المؤلفون: Brest, Patrick, Gustafsson, Mattias, Mossberg, Anki, Gustafsson, Lotta, Düringer, Caroline, Hamiche, Ali, Svanborg, Catharina

المصدر: Cancer Research. 67(23):11327-11334

مصطلحات موضوعية: Histone Deacetylases: metabolism, Histones: metabolism, Histone Deacetylases: antagonists & inhibitors, Hela Cells: drug effects, Enzyme Inhibitors: pharmacology, Cyclin-Dependent Kinase Inhibitor p21: metabolism, Chromatin: ultrastructure, Chromatin: metabolism, Chromatin: drug effects, Cell Survival: drug effects, Acetylation: drug effects, Oleic Acids: pharmacology, Lactalbumin: pharmacology, Jurkat Cells: drug effects, Hydroxamic Acids: pharmacology, Medicin och hälsovetenskap, Klinisk medicin, Cancer och onkologi, Medical and Health Sciences, Clinical Medicine, Cancer and Oncology

URL الوصول: https://lup.lub.lu.se/record/1035674
http://www.ncbi.nlm.nih.gov/pubmed/18056459?dopt=Abstract
http://dx.doi.org/10.1158/0008-5472.CAN-07-1153

المؤلفون: Stylianou, Marios

المساهمون: Umeå universitet. Institutionen för klinisk mikrobiologi, Umeå universitet. Molekylär infektionsmedicin, Sverige

مصطلحات موضوعية: Mast cells, Candida albicans, Yeast to hyphal form, Antifungal drugs, Repurposed drugs, HTS, Antifungal agents -- pharmacology, Candida -- drug effects, Drug repositioning, Glycine -- analogs & derivatives, Hydroxamic acids -- pharmacology, Small molecule libraries -- pharmacology, High-throughput screening assays -- methods, Hyphae -- drug effects

URL الوصول: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-107713

Degree: Diss. (sammanfattning) Umeå : Umeå universitet, 2015

المؤلفون: Awada, Rayan, Verdier, Dorothée, Froger, Solène, Brulard, Eric, de Faria Maraschin, Simone, Etienne, Hervé, Breton, David

المساهمون: UMR - Interactions Plantes Microorganismes Environnement (UMR IPME), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD [France-Sud]), Département Systèmes Biologiques (Cirad-BIOS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)

المصدر: Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.810. ⟨10.1038/s41598-020-57800-6⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, 2020, 10 (1), pp.810. ⟨10.1038/s41598-020-57800-6⟩

مصطلحات موضوعية: MESH: Coffea / cytology, MESH: Hydroxamic Acids / pharmacology, lcsh:Medicine, MESH: Automation, Laboratory, Coffea, Pilot Projects, Hydroxamic Acids, Coffee, MESH: Hight-Throughput Screening Assays / methods, Embryogénèse somatique, lcsh:Science, MESH: Hydroxylamines / pharmacology, Active compounds, MESH: Seeds / cytology, Micropropagation, Coffea arabica, Somatic embryogenesis, MESH: Seeds / growth & development, [SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics, MESH: Reproducibility of Results, MESH: Quinolines / pharmacology, F02 - Multiplication végétative des plantes, Seeds, Quinolines, MESH: Coffea / drug effects, Plant Somatic Embryogenesis Techniques, MESH: Histone Deacetylase inhibitors / pharmacology, MESH: Hight-Throughput Screening Assays / instrumentation, MESH: Plant Somatic Embryogenesis Techniques / methods, Chemical libraries, Multiplication des plantes, Hydroxylamines, Article, Plant Cells, Régénération in vitro, High throughput optimization, MESH: Seeds / drug effects, Automation, Laboratory, Miniaturization, MESH: Plant Cells / drug effects, lcsh:R, Reproducibility of Results, Automated screening system, MESH: Miniaturization, MESH: Pilot Projects, Développement embryonnaire, High-Throughput Screening Assays, Histone Deacetylase Inhibitors, [SDV.BDD.EO]Life Sciences [q-bio]/Development Biology/Embryology and Organogenesis, lcsh:Q, U30 - Méthodes de recherche, Plant regeneration

وصف الملف: text

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ad560625731b76de1f486cba55a1089c
https://hal.umontpellier.fr/hal-03454869

المؤلفون: Raymond J. Pierce, Wolfgang Sippl, Julien Lancelot, Karin Schmidtkunz, Alokta Chakrabarti, Dina Robaa, Jelena Melesina, Tajith B. Shaik, Christophe Romier, Conrad V. Simoben, Manfred Jung, Srinivasaraghavan Kannan, Martin Marek

المساهمون: Romier, Christophe, Martin-Luther-Universität Halle Wittenberg (MLU), Albert-Ludwigs-Universität Freiburg, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), This work and the authors of this article received funding from the European Union’s Seventh Framework Programme for Research, Technological Development and Demonstration under Grant Agreements 241865 (SEtTReND) and 602080 (A-ParaDDisE). Further support was received by the Deutsche Forschungsgemeinschaft (Ju-295/13-1, SI-868/13-1). MM, TBS and CR are supported by institutional funds from the Centre National de la Recherche Scientifique (CNRS), the Institut National de la Santé et de la Recherche Médicale (INSERM) and the Université de Strasbourg., The authors acknowledge the support and the use of resources of the French Infrastructure for Integrated Structural Biology FRISBI ANR-10-INBS-05 and of Instruct-ERIC. We wish to thank members of the ESRF-EMBL joint structural biology groups and the SOLEIL synchrotron for the use of their beamline facilities and for help during data collection. We are grateful to Pierre Legrand (SOLEIL) for his kind assistance for data processing, Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)

المصدر: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules
Molecules, 2018, 23 (3), pp.566. ⟨10.3390/molecules23030566⟩
Molecules, Vol 23, Iss 3, p 566 (2018)
Molecules; Volume 23; Issue 3; Pages: 566
Molecules, MDPI, 2018, 23 (3), pp.566. ⟨10.3390/molecules23030566⟩

مصطلحات موضوعية: 0301 basic medicine, Pyrrolidines, MESH: Helminth Proteins/metabolism, MESH: Histone Deacetylases/metabolism, MESH: Histone Deacetylases/genetics, Pharmaceutical Science, MESH: Protein Structure, Secondary, Gene Expression, Apoptosis, Crystallography, X-Ray, Hydroxamic Acids, Molecular Docking Simulation, MESH: Helminth Proteins/antagonists & inhibitors, MESH: Chelating Agents/chemical synthesis, Protein Structure, Secondary, Analytical Chemistry, 0302 clinical medicine, MESH: Structure-Activity Relationship, MESH: Hydroxamic Acids/chemical synthesis, Drug Discovery, MESH: Zinc/metabolism, MESH: Animals, [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], MESH: Histone Deacetylase Inhibitors/pharmacology, Chelating Agents, Anthelmintics, biology, Chemistry, MESH: Anthelmintics/pharmacology, Helminth Proteins, Schistosoma mansoni, epigenetics, crystal structure, docking, histone deacetylase (HDAC) inhibitors, schistosomiasis, virtual screening, MESH: Histone Deacetylases/chemistry, 3. Good health, MESH: Schistosoma mansoni/drug effects, MESH: Pyrrolidines/pharmacology, Zinc, Biochemistry, Chemistry (miscellaneous), Molecular Medicine, Protein Binding, MESH: Apoptosis/drug effects, MESH: Gene Expression, In silico, 030231 tropical medicine, MESH: Zinc/chemistry, Article, Histone Deacetylases, lcsh:QD241-441, 03 medical and health sciences, Structure-Activity Relationship, lcsh:Organic chemistry, MESH: Molecular Docking Simulation, Structure–activity relationship, MESH: Protein Binding, Animals, MESH: Helminth Proteins/genetics, Protein Interaction Domains and Motifs, Physical and Theoretical Chemistry, MESH: Histone Deacetylase Inhibitors/chemical synthesis, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Virtual screening, MESH: Protein Interaction Domains and Motifs, Binding Sites, Organic Chemistry, MESH: Hydroxamic Acids/pharmacology, HDAC8, MESH: Schistosoma mansoni/growth & development, Epigenome, biology.organism_classification, MESH: Crystallography, X-Ray, MESH: Anthelmintics/chemical synthesis, Histone Deacetylase Inhibitors, 030104 developmental biology, MESH: Binding Sites, Docking (molecular), MESH: Chelating Agents/pharmacology, MESH: Schistosoma mansoni/enzymology, MESH: Helminth Proteins/chemistry, MESH: Schistosoma mansoni/genetics, MESH: Pyrrolidines/chemical synthesis

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57756972e5c4439f4e393638be3994b
http://europepmc.org/articles/PMC6017931

المؤلفون: Philippe Bertrand, Muriel Cuendet, Claudia A. Simões-Pires

المساهمون: School of Pharmaceutical Sciences, University of Geneva [Switzerland]-Université de Lausanne (UNIL), Environnements et Paléoenvironnements OCéaniques (EPOC), Observatoire aquitain des sciences de l'univers (OASU), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Poitiers-Institut de Chimie du CNRS (INC), Université de Lausanne (UNIL)-University of Geneva [Switzerland]

المصدر: Expert Opinion on Therapeutic Patents
Expert Opinion on Therapeutic Patents, Informa Healthcare, 2017, 27 (3), pp.229-236. ⟨10.1080/13543776.2017.1282945⟩
Expert Opinion on Therapeutic Patents, Vol. 27, No 3 (2017) pp. 229-236

مصطلحات موضوعية: 0301 basic medicine, Cell signaling, Antineoplastic Agents, Pharmacology, Histone Deacetylase 6, Hydroxamic Acids, Histone Deacetylases, Patents as Topic, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Neoplasms/drug therapy/pathology, Histone Deacetylases/drug effects, Neoplasms, Drug Discovery, Gene expression, medicine, Humans, Multiple myeloma, ComputingMilieux_MISCELLANEOUS, ddc:615, Hydroxamic acid, biology, Drug discovery, General Medicine, [CHIM.CATA]Chemical Sciences/Catalysis, HDAC6, medicine.disease, 3. Good health, Clinical trial, Histone Deacetylase Inhibitors, 030104 developmental biology, Histone, chemistry, 030220 oncology & carcinogenesis, Drug Design, biology.protein, Antineoplastic Agents/pharmacology, Histone Deacetylase Inhibitors/pharmacology, Hydroxamic Acids/pharmacology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef23a6b5d9f9421e1c0c336f4630210
https://hal.archives-ouvertes.fr/hal-02135789

المؤلفون: Nehad M. Alajez, Musaed Alfayez, Moustapha Kassem, Rimi Hamam, Dalia Ali, Abdullah Aldahmash

المصدر: Ali, D, Hamam, R, Alfayez, M, Kassem, M, Aldahmash, A & Alajez, N M 2016, ' Epigenetic Library Screen Identifies Abexinostat as Novel Regulator of Adipocytic and Osteoblastic Differentiation of Human Skeletal (Mesenchymal) Stem Cells ', Stem Cells Translational Medicine, vol. 5, no. 8, pp. 1036-1047 . https://doi.org/10.5966/sctm.2015-0331
Stem Cells Translational Medicine, Vol 5, Iss 8, Pp 1036-1047 (2016)

مصطلحات موضوعية: 0301 basic medicine, Epigenetic regulation of neurogenesis, Hydroxamic Acids, Epigenesis, Genetic, Myoblasts, Skeletal/drug effects, 0302 clinical medicine, Adipogenesis/drug effects, Osteogenesis, Histone deacetylase inhibitors, Signal Transduction/drug effects, Adipocytes, Oligonucleotide Array Sequence Analysis, lcsh:R5-920, Adipocyte, Adipogenesis, lcsh:Cytology, Osteoblast, Wnt signaling pathway, Epigenetic, Gene Expression Regulation, Developmental, Cell Differentiation, General Medicine, Benzofurans/pharmacology, Cell biology, Osteogenesis/drug effects, Mesenchymal Stem Cells/drug effects, Phenotype, 030220 oncology & carcinogenesis, Stem cell, lcsh:Medicine (General), Signal Transduction, Chromatin Immunoprecipitation, Genotype, Myoblasts, Skeletal, Transcription Factors/genetics, Biology, Epigenesis, Genetic/drug effects, Cell Line, 03 medical and health sciences, Osteoblasts/drug effects, Humans, Cell Lineage, Epigenetics, lcsh:QH573-671, Transcription factor, Benzofurans, Gene Library, Osteoblasts, Gene Expression Profiling, Mesenchymal stem cell, Computational Biology, Mesenchymal Stem Cells, Cell Biology, Cell-Based Drug Development, Screening, and Toxicology, equipment and supplies, Molecular biology, Histone Deacetylase Inhibitors, 030104 developmental biology, Cell Differentiation/drug effects, Mesenchymal stem cells, Histone deacetylase, Gene Expression Profiling/methods, Chromatin immunoprecipitation, Histone Deacetylase Inhibitors/pharmacology, Developmental Biology, Adipocytes/drug effects, Hydroxamic Acids/pharmacology, Transcription Factors

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a0470d79cc6be8aed62e38f8746b4a
https://europepmc.org/articles/PMC4954455/

المؤلفون: Hayashi-Takanaka, Y., Yamagata, K., Wakayama, T., Stasevich, T. J., Kainuma, T., Tsurimoto, T., Tachibana, M., Shinkai, Y., Kurumizaka, H., Nozaki, N., Kimura, Hiroshi

المصدر: Nucleic Acids Research

مصطلحات موضوعية: Male, Cell signaling, Methylation/drug effects, Blastocyst/metabolism, Histones/chemistry/immunology/*metabolism, Gene Regulation, Chromatin and Epigenetics, Hydroxamic Acids, Methylation, Epigenesis, Genetic, Histones, Immunoglobulin Fab Fragments, Mice, Histone H3, Single-cell analysis, Genetics, Animals, Humans, Epigenetics, Antibodies, Monoclonal/immunology, Cells, Cultured, Fluorescent Dyes, Regulation of gene expression, Chromosomes, Human, X, Microscopy, Confocal, biology, Lysine, Antibodies, Monoclonal, Acetylation, Histone Deacetylase Inhibitors, Protein Processing, Post-Translational, Blastocyst, Histone, Biochemistry, biology.protein, Somatic cell nuclear transfer, Female, Single-Cell Analysis, Histone Deacetylase Inhibitors/pharmacology, Hydroxamic Acids/pharmacology, Lysine/metabolism, Fluorescence Recovery After Photobleaching

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57c29c6637c4211c2a278b072222f19f
https://doi.org/10.1093/nar/gkr343

المؤلفون: Obrdlik, Ales, Kukalev, Alexander, Louvet, Emilie, Farrants, Ann-Kristin Ostlund, Caputo, Luca, Percipalle, Piergiorgio

المصدر: Mol Cell Biol. 28(20):6342-57

مصطلحات موضوعية: Acetylation/drug effects, Actins/*metabolism, Hela Cells, Heterogeneous-Nuclear Ribonucleoprotein U/*metabolism, Histones/metabolism, Humans, Hydroxamic Acids/pharmacology, Models, Genetic, Open Reading Frames/genetics, Phosphoproteins/metabolism, Phosphorylation/drug effects, Promoter Regions (Genetics)/genetics, Protein Binding/drug effects, Protein Structure, Tertiary, RNA/metabolism, RNA Polymerase II/chemistry/*metabolism, Repressor Proteins/metabolism, Transcription, Genetic/drug effects, p300-CBP Transcription Factors/*metabolism

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-15998
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=18710935&dopt=Citation

المؤلفون: Fu, Huamei, 1979, Dahlgren, Claes, 1949, Bylund, Johan, 1975

المصدر: Antimicrob Agents Chemother. 47(8):2545-50

مصطلحات موضوعية: MEDICAL AND HEALTH SCIENCES, MEDICIN OCH HÄLSOVETENSKAP, *Amidohydrolases, Aminopeptidases/*antagonists & inhibitors, Anti-Bacterial Agents/*pharmacology, Bacteria/drug effects/*metabolism, Chemotactic Factors/metabolism, Chemotaxis, Leukocyte/drug effects, Enzyme Inhibitors/*pharmacology, Escherichia coli/drug effects/metabolism, Escherichia coli Infections/microbiology, Humans, Hydroxamic Acids/*pharmacology, Interleukin-8/*metabolism, NADPH Oxidase/metabolism, Neutrophils/drug effects/metabolism

URL الوصول: https://gup.ub.gu.se/publication/48847

المؤلفون: Ullerås, E, Miller, S J, Adam, G I, Kanduri, C, Wilcock, A C, Franklin, G C

المصدر: Exp Cell Res. 270(2):188-98

مصطلحات موضوعية: Adenocarcinoma, Breast Neoplasms, Carcinoma, Hepatocellular, Choriocarcinoma, Chromosomes, DNA Methylation, Enhancer Elements (Genetics)/*physiology, Enzyme Inhibitors/pharmacology, Female, Gene Expression Regulation, Neoplastic/drug effects/physiology, Histone Deacetylases/*antagonists & inhibitors/metabolism, Humans, Hydroxamic Acids/pharmacology, Introns, Liver Neoplasms, Mutagenesis/physiology, Promoter Regions (Genetics)/*physiology, Proto-Oncogene Proteins c-sis/*genetics, Rhabdomyosarcoma, Transcription, Genetic/drug effects/physiology, Tumor Cells, Cultured

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-24794
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=11640883&dopt=Citation