المؤلفون: Barbachyn, Michael R., Brickner, Steven J., Gadwood, Robert C., Garmon, Stuart A., Grega, Kevin C., Hutchinson, Douglas K., Munesada, Kiyotaka, Reischer, Robert J., Taniguchi, Mikio, Thomasco, Lisa M., Toops, Dana S., Yamada, Hiromi, Ford, Charles W., Zurenko, Gary E.

المساهمون: Rosen, Barry P., editor^Aff1, Mobashery, Shahriar, editor^Aff1

المصدر: Resolving the Antibiotic Paradox : Progress in Understanding Drug Resistance and Development of New Antibiotics. 456:219-238

المؤلفون: Ryan G. Keddy, Warren M. Kati, Tami Pilot-Matias, Nelson Lissa T, DeAnne Stolarik, Tatyana Dekhtyar, Rubina Mondal, Thomas Reisch, A. Chris Krueger, Hutchinson Douglas K, Donner Pamela L, John T. Randolph, Wenqing Gao, David A. Betebenner, Clarence J. Maring, Preethi Krishnan, Neeta S. Panchal, Christine A. Collins, Todd W. Rockway, Yi Gao, Teresa I. Ng, David W A Beno, John K. Pratt, Dachun Liu, Sachin V. Patel, Charles A. Flentge, Mark A. Matulenko, Rolf Wagner

المصدر: Journal of medicinal chemistry. 61(9)

مصطلحات موضوعية: Pyrrolidines, Genotype, viruses, Hepatitis C virus, Hepacivirus, medicine.disease_cause, Virus Replication, Antiviral Agents, Virus, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, 0302 clinical medicine, Interferon, Drug Discovery, medicine, Animals, Tissue Distribution, NS5A, biology, Chemistry, Ribavirin, virus diseases, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, Virology, digestive system diseases, Ombitasvir, Pibrentasvir, 030220 oncology & carcinogenesis, Drug Design, Molecular Medicine, 030211 gastroenterology & hepatology, Benzimidazoles, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0ea7f78cae0082405f10eb7a8974af
https://pubmed.ncbi.nlm.nih.gov/29653491

المؤلفون: Randolph, John T., Flentge, Charles A., Donner, Pamela, Rockway, Todd W., Patel, Sachin V., Nelson, Lissa, Hutchinson, Douglas K., Mondal, Rubina, Mistry, Neeta, Reisch, Thomas, Dekhtyar, Tatyana, Krishnan, Preethi, Pilot-Matias, Tami, Stolarik, Deanne F., Beno, David W.A., Wagner, Rolf, Maring, Clarence, Kati, Warren M.

المصدر: In Bioorganic & Medicinal Chemistry Letters 15 November 2016 26(22):5462-5467

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المؤلفون: Kenton L. Longenecker, G. Koev, A. Chris Krueger, Jill Beyer, Dachun Liu, John T. Randolph, Kent D. Stewart, Rolf Wagner, Warren M. Kati, Donner Pamela L, David W A Beno, Hutchinson Douglas K, Rubina Mondal, Yaya Liu, Todd W. Rockway, Hock B. Lim, Akhteruzzaman Molla, Clarence J. Maring, Charles A. Flentge, Christopher E. Motter, David A. Degoey

المصدر: Bioorganic & Medicinal Chemistry Letters. 23:3487-3490

مصطلحات موضوعية: Stereochemistry, Hepatitis C virus, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, medicine.disease_cause, Biochemistry, Ns5b polymerase, Bridged Bicyclo Compounds, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Enzyme Inhibitors, Uracil, Molecular Biology, NS5B, Bicyclic molecule, Aryl, Organic Chemistry, RNA-Dependent RNA Polymerase, Rats, chemistry, Replicon cell, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f742a15f796c0f4b5fec021cc5a862f
https://doi.org/10.1016/j.bmcl.2013.04.057

المؤلفون: Ben Hock Lim, Wen W. Jiang, Charles A. Flentge, Akhteruzzaman Molla, Hutchinson Douglas K, Darold L. Madigan, Clarence J. Maring, Rolf Wagner, Warren M. Kati, Yaya Liu, John T. Randolph

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:3747-3750

مصطلحات موضوعية: Genotype, High-throughput screening, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Protease Inhibitors, Nucleotide, Binding site, Uracil, Molecular Biology, NS5B, Polymerase, chemistry.chemical_classification, biology, Aryl, Organic Chemistry, virus diseases, RNA, Dihydrouracil, Molecular biology, digestive system diseases, Kinetics, Amino Acid Substitution, chemistry, biology.protein, Molecular Medicine, Transcription Initiation Site

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267a7d6e32ebd4620edc5318114598d2
https://doi.org/10.1016/j.bmcl.2012.04.017

المؤلفون: Rodger F. Henry, Gennadiy Koev, Larry L. Klein, David W A Beno, Debra Montgomery, John T. Randolph, Wen W. Jiang, Thomas Reisch, Charles A. Flentge, Warren M. Kati, Hutchinson Douglas K, Sherie Masse, Dale J. Kempf, Akhteruzzaman Molla, Kent D. Stewart, Lisa E. Hernandez, Peggy P. Huang, Yaya Liu, Hock Ben Lim, Rubina Mondal

المصدر: Journal of Medicinal Chemistry. 52:3174-3183

مصطلحات موضوعية: Genotype, Hepatitis C virus, Hepacivirus, Microbial Sensitivity Tests, Benzothiadiazines, medicine.disease_cause, Antiviral Agents, Structure-Activity Relationship, chemistry.chemical_compound, Bacterial Proteins, RNA polymerase, Drug Discovery, medicine, Animals, Tissue Distribution, Replicon, Enzyme Inhibitors, NS5B, Polymerase, chemistry.chemical_classification, biology, RNA-Dependent RNA Polymerase, Rats, Enzyme, Liver, Biochemistry, chemistry, Benzothiadiazine, Enzyme inhibitor, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ffd6390ce2350905b2a8bdf538f7a5
https://doi.org/10.1021/jm801485z

المؤلفون: Krueger, A. Chris, Randolph, John T., DeGoey, David A., Donner, Pamela L., Flentge, Charles A., Hutchinson, Douglas K., Liu, Dachun, Motter, Christopher E., Rockway, Todd W., Wagner, Rolf, Beno, David W.A., Koev, Gennadiy, Lim, Hock B., Beyer, Jill M., Mondal, Rubina, Liu, Yaya, Kati, Warren M., Longenecker, Kenton L., Molla, Akhteruzzaman, Stewart, Kent D., Maring, Clarence J.

المصدر: In Bioorganic & Medicinal Chemistry Letters 15 June 2013 23(12):3487-3490

المؤلفون: Charles W. Ford, Gary E. Zurenko, Hutchinson Douglas K, Betty H. Yagi, Janice M. Friis, D E Emmert, Michael J. Genin, Shobe Em, Jackson B. Hester, Stuart A. Garmon, Debra A. Allwine, Wade J. Adams, Ronda D. Schaadt, Judith C. Hamel, Douglas Stapert

المصدر: Journal of Medicinal Chemistry. 41:5144-5147

مصطلحات موضوعية: Male, Fastidious organism, Gram-negative bacteria, Colony Count, Microbial, Administration, Oral, medicine.disease_cause, Haemophilus influenzae, Microbiology, Rats, Sprague-Dawley, Moraxella catarrhalis, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Pyrroles, Oxazoles, Moraxella, Antibacterial agent, biology, Chemistry, Staphylococcal Infections, biology.organism_classification, Anti-Bacterial Agents, Rats, Injections, Intravenous, Pyrazoles, Molecular Medicine, Antibacterial activity, Bacteria

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ede7a71ce1717fa630e0f97cc748d9
https://doi.org/10.1021/jm980546k

المؤلفون: Ford Charles W, Robert A. Conradi, Jenifer L. Adamski, Randy M. Jensen, Debra A. Allwine, Barbachyn Michael R, John A. Tucker, Gary E. Zurenko, Jennifer L. Klock, Hutchinson Douglas K, Steven J. Brickner, Phillip S. Burton, Kevin C. Grega

المصدر: Journal of Medicinal Chemistry. 41:3727-3735

مصطلحات موضوعية: Staphylococcus aureus, Pyrimidine, Pyridines, Stereochemistry, Microbial Sensitivity Tests, Chemical synthesis, Permeability, Piperazines, Pyridazine, Structure-Activity Relationship, chemistry.chemical_compound, Morpholine, Acetamides, Drug Discovery, Enterococcus faecalis, Eperezolid, Humans, Triazene, Oxazoles, Oxazolidinones, Antibacterial agent, Linezolid, Staphylococcal Infections, Anti-Bacterial Agents, Piperazine, Streptococcus pneumoniae, chemistry, Molecular Medicine, Methicillin Resistance, Caco-2 Cells, Triazenes

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d34a88e0c2051e1805ace7c6383cf0a9
https://doi.org/10.1021/jm980274l