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1دورية أكاديمية
المصدر: Hematology, Vol 29, Iss 1 (2024)
مصطلحات موضوعية: Venetoclax, t(11, 14), multiple myeloma, AML, acute myeloid leukemia, BCL2, B-cell lymphoma 2, CAR T-cell, chimeric antigen receptor T-cell, CLL, chronic lymphocytic leukemia, FDA, Food and Drug Administration, IC50, half maximal inhibitory concentration, IL-6: interleukin 6, IMiD, immune-modulators, MM, multiple myeloma, ORR, overall response rate, PFS, progression-free survival, PI, proteasome inhibitor, RRMM, relapsed/refractory multiple myeloma, Diseases of the blood and blood-forming organs, RC633-647.5
وصف الملف: electronic resource
Relation: https://doaj.org/toc/1607-8454
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المؤلفون: Erik De Clercq, Guangdi Li, Yali Wang
المصدر: Acta Pharmaceutica Sinica B. 12:1567-1590
مصطلحات موضوعية: NNRTI, Oncology, HAART, Dapivirine, IC50, half maximal inhibitory concentration, law.invention, F, bioavailability, RPV, rilpivirine, MSM, men who have sex with men, chemistry.chemical_compound, NNRTI, non-nucleoside reverse transcriptase inhibitor, Randomized controlled trial, law, t1/2, elimination half-life, Doravirine, CC50, the 50% cytotoxic concentration, EFV, efavirenz, 3TC, (−)-2′,3′-dideoxy-3′-thiacytidine (common name, lamivudine), General Pharmacology, Toxicology and Pharmaceutics, ABC, abacavir, ESV, elsulfavirine, FDA, US Food and Drug Administration, Drug discovery, AZT, 3′-azido-3′-deoxy-thymidine (common name, zidovudine), IAS-USA, International Antiviral Society-USA, BIC, bictegravir, HIV, human immunodeficiency virus, Clinical Practice, NRTI, nucleoside/nucleotide reverse transcriptase inhibitor, NRTI, DOR, doravirine, Rilpivirine, EC50, half maximal effective concentration, DPV, dapivirine, medicine.medical_specialty, EACS, European AIDS Clinical Society, DRV, darunavir, Tenofovir alafenamide, TAF, tenofovir alafenamide, FTC, (−)-2′,3′-dideoxy-5-fluoro-3′-thiacytidine (common name, emtricitabine), Internal medicine, medicine, HIV treatment, COBI, cobicistat, TDF, tenofovir disoproxil fumarate, CAB, cabotegravir, business.industry, HAART, highly active antiretroviral therapy, Clinical efficacy, Reverse transcriptase, EVG, elvitegravir, chemistry, ATV, atazanavir, DTG, dolutegravir, business
وصف الملف: Print-Electronic
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المؤلفون: Leon P. Loevenich, Thomas Engleitner, Marlies Michl, Sebastian Vosberg, Matjaz Rokavec, Andreas Jung, Heiko Hermeking, Philipp A. Greif, Jens Neumann, Jörg Kumbrink, Roland Rad, Thomas Kirchner, Peter Jung, Rupert Öllinger, Sophie L. Boos
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 517-540 (2022)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: Colorectal cancer, EdU, 5-ethynyl-2’-deoxyuridine, RNP, ribonucleoprotein, Cetuximab, RC799-869, DMSO, dimethyl sulfoxide, medicine.disease_cause, MEK, mitogen-activated protein/extracellular signal-regulated kinase kinase, eKRAS, clustered regularly interspaced short palindromic repeats/Cas9-generated KRASG12D, PDTO, patient-derived tumor organoid, PCR, polymerase chain reaction, ERK, extracellular signal-regulated kinase, GSEA, gene set enrichment analysis, IC50, half-maximal inhibitory concentration, CT-PDTO, chemotherapy-adapted patient-derived tumor organoid, 5’-FU, 5-fluorouracil, Medicine, E2F1, Epidermal growth factor receptor, ANOVA, analysis of variance, Original Research, Aurora Kinase A, biology, TOC, tumor organoid culture, Liver Neoplasms, Gastroenterology, AfaSel, afatinib + selumetinib, FOLFIRI, folinic acid, Combination chemotherapy, Diseases of the digestive system. Gastroenterology, ADF, advanced Dulbecco’s modified Eagle medium/F12, FFPE, formalin-fixed paraffin-embedded, Organoids, CRISPR, clustered regularly interspaced short palindromic repeats, CRC, colorectal cancer, FOLFIRI, Cas9, CRISPR-associated 9 protein, 5’-FU, irinotecan (or SN-38), KRAS, Colorectal Neoplasms, SN-38, irinotecan active metabolite, Chemoresistance, medicine.drug, AURKA, Aurora kinase A, CRC Organoid, c-MYC, c-MYC oncogene, cDNA, complementary DNA, Cmab, cetuximab, E2F, E2 transcription factor, RAS, rat sarcoma viral oncogene homolog, 3D, 3-dimensional, Humans, MSI, microsatellite instable, UMI, unique molecular identifier, EGF, epidermal growth factor, HER, human epithelial growth factor receptor, Hepatology, business.industry, PARP, poly-adenosine diphosphate ribose polymerase, LMU, Ludwig-Maximilians-University, medicine.disease, digestive system diseases, EGFR, epidermal growth factor receptor, Cancer research, biology.protein, TCGA, The Cancer Genome Atlas, business, MAPK, mitogen-activated protein kinase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230937cfbfdbfc2312a8988f38a35f08
http://www.sciencedirect.com/science/article/pii/S2352345X21002228 -
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المؤلفون: Kaneez Fatima, Abha Meena, Suaib Luqman, Nusrat Masood, Zahoor Ahmad Wani
المصدر: Journal of Advanced Research
مصطلحات موضوعية: TRIG, Triglyceraldehyde, Skin Neoplasms, Cell, DOXO, Doxorubicin, Hyaluronidase, Pharmacology, NaOH, Sodium hydroxide, Polymerization, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, Mice, 0302 clinical medicine, BIL, Bilirubin total & direct, Neomenthol, PEP A, pepstatin A, Cancer biomarker, MEF, Mean erythrocyte fragility, HYAL, Hyaluronidase, PBS, Phosphate buffer saline, CM-H2DCFDA, Chloromethyl derivative of dichloro fluorescin diacetate, HA, Hyaluronic acid, Epidermoid carcinoma, Human epidermoid carcinoma, 030220 oncology & carcinogenesis, RBC, Red blood cell, DMEM, Dulbecco’s minimal essential media, SRB, Sulphorhodamine B, BUN, Blood urea nitrogen, FACS, Fluorescence-Activated Cell Sorting, AKLP, Alkaline phosphatase, Hyaluronoglucosaminidase, NADPH, Nicotinamide adenine dinucleotide phosphate hydrogen, TMPD, N,N,N′,N′-tetramethyl-p-phenylenediamine, Article, 03 medical and health sciences, In vivo, Ehrlich Ascites Carcinoma, BE, Binding energy, Humans, CATD, Cathepsin D, LDH, Lactate dehydrogenase, COX-2, Cyclooxygenase 2, FOX, Ferrous oxidation-xylenol orange, DMSO, Dimethyl sulfoxide, mTOR, Mammalian target of rapamycin, In vitro, Ab/Am, Antibiotic/antimycotic, NRU, Neutral red uptake, EC50, Half maximal effective concentration, 030104 developmental biology, IC50, Half maximal inhibitory concentration, EAC, Ehlrich Ascites Carcinoma, RPMI, Roswell park memorial institute, ROS, Reactive oxygen species, 0301 basic medicine, HDL, High density lipoprotein, TNBS, Trinitrobenzenesulphonic acid, PI3K, Phosphotidyl inositol-3 kinase, URIC, Uric acid, DNA, Deoxyribonucleic acid, GAPDH, Glyceraldehyde 3-phosphate dehydrogenase, HEPES, N-2-hydroxyethylpiperazine-N′-2-ethanesulfonic acid, Tubulin, OECD, Organization for Economic Co-operation and Development, SGPT, Alanine aminotransferase, LOX-5, Lipoxygenase-5, DFMO, α-difluoro methyl ornithine, Multidisciplinary, WBC, White blood cell, Chemistry, ELISA, enzyme-linked immunosorbent assay, PKB/Akt, Protein kinase B, AA, Arachidonic acid, RNase A, Ribonuclease A, TPR, Total protein, Molecular Docking Simulation, medicine.anatomical_structure, TCA, Tricarboxylic acid, CHOL, Cholesterol, Ki, Inhibitory constant, medicine.drug, ODC, Ornithine decarboxylase, DHFR, Dihydrofolatereductase, BSA, Bovine serum albumin, PDB, Protein Data Bank, medicine, Animals, MMP, Mitochondrial membrane potential, DCFDA, 2′,7′ dichloro fluorescin diacetate, RNA, Ribonucleic acid, RIPA, Radio immune precipitation assay buffer, EDTA, Ethylene diamine tetra acetic acid, IC50, TPA, 12-O-Tetradecanoylphorbol-13-acetate, ComputingMethodologies_COMPUTERGRAPHICS, TRPM8, Transient receptor potential member 8, Cell Proliferation, HDAC, Histone deacetylase, MTX, Methotrexate, OF, Osmotic fragility, PI, Propidium iodide, FDA, Food and Drug Administration, HEK293 Cells, PDT, Podophyllotoxin, Cell culture, NAC, N-acetyl cysteine, SGOT, Aspartate aminotransferase, CRTN, Creatinine, FBS, Fetal bovine serum, PCR, Polymerase chain reaction, Rh123, Rhodamine 123, Ex vivo, IDT, Integrated DNA Technologies
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المؤلفون: Guanting Li, Wenli Zang, Kexin Shi, Xinyu Zhou, Shuwen Fu, Yinglei Zhai
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 92-106 (2022)مصطلحات موضوعية: α-PD-L1, anti-PD-L1 monoclonal antibody, Carrier-free, IC50, half maximal inhibitory concentration, ITM, immunosuppressive tumor microenvironment, Drug resistance, Review, EPI, epirubicin, Medicine, Nanotechnology, ACT, adoptive cell transfer, ZHO, Z-Histidine-Obzl, DPDNAs, dual pure drug nano-assemblies, General Pharmacology, Toxicology and Pharmaceutics, PTT, photothermal therapy, media_common, DBNP, DOX-Ber nano-assemblies, PDNAs, pure drug nano-assemblies, FRET, Forster Resonance Energy Transfer, ATO, atovaquone, PD-1, PD receptor 1, TME, tumor microenvironment, RBC, red blood cell, Self-assembly, QSNAP, quantitative structure-nanoparticle assembly prediction, Anticancer drug, Pure drug, Cancer treatment, DBNP@CM, DBNP were cloaked with 4T1 cell membranes, Nanomedicine, PAI, photoacoustic imaging, PDT, photodynamic therapy, YSV, tripeptide tyroservatide, Drug delivery, CPT, camptothecin, DCs, dendritic cells, TNBC, triple negative breast, HMGB1, high-mobility group box 1, Drug, Carrier free, ATP, adenosine triphosphate, CTLs, cytotoxic T lymphocytes, media_common.quotation_subject, ICG, indocyanine green, PD-L1, PD receptor 1 ligand, Cancer therapy, ICD, immunogenic cell death, RM1-950, BV, Biliverdin, GEF, gefitinib, PPa, pheophorbide A, ABC, accelerated blood clearance, Ce6, chlorine e6, ROS, reactive oxygen species, NSCLC, non-small cell lung cancer, HCPT, hydroxycamptothecin, Combination therapy, NIR, near-infrared, TEM, transmission electron microscopy, EPR, enhanced permeability and retention, MTX, methotrexate, Nano-DDSs, nanoparticulate drug delivery systems, NPs, nanoparticles, Ber, berberine, Poly I:C, polyriboinosinic:polyribocytidylic acid, UA, ursolic acid, SPDNAs, single pure drug nano-assemblies, business.industry, MPDNAs, multiple pure drug nano-assemblies, ICB, immunologic checkpoint blockade, CI, combination index, TLR4, Toll-like receptor 4, TA, tannic acid, TTZ, trastuzumab, Top I & II, topoisomerase I & II, DOX, doxorubicin, PTX, paclitaxel, EGFR, epithelial growth factor receptor, MDS, molecular dynamics simulations, RNA, ribonucleic acid, dsRNA, double-stranded RNA, Therapeutics. Pharmacology, business, MRI, magnetic resonance imaging
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المؤلفون: Kenneth K.W. To, Jiang Ma, Stella Chai, Chunyuan Zhang, Chun Yin, Sheng Yao, Xu Wu, Thomas Efferth, Yang Ye, Onat Kadioglu, Ge Lin
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1885-1902 (2021)مصطلحات موضوعية: ABCC1, ATP binding cassette subfamily C member 1, IC50, half maximal inhibitory concentration, Multidrug resistance, Pharmacology, NADPH, reduced nicotinamide adenine dinucleotide phosphate, F, bioavailability, chemistry.chemical_compound, PCR, polymerase chain reaction, 0302 clinical medicine, MDR, multidrug resistance, ECL, electrochemiluminescence, t1/2, elimination half-life, LC–MS, liquid chromatography coupled with mass spectrometry, N.D., not detected, General Pharmacology, Toxicology and Pharmaceutics, BBB, blood–brain barrier, media_common, ATF3, activating transcription factor 3, 0303 health sciences, Chemistry, ABC, ATP-binding cassette, NMPA, National Medical Products Administration, PXR, pregnane X receptor, SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, HBSS, Hankʹs balanced salt solution, ABCB1, Combination chemotherapy, Prodrug, Marsdenia tenacissima, Cmax, peak concentration, Paclitaxel, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, 030220 oncology & carcinogenesis, BHI, brain heart infusion, Original Article, AUC0–∞, area under plasma concentration vs. time curve, MRT, mean residence time, Drug, media_common.quotation_subject, RM1-950, Vd, volume of distribution, ABCB1, ATP binding cassette subfamily B member 1, UIC-2, mouse monoclonal ABCB1 antibody, ABCG2, ATP binding cassette subfamily G member 2, CYP, cytochrome P450 isozyme, PI, propidium iodide, TEER, transepithelial electrical resistance, 03 medical and health sciences, PBS, phosphate buffer saline, FBS, fetal bovine serum, Dox, doxorubicin, In vivo, POP, polyoxypregnane, medicine, 030304 developmental biology, EVOM, epithelial tissue voltohmmeter, Tmax, time for peak concentration, Cancer, LBE, lowest binding energy, PE, phycoerythrin, medicine.disease, Multiple drug resistance, Polyoxypregnane, Papp, apparent permeability, N.A., not applicable, Cancer cell, H&E, hematoxylin and eosin, MDR1a, multidrug resistance protein 1a, Therapeutics. Pharmacology, qPCR, quantitative PCR, M. tenacissima, Marsdenia tenacissima, CL, clearance, SD, standard derivation
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المؤلفون: Shengtao Yuan, Han Luwei, Dezhen Peng, Zhiqiang Wang, Hongzhi Du, Li Sun, Zhang Xian, Zhao Liwen, Danyu Du, Ligong Lu, Meixiao Zhan, Zhibo Zhang, Yong Li
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1526-1540 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: BCRP, breast cancer resistance protein, Metabolite, OATP, organic anion transporting polypeptide, IC50, half maximal inhibitory concentration, Preclinical efficacy, Papp, apparent permeability coefficient, chemistry.chemical_compound, 0302 clinical medicine, LC–MS/MS, liquid chromatography–tandem mass spectrometry, Medicine, PDX, patient-derived tumor xenograft, General Pharmacology, Toxicology and Pharmaceutics, AML, acute myeloid leukemia, MDR1, multidrug resistance protein 1, media_common, 0303 health sciences, α-KG, α-ketoglutaric acid, mIDH2 inhibitor, 2-Hydroxyglutarate, ADME, absorption, distribution, metabolism and excretion, 030220 oncology & carcinogenesis, Differentiation, CYP, cytochrome P450, Original Article, Drug, 2-HG, 2-hydroxyglutaric acid, Mutant isocitrate dehydrogenase 2 (mIDH2), media_common.quotation_subject, CDX, cell-line-derived xenograft, RM1-950, IDH2, Acute myeloid leukaemia, 03 medical and health sciences, mIDH2, mutant isocitrate dehydrogenase, Pharmacokinetics, SH1573, AUC, area under the cure, AG-221, enasidenib, Tumor metabolism, Carcinogen, 030304 developmental biology, PD, pharamacodynamics, business.industry, OCT, organ cation transporter, Clinical trial, chemistry, Cell culture, Pharmacodynamics, Cancer research, OAT, organic anion transporter, PK, pharmacokinetics, Therapeutics. Pharmacology, business, EPO, erythropoietin
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المؤلفون: Hong-Min Liu, Ya-Hong Wu, Yihui Song, Min Zhao, Bin Yu
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 750-762 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: PMSF, phenylmethanesulfonyl fluoride, LS, LEOPARD syndrome, Mutant, IC50, half maximal inhibitory concentration, Protein tyrosine phosphatase, HTS, high-throughput screening, chemistry.chemical_compound, 0302 clinical medicine, DiFMUP, 6,8-difluoro-4-methylumbelliferyl phosphate, General Pharmacology, Toxicology and Pharmaceutics, AML, acute myelogenous leukemia, Tm, melting temperature, 0303 health sciences, LB, lysogeny broth, SDS-PAGE, sodium dodecyl sulphate polyacyrlamide gel electrophoresis, High-throughput screening, R2, coefficient of determination, S/B, signal over background, STAT, signal transducer and activator of transcription, SHP2, Src homology phosphotyrosyl phosphatase 2, Biochemistry, 030220 oncology & carcinogenesis, Original Article, BTLA, B and T lymphocyte attenuator, PTP, protein tyrosine phosphatase, SH2, Src homology 2, Proto-oncogene tyrosine-protein kinase Src, Thermal shift assay, Allosteric regulation, Phosphatase, JAK, janus kinase, AKT, protein kinase B, SHP2-WT, wild type Src homology phosphotyrosyl phosphatase 2, SHP2-PTP, protein tyrosine phosphatase domain of Src homology phosphotyrosyl phosphatase 2, 03 medical and health sciences, PI3K, phosphatidylinositol 3 kinase, NS, Noonan syndrome, RAS, rat sarcoma, FI, fluorescence intensity, NPC, no protein control, 030304 developmental biology, ΔTm, melting temperature change, DiFMU, 6,8-difluoro-4-methylumbelliferyl hydroxid, ALK, anaplastic lymphoma kinase, lcsh:RM1-950, HEPES, 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, MEK, extracellular regulated protein kinase kinases, JMML, juvenile myelomonocytic leukaemia, Enzyme assay, PD-1, programmed death 1, p-IRS1, phosphorylated insulin receptor substrate 1, Bis-tris, bis-(2-hydroxyethyl)amino-tris(hydroxymethyl)methane, OD, optical density, lcsh:Therapeutics. Pharmacology, chemistry, DTT, dithiothreitol, SHP2, Allosteric inhibitors, Bioisostere, LOC, ligand only control, SD, standard deviation, MAPK, mitogen-activated protein kinase
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المؤلفون: Ademola O. Olaniran, Adegoke Isiaka Adetunji
المصدر: Saudi Journal of Biological Sciences, Vol 28, Iss 1, Pp 669-679 (2021)
Saudi Journal of Biological Sciencesمصطلحات موضوعية: 0106 biological sciences, 0301 basic medicine, Microorganism, Review, 01 natural sciences, sec, Second, E24, Emulsification index, Food science, MIC, Minimum inhibitory concentration, mg/L, Milligram per liter, lcsh:QH301-705.5, Surface-active compounds, chemistry.chemical_classification, nm, Nanometre, mN/M, Millinewton per metre, h, Hour, biology, Da, Dalton, Chemistry, µL, Microlitre, ˚C, Degree Celsius, CMC, Critical micelle concentration, Substrate type, %, Percent, General Agricultural and Biological Sciences, Two fluid, CTAB, Cethyltrimethylammonium bromide, ST, Surface tension, 03 medical and health sciences, mg/mL, Milligram per milliliter, Bioremediation, SACs, Surface active compounds, Amphiphile, Bioemulsifiers, Biotechnological applications, MBC, Minimum bactericidal concentration, KDa, Kilodalton, g/L, Gram per litre, Biomolecule, mL, Millilitre, µm, Micrometre, µg/mL, Microgram per milliliter, Microbial surfactants, Akt, Threonine protein kinase, biology.organism_classification, v/v, volume per volume, 030104 developmental biology, lcsh:Biology (General), Biosurfactants, IC50, Half-maximal inhibitory concentration, Fermentation, Bacteria, 010606 plant biology & botany
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff4edaafef2c68f596c24d908bfbed8
http://www.sciencedirect.com/science/article/pii/S1319562X20305465 -
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المؤلفون: Jia Meng, Yan Zhao, Guangying Shao, Shun Zhang, Zemei Ge, Baoxue Yang, Xiaoqiang Geng, Shuyuan Wang, Yue Xu, Min Li, Jinzhao He, Runtao Li, Guangping Chen, Hong Zhou, Jianhua Ran
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 181-202 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: AQP1, aquaporin 1, Fa, fraction absorbance, BCRP, breast cancer resistance protein, medicine.medical_treatment, IC50, half maximal inhibitory concentration, Urine, DMF, N,N-dimethylformamide, Pharmacology, Urea transporter inhibitor, chemistry.chemical_compound, CCK-8, cell counting kit-8, HDL-C and LDL-C, high- and low-density lipoprotein, PBS, phosphate buffered saline, Pharmacokinetics, Oral administration, P-gp, P-glycoprotein, medicine, Diuretic, IMCD, inner medulla collecting duct, General Pharmacology, Toxicology and Pharmaceutics, UT, urea transporter, GFR, glomerular filtration rate, lcsh:RM1-950, Transporter, CMC-Na, carboxymethylcellulose sodium, medicine.disease, Structure optimization, r.t., room temperature, Papp, apparent permeability, lcsh:Therapeutics. Pharmacology, chemistry, Toxicity, Urea, Original Article, Hyponatremia, THF, tetrahydrofuran
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