplasms/genetics ; Phosphopyruvate Hydratase/genetics ; Signal Transduction ; Tumor Suppressor Proteins/genetics

المؤلفون: Emerling BM; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA., Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC

المصدر: Cell [Cell] 2013 Nov 07; Vol. 155 (4), pp. 844-57.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Breast Neoplasms/*metabolism , Phosphotransferases (Alcohol Group Acceptor)/*genetics , Phosphotransferases (Alcohol Group Acceptor)/*metabolism , Tumor Suppressor Protein p53/*genetics, Animals ; Breast Neoplasms/drug therapy ; Cell Line, Tumor ; Cell Proliferation ; Cell Respiration ; Cellular Senescence ; Embryo, Mammalian/metabolism ; Gene Knockdown Techniques ; Genes, Lethal ; Heterografts ; Humans ; Mice ; Neoplasm Transplantation ; Phosphotransferases (Alcohol Group Acceptor)/antagonists & inhibitors ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Tumor Suppressor Protein p53/metabolism

المؤلفون: DeLaBarre B; Agios Pharmaceuticals, Cambridge, Massachusetts 02139-4169, United States. byron.delabarre@agios.com, Gross S, Fang C, Gao Y, Jha A, Jiang F, Song J J, Wei W, Hurov JB

المصدر: Biochemistry [Biochemistry] 2011 Dec 20; Vol. 50 (50), pp. 10764-70. Date of Electronic Publication: 2011 Nov 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

مواضيع طبية MeSH: Allosteric Site*, Enzyme Inhibitors/*chemistry , Enzyme Inhibitors/*metabolism , Glutaminase/*antagonists & inhibitors , Glutaminase/*chemistry, Amino Acid Sequence ; Amino Acid Substitution ; Biocatalysis ; Databases, Protein ; Dimerization ; Glutaminase/genetics ; Glutaminase/metabolism ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/chemistry ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Kinetics ; Models, Molecular ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; Mutant Proteins/antagonists & inhibitors ; Mutant Proteins/chemistry ; Mutant Proteins/metabolism ; Point Mutation ; Protein Conformation ; Recombinant Proteins/antagonists & inhibitors ; Recombinant Proteins/chemistry ; Recombinant Proteins/metabolism ; Sequence Alignment ; Sulfides/chemistry ; Sulfides/metabolism ; Thiadiazoles/chemistry ; Thiadiazoles/metabolism

المؤلفون: Lennerz JK; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Hurov JB, White LS, Lewandowski KT, Prior JL, Planer GJ, Gereau RW 4th, Piwnica-Worms D, Schmidt RE, Piwnica-Worms H

المصدر: Molecular and cellular biology [Mol Cell Biol] 2010 Nov; Vol. 30 (21), pp. 5043-56. Date of Electronic Publication: 2010 Aug 23.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 8109087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5549 (Electronic) Linking ISSN: 02707306 NLM ISO Abbreviation: Mol Cell Biol Subsets: MEDLINE

مواضيع طبية MeSH: Adiposity/*physiology , Fatty Liver/*prevention & control , Gluconeogenesis/*physiology , Protein Serine-Threonine Kinases/*deficiency, Adiposity/genetics ; Alleles ; Animals ; Base Sequence ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/physiology ; Crosses, Genetic ; DNA Primers/genetics ; Dietary Fats/administration & dosage ; Embryonic Development/genetics ; Embryonic Development/physiology ; Energy Metabolism/genetics ; Energy Metabolism/physiology ; Fatty Liver/enzymology ; Fatty Liver/genetics ; Female ; Gluconeogenesis/genetics ; Insulin Resistance/genetics ; Insulin Resistance/physiology ; Male ; Mice ; Mice, Knockout ; Obesity/enzymology ; Obesity/genetics ; Obesity/prevention & control ; Phenotype ; Pregnancy ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/physiology ; Starvation/enzymology ; Starvation/genetics ; Starvation/physiopathology

المؤلفون: Hurov JB; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110-1093, USA., Huang M, White LS, Lennerz J, Choi CS, Cho YR, Kim HJ, Prior JL, Piwnica-Worms D, Cantley LC, Kim JK, Shulman GI, Piwnica-Worms H

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2007 Mar 27; Vol. 104 (13), pp. 5680-5. Date of Electronic Publication: 2007 Mar 19.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0027-8424 (Print) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation*, Adipose Tissue/*metabolism , Adiposity/*genetics , Cell Cycle Proteins/*physiology , Insulin/*metabolism , Insulin Resistance/*genetics , Obesity/*genetics , Protein Serine-Threonine Kinases/*physiology, Animals ; Female ; Glucose/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Time Factors