المؤلفون: Jin Zhai, Mary Jo Wildey, Elisa Passini, John Imredy, Frederick Sannajust, Kevin Fitzgerald, Anne Chain, Sebastian Polak, Christopher P. Regan, Pierre Morissette, Patrick Fanelli, Jeffrey Travis, Blanca Rodriguez

المصدر: Toxicology and Applied Pharmacology

مصطلحات موضوعية: 0301 basic medicine, ICH, The International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use, TN, True Negative, PPV, Positive Predictive Value, Pharmacology, TdP, Torsade de Pointes, Toxicology, Membrane Potentials, 0302 clinical medicine, HTS, High Throughput Screening, QTcVdW, Van de Water's Heart Rate QT-corrected Interval, In Silico modeling, Medicine, Translational PKPD modeling, NCEs, New Chemical Entities, CTD90, Ca2+-Transient Duration at 90% repolarization, education.field_of_study, Anesthetized Cardiovascular Guinea Pig, HR, Heart Rate, PNV, Predictive Negative Value, Safety pharmacology, ECG, Electrocardiogram, FIH, First in Human, IKr, rapidly-activating delayed rectifier potassium current, AP, Action Potential, QTc, Heart Rate corrected QT Interval, PX, PatchXpress®, 030220 oncology & carcinogenesis, Electrophysiologic Techniques, Cardiac, FP, False Positive, LVP, Left Ventricular Pressure, Anti-Arrhythmia Agents, In silico, Population, Guinea Pigs, QT interval, Models, Biological, Article, Ventricular action potential, Cell Line, CVGP, Cardiovascular Anesthetized Guinea Pig, GP, Guinea Pig, 03 medical and health sciences, hERG, Human Ether-a-go-go Related Gene, Pharmacokinetics, In vivo, Animals, Humans, Computer Simulation, education, QT corrected interval, BP, Blood Pressure, business.industry, M5P, M5 trees automated pruning model, tPKPD, thranslational pharmacokinetic/pharmacodynamic, FLIPR, Fluorescent Imaging Plate Reader, Arrhythmias, Cardiac, ORd, O'Hara Rudy model, Electrophysiological Phenomena, 030104 developmental biology, HEK293 Cells, Models, Chemical, Pharmacodynamics, Torsade de Pointes, EMw, Electromechanical window, FN, False Negative, TP, True Positive, Calcium, Calcium Channels, LOO, Leave-One-Out, business, APD90, Action Potential Duration at 90% repolarization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291b9744f97d46ac0f6fd500ad2e1c0f
http://europepmc.org/articles/PMC7322544

المؤلفون: Seong Woo, Choi, Si Won, Choi, Young Keul, Jeon, Sung-Hwan, Moon, Yin-Hua, Zhang, Sung Joon, Kim

المصدر: Redox Biology

مصطلحات موضوعية: Male, Patch-Clamp Techniques, Guinea Pigs, Action Potentials, Down-Regulation, LQTS, long QT syndrome, IKr, rapidly activating delayed rectifier potassium current in cardiomyocyte, ICa,L, L-type calcium current in cardiomyocyte, APD, action potential duration, Animals, Humans, IhERG, outward K+ current in hERG overexpressed conditions, Lipid peroxidant, Aldehydes, Cardiac action potential prolongation, hERG channel, Ether-A-Go-Go Potassium Channels, 4-hydroxynonenal, Oxidative Stress, HEK293 Cells, IKs, slowly activating delayed rectifier potassium current in cardiomyocyte, GPVM, guinea pig ventricular myocyte, Lipid Peroxidation, Protein Processing, Post-Translational, TA, total amplitude, RMP, resting membrane potential, Research Paper, Vmax, maximal upstroke velocity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::195ce9268c797b0cc4cbe698142f206d
https://pubmed.ncbi.nlm.nih.gov/30172983

المؤلفون: Zhang Z; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China., Li Y; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China., Yan M; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China., Yu T; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China., Yuan X; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China., Li S; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China.

المصدر: Biochemistry and biophysics reports [Biochem Biophys Rep] 2022 Dec 26; Vol. 33, pp. 101407. Date of Electronic Publication: 2022 Dec 26 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101660999 Publication Model: eCollection Cited Medium: Internet ISSN: 2405-5808 (Electronic) Linking ISSN: 24055808 NLM ISO Abbreviation: Biochem Biophys Rep Subsets: PubMed not MEDLINE