نتائج البحث - "IMMATURE FLAVIVIRUS PARTICLES"

1

Molecular mechanisms involved in antibody-dependent enhancement of dengue virus infection in humans

المصدر: Traffic. 14(1):25-35

مصطلحات موضوعية: dengue virus, molecular mechanisms, PREEXISTING ENHANCING ANTIBODIES, FC-GAMMA-RECEPTOR, intrinsic ADE, BORNE ENCEPHALITIS-VIRUS, WEST-NILE-VIRUS, immune responses, cell entry pathways, IMMATURE FLAVIVIRUS PARTICLES, HEMORRHAGIC-FEVER, ENVELOPE PROTEIN, HUMAN DENDRITIC CELLS, antibody-dependent enhancement, ORIGINAL ANTIGENIC SIN, MEDIATED NEUTRALIZATION

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dris___01423::7b107bdc2a4fe2ad39011c4f4e7887b0
https://research.rug.nl/en/publications/2c8ce2d6-71f4-4d31-9a0d-941f9f79abc3

View record at Wiley

2

Recognition determinants of broadly neutralizing human antibodies against dengue viruses

المؤلفون: Stéphane Duquerroy, Christine Girard-Blanc, William Shepard, Wiyada Wongwiwat, Giovanna Barba-Spaeth, Stéphane Petres, Félix A. Rey, Pablo Guardado-Calvo, Ahmed Haouz, Juthathip Mongkolsapaya, M. Erika Navarro Sanchez, Carlos M. Kikuti, Wanwisa Dejnirattisai, Philippe Dussart, Fernando Arenzana-Seisdedos, Alexander Rouvinski, Marie-Christine Vaney, Philippe Desprès, Gavin R. Screaton

المساهمون: Virologie Structurale - Structural Virology, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11), Imperial College London, Protéopole, Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), Interactions Moléculaires Flavivirus-Hôtes, Institut Pasteur [Paris] (IP), Pathogénie Virale - Viral Pathogenesis, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), Mahidol University [Bangkok], his work was made possible by a Pediatrics Dengue Vaccine Initiative grant to F.A.R., allowing the set up of a production facility of recombinant DENV sE. The co-crystallization with the bnAbs was done with European Union funding (DenFree consortium) to F.A.R. and G.R.S./J.M. F.A.R. acknowledges support from Insitut Pasteur, from the French Government’s ‘Investissements d’Avenir’ program: Laboratoire d’Excellence ‘Integrative Biology of Emerging Infectious Diseases’ (grant number ANR-10-LABX-62-IBEID) and the CNRS. G.S.R. and J.M. were supported by the Medical Research Council, UK, the Wellcome Trust, UK, the National Institute for Health Research Biomedical Research Centre, Funding Scheme. G.R.S. is a Wellcome Trust Senior investigator. We thank staffs at beam lines PROXIMA-1 and PROXIMA-2 at the SOLEIL synchrotron (St Aubin, France) and ID23-2 and ID29 at the European Synchrotron Radiation Facility (Grenoble, France)., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), Tortosa, Pablo, Integrative Biology of Emerging Infectious Diseases - - IBEID2010 - ANR-10-LABX-0062 - LABX - VALID, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris], Pathogénie Virale, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Medical Research Council (MRC), Wellcome Trust, Commission of the European Communities, Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur [Paris]

المصدر: Nature
Nature, 2015, 520 (7545), pp.109-113. ⟨10.1038/nature14130⟩
Nature, Nature Publishing Group, 2015, 520 (7545), pp.109-113. ⟨10.1038/nature14130⟩

مصطلحات موضوعية: Serotype, MECHANISM, Models, Molecular, MONOCLONAL-ANTIBODY, FAB FRAGMENTS, Protein Conformation, viruses, DROSOPHILA S2 CELLS, Dengue virus, medicine.disease_cause, Antibodies, Viral, Crystallography, X-Ray, Epitope, Dengue fever, Epitopes, FUSION, Viral Envelope Proteins, Virus maturation, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, 0303 health sciences, Multidisciplinary, REFINEMENT, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], BORNE ENCEPHALITIS-VIRUS, ENVELOPE GLYCOPROTEIN, 3. Good health, Multidisciplinary Sciences, Flavivirus, IMMATURE FLAVIVIRUS PARTICLES, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Science & Technology - Other Topics, [SDV.IMM]Life Sciences [q-bio]/Immunology, [SDV.IMM] Life Sciences [q-bio]/Immunology, General Science & Technology, [SDV.BBM.BS] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Molecular Sequence Data, Biology, Cross Reactions, Virus, MATURATION, 03 medical and health sciences, Species Specificity, MD Multidisciplinary, medicine, Humans, Antibody-dependent enhancement, 030304 developmental biology, Science & Technology, 030306 microbiology, Dengue Virus, medicine.disease, biology.organism_classification, Virology, Antibodies, Neutralizing, Solubility, Mutation, Protein Multimerization