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المؤلفون: Qilong Wang, Yanze Yang, Mei Du, Jinna Wei, Xianxian Zheng, Zhang Han, Erwei Liu, Xiumei Gao, Yuefei Wang, Patrick Kwabena Oduro
المصدر: Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 50-75 (2022)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: HFD, high-fat diet, Cys, cysteine, cGAS, cyclic GMP–AMP synthase, Review, Poly: I.C, polyinosinic-polycytidylic acid, SAVI, STING-associated vasculopathy with onset in infancy, Bioinformatics, PPI, protein–protein interface, TRAF6, tumor necrosis factor receptor-associated factor 6, TREX1, three prime repair exonuclease 1, STIM1, stromal interaction molecule 1, 0302 clinical medicine, AA, amino acids, GTP, guanosine triphosphate, MLKL, mixed lineage kinase domain-like protein, ICAM-1, intracellular adhesion molecule 1, Medicine, PDE3B/4, phosphodiesterase-3B/4, General Pharmacology, Toxicology and Pharmaceutics, IKK, IκB kinase, NF-κB, nuclear factor-kappa B, cGAMP, 2′,3′-cyclic GMP–AMP, NLRP3, NOD-, LRR- and pyrin domain-containing protein 3, 0303 health sciences, dsDNA, double-stranded DNA, TFAM, mitochondrial transcription factor A, Fatty liver, Damage-associated molecular patterns, IFNIC, interferon-inducible cells, CTD, C-terminal domain, Mitochondria, Crosstalk (biology), Cardiovascular diseases, SNPs, single nucleotide polymorphisms, 030220 oncology & carcinogenesis, Stimulator of interferon genes, AAD, aortic aneurysm and dissection, MI, myocardial infarction, IFNAR, interferon receptors, ER stress, CVDs, cardiovascular diseases, NASH, nonalcoholic steatohepatitis, Intracellular, CDG, c-di-GMP, NTase, nucleotidyltransferase, ATP, adenosine triphosphate, Ser, serine, mTOR, mammalian target of rapamycin, RM1-950, STING, stimulator of interferon genes, hSTING, human stimulator of interferon genes, AKT, protein kinase B, CDNs, cyclic dinucleotides, TLR, Toll-like receptors, ER, endoplasmic reticulum, 03 medical and health sciences, LBD, ligand-binding pocket, ROS, reactive oxygen species, YAP1, Yes-associated protein 1, IFN, interferon, ISGs, IRF-3-dependent interferon-stimulated genes, DAMPs, danger-associated molecular patterns, IFN-I, type 1 interferon, 030304 developmental biology, Inflammation, Ang II, angiotensin II, TNFα, tumor necrosis factor-alpha, business.industry, IRF3, interferon regulatory factor 3, CTT, C-terminal tail, Autophagy, TAK1, transforming growth factor β-activated kinase 1, Metabolic diseases, medicine.disease, HAQ, R71H-G230A-R293Q, IL, interleukin, mtDNA, mitochondrial DNA, AMPK, AMP-activated protein kinase, Sting, Apoptosis, TBK1, TANK-binding kinase 1, CBD, C-binding domain, LPS, lipopolysaccharides, NO2-FA, nitro-fatty acids, PKA, protein kinase A, NAFLD, nonalcoholic fatty liver disease, Therapeutics. Pharmacology, DsbA-L, disulfide-bond A oxidoreductase-like protein, business, Homeostasis, MST1, mammalian Ste20-like kinases 1, TM, transmembrane, STING, cGAS
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المؤلفون: Mahmoud Abu Eid, Emily P. Vonderhaar, Vera L. Tarakanova, Laura McOlash, Matthew J. Riese, Nicholas S. Barnekow, Donna McAllister, Michael B. Dwinell, Bryon D. Johnson
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 41-58 (2021)مصطلحات موضوعية: 0301 basic medicine, Chemokine, medicine.medical_treatment, RC799-869, Receptor, Interferon alpha-beta, Tumor-Intrinsic IFNAR Signaling, RT-PCR, reverse transcriptase polymerase chain reaction, Mice, 0302 clinical medicine, Tumor Microenvironment, Original Research, Mice, Knockout, biology, Gastroenterology, PDA, pancreatic ductal adenocarcinoma, Diseases of the digestive system. Gastroenterology, Cytokine, Flow Immunophenotyping, Stimulator of interferon genes, 030211 gastroenterology & hepatology, TAM, tumor-associated macrophage, medicine.symptom, Signal Transduction, Agonist, Receptors, CXCR3, medicine.drug_class, IFNAR, interferon-α/β-receptor, PBS, phosphate-buffered saline, Treg, regulatory T cell, Inflammation, STING, stimulator of interferon genes, SEM, standard error of the mean, 03 medical and health sciences, Immune system, Cell Line, Tumor, type I IFN, type I interferon, medicine, TDLN, tumor-draining lymph node, Animals, TIL, tumor-infiltrating lymphocyte, Tumor microenvironment, Hepatology, Antitumor Immunity, business.industry, IRF3, interferon regulatory factor 3, Membrane Proteins, DMEM, Dulbecco modified Eagle medium, eye diseases, Mice, Inbred C57BL, Sting, 030104 developmental biology, TBK1, TANK-binding kinase 1, biology.protein, Cancer research, business, SD, standard deviation
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المؤلفون: Tingting Chen, Ancheng Shen, Ao Zhang, Chunyong Ding, Zilan Song
المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 12, Pp 2272-2298 (2020)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: PD-L1, programmed death ligand 1, TBK1, medicine.medical_treatment, ICI, immune checkpoint inhibitor, DC50, concentration for 50% degradation, Review, ACMA, 9-amino-6-chloro-2-methoxyacridine, PD-1, programmed death receptor 1, ULD, ubiquitin-like domain, Anti-tumor, ABZI, amidobenzimidazole, 0302 clinical medicine, GMP, guanosine monophosphate, LBD, ligand-binding domain, GTP, guanosine triphosphate, PRRs, pattern recognition receptors, Interferon, cAIMP, cyclic adenosine-inosine monophosphate, Medicine, CMA, 10-carboxymethyl-9-acridanone, General Pharmacology, Toxicology and Pharmaceutics, IKK, IκB kinase, ISG, interferon stimulated gene, MinEC5×, minimum effective concentration for inducing 5-fold luciferase activity, 0303 health sciences, KD, kinase domain, dsDNA, double-stranded DNA, MG, Mangostin, ITC, isothermal titration calorimetry, Immunogenicity, PBMCs, peripheral-blood mononuclear cells, MDCK, Madin–Darby canine kidney, PROTACs, proteolysis targeting chimeras, FAA, flavone-8-acetic acid, CTD, C-terminal domain, DMXAA, 5,6-dimethylxanthenone-4-acetic acid, DSDP, dispiro diketopiperzine, STAT, signal transducer and activator of transcription, medicine.anatomical_structure, 030220 oncology & carcinogenesis, CDN, cyclic dinucleotide, QC, quinacrine, FP, fluorescence polarization, PDK1, 3-phosphoinositide-dependent protein kinase 1, Immunotherapy, Signal transduction, DCs, dendritic cells, CDA, cyclic diadenosine monophosphate (c-di-AMP), medicine.drug, Ntase, nucleotidyl transferase, ATP, adenosine triphosphate, CDG, cyclic diguanosine monophosphate (c-di-GMP), T cell, SDD, scaffold and dimerization domain, NF-κB, nuclear factor-κB, STING, stimulator of interferon genes, TNFRSF, tumor necrosis factor receptor superfamily, EM, cryo-electron microscopy, ER, endoplasmic reticulum, 03 medical and health sciences, MLK, mixed lineage kinase, Immune system, CBD, cyclic dinucleotide-binding domain, THIQCs, tetrahydroisoquinolone acetic acids, SAR, structure–activity relationship, HCQ, hydrochloroquine, ENPP1, ecto-nucleotide pyrophosphatase/phosphodiesterase, HTS, high throughput screening, 030304 developmental biology, MI, maximum induction, CXCL, chemokine (C-X-C motif) ligand, Innate immune system, PDE, phosphodiesterases, IO, immune-oncology, business.industry, IRF3, interferon regulatory factor 3, i.t., intratumoral, CTT, C-terminal tail, lcsh:RM1-950, BNBC, 6-bromo-N-(naphthalen-1-yl)benzo[d][1,3]dioxole-5-carboxamide, Chimeric antigen receptor, PPi, pyrophosphoric acid, Small molecule modulators, FDA, U.S. Food and Drug Administration, VHL, von Hippel–Lindau, lcsh:Therapeutics. Pharmacology, AMP, adenosine monophosphate, TBK1, TANK-binding kinase 1, Cancer research, cGAMP, cyclic guanosine monophosphate-adenosine monophosphate, business, cGAS, cyclic guanosine monophosphate-adenosine monophosphate synthase, CTLA-4, cytotoxic T lymphocyte associated protein 4, cGAS, STING
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المؤلفون: Wen Li, Hiroshi Kurihara, Chang Yan, Zhuo Luo, Rong-Rong He, Yi-Fang Li, Robert Dallmann, Xue Li
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 3, Pp 383-398 (2020)مصطلحات موضوعية: TRKA, tropomyosin receptor kinase A, CTCF, CCCTC-binding factor, GREs, GR response elements, viruses, Cell, GRs, glucocorticoid receptors, SGKs, serum and glucocorticoid-regulated protein kinases, Stimulation, Review, PTMs, post-translational modifications, Herpes simplex virus type 1, medicine.disease_cause, 0302 clinical medicine, NK cells, natural killer cells, REST, RE1-silencing transcription factor, H3K9, histone H3 on lysines 9, sncRNAs, small non-coding RNAs, HSV-1, herpes simplex virus type 1, General Pharmacology, Toxicology and Pharmaceutics, ICP, infected cell polypeptide, MOI, multiplicity of infection, 0303 health sciences, PDK1, pyruvate dehydrogenase lipoamide kinase isozyme 1, TRIM14, tripartite motif-containing 14, PRRs, pattern-recognition receptors, OCT-1, octamer binding protein 1, Reactivation, HSV-1, RANKL, receptor activator of NF-κB ligands, T3, thyroid hormone, humanities, medicine.anatomical_structure, 4E-BP, eIF4E-binding protein, CPE, cytopathic effect, 030220 oncology & carcinogenesis, Latency, HPK, herpetic simplex keratitis, AD, Alzheimer's disease, DCs, dendritic cells, TCM, traditional Chinese medicine, TRM, tissue resident memory T cells, Recurrent infections, HPT axis, hypothalamic–pituitary–thyroid axis, LAT, latency-associated transcripts, SIRT1, sirtuin 1, AMPK, AMP-dependent kinase, NGF, nerve growth factor, TK, thymidine kinase, DEX, dexamethasone, HPA axis, hypothalamo–pituitary–adrenal axis, mTOR, mammalian target of rapamycin, MAVS, mitochondrial antiviral-signaling protein, ORFs, open reading frames, Biology, Stress, CNS, central nervous system, Inhibitory postsynaptic potential, AKT, protein kinase B, HCF-1, host cell factor 1, Virus, 03 medical and health sciences, ROS, reactive oxygen species, CORT, corticosterone, PRC1, protein regulator of cytokinesis 1, PAMPs, pathogen-associated molecular patterns, medicine, Latency (engineering), 030304 developmental biology, Balance (ability), PML, promyelocytic leukemia protein, IRF3, interferon regulatory factor 3, lcsh:RM1-950, ND10, nuclear domains 10, LSD1, lysine-specific demethylase 1, CTL, cytotoxic T lymphocyte, HDACs, histone deacetylases, LRF, Luman/CREB3 recruitment factor, CoREST, REST corepressor 1, lcsh:Therapeutics. Pharmacology, cGAS, cyclic GMP-AMP synthase, Herpes simplex virus, TG, trigeminal ganglia, Susceptibility, PI3K, phosphoinositide 3-kinases, DAMPs, damage-associated molecular patterns, Immunology, PNS, peripheral nervous system, BCL-2, B-cell lymphoma 2, KLF15, Krüppel-like transcription factor 15
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المؤلفون: Chuanzhu Lv, Ling Huang
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 1, Pp 33-41 (2020)مصطلحات موضوعية: Oatp2, organic anion transport polypeptide 2, SRC1, steroid receptor coactivator 1, Review, Pharmacology, Xenobiotic receptors, chemistry.chemical_compound, AHR, aryl hydrocarbon receptor, 0302 clinical medicine, Glucocorticoid receptor, ARNT, AHR nuclear translocator, PRRs, pattern recognition receptors, Constitutive androstane receptor, GC, glucocorticoid, GREs, glucocorticoid receptor response elements, General Pharmacology, Toxicology and Pharmaceutics, Receptor, NOS, nitric oxide synthase, CYPs, cytochrome P450s, NF-κB, nuclear factor-kappa B, 0303 health sciences, Pregnane X receptor, biology, IBD, inflammatory bowel disease, PCN, pregnenolone-16α-carbonitrile, PXR, pregnane X receptor, NR, nuclear receptor, Inflammatory cytokines, CLP, cecum ligation and puncture, Sult, sulfonyl transferase, 030220 oncology & carcinogenesis, LPS, lipopolysaccharide, DMEs, drug-metabolizing enzymes, Drug-metabolizing enzymes, Mrp, phase III multidrug-resistant protein, COX-2, cyclooxygenase 2, IL-1β, interleukin-1β, HSP90, heat shock protein 90, IRF7, interferon regulatory factor 7, Proinflammatory cytokine, Sepsis, 03 medical and health sciences, PAS, Per/ARNT/Sim, Drug transporters, PKC, protein kinase C, medicine, Ugts, UDP-glucuronic transferase, 030304 developmental biology, Drug metabolism, GR, glucocorticoid receptor, business.industry, DREs, dioxin response elements, IRF3, interferon regulatory factor 3, lcsh:RM1-950, Gsts, phase II glutathione S-transferase, PLA2, phospholipase A2, STAT3, signal transducers and activators of transcription 3, medicine.disease, Aryl hydrocarbon receptor, P-gp, p-glycoprotein, TNF-α, tumor necrosis factor, lcsh:Therapeutics. Pharmacology, chemistry, biology.protein, Xenobiotic, business, AP-1, adaptor protein 1
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المؤلفون: Jiamin Du, Ruihan Chen, Qi Ling, Hong Zhu
المصدر: JHEP Reports
مصطلحات موضوعية: nonalcoholic fatty liver disease, cGAS-STING signalling, ssRNA, single-stranded RNA, Review, SAVI, STING-associated vasculopathy with onset in infancy, PD-L1, programmed cell death protein ligand-1, GVHD, graft-versus-host disease, IFN-I, type I interferon, TNF, tumour necrosis factor, chemistry.chemical_compound, NK cells, natural killer cells, Immunology and Allergy, ALD, alcohol-related liver disease, dsDNA, double-strand DNA, Toll-like receptor, PD-1, programmed cell death protein-1, XRCC, X-ray repair cross complementing, Gastroenterology, Pattern recognition receptor, hepatocellular carcinoma, Cell biology, TGF-β1, transforming growth factor-β1, Stimulator of interferon genes, IRI, ischaemia refusion injury, APCs, antigen-presenting cells, DCs, dendritic cells, HSCs, hepatic stellate cells, liver injury, TLR, Toll-like receptor, AIM2, absent in melanoma 2, NAFLD, non-alcoholic fatty liver disease, aHSCT, allogeneic haematopoietic stem cell transplantation, viral hepatitis, mTOR, mammalian target of rapamycin, STING, stimulator of interferon genes, Biology, CDNs, cyclic dinucleotides, ER, endoplasmic reticulum, AIM2, Cyclic guanosine monophosphate–adenosine monophosphate, PAMPs, pathogen-associated molecular patterns, Internal Medicine, MHC, major histocompatibility complex, NPCs, non-parenchymal cells, Innate immune system, Hepatology, IRF3, interferon regulatory factor 3, Pathogen-associated molecular pattern, LSECs, liver sinusoidal endothelial cells, PPRs, pattern recognition receptors, eye diseases, IL, interleukin, mtDNA, mitochondrial DNA, chemistry, siRNA, small interfering RNA, DAMPs, damage-associated molecular patterns, TBK1, TANK-binding kinase 1, innate immune response, KCs, Kupffer cells, cGAMP, cyclic guanosine monophosphate-adenosine monophosphate, cGAS, cyclic guanosine monophosphate-adenosine monophosphate synthase, HCC, hepatocellular carcinoma, IRF3
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المؤلفون: Michael Fenech, Micheline Kirsch-Volders
المساهمون: Kirsch-Volders, Micheline, Fenech, Michael, Cell Genetics, Biology
المصدر: Mutation Research. Reviews in Mutation Research
مصطلحات موضوعية: cGAS-STING, MAVS, mitochondrial anti-viral signaling protein, SASP, senescence associated secretory phenotype, Health, Toxicology and Mutagenesis, Lymphocyte, medicine.medical_treatment, cGAS, cyclic GMP–AMP synthase, Review, Micronuclei, Biology, ACE2, angiotensin-converting enzyme 2, DDR, DNA damage response, RONS, reactive oxygen and nitrogen species, Immune system, Chromosomal Instability, Chromosome instability, Genetics, medicine, Humans, viruses, aneuploidy, TMPRSS2, transmembrane protease serine 2, ARDS, acute respiratory distress syndrome, Micronuclei, Chromosome-Defective, Inflammation, STING, cyclic GMP–AMP receptor stimulator of interferon genes, SARS-CoV-2, IRF3, interferon regulatory factor 3, RNA, COVID-19, RNA virus, Aneuploidy, biology.organism_classification, Virology, MN, micronuclei or micronucleus, medicine.anatomical_structure, Cytokine, inflammation, PRR, pattern recognition receptors, Stimulator of interferon genes, micronuclei, RIG-1, retinoic acid-inducible gene I, Viruses, Micronucleus test, Cytokine Release Syndrome
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ebb62426c6e38a82d12572e12802e9
https://hdl.handle.net/11541.2/27002 -
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المؤلفون: Hemmen Sabir, Jibrin Danladi
المصدر: Journal of neuroimmunology 358, 577632-(2021). doi:10.1016/j.jneuroim.2021.577632
Journal of Neuroimmunologyمصطلحات موضوعية: 0301 basic medicine, HSF-1, heat shock factor 1, LRR, leucine-rich repeat domain, NSAIDs, Non-steroid anti-inflammatory drugs, HSPs, heat shock proteins, Disease, Review Article, TLRs, Toll-like receptors, Pathogenesis, 0302 clinical medicine, NF-kB, nuclear factor kappa-light-chain-enhancer of activated B-cells, drug effects [SARS-CoV-2], immunology [SARS-CoV-2], Immunology and Allergy, administration & dosage [COVID-19 Vaccines], immunology [COVID-19], Vector (molecular biology), MERS-CoV, Middle East Respiratory Syndrome-corona virus, Heat-Shock Proteins, COVID-19, coronavirus disease 2019, Innate immunity, ACE2, angiotensin converting enzyme 2, Heat shock protein, HSR, heat shock response, diagnosis [Cytokine Release Syndrome], IL-6, interleukin 6, Neurology, immunology [Cytokine Release Syndrome], RBD, receptor binding domains, medicine.symptom, Cytokine Release Syndrome, COVID-19 Vaccines, Coronavirus disease 2019 (COVID-19), Immunology, drug effects [Immunity, Innate], Inflammation, Biology, prevention & control [COVID-19], prevention & control [Cytokine Release Syndrome], 03 medical and health sciences, COX-2, Cyclooxygenase-2, immunology [COVID-19 Vaccines], medicine, JAK-STAT, Janus kinase/signal transducers and activators of transcription, adverse effects [COVID-19 Vaccines], Humans, IFN, interferon, SARS, severe acute respiratory syndrome, PG, prostaglandin, ddc:610, GSDMD, gasdermin D, ARDS, acute respiratory distress syndrome, Innate immune system, IFN-γ, interferon gamma, SARS-CoV-2, IRF3, interferon regulatory factor 3, TNF-α, tumor necrosis factor-alpha, immunology [Heat-Shock Proteins], COVID-19, ASC, apoptosis-associated speck-like protein containing a caspase recruitment domain, biochemical phenomena, metabolism, and nutrition, medicine.disease, diagnosis [COVID-19], Immunity, Innate, NLRP3 inflammasome, immunology [Immunity, Innate], 030104 developmental biology, Neurology (clinical), MRRs, microbial recognition receptors, Cytokine storm, 030217 neurology & neurosurgery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe94851777aa41431356f58c238b2f7
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المؤلفون: Jamal Saada, Ryan J. McAuley, Michela Marcatti, Tony Zifeng Tang, Massoud Motamedi, Bartosz Szczesny
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: NLRP3, nucleotide-binding domain leucine-rich repeat family, pyrin-domain containing 3, MCT3, monocarboxylate transporter 3, genetic structures, microglia, mitochondrial DNA, Retinal Pigment Epithelium, Biochemistry, BrDU, bromodeoxyuridine, 0302 clinical medicine, oxidative stress, 8-oxoG, 8-hydroxy-2′-deoxy-guanosine, AMD, age-related macular degeneration, IL, interleukins, 0303 health sciences, LDH, lactate dehydrogenase, TFAM, mitochondrial transcription factor A, qPCR, quantitative real-time PCR, EVs, extracellular vesicles, RNA-Binding Proteins, IP, immunoprecipitation, RIPK1 and RIPK3, kinases receptor-interacting protein 1 and 3, DNA-Binding Proteins, retinal pigment epithelial, extracellular vesicles, Retinal Pigments, Research Article, MTT assay, 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay, STING, stimulator of interferon genes, DNA, Mitochondrial, 03 medical and health sciences, ROS, reactive oxygen species, TLR9, Toll like receptor 9, Humans, IFN, interferon, Molecular Biology, 030304 developmental biology, Inflammation, ZBP1, Z-DNA binding protein 1, PLA, proximity ligation assay, IRF3, interferon regulatory factor 3, Epithelial Cells, Cell Biology, eye diseases, GOx, glucose oxidase, nuDNA, nuclear DNA, mtDNA, mitochondrial DNA, RPE, retinal pigment epithelial, CRLBP, cellular retinaldehyde-binding protein 1, cGAS, cyclic GMP-AMP synthase, TBK1, TANK-binding kinase 1, LA-qPCR, long amplicon semiquantitative PCR, sense organs, NTA, Nanoparticle Tracking Analysis, 030217 neurology & neurosurgery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6155e8a22f65e20ca59d4f81e0fe350e
https://doi.org/10.1016/j.jbc.2021.101523 -
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المؤلفون: Ruoxi Zhang, Rui Kang, Daolin Tang
المصدر: Chinese Journal of Traumatology
Chinese Journal of Traumatology, Vol 25, Iss 1, Pp 1-10 (2022)مصطلحات موضوعية: Medicine (General), type I IFNs, type I interferons, Review Article, PLCG1, phospholipase C gamma 1, CGAS, cyclic GMP-AMP synthase, Orthopedics and Sports Medicine, MLKL, mixed-lineage kinase domain-like pseudokinase, SQSTM1, sequestosome 1, ALK, ALK receptor tyrosine kinase, caspase, CASP, Shock, Septic, AKT, serine-threonine kinase, DMXAA, 5,6-dimethylxanthenone-4-acetic acid, TNFα, tumor necrosis factor α, CLP, cecal ligation and puncture, GPX4, glutathione peroxidase 4, medicine.symptom, HMGB1, high-mobility group box 1, Cell death, Programmed cell death, AIM2, absent in melanoma 2, Multiple Organ Failure, NF-κB, nuclear factor-κB, RIPK, receptor interacting serine/threonine-protein kinase, Inflammation, CDNs, cyclic dinucleotides, CXCL10, C-X-C motif chemokine ligand 10, CCL2, C-C motif chemokine ligand 2, Sepsis, ER, endoplasmic reticulum, R5-920, Immune system, Immunity, PAMPs, pathogen-associated molecular patterns, medicine, Autophagy, Humans, GSDMD, gasdermin D, PRRs, pattern-recognizing receptors, TLR9, toll-like receptor 9, Innate immune system, STING1, Septic shock, business.industry, IRF3, interferon regulatory factor 3, cfDNA, cell-free DNA, STING1, stimulator of interferon response cGAMP interactor 1, medicine.disease, Immunity, Innate, mtDNA, mitochondrial DNA, EGFR, epidermal growth factor receptor, IFNAR1, interferon alpha and beta receptor subunit 1, IL, interleukin, Immunology, DAMPs, damage-associated molecular patterns, TBK1, TANK-binding kinase 1, LPS, lipopolysaccharides, Surgery, GSDMD-N, N-terminal fragment of GSDMD, cGAMP, cyclic guanosine monophosphate-adenosine monophosphate, nDNA, nuclear DNA, business
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